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1. 发明公开

EP2870128A1 AMINO ACID ANALOGUES AND METHODS FOR THEIR SYNTHESIS 审中-公开
标题翻译： AMINOSÄUREANALOGAUND VERFAHREN ZU IHRER SYNTHESE
公开(公告)号：EP2870128A1
公开(公告)日：2015-05-13
申请号：EP13812699.0
申请日：2013-07-08
申请人： Monash University
发明人： WANG, Zhen , ROBINSON, Andrea , SPICCIA, Nicolas Daniel , JACKSON, William Roy
IPC分类号： C07C6/04 , C07C227/16 , C07C5/03
CPC分类号： C07K1/006 , C07C269/06 , C07C2603/18 , C07D255/02 , C07J9/00 , C07J41/0055 , C07K2/00 , C07C271/22
摘要： A method for the synthesis of an amino acid analogue or a salt, solvate, derivative, isomer or tautomer thereof comprising the steps of: (i) subjecting an amino acid containing a metathesisable group to metathesis with a compound containing a complementary metathesisable group of formula (I) or (II): (Formulae (I), (II)) wherein R
1 and R
2 are independently selected from H and substituted or unsubstituted C
1 to C
4 alkyl; each R
3 is either absent or independently selected from a heteroatom, a substituted or unsubstituted C
1 to C
20 alkyl, and a substituted or unsubstituted C
1 to C
20 alkyl group interrupted by one or more heteroatoms; and each X is independently selected from H and an effector molecule; in the presence of a reagent to catalyse the metathesis to form a dicarba bridge between the amino acid containing a metathesisable group and the compound containing a complementary metathesisable group; and (ii) reducing the dicarba bridge to form a saturated dicarba bridge, wherein the reagent used to catalyse step (i) also catalyses step (ii).
摘要翻译：一种用于合成氨基酸类似物或其盐，溶剂化物，衍生物，异构体或互变异构体的方法，包括以下步骤：（i）使含有可复分解基团的氨基酸与含有互补可分解基团的化合物（I）或（II）：（式（I），（II））其中R 1和R 2独立地选自H和取代或未取代的C 1至C 4烷基; 每个R 3不存在或独立地选自杂原子，取代或未取代的C 1至C 20烷基和被一个或多个杂原子间隔的取代或未取代的C 1至C 20烷基; 并且每个X独立地选自H和效应分子; 在催化复分解的试剂存在下，在含有易位基团的氨基酸与含有互补易位基团的化合物之间形成二桥桥; 和（ii）还原二卡桥以形成饱和二碳桥，其中用于催化步骤（i）的试剂也催化步骤（ii）。

2. 发明公开

EP2488544A1 AFFINITY LIGANDS AND METHODS FOR PROTEIN PURIFICATION 有权
标题翻译：亲和配体和方法蛋白质纯化
公开(公告)号：EP2488544A1
公开(公告)日：2012-08-22
申请号：EP10822912.1
申请日：2010-10-15
申请人： Monash University
发明人： HEARN, Milton TW , BHAGWAT, Anjali Makarand , JACKSON, William Roy , MOUNTFORD, Simon John
IPC分类号： C07K1/22 , C07D213/70 , C07D217/22 , C07D213/32 , C07D215/36 , B01D15/08
CPC分类号： B01D15/3804 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3244 , B01J20/3251 , B01J20/3255 , C07D213/32 , C07D213/70 , C07D215/36 , C07D217/22 , C07K1/22
摘要： The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilise the adsorbents in the purification of proteins by affinity chromatography. The affinity ligand-matrix conjugates of the present invention comprise ligands of general formula (I): wherein m represents an integer from 0-2, n represents an integer from 0-6, p represents an integer from 0-4, R
1 represents H or C
1-3 alkyl, R
2 is an optional substituent, and X is the position at which the ligand is immobilized, optionally via a linker.

3. 发明公开

EP1984386A1 METHODS FOR THE SYNTHESIS OF TWO OR MORE DICARBA BRIDGES IN ORGANIC COMPOUNDS 有权
标题翻译：过程用于两个或更多的有机化合物在Dicarbabrücken合成
公开(公告)号：EP1984386A1
公开(公告)日：2008-10-29
申请号：EP07701508.9
申请日：2007-02-16
申请人： MONASH UNIVERSITY , Polychip Pharmaceuticals Pty. Ltd.
发明人： ROBINSON, Andrea Jane , JACKSON, William Roy , PATEL, Jim , ELARIDI, Jomana
IPC分类号： C07K1/107 , C07C5/23
CPC分类号： C07K1/061 , C07B37/04 , C07K1/006 , C07K1/107 , C07K1/1075 , C07K1/1077
摘要： The present invention relates to methods for forming two or more dicarba bridges in organic compounds, and compounds such as peptides containing two or more dicarba bridges. The series of reactions includes an unblocing reaction which comprises a cross-metathesis with a butadiene-free disposable olefin.

