专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1310494A1 PPAR (delta) ACTIVATORS 有权
标题翻译： PPAR（DELTA）AKTIVATOREN
公开(公告)号：EP1310494A1
公开(公告)日：2003-05-14
申请号：EP01955606.7
申请日：2001-08-09
申请人： NIPPON CHEMIPHAR CO., LTD.
发明人： SAKUMA, Shogo , ENDO, Tsuyoshi , TENDO, Atsushi , TAKAHASHI, Toshihiro , YOSHIDA, Shinichi , KOBAYASHI, Kunio , MOCHIZUKI, Nobutaka , YAMAKAWA, Tomio , KANDA, Takashi , MASUI, Seiichiro
IPC分类号： C07D263/32 , C07D277/24 , C07D413/04 , C07D263/48 , C07D263/34 , C07D277/28 , C07D417/04 , C07D233/64 , C07D233/70 , C07D233/88 , C07D233/90 , A61K31/421 , A61K31/4439 , A61K31/426 , A61K31/4164 , A61K31/4709 , A61K31/506 , A61K31/422 , A61K31/427
CPC分类号： C07D413/04 , C07D263/32 , C07D277/24
摘要： Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient: wherein R 1 and R 2 each are hydrogen, C 1-8 alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X 1 and X 2 are each a free valency, oxygen, S(O) p (wherein p is an integer of 0 to 2), C(=O), C(=O)NH, NHC(=O), CH=CH, or the like; Y is optionally substituted C 1-8 alkylene; Z is oxygen or sulfur; R 3 and R 4 are each optionally substituted C 1-8 alkyl; and R 8 is hydrogen or C 1-8 alkyl, with the proviso that when X 1 is a free valency, X 2 is not O or S(O) p , while when X 1 is C(=O)NH, X 2 is not a free valency.
摘要翻译：通式（I）化合物或其盐和含有化合物或其盐作为活性成分的PPARδ（过氧化物酶体增殖物激活受体δ）的活化剂：其中R 1和R 2各自为氢，C1- 8烷基，可被取代的芳基或杂环基等; A是氧，硫等; X 1和X 2各自为自由价，氧，S（O）p（其中p为0至2的整数），C（= O），C（= O）NH，NHC O），CH = CH等; Y为任选取代的C 1-8亚烷基; Z是氧或硫; R 3和R 4各自为任选取代的C 1-8烷基; 并且R 8是氢或C 1-8烷基，条件是当X 1是自由价时，X 2不是O或S（O）p，而当X 1是C（O） = O）NH，X 2不是自由价。

2. 发明公开

EP1118611A1 PROCESS FOR THE PREPARATION OF OXAZOLIDINONE DERIVATIVE 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON OXAZOLIDINON-DERIVATEN
公开(公告)号：EP1118611A1
公开(公告)日：2001-07-25
申请号：EP99944807.9
申请日：1999-09-24
申请人： NIPPON CHEMIPHAR CO., LTD.
发明人： YAMAMOTO, Masao , YOSHIDA, Shinichi
IPC分类号： C07D263/22
CPC分类号： C07D263/20 , C07D263/22
摘要： The invention relates to a process for preparing (5RS)-5-benzyl-3-[(1SR)-3-morpholino-1-phenylpropyl]-1,3-oxazolidin-2-one or its pharmacologically acceptable salt which is of value as a remedy for treatment of incontinence of urine and thamuria and which is performed by the steps of:

dissolving an acid and a mixture of (2RS)-1- [(1SR)-3-morpholino-1-phenylpropyl]amino-3-phenyl-2-propanol and (2RS) -1- ((lRS,) -3-morpholino-1-phenylpropyl] amino-3-phenyl-2-propanol in a solvent to obtain a salt of the former (1SR)-compound utilizing difference of solubility between the salt of (1SR)-compound and a salt of the latter (1RS)-compound;
bringing a basic compound into contact with the salt of (1SR)-compound to produce a free (1SR)-compound;
reacting thus produced (2RS)-1-[(1SR)-3-morpholino-1-phenylpropyl]amino-3-phenyl-2-propanol with a compound having the formula (I):

