专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1948642A1 4-HETEROARYMETHYL SUBSTITUTED PHTHALAZINONE DERIVATIVES 审中-公开
标题翻译： 4-杂芳基取代的酞嗪酮衍生物
公开(公告)号：EP1948642A1
公开(公告)日：2008-07-30
申请号：EP06794830.7
申请日：2006-10-19
申请人： Kudos Pharmaceuticals Ltd , Maybridge Limited
发明人： JAVAID, Muhammad, Hashim , MENEAR, Keith, Allan , GOMEZ, Sylvie , HUMMERSONE, Marc, Geoffrey , MARTIN, Niall, Morrisson, Barr , SMITH, Graeme, Cameron, Murray , COCKCROFT, Xiao-Ling, Fan , KERRIGAN, Frank
IPC分类号： C07D403/14 , C07D411/14 , A61K31/502 , A61P31/20
CPC分类号： C07D403/10 , C07D403/14 , C07D411/14 , C07D413/14 , C07D487/04
摘要： 1.A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from formula (i), where Y1 is selected from CH and N , Y2 is selected from CH and N, Y3 is selected from CH, CF and N; and formulae (ii), (A) and (B) where Q is O or S; RD is formula (C) wherein RN1 is selected from H and optionally substituted C1-10 alkyl; X is selected from a single bond, NRN2, CRC3RC4 and C=O; RN2 is selected from H and optionally substituted C1-10 alkyl; Rc3 and Rc4 are independently selected from H, R, C(=O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; Y is selected from NRN3 and CRc1Rc2; RC1 and RC2 are independently selected from H, R, C(=O)OR, where R is optionally substituted C1 -10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; RC1 and RC2 together with the carbon atom to which they are attached may form an optionally substituted spiro-fused C5-7 carbocylic or heterocyclic ring; and when X is a single bond RN1 and RC2 may together with the N and C atoms to which they are bound, form an optionally substituted C5-7 heterocylic ring; and when X is CRC3RC4, RC2 and RC4 may together form an additional bond, s uch that there is a double bond between the atoms substituted by RC1 and RC3.
摘要翻译： 1.式（I）的化合物：其中：A和B一起表示任选取代的稠合芳环; D选自式（i），其中Y 1选自CH和N，Y 2选自CH和N，Y 3选自CH，CF和N; 和其中Q是O或S的式（ii），（A）和（B） RD是式（C），其中RN1选自H和任选取代的C1-10烷基; X选自单键NRN2，CRC3RC4和C = O; RN2选自H和任选取代的C1-10烷基; R c3和R c4独立地选自H，R，C（= O）OR，其中R是任选取代的C 1-10烷基，任选取代的C 5-20芳基或任选取代的C 3-20杂环基; Y选自NRN3和CRc1Rc2; RC 1和RC 2独立地选自H，R，C（= O）OR，其中R为任选取代的C 1-10烷基，任选取代的C 5-20芳基或任选取代的C 3-20杂环基; RC1和RC2与它们所连接的碳原子一起可形成任选取代的螺稠合的C5-7碳环或杂环; 并且当X是单键时，RN1和RC2可以与它们所键合的N和C原子一起形成任选取代的C5-7杂环; 并且当X是CRC3RC4时，RC2和RC4可以一起形成额外的键，例如RC1和RC3取代的原子之间存在双键。

2. 发明授权

EP1633724B1 PHTHALAZINONE DERIVATIVES 有权转让
标题翻译：酞嗪酮衍生物
公开(公告)号：EP1633724B1
公开(公告)日：2011-05-04
申请号：EP04720068.8
申请日：2004-03-12
申请人： Kudos Pharmaceuticals Limited , Maybridge Limited
发明人： MARTIN, Niall, Morrison, Barr , SMITH, Graeme, Cameron, Murray , JACKSON, Stephen, Philip , LOH, Vincent, Junior, M. , COCKCROFT, Xiao-Ling, Fan , MATTHEWS, Ian, Timothy, Williams , MENEAR, Keith, Allan , KERRIGAN, Frank , ASHWORTH, Alan
IPC分类号： C07D237/32 , C07D417/12 , C07D401/12 , C07D409/12 , C07D403/12 , C07D413/12 , C07D407/12 , A61K31/502 , A61P31/20
CPC分类号： C07D403/10 , A61K31/00 , C07D237/32 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , C07D495/04
摘要： Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X NRX then n is 1 or 2 and if X = CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRX RY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.
摘要翻译：式（I）化合物：其中A和B一起表示任选取代的稠合芳环; X可以是NRX或CRXRY; 如果X NRX那么n是1或2并且如果X = CRXRY，那么n是1; RX选自H，任选取代的C 1-20烷基，C 5-20芳基，C 3-20杂环基，酰氨基，硫代酰氨基，酯基，酰基和磺酰基; RY选自H，羟基，氨基; 或RX和RY可一起形成螺-C 3-7环烷基或杂环基; RC1和RC2都是氢，或者当X是CRX时，RC1，RC2，RX和RY与它们所连接的碳原子一起可形成任选取代的稠合芳环; 并且R1选自H和卤素。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式