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1. 发明公开

EP1319047A1 CYANINE DYES 有权
标题翻译： CYANINFARBSTOFFE
公开(公告)号：EP1319047A1
公开(公告)日：2003-06-18
申请号：EP01971229.8
申请日：2001-09-18
申请人： Li-Cor, Inc.
发明人： LUGADE, Ananda, G. , NARAYANAN, Narasimhachari , DRANEY, Daniel, R.
IPC分类号： C09B23/00 , C09B23/08 , G01N33/58 , G01N33/533 , C07H21/00
CPC分类号： G01N33/582 , C09B23/0008 , C09B23/0066 , C09B23/086 , G01N33/533
摘要： A compound of the formula (I) is provided: (I), wherein Z is O, S, or NR35 wherein R35 is H or alkyl; R1-R5 are each independently H, alkyl, halo, carboxyl, amino, or SO3 -Cat+, wherein Cat+ is a cation and at least one of R¿1?-R5 is SO3?-Cat+; R¿6 and R7 are each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CR19R20, wherein R19 and R20 are each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; R8 and R13 are each independently alkyl, (CH2)rR25 or (CH2)rR18; wherein at least one of R8 and R13 (CH2)rR18 and wherein r is an integer from 1 to 50, and R25 is a functional group that does not directly react with a carboxyl, hydroxyl, amino, or a thiol group, and R18 is a functional group that can react with a carboxyl, hydroxyl, amino, or thiol group; and R9-R12 and R14-R17 are each independently H, alkyl, halo, amino, sulfonato, R21 COOH, R21OR22, R21SR22, or R21COOR22 wherein R21 is a bond or alkylene and R22 is alkyl, or optionally R11 and R12 together with the atoms to which they are bonded form an aromatic ring, or optionally R16 and R17 together with the atoms to which they are bonded form an aromatic ring. Methods of dye-labeling biomolecules with the compound of formula (1) and dye-labeled biomolecules are also provided.

2. 发明授权

EP1319047B1 CYANINE DYES 有权
标题翻译：青蓝
公开(公告)号：EP1319047B1
公开(公告)日：2006-01-04
申请号：EP01971229.8
申请日：2001-09-18
申请人： LI-COR, INC.
发明人： LUGADE, Ananda, G. , NARAYANAN, Narasimhachari , DRANEY, Daniel, R.
IPC分类号： C09B23/00 , C09B23/08 , G01N33/58 , G01N33/533 , C07H21/00 , C12Q1/68
CPC分类号： G01N33/582 , C09B23/0008 , C09B23/0066 , C09B23/086 , G01N33/533
摘要： A compound of the formula (I) is provided: (I), wherein Z is O, S, or NR35 wherein R35 is H or alkyl; R1-R5 are each independently H, alkyl, halo, carboxyl, amino, or SO3 Cat , wherein Cat is a cation and at least one of R1-R5 is SO3 Cat ; R6 and R7 are each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CR19R20, wherein R19 and R20 are each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; R8 and R13 are each independently alkyl, (CH2) r R25 or (CH2) r R18; wherein at least one of R8 and R13 (CH2) r R18 and wherein r is an integer from 1 to 50, and R25 is a functional group that does not directly react with a carboxyl, hydroxyl, amino, or a thiol group, and R18 is a functional group that can react with a carboxyl, hydroxyl, amino, or thiol group; and R9-R12 and R14-R17 are each independently H, alkyl, halo, amino, sulfonato, R21 COOH, R21OR22, R21SR22, or R21COOR22 wherein R21 is a bond or alkylene and R22 is alkyl, or optionally R11 and R12 together with the atoms to which they are bonded form an aromatic ring, or optionally R16 and R17 together with the atoms to which they are bonded form an aromatic ring. Methods of dye-labeling biomolecules with the compound of formula (1) and dye-labeled biomolecules are also provided.

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