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1. 发明公开

EP0934952A3 Peptides containing an N-substituted glycine residue 审中-公开
标题翻译： N-取代的含有甘氨酸的肽
公开(公告)号：EP0934952A3
公开(公告)日：1999-12-29
申请号：EP98124653.1
申请日：1998-12-24
申请人： Nisshin Flour Milling Co., Ltd.
发明人： Yanai, Makoto , Suzuki, Masashi , Oshida, Norio , Kawamura, Koji , Hiramoto, Shigeru , Yasuda, Orie , Kinoshita, Nobuhiro , Shingai, Akiko , Takasu, Masako
IPC分类号： C07K7/06 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00
摘要： A depsipeptide containing N-substituted glycine residue having the formula (1) or (2):
(wherein R 1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R 2 is a group of the formula -A-B-W-(D) m -(E) n , -A-B-W-(D) m -(E) n -F or -A-B-W-(D) m -(E) n -F-Z; R 3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, or a group of the formula -Z, -Z-G or -Z-G-J; A, B, D, E, F, G and J independently are an N-substituted glycine residue or a residue of an amino acid selected from the group consisting of alanine, valine, leucine, serine, etc.; Wand Z independently are a residue of an amino acid selected from the group consisting of an aspartic acid, a glutamic acid, etc.; at least one of A, B, D, E, F, G and J is an N-substituted glycine residue) or a pharmacologically acceptable salt thereof. The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.

2. 发明公开

EP0934952A2 Peptides containing an N-substituted glycine residue 审中-公开
标题翻译： N-取代基甘氨酸enthaltende肽
公开(公告)号：EP0934952A2
公开(公告)日：1999-08-11
申请号：EP98124653.1
申请日：1998-12-24
申请人： Nisshin Flour Milling Co., Ltd.
发明人： Yanai, Makoto , Suzuki, Masashi , Oshida, Norio , Kawamura, Koji , Hiramoto, Shigeru , Yasuda, Orie , Kinoshita, Nobuhiro , Shingai, Akiko , Takasu, Masako
IPC分类号： C07K7/06 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00
摘要： A depsipeptide containing N-substituted glycine residue having the formula (1) or (2):

(wherein R 1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R 2 is a group of the formula -A-B-W-(D) m -(E) n , -A-B-W-(D) m -(E) n -F or -A-B-W-(D) m -(E) n -F-Z; R 3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, or a group of the formula -Z, -Z-G or -Z-G-J; A, B, D, E, F, G and J independently are an N-substituted glycine residue or a residue of an amino acid selected from the group consisting of alanine, valine, leucine, serine, etc.; Wand Z independently are a residue of an amino acid selected from the group consisting of an aspartic acid, a glutamic acid, etc.; at least one of A, B, D, E, F, G and J is an N-substituted glycine residue) or a pharmacologically acceptable salt thereof.
The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.
摘要翻译：含有具有式（1）或（2）的N-取代的甘氨酸残基的缩酚酸肽：其中R 1是5-20个碳原子的直链或支链烷基或5或5的直链或支链烷氧基甲基 -15的碳原子; R2是式-ABW-（D）m-（E）n，-ABW-（D）m-（E）nF或-ABW-（D）m-（E）nFZ R3是羟基，低级烷氧基，苄氧基或式-Z，-ZG或-ZGJ的基团; A，B，D，E，F，G和J独立地是N-取代的甘氨酸残基或选自丙氨酸，缬氨酸，亮氨酸，丝氨酸等的氨基酸的残基; W和Z独立地是选自天冬氨酸，谷氨酸， A，B，D，E，F，G和J中的至少一个是N-取代的甘氨酸残基）或其药理学上可接受的盐。上述脱脂肽对载脂蛋白E的产生具有促进作用，可用作神经损伤，特别是痴呆和高脂血症的治疗剂。

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