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1. 发明公开

EP3840838A2 ANTIBODY DIRECTED AGAINST S.AUREUS CLUMPING FACTOR A (CLFA) 审中-实审
公开(公告)号：EP3840838A2
公开(公告)日：2021-06-30
申请号：EP19749544.3
申请日：2019-07-24
申请人： MedImmune, LLC , Humabs Biomed SA
发明人： TKACZYK, Christine , SELLMAN, Bret , BORROK III, Martin , CORTI, Davide , MINOLA, Andrea
IPC分类号： A61P31/04 , C07K16/12

2. 发明授权

EP2673373B1 ANTIBODIES THAT SPECIFICALLY BIND STAPHYLOCOCCUS AUREUS ALPHA TOXIN AND METHODS OF USE 有权
公开(公告)号：EP2673373B1
公开(公告)日：2018-08-29
申请号：EP12745207.6
申请日：2012-02-07
申请人： MedImmune, LLC
发明人： SELLMAN, Bret , TKACZYK, Christine , HUA, Lei , CHOWDHURY, Partha , VARKEY, Reena , DAMSCHRODER, Melissa , PENG, Li , OGANESYAN, Vaheh , HILLIARD, Jamese, Johnson
IPC分类号： C12P21/08 , A61K39/40 , A61K39/085 , C07K16/12
CPC分类号： C07K16/1271 , A61K38/14 , A61K39/40 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/90 , C07K2317/92 , G01N33/56938 , G01N2333/31 , G01N2800/20 , G01N2800/44 , G01N2800/709 , A61K2300/00
摘要： Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.

3. 发明公开

EP3864040A1 ANTIBODIES DIRECTED AGAINST STAPHYLOCOCCUS AUREUS LEUKOTOXINS 审中-实审
公开(公告)号：EP3864040A1
公开(公告)日：2021-08-18
申请号：EP19795711.1
申请日：2019-10-08
申请人： Medimmune, LLC , Humabs BioMed SA
发明人： TKACZYK, Christine , SELLMAN, Bret , DU, Qun , DAMSCHRODER, Melissa , CORTI, Davide , MINOLA, Andrea
IPC分类号： C07K16/12 , A61K39/085 , A61P31/00 , A61K39/00

4. 发明授权

EP2917360B1 ANTIBODIES TO S. AUREUS SURFACE DETERMINANTS 有权
公开(公告)号：EP2917360B1
公开(公告)日：2020-01-08
申请号：EP13852597.7
申请日：2013-11-06
申请人： MedImmune, LLC
发明人： SELLMAN, Bret , TKACZYK, Christine , CHOWDHURY, Partha, S. , HUA, Lei , PAVLIK, Peter , BUONPANE, Rebecca , CHANG, Chew-Shun
IPC分类号： C12P21/08 , A61K39/40 , G01N33/554 , A61K39/00 , C07K16/12 , A61K45/06 , G01N33/569

5. 发明公开

EP3470526A3 ANTIBODIES THAT SPECIFICALLY BIND STAPHYLOCOCCUS AUREUS ALPHA TOXIN AND METHODS OF USE 审中-实审
公开(公告)号：EP3470526A3
公开(公告)日：2019-07-17
申请号：EP18190790.8
申请日：2012-02-07
申请人： Medimmune, LLC
发明人： SELLMAN, Bret , TKACZYK, Christine , HUA, Lei , CHOWDHURY, Partha , VARKEY, Reena , DAMSCHRODER, Melissa , PENG, Li , OGANESYAN, Vaheh , HILLIARD, Jamese, Johnson
IPC分类号： C12P21/08 , A61K39/40 , A61K39/085 , C07K16/12
摘要： Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.

6. 发明公开

EP2673373A2 ANTIBODIES THAT SPECIFICALLY BIND STAPHYLOCOCCUS AUREUS ALPHA TOXIN AND METHODS OF USE 有权
标题翻译：抗体特异性结合金黄色葡萄球菌α毒素及其使用方法
公开(公告)号：EP2673373A2
公开(公告)日：2013-12-18
申请号：EP12745207.6
申请日：2012-02-07
申请人： MedImmune, LLC
发明人： SELLMAN, Bret , TKACZYK, Christine , HUA, Lei , CHOWDHURY, Partha , VARKEY, Reena , DAMSCHRODER, Melissa , PENG, Li , OGANESYAN, Vaheh , HILLIARD, Jamese, Johnson
IPC分类号： C12P21/08 , C07K16/00 , A61K39/40 , A61K39/085
CPC分类号： C07K16/1271 , A61K38/14 , A61K39/40 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/90 , C07K2317/92 , G01N33/56938 , G01N2333/31 , G01N2800/20 , G01N2800/44 , G01N2800/709 , A61K2300/00
摘要： Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.