4. 发明公开

EP2870123A1 PROCESSES FOR PRODUCING AMINE COMPOUNDS 审中-公开
标题翻译：生产胺类化合物的过程
公开(公告)号：EP2870123A1
公开(公告)日：2015-05-13
申请号：EP13813996.9
申请日：2013-07-08
申请人： Monash University
发明人： ROBINSON, Andrea J , SPICCIA, Nicolas , JACKSON, William Roy , WOODWARD, Clint
IPC分类号： C07B37/00 , C07B35/00 , C07C209/68 , C07C209/70 , C07C227/16 , C07C231/12 , C07D213/127
CPC分类号： C07C227/16 , C07B35/02 , C07B37/08 , C07C209/68 , C07C209/70 , C07D213/127 , C07C211/22 , C07C211/27 , C07C229/30 , C07C229/08
摘要： The present invention provides processes for producing amine-containing compounds such as diammonium salts and amino acid derivatives comprising the steps of subjecting a salt of an amine bearing an unsaturated group to a self-metathesis reaction with itself to produce a diammonium salt or to a cross-metathesis with a suitable α,β-unsaturated acid, ester or amide to form an amino acid salt or a derivative thereof. The salts produced by the metathesis reactions can then be subjected to hydrogenation to reduce the double bond which is formed in the metathesis reaction.
摘要翻译：本发明提供了制备含胺化合物如二铵盐和氨基酸衍生物的方法，包括使带有不饱和基团的胺的盐与自身发生自身复分解反应以产生二铵盐或交叉 - 与合适的α，β-不饱和酸，酯或酰胺反应以形成氨基酸盐或其衍生物。然后可以使通过复分解反应产生的盐进行氢化以减少在复分解反应中形成的双键。

5. 发明授权

EP2488544B1 AFFINITY LIGANDS AND METHODS FOR PROTEIN PURIFICATION 有权
标题翻译：亲和配体和方法蛋白质纯化
公开(公告)号：EP2488544B1
公开(公告)日：2015-03-18
申请号：EP10822912.1
申请日：2010-10-15
申请人： Monash University
发明人： HEARN, Milton TW , BHAGWAT, Anjali Makarand , JACKSON, William Roy , MOUNTFORD, Simon John
IPC分类号： B01J20/286 , B01J20/289 , C07D213/70 , C07D217/22 , C07D213/32 , C07D215/36 , B01D15/08 , C07K1/22
CPC分类号： B01D15/3804 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3244 , B01J20/3251 , B01J20/3255 , C07D213/32 , C07D213/70 , C07D215/36 , C07D217/22 , C07K1/22

6. 发明公开

EP1899398A1 CROSSLINKING METHOD 审中-公开
标题翻译：交联方法
公开(公告)号：EP1899398A1
公开(公告)日：2008-03-19
申请号：EP06760832.3
申请日：2006-06-30
申请人： Orica Australia Pty Ltd , MONASH UNIVERSITY
发明人： SUCH, Christopher Henry , PATEL, Jim , JACKSON, William Roy , ROBINSON, Andrea Jane , SERELIS, Algirdas Kazimieras
IPC分类号： C08G61/00 , C09D191/00 , C07C67/347 , C09J191/00
CPC分类号： C09D165/00 , C07C67/333 , C08G61/00 , C11C3/00 , C07C69/533
摘要： The invention provides a method of preparing a crosslinked polymer, which method comprises polymerising branched polyunsaturated monomers by a metathesis polymerisation reaction, wherein the branched polyunsaturated monomers contain acyclic ethylenically unsaturated groups that are capable of undergoing polymerisation by a metathesis reaction such that the metathesis polymerisation produces a crosslinked polymer and substantially no non-volatile ethylenically unsaturated by-products.
摘要翻译：本发明提供了一种制备交联聚合物的方法，该方法包括通过易位聚合反应使支化多不饱和单体聚合，其中所述支化多不饱和单体含有能够通过易位反应进行聚合的无环烯属不饱和基团，使得易位聚合产生交联聚合物且基本上不含非挥发性烯键式不饱和副产物。

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