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2. 发明公开

EP2002854A2 BIOMATERIAL, ARTIFICIAL JOINT USING THE SAME AND METHOD OF PRODUCING THE SAME 有权
标题翻译：生物学材料，KÜNSTLICHESGELENK DAMIT UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2002854A2
公开(公告)日：2008-12-17
申请号：EP07739673.7
申请日：2007-03-26
申请人： Japan Medical Materials Corporations , The University of Tokyo , National University Corporation Tokyo Medical and Dental University
发明人： KYOMOTO, Masayuki , ISHIHARA, Kazuhiko , IWASAKI, Yasuhiko , MORO, Toru , NAKAMURA, Kozo , TAKATORI, Yoshio , KAWAGUCHI, Hiroshi , KONNO, Tomohiro , YAMAWAKI, Noboru
IPC分类号： A61L27/42 , A61F2/34 , A61F2/36 , C22C14/00 , C22C19/07
CPC分类号： A61L27/34 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2002/30685 , A61F2002/30934 , A61F2002/3611 , A61F2310/00011 , A61F2310/00179 , A61L27/42 , B05D1/18 , B05D3/067 , B23K35/3618 , C22F1/11 , C22F1/183 , Y10T428/24917 , Y10T428/24926 , Y10T428/31536
摘要： The object of the present invention is to provide a joint prosthesis, bearing material and a production method threreof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
摘要翻译：本发明的目的是提供一种抑制滑动部分磨损的关节假体，轴承材料和制造方法，即使在重复的日常操作中也抑制磨料粉末的产生。为了实现该目的，提供了一种生物材料，包括：由金属，合金或陶瓷制成的基底; 以及层叠在基材上的生物相容性材料层，其中通过表面处理在基材上形成羟基，而生物相容性材料层包含含有磷酸胆碱基团的聚合物，基材和生物相容性材料层通过粘合剂层结合，与基底和生物相容性材料层的羟基组合。

3. 发明授权

EP2233159B1 MEDICAL DEVICE AND METHOD FOR MANUFACTURE THEREOF 有权
标题翻译：医疗器械及其制备方法
公开(公告)号：EP2233159B1
公开(公告)日：2014-05-14
申请号：EP08865567.5
申请日：2008-12-19
申请人： Kyocera Medical Corporation , The University of Tokyo
发明人： KYOMOTO, Masayuki , ISHIHARA, Kazuhiko , NAKAMURA, Kozo , TAKATORI, Yoshio , KAWAGUCHI, Hiroshi , MORO, Toru
IPC分类号： A61K6/04 , A61L27/34 , A61L31/10 , A61L33/00 , A61K6/00 , A61K6/033
CPC分类号： A61L33/0076 , A61K6/033 , A61K6/04 , A61L27/34 , A61L31/10 , Y10T428/31667 , A61K6/0023 , C08L33/08 , C08L33/10

5. 发明授权

EP2311375B1 BONE INSPECTING SYSTEM WITH LOWER LEG SUPPORT DEVICE 有权转让
标题翻译：带小腿支撑装置BONE检查系统
公开(公告)号：EP2311375B1
公开(公告)日：2014-11-26
申请号：EP09800368.4
申请日：2009-07-17
申请人： The University of Tokyo , Hitachi Aloka Medical, Ltd.
发明人： NAKAMURA, Kozo , ONISHI, Isao , MATSUYAMA, Juntaro , TOBITA, Kenji , SAKAI, Ryoichi , OGAWA, Koji , MIYASAKA, Koichi , MINAGAWA, Eiichi
IPC分类号： A61B8/08 , A61B5/00
CPC分类号： A61B8/0875 , A61B5/0053 , A61B5/4504 , A61B5/6828 , A61B8/40 , A61B8/4218

