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1. 发明公开

EP2597472A3 Micro integrated analysis system, testing chip, and testing method 审中-公开
标题翻译：微集成分析系统，测试芯片和测试方法
公开(公告)号：EP2597472A3
公开(公告)日：2014-03-05
申请号：EP13154446.2
申请日：2006-03-28
申请人： Konica Minolta Medical & Graphic, Inc.
发明人： Higashino, Kusunoki , Nakajima, Akihisa , Sando, Yasuhiro
IPC分类号： G01N35/08 , B01L3/00 , B01L7/00 , B01F5/06 , B01F13/00 , G01N35/00
CPC分类号： B01L3/502715 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L7/525 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/1822 , B01L2300/1883 , B01L2400/0439 , B01L2400/0688 , G01N35/00029 , Y10T436/2575
摘要： A micro integrated analysis system includes a testing chip, system main body and heat-insulating section. The chip has a pump connecting section to communicate with micro pumps; a mixing flow path for mixing a specimen and reagent and for reaction processing by heating; and a testing flow path for performing a predetermined test of a mixed solution heated and processed for reaction. The system main body has a holding section to hold the testing chip; micro pumps for injecting a specimen and reagent; a heating section for heating the mixing flow path; and a detection section for performing a test in the testing flow path. The heat-insulating section insulates flow path portions continuing from both an inlet end and outlet end of a heated flow path area of the mixing flow path, from heat of the heating section so as to prevent a rise in temperature.
摘要翻译：微集成分析系统包括测试芯片，系统主体和隔热部分。该芯片具有与微泵连通的泵连接部分; 用于混合试样和试剂并通过加热进行反应处理的混合流路; 以及测试流路，用于执行为了反应而加热和处理的混合溶液的预定测试。系统主体具有用于保持测试芯片的保持部分; 用于注射样本和试剂的微型泵; 加热部分，用于加热混合流路; 以及用于在测试流程中执行测试的检测部分。隔热部分将从混合流路的加热流路区域的入口端和出口端两者连续的流路部分与加热部分的热隔离，从而防止温度升高。

2. 发明公开

EP1705488A2 Analyser 审中-公开
标题翻译： Analysator
公开(公告)号：EP1705488A2
公开(公告)日：2006-09-27
申请号：EP06111453.4
申请日：2006-03-21
申请人： Konica Minolta Medical & Graphic, Inc.
发明人： Sando, Yasuhiro , Nakajima, Akihisa , Higashino, Kusunoki
IPC分类号： G01N35/00
CPC分类号： G01N35/00029 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/502715 , B01L2200/146 , B01L2200/147 , Y10T436/2575
摘要： An analyzer for analysis of a specimen in a testing chip that includes a micropump connecting section that is connected with a micropump to take in liquid from the micropump and includes a micro flow channel in which a reagent and the specimen are mixed so as to react with each other, the analyzer including: a mounting section for mounting the testing chip attachably and detachably thereto; a micropump unit that has a testing chip connecting section to be connected with the micropump connecting section of the testing chip which is mounted on the mounting section, and feeds liquid to the testing chip through the testing chip connecting section; and a pressing mechanism that presses the micropump connecting section and the testing chip connecting section against each other, the connecting sections being connected with each other.
摘要翻译：一种用于分析测试芯片中的样本的分析器，其包括与微型泵连接以从微型泵吸取液体的微型泵连接部分，并且包括微流道，其中将试剂和样品混合以便与彼此分离器包括：用于将测试芯片可安装和可拆卸地安装在其上的安装部分; 微型泵单元，具有与安装在安装部上的测试用芯片的微型泵连接部连接的测试芯片连接部，并通过测试芯片连接部将液体供给到测试芯片; 以及将微型泵连接部和测试用芯片连接部彼此按压的按压机构，连接部彼此连接。

