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1. 发明公开

EP0667167A1 TOPICALLY ABSORBENT HEMOSTATIC MATERIAL 失效
标题翻译： TOPISCH ABSORBIERENDESHÄMOSTATISCHES材料。
公开(公告)号：EP0667167A1
公开(公告)日：1995-08-16
申请号：EP93923681.6
申请日：1993-11-02
申请人： NIPPON MEAT PACKERS, INC. , MITSUBISHI RAYON CO., LTD. , SHIMIZU, Yasuhiko
发明人： SHIMIZU, Yasuhiko , NATSUME, Toru, Research and Development Center , MAKIHARA, Toshikazu, Research and Development Ctr. , AKASAKA, Masanori, Prod. Developm. Lab. Mitsubishi , SAKAKIBARA, Hiroki, Mitsubishi Rayon Co., Ltd.
IPC分类号： A61L15/32
CPC分类号： A61L15/325 , A61L2400/04
摘要： A hemostatic material which is a cotton like material comprising the fibers of an atherocollagen prepared by regenerating a solubilized collagen, wherein the diameters of the collagen fibers range from 10 to 70 mm, the lengths of the fibers range from 3 to 70 mm, and at least part of the collagen molecules that constitute the fibers have been thermally cross-linked. Because this material comprises an assembly of the fibers having suitable lengths and diameters and at least part of the collagen molecules have been thermally cross-linked, it is improved in the effect of stopping bleeding as the first stage of hemostasis and has a sufficient hemostatic activity without detriment to the hemostatic effect inherent in collagen. In addtion, it has such an appropriate specific volum that it can readily be fabricated in accordance with the shape of the bleeding site, can rapidly be applied in effecting hemostasis, and can be brought into tight contact with the bleeding surface, thus having a high hemostatic effect.
摘要翻译：一种止血材料，其是棉状材料，其包含通过再生溶解胶原制备的动脉胶原纤维的纤维，其中胶原纤维的直径为10至70mm，纤维的长度为3-70mm，构成纤维的胶原分子的至少一部分已经被热交联。因为这种材料包括具有适当长度和直径的纤维的组合，并且胶原分子的至少一部分已经被热交联，所以改善止血作为止血的第一阶段的作用并具有足够的止血活性而不影响胶原蛋白固有的止血效果。此外，它具有可以容易地根据出血部位的形状制造的适当的体积，可以快速应用于止血，并且可以与出血表面紧密接触，因此具有高的止血效果。

2. 发明授权

EP0667167B1 ABSORBABLE TOPICAL HEMOSTAT 失效
标题翻译：可吸收局部用止血MEDIUM
公开(公告)号：EP0667167B1
公开(公告)日：2000-02-02
申请号：EP93923681.6
申请日：1993-11-02
申请人： NIPPON MEAT PACKERS, INC. , SHIMIZU, Yasuhiko
发明人： SHIMIZU, Yasuhiko , NATSUME, Toru, Research and Development Center , MAKIHARA, Toshikazu, Research and Development Ctr. , AKASAKA, Masanori, Prod. Developm. Lab. Mitsubishi , SAKAKIBARA, Hiroki, Mitsubishi Rayon Co., Ltd.
IPC分类号： A61L15/32
CPC分类号： A61L15/325 , A61L2400/04