R 2 C=O (I)

wherein R represents a chlorine atom, an alkoxy group, an aryloxy group or an amino group, or a chloroformic acid ester; and
cyclizing the resulting product.
摘要翻译：本发明涉及制备（5RS）-5-苄基-3-Ä（1SR）-3-吗啉代-1-苯基丙基] -1,3-恶唑烷-2-酮或其药理学上可接受的盐的方法，其值为用于治疗尿和性尿失禁的治疗方法，其通过以下步骤进行：将酸和（2RS）-1-Ä（1SR）-3-吗啉代-1-苯基丙基氨基-3-苯基-2 丙醇和（2RS）-1 - （（1R，3R）-3-吗啉代-1-苯基丙基）氨基-3-苯基-2-丙醇在溶剂中反应，得到前者（1SR） - 化合物的盐，利用溶解度差异（1SR） - 化合物的盐和后者的盐（1RS） - 化合物之间;使碱性化合物与（1SR）化合物的盐接触以产生游离（1SR） - 化合物;如此制备的（1SR） 2RS）-1-Ä（1SR）-3-吗啉代-1-苯基丙基氨基-3-苯基-2-丙醇与具有式（I）的化合物反应：R2C = O其中R表示氯原子，烷氧基，芳氧基或氨基，或氯仿a 碳酸酯并使所得产品环化

3. 发明授权

EP1310494B1 PPAR (delta) ACTIVATORS 有权
标题翻译：的PPAR-δ激活剂
公开(公告)号：EP1310494B1
公开(公告)日：2012-01-25
申请号：EP01955606.7
申请日：2001-08-09
申请人： NIPPON CHEMIPHAR CO., LTD.
发明人： SAKUMA, Shogo , ENDO, Tsuyoshi , TENDO, Atsushi , TAKAHASHI, Toshihiro , YOSHIDA, Shinichi , KOBAYASHI, Kunio , MOCHIZUKI, Nobutaka , YAMAKAWA, Tomio , KANDA, Takashi , MASUI, Seiichiro
IPC分类号： C07D263/32 , C07D277/24 , C07D413/04 , C07D263/48 , C07D263/34 , C07D277/28 , C07D417/04 , C07D233/64 , C07D233/70 , C07D233/88 , C07D233/90 , A61P3/10 , A61P3/06 , A61P3/04 , A61P9/10 , A61P9/00 , C07D263/40 , C07D277/26 , A61K31/4164 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/4725 , A61K31/506
CPC分类号： C07D413/04 , C07D263/32 , C07D277/24
摘要： Compounds of the general formula (|) or salts thereof; and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient: (I) wherein R?1 and R2¿ are each hydrogen, C¿1-8? alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X?1 and X2¿ are each a free valency, oxygen, S(O)¿p? (wherein p is an integer of 0 to 2), C(=O), C(=O)NH, NHC(=O), CH=CH, or the like; Y is optionally substituted C1-8 alkylene; Z is oxygen or sulfur; R?3 and R4¿ are each optionally substituted C¿1-8? alkyl; and R?8¿ is hydrogen or C¿1-8? alkyl, with the proviso that when X?1¿ is a free valency, X2 is not O or S(O)¿p?, while when X?1¿ is C(=O)NH, X2 is not a free valency.

