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1. 发明公开

EP4137555A1 APPARATUS FOR BIOLOGICAL MICROORGANISM OBSERVATION 无效
公开(公告)号：EP4137555A1
公开(公告)日：2023-02-22
申请号：EP21191740.6
申请日：2021-08-17
申请人： Nagi Bioscience SA
发明人： CORNAGLIA, Matteo , TACHE, Fabien
IPC分类号： C12M1/34 , C12M3/06 , B01L3/00
摘要： Biological microorganism culture and observation apparatus (1) comprising a support structure (10), one or more chip holders (3) mounted on the support structure, a pump (P) and a valve system (V), each chip holder configured for holding a microfluidic chip (2) having one or more microfluidic channels (54) and culture chambers (52) therein extending between a pump coupling side (44a) of the microfluidic chip and a reservoir side coupling (44b) of the microfluidic chip. The support structure comprises a reservoirs support platform (7) mounted on a movable table (12), the reservoirs support platform (7) configured for holding a plurality of nutrition reservoirs (5) for containing biological microorganisms or nutrients and substances to be tested in a liquid. The chip holder (3) and/or microfluidic chips (2) comprise reservoir side fluidic couplings (26) in the form of hollow tubes extending from the microfluidic chip (2) to a tip (26b) at a free end of the hollow tube, each tip (26b) insertable in a corresponding nutrition reservoir (5). The movable table is coupled a height actuator mechanism (14) and an oscillating mechanism configured to oscillate the reservoir support platform (7) in a horizontal plane by an amplitude less than a diameter (D) of the nutrient reservoir (5), and actuate a vertical movement of the reservoirs support platform with the height actuator mechanism (14).

2. 发明公开

EP4388075A1 APPARATUS FOR MICROSCOPIC WORM OBSERVATION 审中-实审
公开(公告)号：EP4388075A1
公开(公告)日：2024-06-26
申请号：EP22764796.3
申请日：2022-08-16
申请人： Nagi Bioscience SA
发明人： CORNAGLIA, Matteo , TACHE, Fabien
IPC分类号： C12M3/06 , C12M1/00 , C12M1/34 , G01N33/50 , G01N35/10
CPC分类号： C12M23/16 , C12M41/36 , C12M23/40 , C12M41/14 , G01N33/5085 , G01N2333/4353420130101 , G01N33/5014 , G01N2035/0052420130101 , G01N2035/0035620130101

3. 发明公开

EP4388073A1 APPARATUS FOR MICROSCOPIC BIOLOGICAL ORGANISM OBSERVATION 审中-实审
公开(公告)号：EP4388073A1
公开(公告)日：2024-06-26
申请号：EP22764797.1
申请日：2022-08-16
申请人： Nagi Bioscience SA
发明人： CORNAGLIA, Matteo , TACHE, Fabien
IPC分类号： C12M1/34 , C12M3/06 , B01L3/00
CPC分类号： B01L3/502715 , B01L2200/068920130101 , B01L2400/048720130101 , B01L2200/14620130101 , B01L2200/14720130101 , G01N2035/0052420130101 , G01N2035/0035620130101

4. 发明公开

EP4137558A1 APPARATUS FOR MICROSCOPIC WORM OBSERVATION 无效
公开(公告)号：EP4137558A1
公开(公告)日：2023-02-22
申请号：EP21191741.4
申请日：2021-08-17
申请人： Nagi Bioscience SA
发明人： CORNAGLIA, Matteo , TACHE, Fabien
IPC分类号： C12M3/06 , C12M1/00 , C12M1/34 , G01N33/50 , G01N35/10
摘要： Microscopic worm culture and observation apparatus (1) comprising a support structure (10), one or more chip holders (3) mounted on the support structure, a pump (P) and a valve system (V), each chip holder configured for holding a microfluidic chip (2) having one or more microfluidic channels (54) and culture chambers (52) therein extending between a pump side coupling (44a) of the microfluidic chip and a reservoir side coupling (44b) of the microfluidic chip. The support structure comprises a reservoirs support platform (7) mounted on a movable table (12), the reservoirs support platform (7) configured for holding a plurality of nutrition reservoirs (5) for containing microscopic worms or nutrients and substances to be tested in a liquid. The chip holder (3) and/or microfluidic chips (2) comprise reservoir side fluidic couplings (26) in the form of hollow tubes extending from the microfluidic chip (2) to a tip (26b) at a free end of the hollow tube, each tip (26b) insertable in a corresponding nutrition reservoir (5). The support structure comprises an enclosure (15) forming a chamber within which the one or more chip holders and the reservoirs support platform is housed, and a temperature control unit (19) and a temperature sensor (23) for control of the temperature within the chamber, the enclosure comprising an openable or removable cover (17) allowing access to the inside of the enclosure.

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