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1. 发明授权

EP2538972B1 RECOMBINANT CDV COMPOSITIONS AND USES THEREOF 无效转让
标题翻译：重组CDV组合物及其用途
公开(公告)号：EP2538972B1
公开(公告)日：2018-04-25
申请号：EP11707047.4
申请日：2011-02-25
申请人： Merial, Inc.
发明人： AUDONNET, Jean-Christophe , MINKE, Jules
IPC分类号： A61K39/12 , A61K39/175 , A61K39/205 , A61K39/23 , C07K14/015 , C07K14/12 , C07K14/13 , C07K14/145 , C07K14/165 , C12N7/00 , C12N7/04 , C12N15/86
CPC分类号： A61K39/175 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55522 , A61N5/0613 , C07K14/005 , C07K14/535 , C12N7/00 , C12N2710/24043 , C12N2750/14334 , C12N2760/18422 , C12N2760/18434 , C12N2760/18471 , C12N2800/22
摘要： Apparatuses and methods for the prevention, reduction, or elimination of tissue injury by the application of electromagnetic energy. The apparatuses and methods have application for use in various tissues within diverse regions of the body, including for the prevention, reduction, or elimination of acute kidney injury, kidney failure, and contrast-induced nephropathy.

2. 发明授权

EP3093025B1 BLUETONGUE VIRUS RECOMBINANT VACCINES AND USES THEREOF 有权转让
公开(公告)号：EP3093025B1
公开(公告)日：2018-08-01
申请号：EP16171113.0
申请日：2011-03-11
申请人： Merial Inc.
发明人： AUDONNET, Jean-Christophe , GUO, Xuan , COX, Kevin
IPC分类号： A61K39/135 , C12N15/82
CPC分类号： C07K14/005 , A61K39/12 , A61K39/15 , A61K2039/517 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , C12N15/8258 , C12N2720/12134
摘要： The present invention encompasses BTV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing BTV antigens. The invention also encompasses recombinant vectors encoding and expressing BTV antigens, epitopes or immunogens which can be used to protect animals, such as ovines, bovines, or caprines, against BTV.

3. 发明授权

EP2358742B1 VACCINE AGAINST AFRICAN HORSE SICKNESS VIRUS 有权转让
标题翻译：疫苗对非洲马疾病病毒
公开(公告)号：EP2358742B1
公开(公告)日：2018-02-28
申请号：EP09760655.2
申请日：2009-10-22
申请人： Merial, Inc. , The Regents of the University of California , University Of Pretoria
发明人： MINKE, Jules, Maarten , AUDONNET, Jean-Christophe , GUTHRIE, Alan, John , MACLACHLAN, Nigel, James , YAO, Jiansheng
IPC分类号： C07K14/14
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/86 , C12N2710/24043 , C12N2720/12122 , C12N2720/12134
摘要： The present invention provides vectors that contain and express in vivo the genes encoding VP2 and VP5 of African Horse Sickness Virus or an epitope thereof that elicits an immune response in a horse against African horse sickness virus, compositions comprising said vectors, methods of vaccination against African horse sickness virus, and kits for use with such methods and compositions.

4. 发明授权

EP2827897B1 RECOMBINANT EQUINE HERPESVIRUS-1 VACCINE CONTAINING MUTATED GLYCOPROTEIN C AND USES THEREOF 无效转让
公开(公告)号：EP2827897B1
公开(公告)日：2018-10-31
申请号：EP13719247.2
申请日：2013-03-15
申请人： Merial, Inc.
发明人： AUDONNET, Jean-Christophe , MINKE, Jules, Maarten , OSTERRIEDER, Nikolaus , MA, Guanggang
IPC分类号： A61K39/245 , C12N7/04
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2710/16021 , C12N2710/16034 , C12N2710/16722 , C12N2710/16734 , C12N2710/16762
摘要： The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising said recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions.

5. 发明公开

EP3197486A1 FMDV RECOMBINANT VACCINES AND USES THEREOF 审中-公开
标题翻译： FMDV重组疫苗及其用途
公开(公告)号：EP3197486A1
公开(公告)日：2017-08-02
申请号：EP15775553.9
申请日：2015-09-23
申请人： Merial Inc.
发明人： AUDONNET, Jean-Christophe , HANNAS-DJEBBARA, Zahia , MEBATSION, Teshome , CHIANG, Yu-Wei , WIDENER, Justin , REYNARD, Frédéric
IPC分类号： A61K39/12
CPC分类号： A61K39/135 , A61K39/12 , A61K2039/5258 , A61K2039/545 , A61K2039/55577 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/14043 , C12N2770/32123 , C12N2770/32134
摘要： The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
摘要翻译：本发明包括FMDV疫苗或组合物。疫苗或组合物可以是含有FMDV抗原的疫苗或组合物。本发明还包括编码和表达FMDV抗原，表位或免疫原的重组载体，所述FMDV抗原，表位或免疫原可用于保护动物，特别是绵羊，牛，猫或猪免受FMDV的损害。

