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1. 发明授权

EP2850208B1 METHOD FOR DETERMINING IF A SUBJECT HAS AN INCREASED LIKELIHOOD OF HIGH GRADE DYSPLASIA OR ESOPHAGAL ADENOCARCINOMA 有权转让
标题翻译：确定受试者如果患有高级别乳糜泻或嗜酒性腺癌的增加的可能性的方法
公开(公告)号：EP2850208B1
公开(公告)日：2017-07-19
申请号：EP13731426.6
申请日：2013-05-17
申请人： Medical Research Council , Cambridge Enterprise Limited
发明人： DI PIETRO, Massimiliano , FITZGERALD, Rebecca , LIU, Xinxue
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： G01N33/57407 , A61B18/14 , A61B2018/00488 , A61B2018/00577 , C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158 , G01N33/6893 , G01N2800/06

2. 发明授权

EP2959298B1 METHODS 有权
公开(公告)号：EP2959298B1
公开(公告)日：2018-09-05
申请号：EP14706672.4
申请日：2014-02-19
申请人： Cambridge Enterprise Limited , United Kingdom Research and Innovation
发明人： FITZGERALD, Rebecca , ROSS-INNES, Caryn
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/154 , G01N2333/4703 , G01N2333/4748 , G01N2333/912
摘要： The invention relates to a method of aiding detection of a surface abnormality in the oesophagus of a subject, wherein said surface abnormality is selected from the group consisting of low-grade dysplasia (LGD), high-grade dysplasia (HGD), asymptomatic oesophageal adenocarcinoma (OAC) and intra-mucosal cancer (IMC), the method comprising: a) providing a sample of cells from said subject, wherein said sample comprises cells collected from the surface of the subject's oesophagus; b) assaying said cells for at least two markers selected from (i) p53; (ii) c-Myc; (iii) AURKA or PLK1, preferably AURKA; and (iv) methylation of MyoD and Runx3; wherein detection of abnormal levels of at least two of said markers infers that the subject has an increased likelihood of a surface abnormality in the oesophagus. The invention also relates to certain kits, apparatus and uses.

3. 发明公开

EP2850209A1 METHODS TO PREDICT PROGRESSION OF BARRETT ' S ESOPHAGUS TO HIGH GRADE DYSPLASIA ESOPHAGEAL ADENOCARCINOMA 有权转让
标题翻译：方法预测Barrett食管的进展与高档发育不良SPEISERÖHRENADENOKARZINOMEN
公开(公告)号：EP2850209A1
公开(公告)日：2015-03-25
申请号：EP13732213.7
申请日：2013-05-16
申请人： Medical Research Council
发明人： FITZGERALD, Rebecca , BIRD-LIEBERMAN, Elizabeth
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/158 , G01N2333/38 , G01N2333/4739 , G01N2333/4748 , G01N2333/70596 , G01N2400/00 , G01N2800/06
摘要： In some embodiments, a method for aiding prediction of the likelihood of progression from Barrett's esophagus to high grade dysplasia or esophageal adenocarcinoma in a subject, is disclosed. The method can include (a) providing an oesophagal sample from said subject (b) determining if said sample stains abnormally with Aspergillus oryzae lectin; (c) determining if there is a DNA content abnormality in said sample; and (d) determining if there is low grade dysplasia in said sample; wherein if (b) is abnormal and (c) is abnormal and low grade dysplasia is present, then an increased likelihood of progression is determined. The disclosed subject matter also relates to an apparatus, and to different uses of certain materials.

4. 发明公开

EP2850208A1 METHOD FOR DETERMINING IF A SUBJECT HAS AN INCREASED LIKELIHOOD OF HIGH GRADE DYSPLASIA OR ESOPHAGEAL ADENOCARCINOMA 有权转让
标题翻译：方法确定可能性增加高档发育不良或SPEISERÖHRENADENOKARZINOMS当一个人
公开(公告)号：EP2850208A1
公开(公告)日：2015-03-25
申请号：EP13731426.6
申请日：2013-05-17
申请人： Medical Research Council , The University of Cambridge
发明人： DI PIETRO, Massimiliano , FITZGERALD, Rebecca , LIU, Xinxue
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： G01N33/57407 , A61B18/14 , A61B2018/00488 , A61B2018/00577 , C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158 , G01N33/6893 , G01N2800/06
摘要： The invention related to a method for determining if a subject has an increased likelihood of high grade dysplasia (HGD) or esophagal adenocarcinoma (EC), the method comprising; a) providing a sample from an AFI patch of said subject's oesophagus b) assaying said sample for (i) aneuploidy, and (ii) abnormal p53, and (iii) abnormal Cyclin A c) wherein if said sample shows the presence of at least two of (i), (ii) and (iii), then said subject is determined as having an increased likelihood of high grade dysplasia (HGD) or esophagal adenocarcinoma (EC). The invention also relates to certain methods of medical treatment.

