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1. 发明公开

EP3669369A1 METHODS FOR SEQUENCING BIOMOLECULES 审中-公开
公开(公告)号：EP3669369A1
公开(公告)日：2020-06-24
申请号：EP18753413.6
申请日：2018-08-13
申请人： Koninklijke Philips N.V.
发明人： CHEUNG, Yee, Him , DIMITROVA, Nevenka , SANTHANAM, Balaji, Srinivasan
IPC分类号： G16B20/00

2. 发明公开

EP3616103A1 INTERACTIVE PRECISION MEDICINE EXPLORER FOR GENOMIC ABBERATIONS AND TREATMENT OPTIONS 无效转让
公开(公告)号：EP3616103A1
公开(公告)日：2020-03-04
申请号：EP18720602.4
申请日：2018-04-26
申请人： Koninklijke Philips N.V.
发明人： CHEUNG, Yee, Him , DIMITROVA, Nevenka , DE BONT, Johanna, Maria
IPC分类号： G06F19/26 , G06F19/18

3. 发明公开

EP3602358A1 METHOD AND APPARATUS FOR INTRA- AND INTER-PLATFORM INFORMATION TRANSFORMATION AND REUSE IN PREDICTIVE ANALYTICS AND PATTERN RECOGNITION 审中-公开
公开(公告)号：EP3602358A1
公开(公告)日：2020-02-05
申请号：EP18720970.5
申请日：2018-03-28
申请人： Koninklijke Philips N.V.
发明人： VOLYANSKYY, Kostyantyn , DIMITROVA, Nevenka , MAO, Yong
IPC分类号： G06F19/22 , C12Q1/6869

4. 发明公开

EP3443116A1 SUB-POPULATION DETECTION AND QUANTIZATION OF RECEPTOR-LIGAND STATES FOR CHARACTERIZING INTER-CELLULAR COMMUNICATION AND INTRATUMORAL HETEROGENEITY 有权转让
公开(公告)号：EP3443116A1
公开(公告)日：2019-02-20
申请号：EP17719189.7
申请日：2017-04-07
申请人： Koninklijke Philips N.V.
发明人： SANTHANAM, Balaji Srinivasan , CHEUNG, Yee Him , AGRAWAL, Vartika , DE BONT, Johanna Maria , DIMITROVA, Nevenka
IPC分类号： C12Q1/68
摘要： A system for characterizing intercellular communication and heterogeneity in cancer tumors, and more particularly a method for detecting sub-populations and receptor-ligand states for providing predictive information in relation to cancer and cancer treatment is disclosed. The system comprises the steps of obtaining from a NGS sequencer, single-cell RNA-seq for a plurality of cells within a tumor, correlation with a plurality of data sets from a curated gene list of receptor-ligand pairs, normalizing their transcript abundance data, assigning states (e.g. 0,1,2,3) to each curated receptor-ligand pair in each cell (e.g. depending on {L:R}={0:0, 0:1, 1:0, 1:1}), thereby forming a matrix of receptor-ligand states, extracting sub-groups from the matrix that are not invariant and applying unsupervised clustering methods to identifying sub-clusters, identifying sub-populations within the set based on pair-wise distances between individual cells and similarity of cellular transcriptomes, identifying expressed ligands and receptors across the sub-populations, cross-referencing against the curated set of receptor-ligand pairs and providing a visually display the results by a mapping module for the clinician. The method can be used to study intercellular communication to elicit the etiology of diseases, and can be used to measure the disruption of intercellular communication to diagnose similarly disrupted disease patterns across patients.

5. 发明公开

EP3426799A1 ANTIBIOTIC RESISTANCE IDENTIFICATION 有权转让
公开(公告)号：EP3426799A1
公开(公告)日：2019-01-16
申请号：EP17710710.9
申请日：2017-03-10
申请人： Koninklijke Philips N.V.
发明人： MURUGESAN, Karthikeyan , DIMITROVA, Nevenka , LIN, Henry , MAYIGOWDA, Pramod, Bevoor
IPC分类号： C12Q1/68

6. 发明授权

EP2359281B1 METHOD AND DEVICE FOR EFFICIENT SEARCHING OF DNA SEQUENCE BASED ON ENERGY BANDS OF DNA SPECTROGRAM 失效转让
公开(公告)号：EP2359281B1
公开(公告)日：2018-10-24
申请号：EP09760322.9
申请日：2009-11-11
申请人： Koninklijke Philips N.V.
发明人： KUDAVELLY, Srinivas, R. , DIMITROVA, Nevenka
IPC分类号： G06F19/22 , G06F19/24 , G06F19/28
CPC分类号： G06F19/22 , G06F19/24 , G06F19/28
摘要： The present invention discloses a method for DNA sequence analysis based on DNA spectrogram database. Furthermore, a use, a device and a computer-readable medium related to the method are disclosed.

