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1. 发明授权

EP2743692B1 MICROCHIP-BASED APPARATUS FOR EXAMINING PLATELET COMPOSITE FUNCTIONS 有权转让
公开(公告)号：EP2743692B1
公开(公告)日：2018-05-23
申请号：EP12821927.6
申请日：2012-08-09
申请人： Korea University Research and Business Foundation
发明人： SHIN, Se Hyun , NAM, Jeong Hun , LIM, Chae Seung
IPC分类号： G01N33/49 , B01F13/08 , B01L3/00
CPC分类号： G01N33/5044 , B01F13/0818 , B01L3/5027 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2400/0475 , B01L2400/049 , G01N33/4905
摘要： There is provided a microchip-based platelet multi-function test apparatus. The apparatus includes a sample container configured to accommodate a blood sample therein, a stirrer that is installed inside the sample container and induces a shear flow in the blood sample, a parallel channel configured to divide and flow the blood stirred by the stirrer into a plurality of paths, a vacuum device that is connected to an end of each parallel channel, maintains constant pressure, allows the stirred blood to flow along the parallel channel, a light source that is installed in a rear side of the parallel channel and radiates light to the parallel channel, and an image sensor that receives light transmitted through the blood in the parallel channel, converts the light into an electrical signal, and measures a flowing distance of a blood flow. According to the invention, it is possible to test a plurality of platelet functions through a single test, and reduce a test time and a test cost.

2. 发明公开

EP2940476A1 APPARATUS AND METHOD FOR PLATELET FUNCTION AND DRUG RESPONSE TESTING BASED ON MICROFLUIDIC CHIP 审中-公开
标题翻译：装置和方法血小板功能测试和主动反应微流控芯片的基础
公开(公告)号：EP2940476A1
公开(公告)日：2015-11-04
申请号：EP13866953.6
申请日：2013-12-26
申请人： Korea University Research and Business Foundation
发明人： SHIN, Se Hyun , LIM, Chae Seung
IPC分类号： G01N35/08 , G01N33/49 , G01N27/30 , G01N21/00
CPC分类号： G01N33/86 , B01L3/502715 , B01L3/50273 , B01L2200/10 , B01L2300/0627 , B01L2300/0645 , B01L2300/0654 , B01L2300/0663 , B01L2400/0406 , B01L2400/0478 , B01L2400/06 , G01N15/0612 , G01N15/1463 , G01N15/1484 , G01N33/49 , G01N2015/0092
摘要： The present invention relates to an apparatus and a method for testing a function and a drug response of a platelet based on a microfluidic chip. The apparatus for test comprises a measuring device containing a blood sample and measuring aggregation and adhesion of a platelet generated by flow of the blood sample; and a fluid driving device which is connected to the measuring device and generates a oscillating shear flow of the blood sample. Therefore, activation of factors such as a platelet and von Willebrand factor (vWF) etc. can be activated uniformly and completely, and a repeatability of the platelet aggregation can be increased.
摘要翻译：本发明涉及的装置和用于测试功能和基于微流体芯片上的血小板的药物应答的方法。为测试该设备包括一测量装置含血液样品和测量由所述血液样品的流动所产生的血小板的聚集和粘附; 并且被连接到所述测量装置和基因率血样的振荡剪切流动的流体驱动装置的所有。因此，因子活化：诸如血小板和血管性血友病因子（vWF）等可以被均匀地和完全地激活了呼叫，并且血小板聚集的重复性可以增加。

3. 发明公开

EP2940470A1 APPARATUS AND METHOD FOR TESTING MULTI-FUNCTION AND DRUG RESPONSE OF CENTRIFUGAL MICROFLUIDICS-BASED PLATELETS 有权
标题翻译： DEVICE AND METHOD FOR MULTI功能和药物对ADDRESS离心MICROFLUIDICS基于滑动测试
公开(公告)号：EP2940470A1
公开(公告)日：2015-11-04
申请号：EP13868176.2
申请日：2013-12-27
申请人： Korea University Research and Business Foundation
发明人： SHIN, Se Hyun , LIM, Chae Seung , NAM, Jeong Hoon , LIM, Hyun Jung
IPC分类号： G01N33/49 , G01N35/08 , G01N33/15
摘要： The present invention relates to an apparatus and method for testing a multi-function and a drug response of platelet based on a centrifugal microfluidics. The testing apparatus according to the present invention may include: a rotatable disk; a sample chamber arranged at the center of the disk such that a blood sample is accommodated therein; stirring chambers respectively connected to the sample chamber in multiple radial directions so as to introduce a shear flow in the blood sample; microchannels connected to the stirring chambers such that adhesion and cohesion of platelets occur during the 44 movement of the blood sample; and a waste sample chamber in which the blood sample is accommodated after passing through the microchannels. According to the present invention, multiple drug tests can be performed on a single blood sample at one time in multiple channels such that multiple tests is possible with respect to complex platelet functions, and thus testing time is reduced and testing costs can be saved.

