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    • 1. 发明公开
    • COMPOSITION COMPRISING CAFFEOYLSHIKIMIC ACIDS, PROTOCATECHUIC ACID, HYDROXYTYROSOL, HYDROXYBENZOIC ACID AND THEIR DERIVATIVES AND METHOD OF PREPARATION THEREOF
    • 组成CAFFEEOYL-莽草酸,原儿茶酸,羟基酪醇,HYDROXYBENZONSÄURE及其衍生物和方法
    • EP2435397A4
    • 2013-02-27
    • EP10780847
    • 2010-05-26
    • MALAYSIAN PALM OIL BOARD
    • SAMBANDAN T JRHA CHOKYUNANTHONY J SINSKEYSAMBANTHAMURTHI RAVIGADEVITAN YEW AIP MANICKAM KALYANA SUNDRAMWAHID MOHD BASRI
    • C07C69/618A61K36/889C07C39/11C07C65/03
    • A61K36/889
    • A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives. The method includes the steps of pre-concentrating an extract containing the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives and isolating the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, with the caffeoylshikimic acids and their derivatives varying depending on the stationary phase and the composition of the mobile phase.
    • 包括caffeoylshikimic酸,原儿茶酸,羟基酪醇,羟基苯甲酸,一种组合物,所述caffeoylshikimic羧酸及其衍生物从油棕包含的任何部分提取,但并不局限于棕榈油铣削和棕榈油磨流出物的植物液,和使用的方法 在含有caffeoylshikimic酸,原儿茶酸,羟基酪醇,羟基酸的组合物的制备中,所述caffeoylshikimic酸和它们的衍生物。 该方法包括的聚光预提取包含所述caffeoylshikimic酸,原儿茶酸,羟基酪醇,羟基苯甲酸,caffeoylshikimic羧酸及其衍生物和分离所述caffeoylshikimic酸,原儿茶酸,羟基酪醇,羟基苯甲酸,所述caffeoylshikimic酸和从它们的衍生物中的步骤 所述提取物通过液相色谱法,洗脱worin的说caffeoylshikimic酸,原儿茶酸,羟基酪醇,羟基苯甲酸的活性,与caffeoylshikimic羧酸及其衍生物的变化取决于在固定相上,流动相的组成。