6. 发明公开

EP2314221A1 ULTRASONIC PROBE SUPPORT DEVICE 审中-公开
标题翻译：超声波探头支持装置
公开(公告)号：EP2314221A1
公开(公告)日：2011-04-27
申请号：EP09800367.6
申请日：2009-07-17
申请人： The University of Tokyo , Aloka Co., Ltd.
发明人： NAKAMURA, Kozo , ONISHI, Isao , OHASHI, Satoru , MINAGAWA, Eiichi , HIROTA, Koji , SAKAI, Ryoichi , OGAWA, Koji , MIYASAKA, Koichi , MURASHITA, Masaru
IPC分类号： A61B8/08
CPC分类号： A61B8/0858 , A61B5/4514 , A61B5/4528 , A61B8/4209 , A61B8/4281 , A61B8/4405 , A61B90/50 , A61B2090/378
摘要： A mounting unit (16) is aligned by using a mounting unit frame (58) touching the thigh and a knee-contacting portion (62) touching the knee, with the knee being bent. The mounting unit is also equipped with a probe support frame (60) used for moving an ultrasonic probe along the knee cap. The probe support frame moves rotationally about the mechanical center of the knee joint, thereby allowing the ultrasonic probe (78) to move along the knee cap while facing toward the mechanical center of the knee joint and to perform scanning of an ultrasonic beam.
摘要翻译：通过使用与大腿接触的安装单元框架（58）和与膝盖接触的膝盖接触部分（62）使膝盖弯曲来对齐安装单元（16）。安装单元还配备有用于沿着膝盖移动超声波探头的探头支撑框架（60）。探头支撑框架围绕膝关节的机械中心旋转运动，从而允许超声波探头78沿着膝盖移动，同时面向膝关节的机械中心并且执行超声波束的扫描。

7. 发明公开

EP2311375A1 BONE INSPECTING SYSTEM, AND LOWER LEG SUPPORTING DEVICE 有权转让
标题翻译： KNOCHENPRÜFUNGSSYSTEMMITUNTERSCHENKELSTÜTZVORRICHTUNG
公开(公告)号：EP2311375A1
公开(公告)日：2011-04-20
申请号：EP09800368.4
申请日：2009-07-17
申请人： The University of Tokyo , Aloka Co., Ltd.
发明人： NAKAMURA, Kozo , ONISHI, Isao , MATSUYAMA, Juntaro , TOBITA, Kenji , SAKAI, Ryoichi , OGAWA, Koji , MIYASAKA, Koichi , MINAGAWA, Eiichi
IPC分类号： A61B8/08
CPC分类号： A61B8/0875 , A61B5/0053 , A61B5/4504 , A61B5/6828 , A61B8/40 , A61B8/4218
摘要： Provided is a bone inspecting system for placing the lower legs (L) of an examinee (P) on a proximal support block (26) and a distal support block (28) mounted on a turning base (24). The proximal support block supports the heads of fibula, and the distal support block supports the lateral malleolus or medial malleolus of a tibial distal end of the examinee. The turning base is supported turnably on a turning axis positioned near the knees of the examinee, with respect to a main base (22), and is moved up and down by an elevating mechanism (30) disposed near the ankles. The turning base (24) is turned by the elevating mechanism while bearing the lower legs thereon, thereby positioning the lower legs horizontally.
摘要翻译：提供了一种用于将受检者（P）的下腿（L）放置在安装在转动基座（24）上的近侧支撑块（26）和远侧支撑块（28）上的骨检查系统。近端支撑块支撑腓骨头，并且远端支撑块支撑受检者的胫骨远端的外侧踝或内侧踝。转动基座相对于主基座（22）可转动地支撑在位于受检者的膝盖附近的转动轴上，并且通过设置在脚踝附近的升降机构（30）上下移动。通过升降机构转动转动基座（24），同时在其上支撑下腿，从而水平地定位下腿。

8. 发明公开

EP2314222A1 KNEE ACOUSTIC MATCHING DEVICE FOR ULTRASONIC PROBE 有权转让
标题翻译： SCHALLABSTIMMUNGSVORRICHTUNGFÜREINE ULTRASCHALLSONDE IM KNIE
公开(公告)号：EP2314222A1
公开(公告)日：2011-04-27
申请号：EP09800370.0
申请日：2009-07-17
申请人： The University of Tokyo , Aloka Co., Ltd.
发明人： NAKAMURA, Kozo , ONISHI, Isao , OHASHI, Satoru , MINAGAWA, Eiichi , HIROTA, Koji , SAKAI, Ryoichi , OGAWA, Koji , MIYASAKA, Koichi , MURASHITA, Masaru
IPC分类号： A61B8/08
CPC分类号： A61B8/4209 , A61B8/0858 , A61B8/4281
摘要： An acoustic matching device has a water bag (64) that contains water and a water bag support frame (66) that sandwiches and supports the water bag on the left and right sides of the knee and curves along the knee cap. The water bag becomes a plate shape curved along the shape of the water bag support frame, which touches the knee cap and fits the unevenness of the knee. When an ultrasonic probe is moved along the knee cap, the acoustic matching between the knee cap and the ultrasonic probe is obtained.
摘要翻译：声学匹配装置具有包含水的水袋（64）和水袋支撑框架（66），其在膝盖的左侧和右侧夹住并支撑水袋并沿膝盖弯曲。水袋成为沿着水袋支撑框架的形状弯曲的板形，其接触膝盖并适配膝盖的不平坦部分。当超声波探头沿膝盖移动时，获得膝盖与超声波探头之间的声匹配。

