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1. 发明公开

EP3492529A1 METHOD FOR PRESERVING LEUCO CHROMOGEN-CONTAINING AQUEOUS SOLUTION 审中-公开
公开(公告)号：EP3492529A1
公开(公告)日：2019-06-05
申请号：EP17834531.0
申请日：2017-07-28
申请人： Kyowa Medex Co., Ltd.
发明人： SOYA, Haruyo , KATAYAMA, Yuki
IPC分类号： C09B67/00 , C09B21/00 , C09B67/44 , C12Q1/28
摘要： The present invention provides a method for preserving a leuco chromogen-containing aqueous solution comprising: adding at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound to a leuco chromogen-containing aqueous solution; a method for stabilizing a leuco chromogen in an aqueous solution comprising: adding at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound to a leuco chromogen-containing aqueous solution; and a liquid reagent comprising a leuco chromogen and at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound.

2. 发明公开

EP2653506A1 METHOD FOR STORING LEUCO CHROMOGEN-CONTAINING AQUEOUS SOLUTION 审中-公开
标题翻译： VERFAHREN ZUR KONSERVIERUNG EINER LEUKOCHROMOGENHALTIGENWÄSSRIGENLÖSUNG
公开(公告)号：EP2653506A1
公开(公告)日：2013-10-23
申请号：EP11848428.6
申请日：2011-12-12
申请人： Kyowa Medex Co., Ltd.
发明人： SOYA, Haruyo
IPC分类号： C09B67/00 , C07D279/20 , C09B21/00 , C09B67/20
CPC分类号： G01N21/78 , C07D213/72 , C07D279/30 , C09B57/10 , C09B67/0033 , C09B67/0041 , C09B67/0078 , C09B67/0083
摘要： The present invention provides: a method for preserving an aqueous solution containing a leuco chromogen, comprising adding a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof to the aqueous solution containing a leuco chromogen; a method for stabilizing a leuco chromogen, comprising allowing the leuco chromogen to coexist in an aqueous solution comprising a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof; and a liquid reagent comprising a leuco chromogen and a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof.
摘要翻译：本发明提供了一种保存含有无色致发色素的水溶液的方法，包括添加具有至少一个选自亚硝基和偶氮基的取代基的化合物，并具有配位金属离子或其盐含有无色致发色素的水溶液; 一种稳定无色发色团的方法，包括使无色发色体共存于包含具有至少一个选自亚硝基和偶氮基并具有配位金属离子能力的取代基的化合物的水溶液中，或其盐; 和含有无色发色体的液体试剂和具有至少一个选自亚硝基和偶氮基并具有配位金属离子或其盐的能力的取代基的化合物。

3. 发明公开

EP3492600A1 METHOD FOR MEASURING GLYCOSYLATED HEMOGLOBIN 审中-公开
公开(公告)号：EP3492600A1
公开(公告)日：2019-06-05
申请号：EP17834532.8
申请日：2017-07-28
申请人： KYOWA MEDEX CO., LTD.
发明人： SOYA, Haruyo , KATAYAMA, Yuki , OGAWA, Noriyuki
IPC分类号： C12Q1/26 , C12Q1/28 , G01N33/72
摘要： A method is provided for measuring glycated hemoglobin in a hemoglobin-containing sample which comprises reacting glycated hemoglobin in the hemoglobin-containing sample with an enzyme that catalyzes a reaction of oxidizing the glycated hemoglobin to generate hydrogen peroxide, in the presence of at least one anionic surfactant selected from the group consisting of N-acyl taurine in which a hydrogen atom of the amino group may be substituted with a substituent, alkyl sulfoacetic acid, polyoxyethylene alkyl ether acetic acid, N-acyl amino acid in which a hydrogen atom of the amino group may be substituted with a substituent, polyoxyethylene alkyl ether phosphoric acid, polyoxyethylene polycyclic phenyl ether phosphoric acid, alkyl phosphoric acid, and salts thereof, to generate hydrogen peroxide, and measuring the generated hydrogen peroxide.

4. 发明授权

EP2604699B1 METHOD FOR MEASURING GLYCATED HEMOGLOBIN 有权
标题翻译：测量糖化血红蛋白的方法
公开(公告)号：EP2604699B1
公开(公告)日：2017-10-04
申请号：EP11816409.4
申请日：2011-08-09
申请人： Kyowa Medex CO., LTD.
发明人： SOYA, Haruyo , MURAKAMI, Tomomi , TSUNODA, Haruki , OHSUGI, Yu , YODA, Ayako , MATSUSHITA, Masashi
IPC分类号： C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N21/78 , G01N33/72
CPC分类号： C12Q1/37 , C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N21/78 , G01N33/723