3. 发明公开

EP1112725A1 ARTIFICIAL BLOOD VESSEL 审中-公开
标题翻译： KÜNSTLICHESBLUTGEFÄSS
公开(公告)号：EP1112725A1
公开(公告)日：2001-07-04
申请号：EP99933227.3
申请日：1999-08-03
申请人： Tapic International Co., Ltd. , Shimizu, Yasuhiko
发明人： SHIMIZU, Yasuhiko , TAMURA, Nobushige , TERAI, Hiromu , NAKAMURA, Tatsuo, Cosmo-today 1109 , YAMAMOTO, Yasumichi
IPC分类号： A61F2/06
CPC分类号： A61L27/3625 , A61F2/06 , A61L2430/36
摘要： An artificial blood vessel having the following characteristics: (1) having antithrombotic properties; (2) having tissue affinity; (3) enabling endothelium formation to occur quickly; and (4) allowing regeneration of host cells, and its production method. The artificial blood vessel is one extracted from a living body of a heterogeneous species from which all of the cellular components of the blood vessel has been removed. The production method of the artificial blood vessel comprises a step in which a blood vessel extracted from a living body of a heterogeneous species is washed with surfactant to remove all cellular components of said blood vessel.
摘要翻译：具有以下特征的人造血管：（1）具有抗血栓性质; （2）具有组织亲和性; （3）能够快速发生内皮形成; 和（4）允许宿主细胞的再生及其制备方法。人造血管是从血管的全部细胞成分除去的异种物质的活体中提取的。人造血管的制造方法包括以下步骤：用表面活性剂洗涤从异种物质的活体提取的血管以除去所述血管的所有细胞成分。

4. 发明公开

EP0965310A1 ARTIFICIAL BLOOD VESSEL 失效
标题翻译： KÜNSTLICHESBLUTGEFÄSS
公开(公告)号：EP0965310A1
公开(公告)日：1999-12-22
申请号：EP97913487.1
申请日：1997-12-02
申请人： Tapic International Co., Ltd. , SHIMIZU, Yasuhiko
发明人： SHIMIZU, Yasuhiko
IPC分类号： A61F2/06 , A61L27/00
CPC分类号： A61L27/58 , A61F2/06 , A61F2210/0004 , A61L27/24 , A61L27/507 , A61L2430/36
摘要： An artificial blood vessel comprising a tube made of a supporting skeletal material and a collagen layer of ultrafine fibers provided at least outside the tube, and a process for preparing the same. This vessel is advantageous in that the material therefor is easily available, that the application to a living body causes no significant rejection, that a suture may be held after implantation for a long period of time, and that, after a given period of time, it can be entirely or partially absorbed into the living body and decomposed.
摘要翻译：包括由支撑骨架材料制成的管和至少设置在管外部的超细纤维的胶原层的人造血管及其制备方法。该容器的优点在于，其材料容易获得，对生物体的应用不会引起明显的排斥，可以在植入后长时间保持缝合线，并且在给定的时间段之后，它可以完全或部分地吸收到生物体中并分解。

5. 发明公开

EP1201202A1 ARTIFICIAL NEURAL TUBE 审中-公开
标题翻译：克尔斯特里奇
公开(公告)号：EP1201202A1
公开(公告)日：2002-05-02
申请号：EP00940915.2
申请日：2000-07-03
申请人： Tapic International Co., Ltd. , Shimizu, Yasuhiko
发明人： SHIMIZU, Yasuhiko
IPC分类号： A61F2/04 , A61L27/00
CPC分类号： A61L27/58 , A61F2/04 , A61F2210/0004 , A61L27/18 , A61L27/227 , A61L27/24 , A61L2430/32 , C08L67/04
摘要： The present invention is to provide an artificial tube for nerve which remains in a body until a nerve regenerates, does not remain in the body as a foreign body after regeneration of the nerve, induces axons regenerated from severed nerve stumps, promotes infiltration of blood capillaries from the body and promotes regeneration of nerve tissue, and a method for producing the same. The artificial tube for nerve has fine fibrous collagen bodies (30) in the lumen of a tube comprised of a biodegradable and absorbable material, the voids inside the fine fibrous collagen bodies being filled with laminin.
摘要翻译：本发明提供一种人造神经管，保留在体内，直到神经再生，神经再生后不会留在体内作为异物，引起从断开的神经根再生的轴突，促进血管毛细血管渗透从身体促进神经组织的再生及其制造方法。用于神经的人造管在由可生物降解和可吸收材料组成的管的内腔中具有细纤维胶原体（30），细纤维胶原体内的空隙填充有层粘连蛋白。

