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1. 发明公开

EP2948480A1 TARGETING CONSTRUCTS BASED ON NATURAL ANTIBODIES AND USES THEREOF 无效
标题翻译：靶向构建基于天然抗体及其应用
公开(公告)号：EP2948480A1
公开(公告)日：2015-12-02
申请号：EP14742889.0
申请日：2014-01-23
申请人： MUSC Foundation For Research Development , The Regents of the University of Colorado, a body corporate , Department Of Veterans Affairs
发明人： ROHRER, Baerbel M. , HOLERS, Michael , TOMLINSON, Stephen , THURMAN, Joshua M. , ATKINSON, Carl , KULIK, Liudmila
IPC分类号： C07K19/00 , A61K39/395 , A61P37/00 , A61P27/02
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/33 , C07K2317/622 , C07K2317/76 , C07K2317/94
摘要： The present invention provides targeted delivery methods and constructs for treating inflammatory diseases and/or detecting in vivo tissue injuries in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The invention also provides methods of inhibiting complement-driven inflammation in the eye in an individual, comprising administering to the individual an antibody or a fragment thereof or compositions thereof, wherein the antibody or fragment thereof specifically binds to Annexin IV or phospholipid. Also provided are related methods of treating a complement-associated ocular disease or an ocular disease involving oxidative damage. Additionally, the invention provides methods of detecting complement- mediated injury in an eye tissue of an individual, comprising administering to the individual a construct or compositions thereof, wherein the construct comprises (a) an antibody or fragment thereof that specifically binds to Annexin IV or phospholipid; and (b) a detectable moiety.

2. 发明公开

EP3151845A2 MAP44 POLYPEPTIDES AND CONSTRUCTS BASED ON NATURAL ANTIBODIES AND USES THEREOF 无效
标题翻译： MAP44多肽构建了基于自然科学抗体及其应用
公开(公告)号：EP3151845A2
公开(公告)日：2017-04-12
申请号：EP15802708.6
申请日：2015-06-04
申请人： The Regents of the University of Colorado, a body corporate
发明人： HOLERS, Michael, V. , BANDA, Nirmal , KULIK, Liudmila
IPC分类号： A61K38/00 , A61P19/02 , A61K39/395
CPC分类号： A61K38/482 , A01K67/027 , A01K2207/10 , A01K2227/105 , A61K38/00 , A61K48/00 , C07K16/18 , C07K16/44 , C07K2317/622 , C07K2319/00 , C12N9/6424 , C12N2710/10041 , C12Y304/21
摘要： The present invention provides delivery methods and constructs for treating inflammatory diseases in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The antibody is used to deliver a MAp44 polypeptide or fragment thereof to sites of inflammation, where it inhibits the lectin pathway of complement activation.
摘要翻译：本发明提供了递送方法和构建了在个体中治疗炎性疾病。靶向递送方法利用在抗体确实认识到被发现存在于炎症部位的表位。抗体被用于递送MAp44多肽或其片段炎症，其抑制补体激活的凝集素途径的位点。

3. 发明公开

EP2585110A1 ANTIBODIES TO THE C3D FRAGMENT OF COMPLEMENT COMPONENT 3 审中-公开
标题翻译： ANTIKÖRPERGEGEN DAS C3D-FRAGMENT DER KOMPLEMENTKOMPONENTE 3
公开(公告)号：EP2585110A1
公开(公告)日：2013-05-01
申请号：EP11798880.8
申请日：2011-06-22
申请人： The Regents of the University of Colorado, A Body Corporate
发明人： HOLERS, V., Michael , THURMAN, Joshua, M. , KULIK, Liudmila
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/18 , C07K14/472 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to methods and materials for modulating the complement alternative pathway (CAP), the complement classical pathway (CCP), the complement lectin/mannose pathway (CMP), or combinations thereof, as well as methods and materials for targeting diagnostic, prophylactic and therapeutic agents to localized areas of tissue within the body where they may more directly exert their effects upon the intended target cells or tissue, with reduced, associated systemic effects compared with administration of the same or similar agents in an untargeted, systemic manner. The methods and materials of the present invention may therefore allow for increased efficacy, lower threshold effective dosages and/or lower effective maintenance doses, and/or reduced associated undesired or adverse effects in terms of frequency or severity of occurrence, or both. The present invention also relates to methods and materials for modulating a host humoral immune response, especially reducing, inhibiting, or preventing a host humoral immune response.
摘要翻译：本发明涉及用于调节补体替代途径（CAP），补体经典途径（CCP），补体凝集素/甘露糖途径（CMP）或其组合的方法和材料，以及用于靶向诊断的方法和材料，预防和治疗剂到体内组织的局部区域，在那里它们可以更直接地将它们的作用发挥到预期的靶细胞或组织上，与以相同或相似的药物以非靶向的系统方式施用相比，具有减少的相关系统效应。因此，本发明的方法和材料可以允许增加功效，降低阈值有效剂量和/或降低有效维持剂量，和/或减少在发生频率或严重程度方面的相关不良或不良影响，或两者。本发明还涉及用于调节宿主体液免疫应答，特别是减少，抑制或预防宿主体液免疫应答的方法和材料。

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