专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP1949410B1 MULTI-REFLECTING TIME-OF-FLIGHT MASS SPECTROMETER WITH ORTHOGONAL ACCELERATION 有权
标题翻译：正交加速的多反射飞行时间质谱仪
公开(公告)号：EP1949410B1
公开(公告)日：2017-09-27
申请号：EP06816588.5
申请日：2006-10-11
申请人： LECO CORPORATION
发明人： VERENTCHIKOV, Anatoli, N. , YAVOR, Mikhail, I. , KHASIN, Yuri
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , H01J49/406

2. 发明公开

EP1522087A1 TANDEM TIME OF FLIGHT MASS SPECTROMETER AND METHOD OF USE 有权
标题翻译：飞行时间质谱仪的串联时间和使用方法
公开(公告)号：EP1522087A1
公开(公告)日：2005-04-13
申请号：EP03726518.8
申请日：2003-04-29
申请人： LECO CORPORATION
发明人： VERENTCHIKOV, Anatoli, N.
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/004
摘要： To provide comprehensive (i.e. rapid and sensitive) MS-MS analysis, the inventor employs a time-nested separation, using two time-of-flight (TOF) mass spectrometers. Parent ions are separated in a slow and long TOF1, operating at low ion energy (1 to l00eV), and fragment ions are mass analyzed in a fast and short TOF2, operating at much higher keV energy. Low energy fragmentation cell between TOF1 and TOF2 is tailored to accelerate fragmentation and dampening steps, mostly by shortening the cell and employing higher gas pressure. Since separation in TOF1 takes milliseconds and mass analysis in TOF2- microseconds, the invention provides comprehensive MS-MS analysis of multiple precursor ions per single ion pulse. Slow separation in TOF1 becomes possible with an introduction of novel TOF1 analyzers. The TOF-TOF could be implemented using a static TOF1, here described on the examples of spiratron, planar and cylindrical multi-pass separators with griddles spatial focusing ion mirrors. Higher performance is expected with the use of novel hybrid TOF 1 analyzers, combining radio frequency (RF) and quadratic DC fields. RF field retains low-energy ions within TOF 1 analyzer, while quadratic DC field improves resolution by compensate for large relative energy spread.
摘要翻译：为了提供全面的（即快速和灵敏的）MS-MS分析，发明人采用时间嵌套分离，使用两个飞行时间（TOF）质谱仪。母离子在缓慢且长的TOF1中分离，以低离子能量（1至100eV）操作，并且碎片离子在快速且短的TOF2中进行质量分析，在更高的keV能量下操作。 TOF1和TOF2之间的低能量碎裂室适合加速破碎和抑制步骤，主要是通过缩短池和采用更高的气体压力。由于TOF1中的分离需要几毫秒的时间并且TOF2微秒内的质量分析，因此本发明提供了每单个离子脉冲的多个前体离子的全面MS-MS分析。引入新颖的TOF1分析仪，可以在TOF1中快速分离。 TOF-TOF可以使用静态TOF1来实现，这里用spiratron，平面和圆柱形多通道分离器以及栅格空间聚焦离子镜的例子进行描述。使用新型混合TOF 1分析仪，结合无线电频率（RF）和二次DC场，可以获得更高的性能。 RF场保留TOF 1分析仪内的低能离子，而二次DC场通过补偿较大的相对能量扩散来提高分辨率。

3. 发明授权

EP1665326B1 MULTI REFLECTING TIME-OF-FLIGHT MASS SPECTROMETER AND A METHOD OF USE 有权
标题翻译：多次反射飞行时间质谱仪和方法供其使用
公开(公告)号：EP1665326B1
公开(公告)日：2010-04-14
申请号：EP04755637.8
申请日：2004-06-18
申请人： LECO CORPORATION
发明人： VERENTCHIKOV, Anatoli, N. , YAVOR, Mikhail , MITCHELL, Joel, C. , ARTAEV, Viatcheslav
IPC分类号： H01J49/00
CPC分类号： H01J49/406

