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1. 发明公开

EP2483688A1 METHOD FOR CHARACTERIZATION OF BIOLOGICAL BONDS 有权转让
标题翻译：程序对生物债券的鉴定
公开(公告)号：EP2483688A1
公开(公告)日：2012-08-08
申请号：EP10760058.7
申请日：2010-09-07
申请人： Koninklijke Philips Electronics N.V.
发明人： VAN OMMERING, Kim , SCHLEIPEN, Johannes, J. H. B. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , G01N21/552 , G01N33/54313
摘要： The invention relates to the field of intensity measurements of a light scattering label bound to a surface of a support using an optical evanescent field. According to the invention, the method comprises the steps: a) Providing an assay comprising at least one light scattering label bound to a surface of a support by at least one bond; b) Measuring the fluctuations in the intensity of scattered light of the label in an optical evanescent field over time while the label is bound to the surface. The method according to the invention allows to identify different bonds and/or to distinguish between different bonds.

2. 发明公开

EP2329269A1 MAGNETIC-LABEL SENSOR AND CARTRIDGE 审中-公开
标题翻译：磁传感器和标签CASSETTE
公开(公告)号：EP2329269A1
公开(公告)日：2011-06-08
申请号：EP09787209.7
申请日：2009-09-16
申请人： Koninklijke Philips Electronics N.V.
发明人： VAN ZON, Hans , OVSYANKO, Mikhail, M. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01N33/543 , G01N35/00
CPC分类号： G01N21/552 , G01N15/1463 , G01N2015/1493
摘要： A cartridge (1,3) for a magnetic-label sensor, in particular for a magnetic-label biosensor, comprises a sensor area (4), a fluid channel (2) in contact with said sensor area and first (A) and second (Bl, B2) reservoirs in fluid communication with said fluid channel. The first reservoir comprises a first type of magnetic particles (8) and the second reservoir comprises a second type of magnetic particles (8a). The first type of magnetic particles are functionalized for binding with said sensor area, whereas the second type of magnetic particles are non- functionalized for binding with said sensor area. The magnetic particles (8, 8a) are manipulated using magnet (13). Detection is based on frustrated total internal reflection (FTIR) is hereby light from laser/LED (II) is reflected at sensor area (4) and detected by photodetector/CCD(12).

3. 发明公开

EP2263084A1 CARTRIDGE FOR ASSAYS WITH MAGNETIC PARTICLES 有权转让
标题翻译： KARTUSCHEFÜR测定MIT MAGNETISCHEN PARTIKELN
公开(公告)号：EP2263084A1
公开(公告)日：2010-12-22
申请号：EP09723313.4
申请日：2009-03-11
申请人： Koninklijke Philips Electronics N.V.
发明人： SIJBERS, Mara, J., J. , VAN LANKVELT, Petrus, J., W. , DE THEIJE, Femke, K. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01N33/53
CPC分类号： G01N33/54333 , B03C1/282 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N27/745 , G01N33/54373 , G01N33/946 , G01N33/948 , G01N33/9486
摘要： The invention relates to a cartridge (100) and a corresponding sensor device for the detection of target components in a liquid sample. The cartridge (100) comprises a sample chamber(SC), at least two reservoirs(131, 132) that can be furnished with magnetic particles(MP, MP′), and at least two corresponding sensitive zones (121, 122) in which solved magnetic particles and/or target components can be detected. When a magnetic actuation field(B) of a given configuration is established in the sample chamber, the magnetic particles of different reservoirs migrate predominantly to different sensitive zones. Thus a mixing of magnetic particles can be avoided.
摘要翻译：本发明涉及一种用于检测液体样品中的目标组分的盒（100）和相应的传感器装置。盒（100）包括样品室（SC），至少两个能够配备有磁性颗粒（MP，MP'）和至少两个对应的敏感区域（121,122）的储存器（131,132），其中可以检测到溶解的磁性颗粒和/或目标组分。当在样品室中建立给定构造的磁致动场（B）时，不同储层的磁性颗粒主要迁移到不同的敏感区域。因此，可以避免磁性颗粒的混合。