6. 发明公开

EP1104680A1 TOPICALLY ABSORBENT HEMOSTATIC MATERIAL 审中-公开
标题翻译： TOPISCH ABSORBIERENDESHÄMOSTATISCHES材料
公开(公告)号：EP1104680A1
公开(公告)日：2001-06-06
申请号：EP99933226.5
申请日：1999-08-03
申请人： Tapic International Co., Ltd. , Shimizu, Yasuhiko
发明人： SHIMIZU, Yasuhiko , YAMAMOTO, Yasumichi , MATSUMOTO, Kazuya
IPC分类号： A61L15/64
CPC分类号： A61L15/64 , A61L15/26 , A61L15/325 , A61L2400/04 , C08L67/04
摘要： A topically absorbent hemostatic material which has an excellent adhesiveness to a bleeding wound face, is capable of exerting a sufficient and stable hemostatic effect, has no toxicity to a living body, is safely and quickly degraded in vivo after using and can be easily handled. This material is characterized in that a fiber surface made of a highly biocompatible and biodegradable material is coated with extracted collagen.
摘要翻译：能够发挥充分且稳定的止血效果，对生物体无毒性的，具有优异的与出血性伤口面粘合性的吸水性止血材料，使用后体内安全，快速地降解，易于处理。该材料的特征在于，由高度生物相容性和生物可降解材料制成的纤维表面涂覆有提取的胶原蛋白。

7. 发明公开

EP0943346A1 COLLAGEN MATERIAL AND PROCESS FOR PRODUCING THE SAME 失效
标题翻译： KERLAGENLAMINAT MATERIAL UND VERFAHREN ZU DESSEN HERSTELLUNG
公开(公告)号：EP0943346A1
公开(公告)日：1999-09-22
申请号：EP97912506.9
申请日：1997-11-19
申请人： Tapic International Co., Ltd. , SHIMIZU, Yasuhiko
发明人： SHIMIZU, Yasuhiko
IPC分类号： A61L27/00
CPC分类号： C08L89/06 , A61F2310/00365 , A61L27/24 , A61L31/044 , Y10S128/08 , Y10S623/909 , Y10S623/924 , Y10S623/925 , Y10T442/2525
摘要： The present invention relates to a collagen material comprising a laminate in which a collagen ultra-fine fibrous non-woven fabric-like multi-layer structure is sandwiched between non-fibrous collagen layers, a thread-like material containing said collagen material, their production processes, and a medical material containing said collagen material, and particularly a medical alternative membrane comprised of said medical material. These use collagen for their raw material without combining the use of a synthetic polymer material, possess physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and the alternative medical membrane can be used as a material for filling in the missing portions of biomembranes such as endocranium, pericardium, pleura, peritonium or serous membrane, presents no ethical problems, is in stable Supply, has no risk of infection, does not cause cell degeneration, allows control of the rate of degradation following application to the body, and has an action that promotes regeneration of biomembranes.
摘要翻译：本发明涉及包含层叠体的胶原材料，其中胶原超细纤维状无纺布状多层结构夹在非纤维胶原层之间，含有胶原材料的线状材料，其生产方法和含有所述胶原材料的医疗材料，特别是包含所述医疗材料的医疗替代膜。这些使用胶原蛋白作为其原料，而不合并使用合成聚合物材料，具有允许缝合同时仍然保持胶原蛋白固有的生物化学性质的物理性质，并且替代的医用膜可以用作填充材料在生物膜如内脏，心包膜，胸膜，peritonium或浆膜的缺失部分，不存在伦理问题，处于稳定供应，没有感染的风险，不会引起细胞变性，允许控制应用后的降解速率并且具有促进生物膜再生的作用。