4. 发明授权

EP1757610B1 CONDENSED PYRIMIDINE DERIVATIVE AND XANTHINE OXIDASE INHIBITOR 有权
标题翻译：稠合嘧啶衍生物和黄嘌呤氧化酶抑制剂
公开(公告)号：EP1757610B1
公开(公告)日：2011-06-08
申请号：EP05751417.6
申请日：2005-06-13
申请人： Nippon Chemiphar Co., Ltd.
发明人： YOSHIDA, Shinichi , KOBAYASHI, Kunio , MOCHIDUKI, Nobutaka , YAMAKAWA, Tomio , KOBAYASHI, Tadashi , SHINOHARA, Yoriko
IPC分类号： C07D498/04 , A61K31/519 , A61P19/06 , A61P43/00 , C07D513/04
CPC分类号： C07D513/04 , C07D498/04
摘要： Disclosed is a compound represented by the following general formula (I) (wherein R1 represents an aryl group having 6-10 carbon atoms or a heteroaryl group which may have, as a substituent, a group selected from an alkyl group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms which is substituted with a halogen atom, an alkoxy group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms which is substituted with an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, a formyl group, a carboxyl group, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an aryl group having 6-10 carbon atoms and an aryloxy group having 6-10 carbon atoms; R2 represents a cyano group, a nitro group or the like; R3 represents an hydroxyl group or the like; X represents an oxygen atom, a sulfur atom or the like; and Y represents an oxygen atom or a sulfur atom). Also disclosed is a xanthine oxidase inhibitor containing such a compound.

5. 发明公开

EP1911760A1 XANTHINE OXIDASE INHIBITOR 审中-公开
标题翻译： XANTHINOXIDASEINHIBITOR
公开(公告)号：EP1911760A1
公开(公告)日：2008-04-16
申请号：EP06780819.6
申请日：2006-06-29
申请人： Nippon Chemiphar Co., Ltd.
发明人： NISHINO, Takeshi , YOSHIDA, Shinichi , TENDO, Atsushi , YAMAKAWA, Tomio , KOBAYASHI, Tadashi , SHINOHARA, Yoriko
IPC分类号： C07D473/00 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/541 , A61P19/06 , A61P43/00 , C07D498/04 , C07D513/04
CPC分类号： C07D473/00 , C07D498/04 , C07D513/04
摘要： A compound represented by the following formula (I) is used as a xanthine oxidase inhibitor:

in which R 1 is phenyl or pyridyl each optionally having, as a substituent, C 1-8 alkyl, C 1-8 haloalkyl, C 1-8 alkoxy, carboxyl, halogeno, hydroxyl, nitro, cyano, amino, etc.; R 2 is cyano, nitro, etc.; X is oxygen, sulfur, etc.; and Y is sulfur, NH, etc.
摘要翻译：将下式（I）表示的化合物用作黄嘌呤氧化酶抑制剂：其中R 1为苯基或吡啶基，每个任选具有C 1-8烷基，C 1-8卤代烷基，C 1-8烷基烷氧基，羧基，卤代，羟基，硝基，氰基，氨基等; R 2是氰基，硝基等; X是氧，硫等; Y为硫，NH等

6. 发明公开

EP1757610A1 CONDENSED PYRIMIDINE DERIVATIVE AND XANTHINE OXIDASE INHIBITOR 有权
标题翻译：新戊酰氧化酶抑制剂的邻苯二酚
公开(公告)号：EP1757610A1
公开(公告)日：2007-02-28
申请号：EP05751417.6
申请日：2005-06-13
申请人： Nippon Chemiphar Co., Ltd.
发明人： YOSHIDA, Shinichi , KOBAYASHI, Kunio , MOCHIDUKI, Nobutaka , YAMAKAWA, Tomio , KOBAYASHI, Tadashi , SHINOHARA, Yoriko
IPC分类号： C07D498/04 , A61K31/519 , A61P19/06 , A61P43/00 , C07D513/04
CPC分类号： C07D513/04 , C07D498/04
摘要： The invention relates to compounds of the following formula (I) or their salts:

in which R 1 is a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; R 2 is cyano, nitro, or the like; R 3 is hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.
摘要翻译：本发明涉及下式（I）的化合物或其盐：其中R 1是可具有取代基的苯基，萘基，吡啶基等基团，例如具有1-8个碳原子的烷基，具有1-8个碳原子的烷氧基，具有2-8个碳原子的烷氧基羰基，羧基，卤素，羟基，硝基或氰基; R 2是氰基，硝基等; R 3是羟基等; X是氧，硫等; Y为氧或硫，含有该化合物的黄嘌呤氧化酶抑制剂。

