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1. 发明公开

EP3363499A1 ANTI-TIM-3 ANTIBODY 审中-公开
公开(公告)号：EP3363499A1
公开(公告)日：2018-08-22
申请号：EP18163771.1
申请日：2011-06-10
申请人： Kyowa Hakko Kirin Co., Ltd. , Kyushu University National University Corporation
发明人： TAKAYANAGI, Shin-ichiro , TOMURA, Hitomi , TAWARA, Tomonori , INAGAKI, Yoshimasa , AKASHI, Koichi , KUBOTA, Tsuguo , KIKUSHIGE, Yoshikane
IPC分类号： A61P7/00 , A61K39/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08
CPC分类号： C07K16/2803 , C07K16/2818 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/92 , G01N33/56972
摘要： The present invention provides an anti-human TIM-3 antibody which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure thereof and exhibits higher effector activity such as an antibody-dependent cellular cytotoxicity (ADCC activity) for diseases relating to a human TIM-3 expressing cell. The present invention provides a monoclonal antibody or antibody fragment thereof which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure and exhibits ADCC activity; a hybridoma which produces the antibody; a DNA encoding the antibody; a vector comprising the DNA; a transformant which is obtainable by introducing the vector; a method for producing the antibody or the antibody fragment thereof which comprises using the hybridoma or the transformant; a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment thereof as an active ingredient. In addition, the present invention provides an anti-human TIM-3 antibody having high ADCC activity by screening an anti-human TIM-3 antibody which competes with the monoclonal antibody or the antibody fragment thereof.

2. 发明授权

EP2417984B1 METHOD FOR TREATMENT OF BLOOD TUMOR USING ANTI-TIM-3 ANTIBODY 有权
标题翻译：方法血液肿瘤的治疗中使用抗TIM抗体
公开(公告)号：EP2417984B1
公开(公告)日：2016-03-30
申请号：EP10761756.5
申请日：2010-04-09
申请人： Kyowa Hakko Kirin Co., Ltd. , Kyushu University, National University Corporation
发明人： TAKANAYAGI, Shinichiro , INAGAKI, Yoshimasa , AKASHI, Koichi , KIKUSHIGE, Yoshikane
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , C07K16/28 , C12N15/09
CPC分类号： G01N33/57426 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/57407 , G01N2333/70503
摘要： Disclosed is a therapeutic method comprising administering a TIM-3 antibody to a subject who is suspected to be suffering from blood tumor and in whom TIM-3 has been expressed in a Lin(-)CD34(+)CD38(-) cell fraction of bone marrow or peripheral blood or a subject who has been received any treatment for blood tumor. Also disclosed is a composition for preventing or treating blood tumor, which comprises a TIM-3 antibody as an active ingredient. Conceived diseases include those diseases which can be treated through the binding or targeting of the TIM-3 antibody to blood tumor cells (AML cells, CML cells, MDS cells, ALL cells, CLL cells, multiple myeloma cells, etc.), helper T cell (e.g., Th1 cells, Th17 cells), and antigen-presenting cells (e.g., dendritic cells, monocytes, macrophages, and cells resembling to the aforementioned cells (hepatic stellate cells, osteoclasts, microglial cells, intraepidermal macrophages, dust cells (alveolar macrophages),etc)), all of which are capable of expressing TIM-3. The diseases for which the therapeutic use is to be examined include blood diseases in which the expression of TIM-3 is observed in bone marrow or peripheral blood, particularly blood tumor.

3. 发明公开

EP2417984A1 METHOD FOR TREATMENT OF BLOOD TUMOR USING ANTI-TIM-3 ANTIBODY 有权
标题翻译： VERFAHREN ZUR BEHANDLUNG VON BLUTKREBS MITTELS抗刺激剂
公开(公告)号：EP2417984A1
公开(公告)日：2012-02-15
申请号：EP10761756.5
申请日：2010-04-09
申请人： Kyowa Hakko Kirin Co., Ltd. , Kyushu University, National University Corporation
发明人： AKASHI, Koichi , KIKUSHIGE, Yoshikane
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , C07K16/28 , C12N15/09
CPC分类号： G01N33/57426 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/57407 , G01N2333/70503
摘要： Disclosed is a therapeutic method comprising administering a TIM-3 antibody to a subject who is suspected to be suffering from blood tumor and in whom TIM-3 has been expressed in a Lin(-)CD34(+)CD38(-) cell fraction of bone marrow or peripheral blood or a subject who has been received any treatment for blood tumor. Also disclosed is a composition for preventing or treating blood tumor, which comprises a TIM-3 antibody as an active ingredient. Conceived diseases include those diseases which can be treated through the binding or targeting of the TIM-3 antibody to blood tumor cells (AML cells, CML cells, MDS cells, ALL cells, CLL cells, multiple myeloma cells, etc.), helper T cell (e.g., Th1 cells, Th17 cells), and antigen-presenting cells (e.g., dendritic cells, monocytes, macrophages, and cells resembling to the aforementioned cells (hepatic stellate cells, osteoclasts, microglial cells, intraepidermal macrophages, dust cells (alveolar macrophages),etc)), all of which are capable of expressing TIM-3. The diseases for which the therapeutic use is to be examined include blood diseases in which the expression of TIM-3 is observed in bone marrow or peripheral blood, particularly blood tumor.
摘要翻译：公开了一种治疗方法，其包括对怀疑患有血液肿瘤的受试者施用TIM-3抗体，并且其中TIM-3已经在Lin（ - ）CD34（+）CD38（ - ）细胞级分中表达骨髓或外周血或受到血肿治疗的受试者。还公开了用于预防或治疗血液肿瘤的组合物，其包含TIM-3抗体作为活性成分。被认为的疾病包括可以通过TIM-3抗体对血液肿瘤细胞（AML细胞，CML细胞，MDS细胞，ALL细胞，CLL细胞，多发性骨髓瘤细胞等）的结合或靶向治疗的那些疾病，辅助T 细胞（例如，Th1细胞，Th17细胞）和抗原呈递细胞（例如，树突状细胞，单核细胞，巨噬细胞和类似于上述细胞的细胞（肝星状细胞，破骨细胞，小神经胶质细胞，表皮内巨噬细胞，尘埃细胞（肺泡巨噬细胞）等）），所有这些都能表达TIM-3。要检查治疗用途的疾病包括其中在骨髓或外周血，特别是血液肿瘤中观察到TIM-3的表达的血液疾病。

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