7. 发明授权

EP2289173B1 METHOD, APPARATUS, AND COMPUTER PROGRAM PRODUCT FOR COMPRESSION AND DECOMPRESSION OF A GENE SEQUENCING IMAGE 有权转让
标题翻译：用于基因测序图像的压缩和解压的方法，装置和计算机程序产品
公开(公告)号：EP2289173B1
公开(公告)日：2017-10-11
申请号：EP09746233.7
申请日：2009-05-11
申请人： Koninklijke Philips N.V.
发明人： DHAND, Harsh , DIMITROVA, Nevenka , MISRA, Hansraj
IPC分类号： H03M7/30
CPC分类号： G06T9/00 , H03M7/30

8. 发明公开

EP3189458A1 METHODS AND SYSTEMS FOR VISUALIZING GENE EXPRESSION DATA 有权转让
标题翻译：用于可视化基因表达数据的方法和系统
公开(公告)号：EP3189458A1
公开(公告)日：2017-07-12
申请号：EP15774976.3
申请日：2015-08-27
申请人： Koninklijke Philips N.V.
发明人： MANKOVICH, Alexander Ryan , DIMITROVA, Nevenka , AGRAWAL, Vartika , BANERJEE, Nilanjana
IPC分类号： G06F19/26
摘要： Methods and systems for visualizing gene expression data in a way that permits the comparison of different patient groups to facilitate medical applications, including cancer diagnostics and treatment planning, particularly breast cancer. The method organises gene expression data for at least one patient into a plurality of windows of a specified size, calculates an average RSEM score for all of the genes in each window and presents the average RSEM scores in a two-dimensional array, wherein one axis organises the windows by patient and the other axis organises the windows by sequence.
摘要翻译：用于可视化基因表达数据的方法和系统，其允许比较不同患者组以便于医学应用，包括癌症诊断和治疗计划，特别是乳腺癌。该方法将至少一个患者的基因表达数据组织成多个规定大小的窗口，计算每个窗口中所有基因的平均RSEM分数，并以二维阵列呈现平均RSEM分数，其中一个轴由病人组织窗户，另一个轴按顺序组织窗户。

9. 发明公开

EP3138034A1 GENOMIC INFORMATICS SERVICE 审中-公开
标题翻译： GENOMISCHER INFORMATIKDIENST
公开(公告)号：EP3138034A1
公开(公告)日：2017-03-08
申请号：EP15721338.0
申请日：2015-04-24
申请人： Koninklijke Philips N.V. , Intertrust Technologies Corporation
发明人： DIMITROVA, Nevenka , CAREY, William Knox , KRASINSKI, Raymond J. , NILSSON, Jarl , GRANTHAM, Bart , MANKOVICH, Alexander Ryan , AGRAWAL, Vartika
IPC分类号： G06F19/28
CPC分类号： G06F21/6245 , G06F19/00 , G06F19/28 , G06F21/32 , G16H10/60
摘要： Methods and apparatus for a secure framework for storing and analyzing genomic data. Embodiments of the present invention apply persistent governance to sensitive information and to the analytics that operate upon it, managing the interaction between the two.
摘要翻译：用于存储和分析基因组数据的安全框架的方法和装置。本发明的实施例将持续治理应用于敏感信息和对其进行操作的分析，管理两者之间的相互作用。

10. 发明公开

EP2925887A2 PREDICTIVE OUTCOME ASSESSMENT FOR CHEMOTHERAPY WITH NEOADJUVANT BEVACIZUMAB 失效
标题翻译：精油ÜRÜUNG IE IE IE IE B B B B B B B B B B B B B B B B B B B
公开(公告)号：EP2925887A2
公开(公告)日：2015-10-07
申请号：EP13826603.6
申请日：2013-11-22
申请人： Koninklijke Philips N.V.
发明人： VARADAN, Vinay , KAMALAKARAN, Sitharthan , JANEVSKI, Angel , BANERJEE, Nilanjana , DIMITROVA, Nevenka , HARRIS, Lyndsay
IPC分类号： C12Q1/68
CPC分类号： G06F19/24 , A61K39/3955 , A61K45/06 , C07K16/22 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G06F19/704
摘要： In a predictive outcome assessment test for predicting whether a patient undergoing a breast cancer treatment regimen will achieve pathological complete response (pCR), differential gene expression level information are generated for an input set of genes belonging to the TGF-&bgr; signaling pathway. The differential gene expression level information compares baseline gene expression level information from a baseline sample (70) of a breast tumor of a patient acquired before initiating (71) a breast cancer therapy regimen to the patient and response gene expression level information from a response sample (72) of the breast tumor acquired after initiating the breast cancer therapy regimen by administering a first dose of bevacizumab to the patient. A pCR prediction for the patient is computed based on the differential gene expression level information for the input set of genes belonging to the TGF-&bgr; signaling pathway. Related predictive outcome assessment test development methods are also disclosed.
摘要翻译：在用于预测经历乳腺癌治疗方案的患者是否将达到病理学完全应答（pCR）的预测性结果评估测试中，针对属于TGF-β的基因的输入集合产生差异基因表达水平信息。信号通路。差异基因表达水平信息比较了在开始（71）乳腺癌治疗方案与患者之前获得的患者的乳腺肿瘤的基线样品（70）的基线基因表达水平信息和来自响应样品的响应基因表达水平信息（72）通过向患者施用第一剂贝伐珠单抗来启动乳腺癌治疗方案后获得的乳腺肿瘤。基于属于TGF-β基因的输入基因组的差异基因表达水平信息计算患者的pCR预测值; 信号通路。还公开了相关预测结果评估测试开发方法。

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