3. 发明公开

EP1705488A3 Analyser 审中-公开
标题翻译：分析仪
公开(公告)号：EP1705488A3
公开(公告)日：2011-11-09
申请号：EP06111453.4
申请日：2006-03-21
申请人： Konica Minolta Medical & Graphic, Inc.
发明人： Sando, Yasuhiro , Nakajima, Akihisa , Higashino, Kusunoki
IPC分类号： G01N35/00 , B01L3/00 , B01F5/06 , B01F13/00
CPC分类号： G01N35/00029 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/502715 , B01L2200/146 , B01L2200/147 , Y10T436/2575
摘要： An analyzer for analysis of a specimen in a testing chip that includes a micropump connecting section that is connected with a micropump to take in liquid from the micropump and includes a micro flow channel in which a reagent and the specimen are mixed so as to react with each other, the analyzer including: a mounting section for mounting the testing chip attachably and detachably thereto; a micropump unit that has a testing chip connecting section to be connected with the micropump connecting section of the testing chip which is mounted on the mounting section, and feeds liquid to the testing chip through the testing chip connecting section; and a pressing mechanism that presses the micropump connecting section and the testing chip connecting section against each other, the connecting sections being connected with each other.
摘要翻译：一种分析装置，用于分析测试芯片中的样本，所述分析装置包括：微型泵连接部分，其与微型泵连接以从微型泵中取入液体并且包括微型流动通道，其中混合有试剂和样本以与所述分析装置包括：安装部分，用于安装可拆卸地连接的测试芯片; 微型泵单元，其具有测试芯片连接部分，以与安装在安装部分上的测试芯片的微型泵连接部分连接，并通过测试芯片连接部分向测试芯片供给液体; 以及按压机构，其将微型泵连接部和测试芯片连接部相互按压，连接部相互连接。

4. 发明公开

EP1927401A1 Micro total analysis chip and micro total analysis system 审中-公开
标题翻译：微全分析芯片和微全分析系统
公开(公告)号：EP1927401A1
公开(公告)日：2008-06-04
申请号：EP07120060.4
申请日：2007-11-06
申请人： Konica Minolta Medical & Graphic, Inc.
发明人： Higashino, Kusunoki , Nakajima, Akihisa , Sando, Yasuhiro , Aoki, Youichi
IPC分类号： B01L3/00 , G01N15/14 , C12M1/34
CPC分类号： B01L3/502746 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0439 , B01L2400/0487 , B01L2400/086 , B01L2400/088
摘要： A micro total analysis chip including: a main flow path for feeding a liquid; and a divided flow path branched into a plurality of divided paths for dividing and feeding the liquid fed from the main flow path at a predetermined division ratio, wherein a ratio of flow path resistance between each of the divided paths is approximately equal to a reciprocal of the predetermined ratio with which the liquid is divided and fed to the each of the divided paths.
摘要翻译：一种微全分析芯片，包括：供给液体的主流路; 以及分支流路，分支成多个分支路径，用于以预定的分配比分配和供给从主流路供给的液体，其中每个分支路径之间的流路阻力的比率近似等于液体被分割并供给到每个分开的路径的预定比率。

5. 发明授权

EP1705543B1 Micro total analysis system 有权
标题翻译：微量分析系统
公开(公告)号：EP1705543B1
公开(公告)日：2012-05-16
申请号：EP06111218.1
申请日：2006-03-15
申请人： Konica Minolta Medical & Graphic, Inc.
发明人： Higashino, Kusunoki , Nakajima, Akihisa , Sando, Yasuhiro
IPC分类号： G05D11/13 , B01L3/00
CPC分类号： B01F15/042 , B01F11/0071 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2300/0867 , B01L2400/0439 , B01L2400/0487 , B01L2400/084 , F04B43/046 , G05D7/0694 , G05D11/132 , Y10T137/0318 , Y10T137/0324 , Y10T436/25

