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1. 发明授权

EP2405973B1 THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS 失效
标题翻译：噻唑并嘧啶调节剂作为免疫抑制剂
公开(公告)号：EP2405973B1
公开(公告)日：2015-04-22
申请号：EP10711871.3
申请日：2010-03-15
申请人： Katholieke Universiteit Leuven, K.U. Leuven R&D
发明人： HERDEWIJN, Piet , DE JONGHE, Steven , GAO, Ling-Jie , JANG, Mi-Yeon , VANDERHOYDONCK, Bart , WAER, Mark Jozef Albert , LIN, Yuan , HERMAN, Jean Ferdinand , LOUAT, Thierry André Michel
IPC分类号： A61P29/00 , C07D513/04 , A61K31/519
CPC分类号： C07D473/32 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D473/18 , C07D513/04

2. 发明授权

EP2575969B1 ANTIVIRAL ACTIVITY OF BICYCLIC HETEROCYCLES 有权
公开(公告)号：EP2575969B1
公开(公告)日：2018-08-15
申请号：EP11720777.9
申请日：2011-05-20
申请人： Katholieke Universiteit Leuven K.U. Leuven R&D
发明人： DE JONGHE, Steven , GAO, Ling-Jie , HERDEWIJN, Piet , HERMAN, Jean , JANG, Miyeon , LEYSSEN, Pieter , LOUAT, Thierry , NEYTS, Johan , PANNECOUQUE, Christophe , VANDERHOYDONCK, Bart
IPC分类号： A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61K31/519 , A61K31/52 , A61K31/551 , A61K31/5377 , C07D473/00 , C07D513/04
CPC分类号： A61K31/551 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D473/00 , C07D513/04 , Y02A50/385 , Y02A50/465
摘要： The present invention relates to compound of Formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with RNA-viruses belonging to the family of the Retroviridae, the family of the Flaviviridae and the family of the Picornaviridae and more preferably infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HIV2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of viral disorders and pathologic conditions such as, but not limited to, viral infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HIV2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus.

3. 发明公开

EP2575969A1 ANTIVIRAL ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES 审中-公开
标题翻译： ANTIVIRALEAKTIVITÄTNEUER BICYCLISCHER HETEROCYCLEN
公开(公告)号：EP2575969A1
公开(公告)日：2013-04-10
申请号：EP11720777.9
申请日：2011-05-20
申请人： Katholieke Universiteit Leuven, K.U. Leuven R&D
发明人： DE JONGHE, Steven , GAO, Ling-Jie , HERDEWIJN, Piet , HERMAN, Jean , JANG, Miyeon , LEYSSEN, Pieter , LOUAT, Thierry , NEYTS, Johan , PANNECOUQUE, Christophe , VANDERHOYDONCK, Bart
IPC分类号： A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61K31/519 , A61K31/52 , A61K31/551
CPC分类号： A61K31/551 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D473/00 , C07D513/04 , Y02A50/385 , Y02A50/465
摘要： The present invention relates to compound of Formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with RNA-viruses belonging to the family of the Retroviridae, the family of the Flaviviridae and the family of the Picornaviridae and more preferably infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HIV2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of viral disorders and pathologic conditions such as, but not limited to, viral infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HIV2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus.
摘要翻译：本发明涉及式I，II，III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物，其中R1，R2，R3，R4，R5， R6，R7，R8，R9，R11和R12如权利要求1中所定义或如在本发明的描述中详细描述的，以及所述化合物用于治疗或预防病毒感染及其用于制造治疗或预防病毒感染的药物，特别是属于逆转录病毒科家族，黄病毒科和微小核糖核酸病毒科家族的RNA病毒的感染，更优选人免疫缺陷病毒1（HIV1），人类免疫缺陷病毒2 （HN2），丙型肝炎病毒（HCV），登革热病毒和诸如柯萨奇病毒，鼻病毒和脊髓灰质炎病毒的肠道病毒。本发明还涉及所述化合物的药物组合物和所述药物组合物用于治疗或预防病毒感染的用途。本发明还涉及所述化合物作为生物活性成分的用途，更具体地说，作为用于治疗病毒病症和病理状况的药物，例如但不限于用人免疫缺陷病毒1（HIV1），人类免疫缺陷病毒病毒2（HN2），丙型肝炎病毒（HCV），登革热病毒和诸如柯萨奇病毒，鼻病毒和Poliovints的肠道病毒。

4. 发明公开

EP2405973A2 THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS 失效
标题翻译：噻唑并嘧啶调节剂作为免疫抑制剂
公开(公告)号：EP2405973A2
公开(公告)日：2012-01-18
申请号：EP10711871.3
申请日：2010-03-15
申请人： Katholieke Universiteit Leuven, K.U. Leuven R&D
发明人： HERDEWIJN, Piet , DE JONGHE, Steven , GAO, Ling-Jie , JANG, Mi-Yeon , VANDERHOYDONCK, Bart , WAER, Mark Jozef Albert , LIN, Yuan , HERMAN, Jean Ferdinand , LOUAT, Thierry André Michel
IPC分类号： A61P29/00 , C07D513/04 , A61K31/519
CPC分类号： C07D473/32 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D473/18 , C07D513/04
摘要： The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , R
9 , R
11 , and R
12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.

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