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1. 发明公开

EP0759079A1 DNA ENCODING PRECURSOR OF INTERLEUKIN-1$g(b) CONVERTING ENZYME-RELATED CYSTEINE PROTEINASE III (ICE rel?-III) 失效转让
标题翻译： DNA编码PRE白细胞介素1-G（B），从而导致酶 - 相关蛋白酶III（ICE RELα-Ⅲ）码中的
公开(公告)号：EP0759079A1
公开(公告)日：1997-02-26
申请号：EP95914255.0
申请日：1995-04-04
申请人： MERCK FROSST CANADA INC.
发明人： NICHOLSON, Donald W. , ALI, Ambereen , MUNDAY, Neil A. , VAILLANCOURT, John P.
IPC分类号： G01N33 , A61K38 , A61K48 , A61P9 , A61P25 , A61P31 , A61P35 , A61P37 , A61P43 , C07H21 , C07K16 , C12N1 , C12N5 , C12N9 , C12N15 , C12Q1 , C12R1
CPC分类号： C12N9/6475 , A61K38/00
摘要： A complementary DNA (cDNA) encoding full length form of ICErel-III is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICErel-III. The cDNA and the recombinant ICErel-III protein derived therefrom are useful in diagnostic kits, laboratory reagents and assays. The cDNA and the recombinant ICErel-III protein may be used to identify compounds that affect ICErel-III function, inflammation and cell apoptosis. ICErel-III function, inflammation and cell apoptosis may also be modulated by ICErel-III antisense or gene therapy.

2. 发明公开

EP0754234A1 DNA ENCODING PRECURSOR OF INTERLEUKIN-1BETA CONVERTING ENZYME-RELATED CYSTEINE PROTEINASE II (ICE rel-II) 失效转让
标题翻译： DNA编码白细胞介素PRE素-1β转化酶码的
公开(公告)号：EP0754234A1
公开(公告)日：1997-01-22
申请号：EP95914256.0
申请日：1995-04-04
申请人： MERCK FROSST CANADA INC.
发明人： NICHOLSON, Donald W. , ALI, Ambereen , MUNDAY, Neil A. , VAILLANCOURT, John P.
IPC分类号： C12N15 , A61K38 , A61K48 , A61P3 , A61P9 , A61P25 , A61P31 , A61P35 , A61P43 , C07K16 , C12N1 , C12N5 , C12N9 , C12Q1 , C12R1
CPC分类号： C12N9/6475 , A61K38/00
摘要： A complementary DNA (cDNA) encoding full length form of ICErel-II is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICErel-II. The cDNA and the recombinant ICErel-II protein derived therefrom are useful in diagnostic kits, laboratory reagents and assays. The cDNA and the recombinant ICErel-II protein may be used to identify compounds that affect ICErel-II function, inflammation and cell apoptosis. ICErel-II function, inflammation and cell apoptosis may also be modulated by ICErel-II antisense or gene therapy.

3. 发明公开

EP0822983A1 APOPAIN 失效
公开(公告)号：EP0822983A1
公开(公告)日：1998-02-11
申请号：EP96913801.0
申请日：1996-04-17
申请人： MERCK & CO., INC. , MERCK FROSST CANADA INC.
发明人： MILLER, Douglas, K. , THORNBERRY, Nancy, A. , NICHOLSON, Donald, W. , ALI, Ambereen , VAILLANCOURT, John, P.
IPC分类号： C12N15 , A61K31 , A61K45 , A61K48 , A61P9 , A61P25 , A61P31 , A61P35 , A61P37 , A61P43 , C07B61 , C07K5 , C07K16 , C12N9 , C12Q1
CPC分类号： C12N9/6475 , A61K48/00 , C07K5/1021
摘要： The present invention is directed to an isolated and purified enzyme designated apopain, methods of using apopain to screen for compounds which modulate the activity of apopain, and compounds identified by the screens. A synthetic DNA molecule encoding full length apopain is prepared from the purified enzyme. The synthetic apopain-encoding DNA is formulated so as to optimize expression in a variety of recombinant hosts. The DNA clones produce recombinant full-length apopain and derivatives thereof. Purified native apopain and recombinant apopain are useful for identifying modulators of apopain activity and hence modifiers of pathological conditions related to the pro-inflammatory or pro-apoptotic effects of apopain. Apopain antisense molecules are useful for therapeutically reducing or eliminating the pro-inflammatory or pro-apoptotic effects of apopain, whereas gene transplantation or gene therapy with apopain is useful for enhancing the pro-inflammatory or pro-apoptotic effects of apopain. These therapies are beneficial in the treatment of immune, proliferative and degenerative diseases including, but not limited to, immune deficiency syndromes (such as AIDS), autoimmune diseases, pathogenic infections, cardiovascular and neurological injury, alopecia, aging, cancer, Parkinson's disease and Alzheimer's disease.
摘要翻译：本发明涉及一种称为apopain的分离和纯化的酶，使用apopain筛选调节apopain活性的化合物和通过筛选鉴定的化合物的方法。从纯化的酶制备编码全长apopain的合成DNA分子。配制合成的apopain编码DNA以优化多种重组宿主中的表达。 DNA克隆产生重组全长apopain及其衍生物。纯化的天然apopain和重组apopain可用于鉴定apopain活性的调节剂，并因此用于与apopain的促炎或促凋亡效应相关的病理状态的调节剂。 Apopain反义分子可用于治疗性减少或消除apopain的促炎症或促凋亡作用，而基因移植或含apopain的基因治疗可用于增强apopain的促炎或促凋亡作用。这些疗法有益于治疗免疫，增殖和退行性疾病，包括但不限于免疫缺陷综合征（例如AIDS），自身免疫性疾病，致病性感染，心血管和神经学损伤，脱发，衰老，癌症，帕金森病和阿尔茨海默氏病。

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