6. 发明公开

EP1950555A3 Microchip inspection system, microchip inspection apparatus and a computer readable medium 审中-公开
标题翻译：微芯片检查系统，微型芯片检查装置和计算机可读介质
公开(公告)号：EP1950555A3
公开(公告)日：2010-03-17
申请号：EP08150345.0
申请日：2008-01-17
申请人： Konica Minolta Medical & Graphic, Inc.
发明人： Sawazumi, Tsuneo , Nakajima, Akihisa , Sando, Yasuhiro
IPC分类号： G01N21/64 , B01L3/00 , B01L7/00
CPC分类号： G01N21/6428 , B01L3/5027 , B01L7/52 , B01L2200/027 , B01L2300/0816 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487
摘要： A microchip inspection system including: a microchip having at least a target substance and a reagent which is fluorescently labeled and is specifically combined with the target substance, wherein a reaction of the target substance and the reagent is performed and detecting a fluorescence intensity in a detected section of the microchip is performed; a microchip holder; a photo detection section; a reaction start device; and a control section for controlling a reaction start timing of the reaction start device and a detection timing of the fluorescence intensity before and after a reaction by the photo detection section, wherein the control section correlates a detection timing of the fluorescence intensity before the reaction by the photo detection section with the reaction start timing by the reaction start device.

7. 发明公开

EP1923707A2 Microfluidic analysis system and program 审中-公开
标题翻译： Mikrofluidik-分析系统和程序
公开(公告)号：EP1923707A2
公开(公告)日：2008-05-21
申请号：EP07120451.5
申请日：2007-11-12
申请人： Konica Minolta Medical & Graphic, Inc.
发明人： Sando, Yasuhiro , Nakajima, Akihisa , Higashino, Kusunoki , Aoki, Youichi
IPC分类号： G01N35/10 , B01L3/00 , G01N11/04
CPC分类号： G01N35/1016 , B01L3/502715 , B01L3/50273 , B01L2200/143 , B01L2200/147 , B01L2300/0816 , B01L2400/0439 , B01L2400/0487 , B01L2400/082 , G01F1/7086 , G01N11/04 , G01N2011/0013 , G01N2035/1034 , Y10T137/2196 , Y10T137/6416
摘要： There is described a microluidic analysis system, which makes it possible not only to correct the influence of the viscosity change of the liquid, but also to accurately conduct the liquid conveyance controlling operation. The microchip inspection system includes: a micro pump to inject a driving liquid from a liquid flow path into a microchip; a liquid temperature adjusting section to adjust a liquid temperature of the driving liquid; a driving liquid detecting section to detect presence or absence of the driving liquid at two predetermined positions located in the liquid flow path, so as to output detection signals; a fluid velocity calculating section to calculate a fluid velocity based on the detection signals outputted by the driving liquid detecting section; and a liquid temperature controlling section to control the liquid temperature adjusting section, based on the fluid velocity calculated by the fluid velocity calculating section.
摘要翻译：描述了一种微流体分析系统，其不仅可以校正液体的粘度变化的影响，而且可以准确地进行液体输送控制操作。微芯片检查系统包括：将来自液体流路的驱动液体注入微芯片的微型泵; 液体温度调节部分，用于调节驱动液体的液体温度; 驱动液体检测部分，用于检测位于所述液体流路中的两个预定位置处的驱动液体的有无，以便输出检测信号; 流体速度计算部，其基于由所述驱动液体检测部输出的检测信号来计算流体速度; 以及液体温度控制部，其基于由所述流体速度计算部计算出的流体速度来控制所述液体温度调节部。

8. 发明公开

EP2597471A3 Micro integrated analysis system, testing chip, and testing method 审中-公开
标题翻译：微型综合分析系统测试芯片和测试方法
公开(公告)号：EP2597471A3
公开(公告)日：2014-03-05
申请号：EP13154445.4
申请日：2006-03-28
申请人： Konica Minolta Medical & Graphic, Inc.
发明人： Higashino, Kusunoki , Nakajima, Akihisa , Sando, Yasuhiro
IPC分类号： G01N35/08 , B01L3/00 , B01L7/00 , B01F5/06 , B01F13/00 , G01N35/00
CPC分类号： B01L3/502715 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L7/525 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/1822 , B01L2300/1883 , B01L2400/0439 , B01L2400/0688 , G01N35/00029 , Y10T436/2575
摘要： A micro integrated analysis system includes a testing chip, system main body and heat-insulating section. The chip has a pump connecting section to communicate with micro pumps; a mixing flow path for mixing a specimen and reagent and for reaction processing by heating; and a testing flow path for performing a predetermined test of a mixed solution heated and processed for reaction. The system main body has a holding section to hold the testing chip; micro pumps for injecting a specimen and reagent; a heating section for heating the mixing flow path; and a detection section for performing a test in the testing flow path. The heat-insulating section insulates flow path portions continuing from both an inlet end and outlet end of a heated flow path area of the mixing flow path, from heat of the heating section so as to prevent a rise in temperature.

