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2. 发明公开

EP0136036A2 Technetium complexes and their uses 有权转让
标题翻译： Technetiumkomplexe und ihre Verwendung。
公开(公告)号：EP0136036A2
公开(公告)日：1985-04-03
申请号：EP84305573.2
申请日：1984-08-16
申请人： Mallinckrodt, Inc. (a Delaware corporation)
发明人： Dean, Richard T. , Miller, Frederick W. , Wester, Dennis W.
IPC分类号： A61K49/02 , C07F9/142 , C07F9/15 , C07F9/48
CPC分类号： A61K51/0476 , A61K51/0489 , A61K2123/00 , C07F9/142 , C07F9/48 , C07F9/65748
摘要： New technetium [99m] (1) complexes can be used in imaging compositions for example in myocardial imaging. The complexes have one of the following formulae: wherein R 1 , R 2 and R 3 are independently selected from the group consisting of lower alkyl, lower alkoxy, and lower alkoxy-substituted lower alkyl, provided each phosphorus is bonded through at least one oxygen to a carbon; and A - is a non-deleterious, chemically suitable, pharmaceutically acceptable anion; wherein X is a bridging substituent selected from the group consisting of lower alkylenedioxy, and lower oxyalkyl; R 1 has the same meaning as set forth above, provided each phosphorus is bonded through at least one oxygen to a carbon, and A - has the same meaning as set forth above; wherein Y is a trivalent bridging substituent selected from the group consisting of lower tris(oxyalkylene)alkane, lower oxydiai- kyl, and lower dioxyalkyl, provided each phosphorus is bonded through at least one oxygen to a carbon; and A - has the same meaning as set forth above; wherein R 4 , R 5 , R7 and R 8 are independently selected from the group consisting of, lower alkyl, lower alkoxy, and lower alkoxy-substituted lower alkyl; R 6 is a linking substituent selected from the group consisting of lower alkylene, oxygen, lower alkylenedioxy and lower oxyalkylene, provided each phosphorus is bonded through at least one oxygen to a carbon; and A - has the same meaning as set forth above; and wherein X, R 6 and A have the same meaning as set forth above and provided each phosphorus is bonded through at least one oxygen to a carbon.
摘要翻译：新的锝[99m]（1）配合物可用于成像组合物，例如心肌成像。络合物具有下式之一：... <99m Tc（I）[P（R 1，R 2，R 3）]] 6 + A 1其中R 1 >，R 2和R 3独立地选自低级烷基，低级烷氧基和低级烷基取代的低级烷基，条件是每个磷通过至少一个氧键连接到碳上; 和A < - >是一种非有害的，化学上合适的药学上可接受的阴离子; ... 99m Tc（I）[P（X。R 1）] 6 + 选自低级亚烷基二氧基和低级烷氧基的桥接取代基; R 1具有与上述相同的含义，条件是每个磷通过至少一个氧键连接到碳上，并且A - 具有与上述相同的含义; ... 99m Tc（I）[ 其中Y是选自下三（氧亚烷基）烷烃，低级氧代二烷基和低级二烷基烷基的三价桥连取代基，其中每个磷通过至少一个氧键连接到碳; 和A < - 具有与上述相同的含义; ... <99m Tc（I）[R 4，R 5 -PR 6 -PR 7，R 8] 3 < 其中R 4，R 5，R 7和R 8独立地选自低级烷基，低级烷氧基和低级烷氧基取代的低级烷基 ; R 6是选自低级亚烷基，氧，低亚烷基二氧基和低级氧化亚烷基的连接取代基，条件是每个磷通过至少一个氧键连接到一个碳上; 和A < - >具有与上述相同的含义; 和... <99m Tc（I）[XPR 6 -PX] 3 + A - 5 ...其中X，R 6和A - 具有与上述相同的含义并且各自提供磷通过至少一个氧键连接成一个碳。

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