8. 发明公开

EP0943345A1 ARTIFICIAL ESOPHAGUS 失效
标题翻译： KÜNSTLICHESPEISERÖHRE
公开(公告)号：EP0943345A1
公开(公告)日：1999-09-22
申请号：EP97912505.1
申请日：1997-11-19
申请人： Tapic International Co., Ltd. , SHIMIZU, Yasuhiko
发明人： SHIMIZU, Yasuhiko
IPC分类号： A61L27/00 , A61F2/04
CPC分类号： A61F2/04 , A61L27/34 , C08L89/06
摘要： The present invention is characterized by being an artificial esophagus having a fine fibrous collagen layer on the outer surface of a tube. The object of the present invention is to provide an artificial esophagus that is able to maintain for a desired duration the characteristic effect of collagen of promoting regeneration of esophageal epithelium at the portion where the esophagus is missing to regenerate a new esophagus, is degraded and absorbed by the body together with generation of new esophagus without leaving a foreign object in the body, has physical properties (strength) that do not require the surgeon who performs suturing to have a sophisticated technique, prevents hemorrhage and leakage of air from the sutured site, and allows a stent to be easily removed following esophagus reconstruction.
摘要翻译：本发明的特征在于在管的外表面上具有细纤维胶原层的人造食道。本发明的目的是提供一种人造食道，其能够维持期望的持续时间，在食管缺失的部分处再次产生食管上皮的部分，促进食管上皮再生的部位的胶原蛋白的特征性作用被降解和吸收通过身体连同新食管的生成，不会在身体中留下异物，具有不需要外科医生进行缝合以具有尖端技术的物理特性（强度），防止从缝合部位出血和泄漏空气，并允许在食管重建后容易地移除支架。

9. 发明授权

EP0945145B1 ARTIFICIAL NEURAL CANAL 失效
标题翻译：人工神经CHANNEL
公开(公告)号：EP0945145B1
公开(公告)日：2003-04-09
申请号：EP97912504.4
申请日：1997-11-19
申请人： Tapic International Co., Ltd. , SHIMIZU, Yasuhiko
发明人： SHIMIZU, Yasuhiko
IPC分类号： A61L27/00 , A61F2/04
CPC分类号： A61B17/1128 , A61F2/04 , A61L27/34 , A61L27/58 , A61L31/041 , A61L31/047 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/414 , A61L2300/604 , A61L2300/608 , A61L2430/32 , C08L89/06 , A61L31/044 , C08L5/10 , A61L31/148 , C08L67/04
摘要： The present invention offers an artificial tube for nerve which can remain in the body until the nerve regenerates while does not remain as a foreign body in the body following nerve regeneration, and which induces axons regenerated from severed nerve stumps, can promote infiltration of blood capillaries from the body and regeneration of nerve tissue. The present invention comprises a tube 10 or 20 having coating layers 12, 13 or 22, 23 composed of gelatin or collagen on the inner and outer surfaces of a tube 11 or 21 composed of a material being biodegradable and absorbable in vivo, and a collagen body 30 or 40 having cavities 32, 33 or 41 which pass through said tube so as to be substantially parallel to the axis of said tube; wherein, said cavities are filled with a matrix gel.

10. 发明公开

EP1245201A1 ARTIFICIAL TRACHEA 审中-公开
标题翻译： KÜNSTLICHETRACHEA
公开(公告)号：EP1245201A1
公开(公告)日：2002-10-02
申请号：EP00962972.6
申请日：2000-09-29
申请人： Tapic International Co., Ltd. , Shimizu, Yasuhiko
发明人： SHIMIZU, Yasuhiko , NAKAMURA, Tatsuo
IPC分类号： A61F2/04
CPC分类号： A61L27/16 , A61F2/04 , A61F2002/046 , A61L27/24 , A61L27/40 , A61L2430/22 , C08L23/12 , C08L89/06
摘要： The present invention has an object to provide an artificial trachea that is able to be used safely in the clinical application, and especially an artificial trachea for the intrathoracic trachea, and the artificial trachea comprises a polypropylene mesh tube for the base material, around the outer periphery of which a polypropylene filamentous stent is wound in a spiral shape, an amorphous collagen thin layer formed on the surface of the base material, and a fine fibrous collagen layer 20 formed on the inner and outer surface of the amorphous collagen thin layer, to which thermal dehydration crosslinking is performed.
摘要翻译：本发明的目的是提供一种能够在临床应用中安全使用的人造气管，特别是用于胸内气管的人造气管，并且人造气管包括用于基材的聚丙烯网管，围绕外侧其周边卷绕成螺旋形状的聚丙烯丝状支架，形成在基材表面上的无定形胶原薄层和形成在非晶胶原薄层的内表面和外表面上的细纤维胶原层20至进行热脱水交联。

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