4. 发明公开

EP2171491A2 SENSOR CARTRIDGE 审中-公开
标题翻译：传感器盒
公开(公告)号：EP2171491A2
公开(公告)日：2010-04-07
申请号：EP08789314.5
申请日：2008-07-16
申请人： Koninklijke Philips Electronics N.V.
发明人： IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01R33/09
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译：本发明提供了一种用于区别确定流体样本中的至少两个不同目标部分的传感器盒（10）。传感器盒（10）包括反应室（1）和至少一个彼此不同的第一和第二区域（2,3）。第一区域（2）包括用第一类探针标记的用于特异性结合第一类型靶标部分的磁性或可磁化物体（4a），第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b）用于特异性结合第二类型目标部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可直接与样品流体接触。本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同目标部分的存在和/或量的方法。

5. 发明公开

EP2331941A1 DETECTION SYSTEM AND METHOD 有权转让
标题翻译：检测系统和方法
公开(公告)号：EP2331941A1
公开(公告)日：2011-06-15
申请号：EP09787258.4
申请日：2009-09-21
申请人： Koninklijke Philips Electronics N.V.
发明人： WIMBERGER-FRIEDL, Reinhold , NIEUWENHUIS, Jeroen, H. , SCHLEIPEN, Johannes, J., H., B.
IPC分类号： G01N21/64 , G01N21/77 , G01N33/543
CPC分类号： G01N21/6428 , G01N21/648
摘要： A detection system combines an excitation radiation source (18) providing excitation radiation (10) to an analysis region of a sample (14) within a substrate (16) having a detection surface, a detector (22) for detecting radiation collected from the analysis region comprising the detection surface of the sample resulting from the excitation, and a magnet arrangement (24) beneath the analysis region of the sample, and stationary with respect to the excitation radiation source and light coupling arrangement, for attracting magnetic beads (15) within the sample to the substrate surface The detection radiation is collected from the detection surface of the substrate, to give an enhanced surface specificity The invention combines the advantages of surface detection with a simple low cost magnetic system for bringing the target to the surface

6. 发明公开

EP2265930A2 A CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 无效转让
标题翻译：载体光学检测小子样体积
公开(公告)号：EP2265930A2
公开(公告)日：2010-12-29
申请号：EP09729678.4
申请日：2009-04-07
申请人： Koninklijke Philips Electronics N.V.
发明人： SCHLEIPEN, Johannes, J., H., B. , EVERS, Toon, H. , NIEUWENHUIS, Jeroen, H. , DITTMER, Wendy, U. , BRULS, Dominique, M. , PRINS, Menno, W., J. , NEIJZEN, Jacobus, H., M. , BOURQUIN, Yannyk, P., J.
IPC分类号： G01N21/25 , G01N21/41
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (L1) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.

7. 发明公开

EP2220478A2 MICROELECTRONIC SENSOR DEVICE WITH AN ARRAY OF DETECTION CELLS 审中-公开
标题翻译：的检测单元阵列，微电子传感器装置
公开(公告)号：EP2220478A2
公开(公告)日：2010-08-25
申请号：EP08807728.4
申请日：2008-09-19
申请人： Koninklijke Philips Electronics N.V.
发明人： VAN LANKVELT, Petrus, J., W. , NIEUWENHUIS, Jeroen, H. , VAN ZON, Hans
IPC分类号： G01N15/06 , G01N33/543 , G01R33/12 , G01N15/10
CPC分类号： G01N27/745 , G01N15/0656 , G01N33/54326 , G01N33/54333 , G01N2015/0693 , G01R33/1269
摘要： The invention relates to a microelectronic sensor device with a matrix array of rows (R4, R5) and columns (Cl, C2) of detection cells (10), wherein each detection cell comprises an activation element (30) for transferring target particles (e.g. magnetic beads) into an activated state and a sensor element (20) for detecting activated target particles. According to a preferred embodiment, the activation elements (20) of each row of the matrix as well as the sensor elements (20) of each column of the matrix are connected in series. By activating one row and reading out one column, each detection cell (10) can thus individually be addressed with a limited number of column- and row-address circuits.