9. 发明公开

EP2226075A1 MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE 审中-公开
标题翻译：材料关节挛缩的预防和材料组织粘连防止
公开(公告)号：EP2226075A1
公开(公告)日：2010-09-08
申请号：EP08852570.4
申请日：2008-11-14
申请人： The University of Tokyo , KAKEN PHARMACEUTICAL CO., LTD.
发明人： MORO, Toru , NAKAMURA, Kozo , KAWAGUCHI, Hiroshi , ISHIYAMA, Noriyuki , ISHIHARA, Kazuhiko , KONNO, Tomohiro , OHYAMA, Tadashi , YOSHIKAWA, Mizuna
IPC分类号： A61K31/80 , A61K31/715 , A61K31/765 , A61P41/00 , A61P43/00
CPC分类号： A61K31/715 , A61K31/765 , A61K31/80
摘要： The present invention provides a tissue adhesion prevention material preparable at an affected area at the time of surgical procedure by producing a three-dimensional polymeric structure having a flexible structure and high solute permeability in a medium comprising water as the main component under mild conditions appropriate for body tissue components (i.e., at ordinary temperature and pressure) without conducting a chemical reaction or employing a physical procedure such as heating or light or radiation irradiation. This makes it possible to provide a tissue adhesion prevention material and a joint contracture prevention materials, which can effectively prevent postoperative adhesion of a tissue in the affected area to the surrounding tissue and contracture of the movable part of a joint.
The tissue adhesion prevention material and/or the joint contracture prevention material of the present invention comprise, as the main component, a composition comprising a compound having a polyvalent hydroxyl group and a polymer containing phosphorylcholine groups and phenylboronic acid groups.
摘要翻译：本发明通过产生具有包含水作为适合在温和条件下的主要成分在培养基中的柔性结构和高溶质透过性的三维聚合物结构提供在受影响的区域中的组织粘连防止材料制备的在外科手术过程的时间体的组织成分（即，在普通的温度和压力）不进行化学反应或物理用人过程：如加热或光或放射线照射。这使得可以提供一种组织粘连防止材料和关节挛缩预防材料，可有效地防止在患处的关节的可动部的周围组织和挛缩的组织的术后粘连。的组织粘连防止材料和/或本发明的关节挛缩预防材料包括，作为主要成分，其包括具有多价羟基和聚合物含磷酸胆碱基团和苯基硼酸基团的化合物的组合物。

10. 发明公开

EP2204197A1 BIOCOMPATIBLE AND LOW-WEAR MATERIAL, ARTIFICIAL JOINT USING THE SAME AND METHOD OF PRODUCING THE SAME 有权
标题翻译： BIOVERTRÄGLICHESVERSCHLEISSARMES材料，KÜNSTLICHESGELENK DAMIT UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2204197A1
公开(公告)日：2010-07-07
申请号：EP08836671.1
申请日：2008-10-02
申请人： Japan Medical Materials Corporation , The University of Tokyo
发明人： KYOMOTO, Masayuki , ISHIHARA, Kazuhiko , NAKAMURA, Kozo , TAKATORI, Yoshio , KAWAGUCHI, Hiroshi , MORO, Toru
IPC分类号： A61L27/00 , A61F2/30 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44
CPC分类号： A61L27/34 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61F2002/30003 , A61F2002/30026 , A61F2002/30065 , A61F2002/30673 , A61F2002/30685 , A61F2002/30934 , A61F2002/30971 , A61F2310/00011 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00389 , A61F2310/00916 , A61F2310/00976 , A61L27/50 , A61L2400/18 , A61L2430/24
摘要： The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1, wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2, while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
摘要翻译：本发明的目的是提供一种滑动构件，假体和制造滑动构件的方法，其可以通过抑制滑动部分的摩擦来抑制磨损碎屑的产生，并且还可以在体内保持令人满意的机械特性。一种滑动构件，包括：能够形成羟基的基底1; 以及层叠在基板1的适当部分上的生物相容性材料层4，其中通过表面处理在基材1的表面的至少所需部分上形成羟基以形成表面处理层2，同时生物相容性材料层 4由含有磷酸胆碱基团的聚合物形成，并且其中基底1和生物相容性材料层4分别经由由与由羟基和生物相容性材料共价键合的二氧化硅形成的粘合剂层3连接。

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