4. 发明公开

EP4046716A1 MICRO-FLUIDIC APPARATUS HAVING PORE STRUCTURE FOR DETECTING NUCLEIC ACIDS 审中-公开
公开(公告)号：EP4046716A1
公开(公告)日：2022-08-24
申请号：EP22157434.6
申请日：2022-02-18
申请人： Korea University Research and Business Foundation
发明人： HAN, Chang Soo , SHIN, Se Hyun
IPC分类号： B01L3/00 , B01L7/00
摘要： A microfluidic apparatus having a pore structure for detecting nucleic acids according to the present disclosure includes a body: a sample region provided on one side of the body and into which a sample containing a target nucleic acid to be detected is injected; a discharge region provided on the other side of the body so as to be spaced apart from the sample region and configured to discharge the sample in which the target nucleic acid has been detected; a connector configured to connect the sample region and the discharge region to each other to provide a flow path through which the sample flows; a pore region provided inside the connector, having at least one pore, and configured to induce clogging of the pore through amplification of the target nucleic acid contained in the sample; and an electrode region for determining whether the target nucleic acid is amplified by measuring a change in the electrical signal of the sample passing through the pore region, wherein probe linkers that bind to and amplify the target nucleic acid are provided in the pore region, and the electrode region measures the degree of clogging of the at least one pore by binding between the target nucleic acid and the probe linkers to detect the target nucleic acid. With this configuration, since a target nucleic acid is detected based on the degree of clogging of the pore, fast and simple nucleic acid detection is possible.

5. 发明公开

EP2799880A1 APPARATUS AND METHOD FOR MEASURING HEMOSTATIC FUNCTION USING BLOOD MOBILITY 审中-公开
标题翻译： VORRICHTUNG UND VERFAHREN ZUR MESSUNG EINERHÄMOSTASEFUNKTIONMITHILFE DERBLUTMOBILITÄT
公开(公告)号：EP2799880A1
公开(公告)日：2014-11-05
申请号：EP12862839.3
申请日：2012-12-26
申请人： Korea University Research and Business Foundation
发明人： LIM, Chae Seung , SHIN, Se Hyun , KIM, Kyoeng A
IPC分类号： G01N33/86 , G01N35/08 , G01N33/49
CPC分类号： G01N33/86 , B01L3/5027 , B01L2300/0838 , B01L2300/087 , G01N33/4905
摘要： The present invention relates to an apparatus and a method for measuring a hemostatic function using blood mobility. The present invention can comprise a measurement kit; and one or more capillaries provided at the measurement kit in which a blood inlet is formed at one end and an opening communicating with the outside is formed at the other end. In addition, recesses inwardly recessed can be formed longitudinally on at least one lateral side of the capillaries. According to the present invention, it is possible to rapidly measure the hemostatic function of blood and to examine multiple samples at one time by measuring the mobility of a very small amount of blood moving the capillaries.
摘要翻译：本发明涉及使用血液流动性测量止血功能的装置和方法。本发明可以包括测量套件; 并且在另一端形成有一个或多个毛细管，该毛细管设置在其一端形成血液入口的测量套件和与外部连通的开口。此外，凹进的凹部可以在毛细管的至少一个侧面上纵向地形成。根据本发明，可以通过测量移动毛细血管的少量血液的流动性来快速测量血液的止血功能并一次检查多个样品。

6. 发明公开

EP3882614A1 BIOMOLECULE DETECTION DEVICE USING MICROPORES 审中-公开
公开(公告)号：EP3882614A1
公开(公告)日：2021-09-22
申请号：EP19885183.4
申请日：2019-11-13
申请人： Korea University Research and Business Foundation
发明人： HAN, Chang Soo , BONG, Ki Wan , SHIN, Se Hyun , RYU, Ji Hun , KIM, Hyeon Ung
IPC分类号： G01N27/26 , G01N21/64 , G01N33/543
摘要： The present invention relates to a biomolecule detection apparatus capable of easily and quickly detecting various biomolecules associated with diseases and determining the presence or absence of a specific disease. The biomolecule detection apparatus of the present invention includes a micropore device, a microchip, and sensing electrodes. According to the present invention, a microscale pore is formed inside the micropore device. In addition, the microchip is configured to pass through the microscale pore along the flow of a conductive liquid supplied inside the micropore device, has a surface coated with a sensing molecule complementarily bound to a target biomolecule, and has a unique code for identifying the complementarily bound target biomolecule. The sensing electrodes serve to sense the code by measuring change in current flowing through the pore when the microchip passes through the pore.

7. 发明授权

EP2940470B1 APPARATUS FOR TESTING PLATELET AGGREGATION IN RESPONSE TO A DRUG 有权
公开(公告)号：EP2940470B1
公开(公告)日：2020-03-25
申请号：EP13868176.2
申请日：2013-12-27
申请人： Korea University Research and Business Foundation
发明人： SHIN, Se Hyun , LIM, Chae Seung , NAM, Jeong Hoon , LIM, Hyun Jung
IPC分类号： G01N33/49 , G01N35/08 , G01N33/15 , B01L3/00 , B01F13/00 , B01F13/08 , B01F15/02 , G01N33/50 , G01N35/00

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