5. 发明公开

EP2813577A1 METHOD FOR SUPPRESSING THE EFFECTS OF ASCORBIC ACID 审中-公开
标题翻译： VERFAHREN ZURUNTERDRÜCKUNGDER WIRKUNGEN VONASCORBINSÄURE
公开(公告)号：EP2813577A1
公开(公告)日：2014-12-17
申请号：EP13746840.1
申请日：2013-02-06
申请人： Kyowa Medex Co., Ltd.
发明人： SOYA, Haruyo
IPC分类号： C12Q1/28 , C12Q1/37
CPC分类号： C12Q1/54 , C12Q1/26 , C12Q1/37 , C12Q2523/113
摘要： Provided is a method for suppressing an effect of ascorbic acid on a measurement of glycated hemoglobin in a glycated hemoglobin-containing sample. The method of the present invention is a method for suppressing an effect of ascorbic acid on the measurement of glycated hemoglobin in a glycated hemoglobin-containing sample, comprising reacting the glycated hemoglobin-containing sample with a proteolytic enzyme, reacting a generated glycated peptide with a glycated peptide oxidase, and then measuring a generated hydrogen peroxide, wherein the reaction of the glycated peptide with the glycated peptide oxidase is performed in the presence of a halogen oxide and a substance selected from the group consisting of a substance represented by formula (I), wherein R 1 represents substituted or unsubstituted alkyl and a substance represented by the general formula (II), wherein R 2 represents substituted or unsubstituted alkyl; andrepresents a single bond or a double bond.
摘要翻译：本发明提供抑制含糖血红蛋白的样品中抗坏血酸对糖化血红蛋白测定的影响的方法。本发明的方法是抑制抗坏血酸对糖化血红蛋白含量样品中糖化血红蛋白测定的影响的方法，包括使含糖基血红蛋白的样品与蛋白水解酶反应，使生成的糖化肽与糖化肽氧化酶，然后测量产生的过氧化氢，其中糖化肽与糖化肽氧化酶的反应在卤素氧化物和选自由式（I）表示的物质的存在下进行，其中R 1表示取代或未取代的烷基和由通式（II）表示的物质，其中R 2表示取代或未取代的烷基; 并且表示单一债券或双重债券。

6. 发明公开

EP2722396A1 METHOD FOR MEASURING GLYCOSYLATED HEMOGLOBIN, MEASUREMENT REAGENT, AND MEASUREMENT KIT 审中-公开
标题翻译： VERFAHREN ZUR MESSUNG VON GLYKOSILIERTEMHÄMOGLOBIN，MESSREAGENZ SOWIE MESSKIT
公开(公告)号：EP2722396A1
公开(公告)日：2014-04-23
申请号：EP12800757.2
申请日：2012-06-14
申请人： Kyowa Medex Co., Ltd.
发明人： SOYA, Haruyo
IPC分类号： C12Q1/37 , C12Q1/26 , C12Q1/28
CPC分类号： C12Q1/37 , G01N33/725 , G01N2333/904 , G01N2333/95
摘要： Described is a method for accurately and highly sensitively measuring glycated hemoglobin in a hemoglobin-containing sample without being influenced by hemoglobin. It is related to a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising: reacting hemoglobin-containing sample with a protease in the presence of a surfactant; and then reacting the obtained reaction product with fructosyl peptide oxidase, wherein the latter reaction or both of the former reaction and the latter reaction are performed in the presence of a halogen oxide, and measuring the generated hydrogen peroxide. The method for measuring glycated hemoglobin in a hemoglobin-containing sample provided by the present invention is useful in, for example, the measurement of glycated hemoglobin useful in the diagnosis of diabetes mellitus.
摘要翻译：描述了一种用于在不受血红蛋白影响的情况下准确且高度敏感地测量含血红蛋白样品中的糖化血红蛋白的方法。其涉及含血红蛋白的样品中糖化血红蛋白测定方法，其特征在于，在表面活性剂存在下，使含血红蛋白的样品与蛋白酶反应; 然后使所得反应产物与果糖基肽氧化酶反应，其中后一反应或前一反应和后一反应两者都在卤氧化物的存在下进行，并测量产生的过氧化氢。由本发明提供的含血红蛋白的样品中的糖化血红蛋白测定方法可用于例如可用于糖尿病诊断的糖化血红蛋白的测定。

