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1. 发明公开

EP0834509A1 Process for preparing dihydropyrane compound 失效
标题翻译：制备二氢吡喃化合物的方法
公开(公告)号：EP0834509A1
公开(公告)日：1998-04-08
申请号：EP97116860.4
申请日：1997-09-29
申请人： Kao Corporation
发明人： Nishioka, Tohru , Tanaka, Shigeyoshi , Koshino, Junji , Yamashita, Osamu , Ozawa, Tadahiro , Kohama, Makoto
IPC分类号： C07D309/18
CPC分类号： C07D309/18
摘要： To provide a simple process for economically preparing a dihydropyrane compound at a high productivity and a high reaction yield.
To use a compound selected from the group consisting of a base and a compound (VIII) having a weaker coordination power to the Lewis acid than the aldehyde compound and having an activity to dissolve the Lewis acid, coordinated by the compound (VIII), in a solvent as a co-catalyst in reacting aldehyde with a diene compound in the presence of a Lewis acid to prepare a 5,6-dihydro-2H-pyrane compound represented by formula (III):
in which R 1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, aryl group which may be substituted with alkyl group, having 6 to 12 total carbon atoms; R 2 and R 3 represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms.
摘要翻译：提供一种以高生产率和高反应收率经济地制备二氢吡喃化合物的简单方法。为了使用选自碱和路易斯酸配位能力弱于醛化合物且具有溶解路易斯酸的活性（由化合物（VIII）配位）的路易斯酸的化合物（VIII）的化合物，在路易斯酸存在下使醛与二烯化合物反应以制备由式（III）表示的5,6-二氢-2H-吡喃化合物作为助催化剂的溶剂：其中R 1表示氢原子，具有1至12个碳原子的烷基，可以被烷基取代的具有6至12个总碳原子的芳基; R2和R3代表氢原子或具有1至6个碳原子的烷基。

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