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2. 发明公开

EP0874651A1 BLOOD HEAT EXCHANGE SYSTEM EMPLOYING MICRO-CONDUIT 失效
标题翻译：采用微型导管的血液热交换系统
公开(公告)号：EP0874651A1
公开(公告)日：1998-11-04
申请号：EP97901996.0
申请日：1997-01-10
申请人： MEDTRONIC, INC.
发明人： GREMEL, Robert, F. , HIER, Peter, J. , KUBISA, Peter, Z. , REEDER, Gary, D. , PALERMO, Henry, W. , PLUNKETT, Sean, D.
IPC分类号： A61M1 , B01D19 , F28F21
CPC分类号： F28F21/062 , B01D19/0031 , F28F2260/02
摘要： Micro-conduit (102) with enhanced wetting characteristics for use in providing a blood heat exchanger apparatus (300) with improved heat exchange capability. The micro-conduit (102) comprises a plurality of elongated fibers (100), which may be made of a hydrophobic material such as polypropylene or polyethylene. Each fiber (100) is open at two opposing ends, and has an inner surface (152) between the open ends. The inner surface (152) is coated with a wetting agent, such as phosphatidyl choline or another amphiphilic material with a hydrophilic end and a hydrophobic end. The fibers (100) may have a shape and size that, without presence of the wetting agent, would otherwise substantially impair free passage of water. The micro-conduit (102) may be provided as a heat exchanger micro-conduit wrapping material (304), wherein micro-conduit fibers (100) are attached to a thin flexible interconnect, such as woven netting, to maintain the fibers (100) at predetermined spacings in substantially parallel alignment with each other. The wrapping material is wrapped about an elongated spindle (306) to provide a generally cylindrical heat exchange core (304). Opposing first and second seals (314, 316) are created by applying potting compound between fibers (100) proximate the spindle's first end (308) and proximate the spindle's second end (310). After ends of the fibers (100) are trimmed and sealed, a shell (312) is placed around the core (304).
摘要翻译：具有增强的润湿特性的微导管（102）用于提供具有改进的热交换能力的血液热交换器装置（300）。微导管（102）包括多个细长纤维（100），其可以由诸如聚丙烯或聚乙烯的疏水材料制成。每根纤维（100）在两个相对的端部开口，并且在开口端之间具有内表面（152）。内表面（152）涂覆有润湿剂，例如磷脂酰胆碱或具有亲水端和疏水端的另一两亲性材料。纤维（100）的形状和尺寸可以在不存在润湿剂的情况下实质上损害水的自由通过。微导管（102）可以作为热交换器微导管包裹材料（304）提供，其中微导管纤维（100）连接到薄柔性互连（例如织网），以保持纤维（100 ）以预定的间距彼此基本平行对齐。包装材料围绕细长轴（306）缠绕以提供大致圆柱形的热交换芯（304）。相邻的第一密封件和第二密封件（314,316）通过在靠近心轴的第一端（308）并靠近心轴的第二端（310）的纤维（100）之间施加封装化合物来形成。在纤维（100）的端部被修剪和密封之后，将壳（312）放置在芯（304）周围。

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