7. 发明授权

EP1452528B1 XANTHINE OXIDASE INHIBITORS 失效转让
标题翻译： XANTHINOXIDASEINHIBITOREN
公开(公告)号：EP1452528B1
公开(公告)日：2008-08-13
申请号：EP02780099.4
申请日：2002-11-14
申请人： NIPPON CHEMIPHAR CO., LTD.
发明人： YOSHIDA, Shinichi , TENDO, Atsushi , KOBAYASHI, Kunio , MOCHIDUKI, Nobutaka , YAMAKAWA, Tomio , SHINOHARA, Yoriko
IPC分类号： C07D235/18 , C07D263/56 , C07D277/66 , C07D471/04 , C07D473/30 , C07D473/34 , C07D473/40 , C07D498/04 , A61K31/4184 , A61K31/423 , A61K31/428 , A61P9/00
CPC分类号： C07D263/57 , C07D235/18 , C07D277/66 , C07D401/14 , C07D471/04 , C07D473/00 , C07D473/30 , C07D473/34 , C07D473/40 , C07D487/04 , C07D513/04
摘要： Compounds represented by the general formula (I), and xanthine oxidase inhibitors containing the same as the active ingredient: (I) wherein R1 is OR4 or the like (wherein R4 is optionally substituted C1-8 alkyl or the like); R2 is halogeno, nitro, cyano, carboxyl, or the like; R3 is hydrogen, halogeno, hydroxyl, amino, carboxyl, or the like; X is NR11, oxygen, or sulfur (wherein R11 is hydrogen or optionally substituted C1-8 alkyl); and Y and Z are each CR12 or nitrogen (wherein R12 is the same as defined for R3).

8. 发明公开

EP1452528A1 XANTHINE OXIDASE INHIBITORS 失效转让
标题翻译： XANTHINOXIDASEINHIBITOREN
公开(公告)号：EP1452528A1
公开(公告)日：2004-09-01
申请号：EP02780099.4
申请日：2002-11-14
申请人： NIPPON CHEMIPHAR CO., LTD.
发明人： YOSHIDA, Shinichi , TENDO, Atsushi , KOBAYASHI, Kunio , MOCHIDUKI, Nobutaka , YAMAKAWA, Tomio , SHINOHARA, Yoriko
IPC分类号： C07D235/18 , C07D263/56 , C07D277/66 , C07D471/04 , C07D473/30 , C07D473/34 , C07D473/40 , C07D498/04 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/519 , A61K31/52 , A61K31/522 , A61P3/00 , A61P13/12 , A61P19/06 , A61P43/00
CPC分类号： C07D263/57 , C07D235/18 , C07D277/66 , C07D401/14 , C07D471/04 , C07D473/00 , C07D473/30 , C07D473/34 , C07D473/40 , C07D487/04 , C07D513/04
摘要： The invention relates to compounds of the following formula (I) or their salts:
in which R 1 represents OR 4 or others, in which R 4 is an alkyl group having 1-8 carbon atoms which may have a substituent or the like; R 2 is halogen, nitro, cyano, carboxyl, or the like; R 3 is hydrogen, halogen, hydroxyl, amino, carboxyl, or the like; X is NR 11 , oxygen, or sulfur, in which R 11 is hydrogen, or an alkyl group having 1-8 carbon atom which may have a substituent; and each of Y and Z is CR 12 or nitrogen, in which R 12 has the same meaning as R 3 above, and a xanthine oxidase inhibitor containing the compound as an active ingredient.
摘要翻译：本发明涉及下式（I）的化合物或其盐：其中R 1表示OR 4或其它的其中R 4为具有1-8个碳原子的烷基的CHEM 可以具有取代基等; R 2是卤素，硝基，氰基，羧基等; R 3是氢，卤素，羟基，氨基，羧基等; X是NR 11，氧或硫，其中R 11是氢，或具有1-8个碳原子的可以具有取代基的烷基; Y和Z各自为CR 12或氮，其中R 12具有与上述R 3相同的含义，和含有该化合物作为活性成分的黄嘌呤氧化酶抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式