8. 发明公开

EP2170515A2 MICROFLUIDIC METHODS AND SYSTEMS FOR USE IN DETECTING ANALYTES 有权
标题翻译： FOR USE中分析微流控的方法和系统
公开(公告)号：EP2170515A2
公开(公告)日：2010-04-07
申请号：EP08789279.0
申请日：2008-07-11
申请人： Koninklijke Philips Electronics N.V.
发明人： VERHOECKX, Godefridus, J. , VAN DAMME, Hendrik, S. , NIEUWENHUIS, Jeroen, H. , SHULEPOV, Sergei , WEEKAMP, Johannes, W. , SIJBERS, Mara, J., J. , BRANS, Harold, J., A. , DE THEIJE, Femke, K. , IMMINK, Albert, H, .J.
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L2200/12 , B01L2200/16 , B01L2300/0627 , B01L2300/0636 , B01L2300/161 , B01L2400/0406 , B01L2400/0487 , Y10T29/49826
摘要： A microfluidic reactor arrangement (100) for use in detecting an analyte in a fluid sample (106) is described. The reactor arrangement is provided with a reagent providing means such that the reagent can be introduced after assembly of the reactor arrangement. The latter can be performed by introducing the reagent in the form of a solution or a dispersion and fixing it on a holding means (118) by removal of the liquid, i.e. by drying, the holding means comprising the reagent in a solid version in the detector chamber. Prior to the introduction of the reagent, components of the reactor arrangement already present, such as the sample inlet can be hydrophilised by a wetting hydrophilising technique. The invention relates to a manufacturing technique as well as to the resulting product. The invention furthermore relates to functionalizing of the reactor arrangement with a particular reagent for particular applications. The latter can be performed well after fabrication and assembly of the major reactor arrangement components.

9. 发明公开

EP2005139A2 MAGNETORESISTIVE SENSOR AS TEMPERATURE SENSOR 审中-公开
标题翻译：磁阻传感器作为温度传感器
公开(公告)号：EP2005139A2
公开(公告)日：2008-12-24
申请号：EP07735241.7
申请日：2007-03-23
申请人： Koninklijke Philips Electronics N.V.
发明人： NIEUWENHUIS, Jeroen, H. , JANSEN, Theodorus, P., H., G. , VEEN, Jeroen , KAHLMAN, Josephus, A., H., M. , IMMINK, Albert, H., J.
IPC分类号： G01N15/06 , G01R33/09 , G01N33/543 , G01R33/12 , G01N35/00
CPC分类号： G01R33/09 , B82Y25/00 , G01R33/007 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (Iadj) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (Isense) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (Iadj) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f1) is different from the first frequency (f1}). The invention also relates to a corresponding method.

10. 发明授权

EP2170515B1 MICROFLUIDIC METHODS AND SYSTEMS FOR USE IN DETECTING ANALYTES 有权
标题翻译： FOR USE中分析微流控的方法和系统
公开(公告)号：EP2170515B1
公开(公告)日：2012-02-29
申请号：EP08789279.0
申请日：2008-07-11
申请人： Koninklijke Philips Electronics N.V.
发明人： VERHOECKX, Godefridus, J. , VAN DAMME, Hendrik, S. , NIEUWENHUIS, Jeroen, H. , SHULEPOV, Sergei , WEEKAMP, Johannes, W. , SIJBERS, Mara, J., J. , BRANS, Harold, J., A. , DE THEIJE, Femke, K. , IMMINK, Albert, H, .J.
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L2200/12 , B01L2200/16 , B01L2300/0627 , B01L2300/0636 , B01L2300/161 , B01L2400/0406 , B01L2400/0487 , Y10T29/49826
摘要： A microfluidic reactor arrangement (100) for use in detecting an analyte in a fluid sample (106) is described. The reactor arrangement is provided with a reagent providing means such that the reagent can be introduced after assembly of the reactor arrangement. The latter can be performed by introducing the reagent in the form of a solution or a dispersion and fixing it on a holding means (118) by removal of the liquid, i.e. by drying, the holding means comprising the reagent in a solid version in the detector chamber. Prior to the introduction of the reagent, components of the reactor arrangement already present, such as the sample inlet can be hydrophilised by a wetting hydrophilising technique. The invention relates to a manufacturing technique as well as to the resulting product. The invention furthermore relates to functionalizing of the reactor arrangement with a particular reagent for particular applications. The latter can be performed well after fabrication and assembly of the major reactor arrangement components.

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