6. 发明公开

EP3142486A1 METHODS FOR FREEZE-DRYING AND REHYDRATING BIOLOGICS 无效转让
标题翻译：维生素ZR GEFRIERTROCKNUNG UND REHYDRIEREN BIOLOGISCHEN SUBSTANZEN
公开(公告)号：EP3142486A1
公开(公告)日：2017-03-22
申请号：EP15725948.2
申请日：2015-05-13
申请人： Merial, Inc. , Vitamfero S.A , L'Institut National Superieur des Sciences Agronomiques de l'Alimentation &de l'Environnement , L'Université de Bourgogne
发明人： GENIN, Noel Yves Henri Jean , AUDONNET, Jean-Christophe , ROY, Didier , SECHE, Edouard , GERVAIS, Patrick , KHALDI-PLASSART, Samira , USEO, Romain , DE CONINCK, Joëlle
IPC分类号： A01N1/02 , A61K39/002 , A61K9/19
CPC分类号： A61K39/002 , A01N1/02 , A01N1/0221 , A01N1/0278 , A01N1/0284 , A61K9/0019 , A61K9/19 , A61K2039/522 , Y02A50/41 , Y02A50/412
摘要： The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the present invention relates to methods for freeze-drying biological preparations, including peptides, antigens, antibodies, and especially, cells. Importantly, the disclosed methods preserve the viability, infectivity and immunogenicity of cells from the Apicomplexa phylum, the Sarcocystidae family, and in particular, cells from the Toxoplasma genus.
摘要翻译：本发明一般涉及免疫学和疫苗技术领域。更具体地，本发明涉及用于冷冻干燥生物制剂的方法，包括肽，抗原，抗体，特别是细胞。重要的是，所公开的方法保留了Apicomplexa门，Sarcocystidae家族，特别是来自弓形虫属细胞的细胞的活力，感染性和免疫原性。

7. 发明授权

EP2545067B1 BLUETONGUE VIRUS RECOMBINANT VACCINES AND USES THEREOF 有权转让
标题翻译：蓝舌病毒重组疫苗及其用途
公开(公告)号：EP2545067B1
公开(公告)日：2016-11-30
申请号：EP11711411.6
申请日：2011-03-11
申请人： Merial, Inc.
发明人： AUDONNET, Jean-Christophe , GUO, Xuan , COX, Kevin
IPC分类号： C07K14/14 , C12N15/82 , A61K39/15
CPC分类号： C07K14/005 , A61K39/12 , A61K39/15 , A61K2039/517 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , C12N15/8258 , C12N2720/12134

8. 发明公开

EP3093025A1 BLUETONGUE VIRUS RECOMBINANT VACCINES AND USES THEREOF 有权转让
标题翻译：重组蓝舌疫苗及其用途
公开(公告)号：EP3093025A1
公开(公告)日：2016-11-16
申请号：EP16171113.0
申请日：2011-03-11
申请人： Merial Inc.
发明人： AUDONNET, Jean-Christophe , GUO, Xuan , COX, Kevin
IPC分类号： A61K39/135 , C12N15/82
CPC分类号： C07K14/005 , A61K39/12 , A61K39/15 , A61K2039/517 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , C12N15/8258 , C12N2720/12134
摘要： The present invention encompasses BTV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing BTV antigens. The invention also encompasses recombinant vectors encoding and expressing BTV antigens, epitopes or immunogens which can be used to protect animals, such as ovines, bovines, or caprines, against BTV.

9. 发明授权

EP2714077B1 NEEDLE-FREE ADMINISTRATION OF PRRSV VACCINES 有权转让
标题翻译：免疫管理PRRSV疫苗
公开(公告)号：EP2714077B1
公开(公告)日：2018-02-28
申请号：EP12726290.5
申请日：2012-05-24
申请人： Merial, Inc. , Chulalongkorn University
发明人： SURADHAT, Sanipa , AUDONNET, Jean-Christophe , CHARREYRE, Catherine
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C12N2770/10034
摘要： The invention provides novel methods and compositions for the vaccination of porcine animals against porcine reproductive and respiratory syndrome virus (PRRSV). Described herein are immunological and/or vaccine compositions comprising a DNA vector encoding a PRRSV protein, particularly a truncated ORF7 protein, which are administered to porcines using needle-free delivery. The plasmid can include more than one nucleic acid molecule such that the plasmid can express more than one antigen. Also disclosed are methods for using and kits employing such compositions.

10. 发明公开

EP3124613A1 ANTIBIOTIC-FREE PLASMID 有权转让
标题翻译：抗生素血浆
公开(公告)号：EP3124613A1
公开(公告)日：2017-02-01
申请号：EP16164124.6
申请日：2010-05-24
申请人： Merial, Inc.
发明人： AUDONNET, Jean-Christophe , JOLIVET, Edmond
IPC分类号： C12N15/73 , C12N15/63 , C12N15/68
摘要： The present invention provides a method of maintaining a gram negative bacterium plasmid without the use of antibiotic selection pressure. Further, the invention relates to the drugless plasmids produced including drugless plasmids containing a heterologous gene. The invention also provides formulations and/or compositions comprising the drugless plasmids comprising a heterologous gene, formulations and/or compositions comprising a protein or an immunogen expressed using the drugless plasmids, and methods of administering such formulations and/or compositions to a host. The invention relates to gram negative bacteria containing the drugless plasmids.
摘要翻译：本发明提供了不使用抗生素选择压力来维持革兰氏阴性细菌质粒的方法。此外，本发明涉及包含含有异源基因的无毒素质粒产生的无毒素质粒。本发明还提供了包含含有异源基因的无药物质粒的制剂和/或组合物，包含使用无药物质粒表达的蛋白质或免疫原的制剂和/或组合物，以及将这些制剂和/或组合物施用于宿主的方法。本发明涉及含有无毒素质粒的革兰氏阴性细菌。

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