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2. 发明公开

EP0871637A4 TUNGSTEN CLUSTERS 失效
标题翻译： WOLFRAM-CLUSTER
公开(公告)号：EP0871637A4
公开(公告)日：2000-01-05
申请号：EP96921784
申请日：1996-06-26
申请人： MALLINCKRODT MEDICAL INC
发明人： FUNG ELLA Y , COOPER STEPHEN R
IPC分类号： A61K49/04 , C07F11/00 , G01N24/00
CPC分类号： A61K49/04 , C07F11/005 , Y10T436/24
摘要： The present invention provides new tri-tungsten compounds of general structure (I) wherein R is -CkH1Zm or -(CkH1Zn) (C6H(5-q) Zq)p; R is -CkH1Zm or -(CkH1Zn) (C6H(5-q) Zq)p; R is -CkH1Zm or -(CkH1Zn) (C6H(5-q) Zq)p; R is -CkH1Zm or -(CkH1Zn) (C6H(5-q) Zq)p; R is -CkH1Zm or -(CkH1Zn) (C6H(5-q) Zq)p; R is -CkH1Zm or -(CkH1Zn) (C6H(5-q) Zq)p; Z is a functional group attachable on aliphatic chains or aromatic rings; R is an anionic molecule, neutral molecule, -CkH1Zm ou -(CkH1Zn) (C6H(5-q) Zq)p; R is an anionic molecule, neutral molecule, -CkH1Zm or -(CkH1Zn) (C6H(5-q) Zq)p; R is an anionic molecule, neutral molecule, -CkH1Zm or -(CkH1Zn) (C6H(5-q) Zq)p; k is about 0-20; 1 is about 0-50; m is about 1-50; n is about 0-50; p is about 1-10; q is about 1-5; M is a counter positive or negative ion; and a is about -6 - +6. W in the structure is the generally accepted one letter symbol for tungsten. Methods of imaging using compounds of the invention and processes for producing compounds of the invention are also disclosed.
摘要翻译：本发明提供了通式（I）的新三钨化合物，其中R 1是-CkH 1 Z m或 - （C k H 1 z n）（C 6 H（5-q）Z q）p; R 2是-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; R3是-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; R4为-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; R5为-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; R 6是-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; Z是可连接在脂族链或芳族环上的官能团; R 7是阴离子分子中性分子-C k H 1 Z m O - （C k H 1 Zn）（C 6 H（5-q）Z q）p; R 8是阴离子分子，中性分子-C k H 1Z m或 - （C k H 1 Z n）（C 6 H（5-q）Z q）p; R 9是阴离子分子，中性分子-C k H 1 Z m或 - （C k H 1 Z n）（C 6 H（5-q）Z q）p; k约为0-20; 1约为0-50; m约为1-50; n约为0-50; p约为1-10; q约为1-5; M是反阳性或阴性离子; a约为-6 - +6。结构中的W是钨普遍接受的单字母符号。还公开了使用本发明化合物的成像方法和生产本发明化合物的方法。

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