5. 发明授权

EP2850209B1 METHODS TO PREDICT PROGRESSION OF BERRET'S ESOPHAGUS TO HIGH GRADE DYSPLASIA OR ESOPHAGEAL ADENOCARCINOMA 有权转让
公开(公告)号：EP2850209B1
公开(公告)日：2019-01-02
申请号：EP13732213.7
申请日：2013-05-16
申请人： Medical Research Council
发明人： FITZGERALD, Rebecca , BIRD-LIEBERMAN, Elizabeth
IPC分类号： C12Q1/68 , G01N33/574

6. 发明公开

EP2850210A1 METHODS TO ASSESS THE LIKELIHOOD OF DYSPLASIA OR ESOPHAGEAL ADENOCARCINOMA 有权转让
标题翻译： VERFAHREN ZUR BEURTEILUNG DER WAHRSCHEINLICHKEIT VON DYSPLASIEN ODERSPEISERÖHRENADENOKARZINOMEN
公开(公告)号：EP2850210A1
公开(公告)日：2015-03-25
申请号：EP13732214.5
申请日：2013-05-17
申请人： Medical Research Council
发明人： FITZGERALD, Rebecca , ALVI, Muhammad , LIU, Xinxue
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154
摘要： In some embodiments, a method for aiding assessment of the likelihood of dysplasia or esophageal adenocarcinoma being present in a subject can include (a) providing an esophagal sample from said subject (b) determining the methylation status of (i) SLC22A18, (ii) PIGR, (iii) GJA12 and (iv) RIN2 in said sample wherein if 2 or more of said genes are methylated then an increased likelihood of presence of dysplasia or esophageal is determined. The invention also relates to apparatus for same.
摘要翻译：在一些实施方案中，用于帮助评估发现不良或食管腺癌存在于受试者中的可能性的方法可以包括（a）提供来自所述受试者的食管样品（b）确定（i）SLC22A18的甲基化状态，（ii） PIGR，（iii）所述样品中的GJA12和（iv）RIN2，其中如果2个或更多个所述基因被甲基化，则确定存在发育不良或食管的可能性增加。本发明还涉及其装置。

7. 发明公开

EP2959298A2 METHODS 有权
标题翻译：方法
公开(公告)号：EP2959298A2
公开(公告)日：2015-12-30
申请号：EP14706672.4
申请日：2014-02-19
申请人： Cambridge Enterprise Ltd. , Medical Research Council
发明人： FITZGERALD, Rebecca , ROSS-INNES, Caryn
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/154 , G01N2333/4703 , G01N2333/4748 , G01N2333/912
摘要： The invention relates to a method of aiding detection of a surface abnormality in the oesophagus of a subject, wherein said surface abnormality is selected from the group consisting of low-grade dysplasia (LGD), high-grade dysplasia (HGD), asymptomatic oesophageal adenocarcinoma (OAC) and intra-mucosal cancer (IMC), the method comprising: a) providing a sample of cells from said subject, wherein said sample comprises cells collected from the surface of the subject's oesophagus; b) assaying said cells for at least two markers selected from (i) p53; (ii) c-Myc; (iii) AURKA or PLK1, preferably AURKA; and (iv) methylation of MyoD and Runx3; wherein detection of abnormal levels of at least two of said markers infers that the subject has an increased likelihood of a surface abnormality in the oesophagus. The invention also relates to certain kits, apparatus and uses.
摘要翻译：本发明涉及辅助检测受试者食管表面异常的方法，其中所述表面异常选自低度发育不良（LGD），高度发育异常（HGD），无症状食管腺癌（OAC）和粘膜内癌（IMC），所述方法包括：a）提供来自所述受试者的细胞样品，其中所述样品包含从受试者食管表面收集的细胞; 10b）测定所述细胞中至少两种选自以下的标记：（i）p53; （ii）c-Myc; （iii）AURKA或PLK1，最好是AURKA; 和（iv）MyoD和Runx3的甲基化; 其中检测到至少两种所述标志物的异常水平推断受试者具有增加的食道表面异常可能性。本发明还涉及某些试剂盒，装置和用途。

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