7. 发明公开

EP3864041A2 COMBINATIONS OF ANTI-STAPHYLOCOCCUS AUREUS ANTIBODIES 审中-实审转让
公开(公告)号：EP3864041A2
公开(公告)日：2021-08-18
申请号：EP19871705.0
申请日：2019-10-08
申请人： Medimmune, LLC
发明人： TKACZYK, Christine , SELLMAN, Bret , DU, Qun , DAMSCHRODER, Melissa , COHEN, Taylor
IPC分类号： C07K16/12 , C07K16/22 , A61P31/04 , A61K39/395

8. 发明公开

EP3640338A1 ANTIBODIES TO S. AUREUS SURFACE DETERMINANTS 审中-实审
公开(公告)号：EP3640338A1
公开(公告)日：2020-04-22
申请号：EP19211610.1
申请日：2013-11-06
申请人： MedImmune, LLC
发明人： SELLMAN, Bret , TKACZYK, Christine , CHOWDHURY, Partha, S. , HUA, Lei , PAVLIK, Peter , BUONPANE, Rebecca , CHANG, Chew-Shun
IPC分类号： C12P21/08 , A61K39/40 , G01N33/554 , A61K39/00 , C07K16/12 , A61K45/06 , G01N33/569
摘要： Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.

9. 发明公开

EP3470526A2 ANTIBODIES THAT SPECIFICALLY BIND STAPHYLOCOCCUS AUREUS ALPHA TOXIN AND METHODS OF USE 审中-实审
公开(公告)号：EP3470526A2
公开(公告)日：2019-04-17
申请号：EP18190790.8
申请日：2012-02-07
申请人： Medimmune, LLC
发明人： SELLMAN, Bret , TKACZYK, Christine , HUA, Lei , CHOWDHURY, Partha , VARKEY, Reena , DAMSCHRODER, Melissa , PENG, Li , OGANESYAN, Vaheh , HILLIARD, Jamese, Johnson
IPC分类号： C12P21/08 , A61K39/40 , A61K39/085 , C07K16/12
CPC分类号： C07K16/1271 , A61K38/14 , A61K39/40 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/90 , C07K2317/92 , G01N33/56938 , G01N2333/31 , G01N2800/20 , G01N2800/44 , G01N2800/709 , A61K2300/00
摘要： Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.

10. 发明公开

EP2928490A1 METHODS OF TREATING S. AUREUS-ASSOCIATED DISEASES 有权
标题翻译： VERFAHREN ZUR BEHANDLUNG VON MIT S. AUREUS ASSOZIIERTEN ERKRANKUNGEN
公开(公告)号：EP2928490A1
公开(公告)日：2015-10-14
申请号：EP13853844.2
申请日：2013-11-05
申请人： MedImmune, LLC
发明人： SELLMAN, Bret , TKACZYK, Christine , HAMILTON, Melissa , HUA, Lei
IPC分类号： A61K39/085
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , C07K2317/52 , C07K2317/565 , C07K2317/76
摘要： The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating S. aureus-associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (anti-AT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus associated pneumonia in an immunocompromised mammalian subject.
摘要翻译：本发明提供了预防和/或治疗金黄色葡萄球菌相关菌血症和败血症的方法，以及在使用抗-S的免疫受损患者中预防和/或治疗金黄色葡萄球菌相关性肺炎的方法。金黄色葡萄球菌α毒素（抗AT）抗体。还提供了降低哺乳动物受试者的血液或心脏中的金黄色葡萄球菌细菌负荷的方法，包括向受试者施用有效量的分离的抗S。金黄色葡萄球菌α毒素（抗AT）抗体或其抗原结合片段。在哺乳动物受试者中降低金黄色葡萄球菌细菌凝集和/或血栓栓塞损伤形成的方法，包括向受试者施用有效量的分离的抗S。还提供了金黄色葡萄球菌α毒素（抗AT）抗体或其抗原结合片段。还提供了在免疫受损的哺乳动物受试者中预防或降低金黄色葡萄球菌相关性肺炎的严重性的方法。

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