9. 发明公开

EP1950555A2 Microchip inspection system, microchip inspection apparatus and a computer readable medium 审中-公开
标题翻译： Mikrochip-Inspektionssystem，Mikrochip-Inspektionsvorrichtung und computerlesbares中等
公开(公告)号：EP1950555A2
公开(公告)日：2008-07-30
申请号：EP08150345.0
申请日：2008-01-17
申请人： Konica Minolta Medical & Graphic, Inc.
发明人： Sawazumi, Tsuneo , Nakajima, Akihisa , Sando, Yasuhiro
IPC分类号： G01N21/64 , B01L3/00 , B01L7/00
CPC分类号： G01N21/6428 , B01L3/5027 , B01L7/52 , B01L2200/027 , B01L2300/0816 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487
摘要： A microchip inspection system including: a microchip having at least a target substance and a reagent which is fluorescently labeled and is specifically combined with the target substance, wherein a reaction of the target substance and the reagent is performed and detecting a fluorescence intensity in a detected section of the microchip is performed; a microchip holder; a photo detection section; a reaction start device; and a control section for controlling a reaction start timing of the reaction start device and a detection timing of the fluorescence intensity before and after a reaction by the photo detection section, wherein the control section correlates a detection timing of the fluorescence intensity before the reaction by the photo detection section with the reaction start timing by the reaction start device.
摘要翻译：一种微芯片检查系统，包括：至少具有目标物质的微芯片和荧光标记的试剂，并与目标物质特异性结合，其中进行目标物质与试剂的反应，并检测检测到的物质的荧光强度执行微芯片的截面; 微芯片座; 光检测部; 反应启动装置; 以及控制部分，用于控制反应开始装置的反应开始时间和由光检测部分反应之前和之后的荧光强度的检测定时，其中控制部分将反应之前的荧光强度的检测定时与该光检测部分具有反应开始装置的反应开始定时。

10. 发明公开

EP1925365A1 Micro total analysis chip and micro total analysis system 审中-公开
标题翻译： Gesamtmikroanalysechip和Gesamtmikroanalysesystem
公开(公告)号：EP1925365A1
公开(公告)日：2008-05-28
申请号：EP07120205.5
申请日：2007-11-07
申请人： Konica Minolta Medical & Graphic, Inc.
发明人： Higashino, Kusunoki , Nakajima, Akihisa , Sando, Yasuhiro , Aoki, Youichi
IPC分类号： B01L3/00 , G01N15/14 , C12M1/34
CPC分类号： B01L3/502746 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0622 , B01L2400/086
摘要： A micro total analysis chip including: a main flow path for feeding a liquid; and a divided flow path for dividing and feeding the liquid at a predetermined division ratio, each divided path of the plurality of divided paths having a high flow path resistance portion comprising a narrowed down flow path narrower than a preceding part and a subsequent part of the each divided path, wherein a flow path resistance R of the high flow path resistance portion of a first divided path in the divided paths satisfies an expression of: R x Q > σ x L/S , where, Q is a flow rate of the first divided path, S is a sectional area and L is a sectional circumferential length of a flow path of other divided path of the plurality of divided paths, and σ is a surface tension of the liquid.
摘要翻译：一种微总分析芯片，包括：用于供给液体的主流路; 以及分割流路，用于以预定的分割比分配和供给液体，所述多个分割路径的每个划分路径具有高流动阻力部分，该流道阻力部分包括比前一部分更窄的缩窄流动路径，以及随后的部分每个划分的路径，其中分割路径中的第一分割路径的高流路阻力部分的流路阻力R满足以下表达式：R x Q>×L / S，其中，Q是第一分割路径S是截面积，L是多个分割路径的其他分割路径的流路的截面周长，Ã是液体的表面张力。

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