7. 发明公开

EP2604699A1 METHOD FOR MEASURING GLYCOSYLATED HEMOGLOBIN 有权
标题翻译：测量糖化血红蛋白的方法
公开(公告)号：EP2604699A1
公开(公告)日：2013-06-19
申请号：EP11816409.4
申请日：2011-08-09
申请人： Kyowa Medex CO., LTD.
发明人： SOYA, Haruyo , MURAKAMI, Tomomi , TSUNODA, Haruki , OHSUGI, Yu , YODA, Ayako , MATSUSHITA, Masashi
IPC分类号： C12Q1/26 , C12Q1/28 , G01N21/78 , G01N33/72
CPC分类号： C12Q1/37 , C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N21/78 , G01N33/723
摘要： It is to provide a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising: reacting glycated hemoglobin in the hemoglobin-containing sample with a proteolytic enzyme in the presence of at least one salt selected from the group consisting of a pyridinium salt, a phosphonium salt, an imidazolium salt, and an isoquinolinium salt; reacting the obtained reaction product with fructosyl peptide oxidase; and measuring the generated hydrogen peroxide. The present invention provides a method for accurately measuring glycated hemoglobin in a hemoglobin-containing sample.
摘要翻译：本发明提供一种含血红蛋白试样中的糖化血红蛋白的测定方法，其特征在于，使含血红蛋白试样中的糖化血红蛋白与蛋白质分解酶在选自吡啶鎓盐，鏻盐，咪唑鎓盐和异喹啉鎓盐; 使所得反应产物与果糖基肽氧化酶反应; 并测量生成的过氧化氢。本发明提供了精确测量含血红蛋白样品中糖化血红蛋白的方法。

8. 发明公开

EP2604698A1 METHOD FOR MEASURING GLYCATED HEMOGLOBIN 审中-公开
标题翻译： VERFAHREN ZUR MESSUNG VON GLYKIERTEMHÄMOGLOBIN
公开(公告)号：EP2604698A1
公开(公告)日：2013-06-19
申请号：EP11816408.6
申请日：2011-08-09
申请人： Kyowa Medex CO., LTD.
发明人： MURAKAMI, Tomomi , SOYA, Haruyo , OHSUGI, Yu , YODA, Ayako , TSUNODA, Haruki , MATSUSHITA, Masashi
IPC分类号： C12Q1/26 , C12Q1/28 , C12Q1/37
CPC分类号： G01N33/723 , C12Q1/26 , C12Q1/37
摘要： It is to provide a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising reacting the hemoglobin-containing sample with a proteolytic enzyme in the presence of a surfactant, and then reacting the obtained reaction product with fructosyl peptide oxidase, wherein at least one of the former reaction and the latter reaction is performed in the presence of an isothiazolinone derivative; and measuring the generated hydrogen peroxide. The present invention provides a method for accurately and highly sensitively measuring glycated hemoglobin in a hemoglobin-containing sample without being influenced by hemoglobin.
摘要翻译：提供一种测定含血红蛋白的样品中的糖化血红蛋白的方法，包括在表面活性剂存在下使含血红蛋白的样品与蛋白水解酶反应，然后使所得反应产物与果糖基肽氧化酶反应，其中至少前一反应和后一反应之一在异噻唑啉酮衍生物的存在下进行; 并测量所产生的过氧化氢。本发明提供一种在不受血红蛋白影响的情况下，对含有血红蛋白的样品中的糖化血红蛋白进行精确高度灵敏测定的方法。

9. 发明公开

EP2604657A1 METHOD FOR PRESERVING AQUEOUS SOLUTION CONTAINING LEUCO CHROMOGEN 审中-公开
标题翻译： VERFAHREN ZUR KONSERVIERUNG EINERWÄSSRIGENLÖSUNGMIT LEUKOCHROMOGEN
公开(公告)号：EP2604657A1
公开(公告)日：2013-06-19
申请号：EP11816410.2
申请日：2011-08-09
申请人： Kyowa Medex CO., LTD.
发明人： SOYA, Haruyo , MURAKAMI, Tomomi , TSUNODA, Haruki , OHSUGI, Yu , YODA, Ayako , MATSUSHITA, Masashi
IPC分类号： C09B67/00 , C09B67/44
CPC分类号： C07D279/30 , C09B11/12 , C09B21/00 , C09B67/0077 , C09B67/0083 , C12Q1/28 , G01N33/723
摘要： It is to provide a method for preserving an aqueous solution comprising a leuco chromogen, comprising adding at least one compound selected from the group consisting of polyoxyethylene alkylamine and polyoxyethylene alkenylamine to the aqueous solution containing a leuco chromogen, and a method for stabilizing a leuco chromogen, comprising allowing the leuco chromogen to coexist in an aqueous solution comprising at least one compound selected from the group consisting of polyoxyethylene alkylamine and polyoxyethylene alkenylamine. The present invention provides a method for preserving an aqueous solution comprising a leuco chromogen for stably preserving the leuco chromogen in an aqueous solution and a method for stabilizing a leuco chromogen.
摘要翻译：提供一种保存含有无色致发色素的水溶液的方法，包括将至少一种选自聚氧乙烯烷基胺和聚氧乙烯链烯基胺的化合物加入到含有无色致发色素的水溶液中，以及使无色发色剂稳定的方法包括使无色发色体共存于包含至少一种选自聚氧乙烯烷基胺和聚氧乙烯链烯基胺的化合物的水溶液中。本发明提供了一种保存水溶液的方法，该方法包括用于在水溶液中稳定保留无色发色团的无色发色体和稳定无色发色体的方法。

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