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    • 3. 发明公开
    • Non-occulusive adhesive patch for applying medication to the skin
    • Atmungsaktiver,klebenderKörperzur Verabreichung eines Medikaments an die Haut。
    • EP0674913A2
    • 1995-10-04
    • EP94115594.7
    • 1994-10-04
    • LecTec Corporation
    • Rolf, DavidSjoblom Urmann, Elisabeth K.
    • A61M35/00A61K9/70
    • A61K9/7061A61F13/00995A61F2013/00646A61K9/7023Y10S514/953Y10S514/965
    • A non-occlusive medication patch (32) to be applied to the skin includes a porous self-supporting backing layer (10) to give the patch the required integrity and strength by acting as a supporting framework for other components, and a flexible hydrophilic pressure-sensitive adhesive reservoir (20) comprising a natural or synthetic polymer for the sustained release of medication to be absorbed topically through the skin into the body of a patient. The reservoir has two portions: first, an external coating layer (24) with an exposed lower skin-contacting surface (24b) that forms a pressure-sensitive bond with the skin, and second, an upper internal portion (24a) which infiltrates the porous backing (10) and becomes solidified therein after being applied so that the reservoir and the backing are unified, enabling the backing itself to act as a storage location for the medication-containing reservoir (20). The medication within the reservoir migrates over time from within the backing (10) through the lower coating layer (24b) and passes through the skin to provide sustained release of the medication into the body of a patient.
    • 要施加到皮肤上的非闭塞药物贴片(32)包括多孔自支撑背层(10),以通过充当其它部件的支撑框架而赋予贴片所需的完整性和强度,以及柔性亲水压力 敏感粘合剂储存器(20),其包含用于持续释放药物的天然或合成聚合物,以被局部地吸收通过皮肤进入患者体内。 储存器具有两部分:首先,具有与皮肤形成压敏粘合的暴露的下皮肤接触表面(24b)的外部涂层(24),以及第二部分,其浸入 多孔背衬(10),并且在施加之后变得固化,使得储存器和背衬是一体的,使得背衬本身能够用作含药物储存器(20)的储存位置。 储存器内的药物随着时间的推移从背衬(10)内穿过下部涂层(24b)迁移并通过皮肤,以将药物持续释放到患者体内。