4. 发明授权

EP1522087B1 TANDEM TIME OF FLIGHT MASS SPECTROMETER AND METHOD OF USE 有权
标题翻译： TANDEM FLUZEITMASSENSPEKTROMETER和程序
公开(公告)号：EP1522087B1
公开(公告)日：2011-03-09
申请号：EP03726518.8
申请日：2003-04-29
申请人： LECO CORPORATION
发明人： VERENTCHIKOV, Anatoli, N.
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/004
摘要： To provide comprehensive (i.e. rapid and sensitive) MS-MS analysis, the inventor employs a time-nested separation, using two time-of-flight (TOF) mass spectrometers. Parent ions are separated in a slow and long TOF1, operating at low ion energy (1 to l00eV), and fragment ions are mass analyzed in a fast and short TOF2, operating at much higher keV energy. Low energy fragmentation cell between TOF1 and TOF2 is tailored to accelerate fragmentation and dampening steps, mostly by shortening the cell and employing higher gas pressure. Since separation in TOF1 takes milliseconds and mass analysis in TOF2- microseconds, the invention provides comprehensive MS-MS analysis of multiple precursor ions per single ion pulse. Slow separation in TOF1 becomes possible with an introduction of novel TOF1 analyzers. The TOF-TOF could be implemented using a static TOF1, here described on the examples of spiratron, planar and cylindrical multi-pass separators with griddles spatial focusing ion mirrors. Higher performance is expected with the use of novel hybrid TOF 1 analyzers, combining radio frequency (RF) and quadratic DC fields. RF field retains low-energy ions within TOF 1 analyzer, while quadratic DC field improves resolution by compensate for large relative energy spread.

5. 发明公开

EP1949410A1 MULTI-REFLECTING TIME-OF-FLIGHT MASS SPECTROMETER WITH ORTHOGONAL ACCELERATION 有权
标题翻译：多反射时间质谱仪正交加速
公开(公告)号：EP1949410A1
公开(公告)日：2008-07-30
申请号：EP06816588.5
申请日：2006-10-11
申请人： LECO CORPORATION
发明人： VERENTCHIKOV, Anatoli, N. , YAVOR, Mikhail, I. , KHASIN, Yuri
IPC分类号： H01J49/00 , B01D59/44 , G21K7/00
CPC分类号： H01J49/401 , H01J49/406
摘要： The disclosed apparatus includes a multi-reflecting time-of-flight mass spectrometer (MR-TOF MS) (11) comprising a pair of grid- free ion mirrors (12), a drift space (13), an orthogonal ion accelerator (14), an optional deflector (15), an ion detector (16), a set of periodic lenses (17), and an edge deflector (18). To improve the duty cycle of the ion injection at a low repetition rate dictated by a long flight in the MR-TOF MS, multiple measures may be taken. The incoming ion beam and the accelerator may be oriented substantially transverse to the ion path in the MR-TOF, while the initial velocity of the ion beam is compensated by tilting the accelerator and steering the beam for the same angle. To further improve the duty cycle of any multi-reflecting or multi-turn mass spectrometer, the beam may be time-compressed by modulating the axial ion velocity with an ion guide. The residence time of the ions in the accelerator may be improved by trapping the beam within an electrostatic trap. Apparatuses with a prolonged residence time in the accelerator provide improvements in both sensitivity and resolution.

6. 发明公开

EP1665326A2 MULTI REFLECTING TIME-OF-FLIGHT MASS SPECTROMETER AND A METHOD OF USE 有权
标题翻译：多次反射飞行时间质谱仪和方法供其使用
公开(公告)号：EP1665326A2
公开(公告)日：2006-06-07
申请号：EP04755637.8
申请日：2004-06-18
申请人： LECO CORPORATION
发明人： VERENTCHIKOV, Anatoli, N. , YAVOR, Mikhail , MITCHELL, Joel, C. , ARTAEV, Viatcheslav
IPC分类号： H01J49/00
CPC分类号： H01J49/406
摘要： A multiple reflecting time-of-flight mass spectrometer (MR-TOF MS) and method of analysis are disclosed. The flight path of ions is folded along a trajectory by electrostatic mirrors. The longer flight path provides higher resolution while maintaining a moderate instrument size.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式