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1. 发明授权

EP0395124B1 Process for producing L-phenylalanine 失效
标题翻译：一种用于生产L-苯丙氨酸的过程。
公开(公告)号：EP0395124B1
公开(公告)日：1994-06-01
申请号：EP90111662.4
申请日：1985-02-07
申请人： KYOWA HAKKO KOGYO CO., LTD
发明人： Araki, Kazumi , Ozeki, Toshitsugu , Ito, Yukiyoshi , Ishino, Shuichi , Anazawa, Hideharu , Kamimori, Shigeru
IPC分类号： C12P13/22
CPC分类号： C12P13/222 , Y10S435/822 , Y10S435/83 , Y10S435/832 , Y10S435/843 , Y10S435/847 , Y10S435/85 , Y10S435/852 , Y10S435/859 , Y10S435/873 , Y10S435/877 , Y10S435/879 , Y10S435/881

2. 发明公开

EP0542240A2 Process for producing flavine nucleotides 失效
标题翻译： Verfahren zur Herstellung von Flavin-Nukleotiden。
公开(公告)号：EP0542240A2
公开(公告)日：1993-05-19
申请号：EP92119308.2
申请日：1992-11-11
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Kitatsuji, Katsura , Ishino, Shuichi , Teshiba, Sadao , Arimoto, Masaru
IPC分类号： C12N15/52 , C12P19/32 , C12P19/36 , C12N1/21
CPC分类号： C12N9/12 , C12N15/52 , C12P19/34 , C12P19/36
摘要： Flavine nucleotides, which are useful as ingredients of nutrient compositions, raw materials for various pharmaceutical products, biochemical research reagents and so on, are produced from flavine nucleotide precursors and ATP by utilizing cells or a culture of a microorganism which belongs to the genus Escherichia , Enterobactor or Pseudomonas and harbors a recombinant DNA comprising a vector DNA and a DNA fragment carrying the genetic information relevant to the synthesis of FMN and/or FAD, or treated cells or a treated culture of the microorganism.
摘要翻译：作为营养成分的成分，各种药品原料，生物化学试剂等有用的黄苷核苷酸是通过利用细胞或属于埃希氏杆菌属的微生物的培养物从黄烷核苷酸前体和ATP产生的，肠杆菌或假单胞菌，并且携带包含载体DNA和携带与FMN和/或FAD的合成或经处理的细胞或经处理的微生物培养物相关的遗传信息的DNA片段的重组DNA。

3. 发明公开

EP0395124A1 Process for producing L-phenylalanine 失效
标题翻译： Verfahren zur Herstellung von L-Phenylalanin。
公开(公告)号：EP0395124A1
公开(公告)日：1990-10-31
申请号：EP90111662.4
申请日：1985-02-07
申请人： KYOWA HAKKO KOGYO CO., LTD
发明人： Araki, Kazumi , Ozeki, Toshitsugu , Ito, Yukiyoshi , Ishino, Shuichi , Anazawa, Hideharu , Kamimori, Shigeru
IPC分类号： C12P13/22
CPC分类号： C12P13/222 , Y10S435/822 , Y10S435/83 , Y10S435/832 , Y10S435/843 , Y10S435/847 , Y10S435/85 , Y10S435/852 , Y10S435/859 , Y10S435/873 , Y10S435/877 , Y10S435/879 , Y10S435/881
摘要： A process for producing L-phenylalanine is carried out by culturing a microorganism belonging to the genus Serratia , Escherichia , Pseudomonas , Enterobacter , Salmonella , Erwinia , Proteus , Citrobacter , Paracoccus , Arthriobacter , Bacillus , Brevibacterium , Corynebacterium , Flavobacterium , Klebsiella , Kluyvera or Micrococcus having the ability to convert phenypyruvic acid into L-phenylalanine in the presence of fumaric acid and ammonium ion or urea, in a culture medium containing phenylpyruvic acid, fumaric acid and ammonium ion or urea or causing cells of said microorganism or product of treatment thereof to react on phenylpyruvic acid, fumaric acid and ammonium ion or urea in an aqueous solution; forming L-phenylalanine in the resultant culture broth or aqueous solution; and recovering L-phenylalanine therefrom.
摘要翻译：生产L-苯丙氨酸的方法是通过培养属于沙雷氏菌属，大肠杆菌属，假单胞菌属，肠杆菌属，沙门氏菌属，欧文氏菌属，变形杆菌属，柠檬酸杆菌属，副球菌属，杆状杆菌属，芽孢杆菌属，短杆菌属，棒状杆菌属，黄杆菌属，克雷伯杆菌属，克鲁维酵母属或在含有苯丙酮酸，富马酸和铵离子或尿素的培养基中，在富马酸和铵离子或尿素存在下，将苯丙氨酸转化为L-苯丙氨酸的能力的微球菌，或引起所述微生物的细胞或其处理产物在水溶液中与苯基丙酮酸，富马酸和铵离子或脲反应; 在所得培养液或水溶液中形成L-苯丙氨酸; 并从中回收L-苯丙氨酸。

4. 发明公开

EP0151488A3 Process for producing L-phenylalanine 失效
标题翻译：生产L-苯乙胺的方法
公开(公告)号：EP0151488A3
公开(公告)日：1987-09-09
申请号：EP85101298
申请日：1985-02-07
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Araki, Kazumi , Ozeki, Toshitsugu , Ito, Yukiyoshi , Ishino, Shuichi , Anazawa, Hideharu , Kamimori, Shigeru
IPC分类号： C12P13/22 , C12N01/20 , C12R01/00 , C12R01/07 , C12R01/15 , C12R01/20 , C12R01/22 , C12R01/42
CPC分类号： C12P13/222 , Y10S435/822 , Y10S435/83 , Y10S435/832 , Y10S435/843 , Y10S435/847 , Y10S435/85 , Y10S435/852 , Y10S435/859 , Y10S435/873 , Y10S435/877 , Y10S435/879 , Y10S435/881
摘要： A process for producing L-phenylalanine is carried out by (1) culturing a microorganism belonging to the genus Citrobacter, Erwinia, Enterobacter, Klebsiella, Microbacterium, Salmonella, Bacillus, Corynebacterium or Flavobacterium having the ability to convert phenylpyruvic acid into L-phenylalanine in the presence of an amino group donor, in a culture medium containing phenylpyruvic acid and an amino group donor or causing cells of the microorganism or product of treatment thereof to react on phenylpyruvic acid and an amino group donor in an aqueous solution; or by (2) culturing a microorganism belonging to the genus Serratia, Escherichia, Pseudomonas, Enterobacter, Salmonella, Erwinia, Proteus, Citrobacter, Paracoccus, Arthrobacter, Bacillus, Brevibacterium, Corynebacterium, Flavobacterium, Klebsiella, Kluyvera or Micrococcus having the ability to convert phenypyruvic acid into L-phenylalanine in the presence of fumaric acid and ammonium ion or urea, in a culture medium containing phenylpyruvic acid, fumaric acid and ammonium ion or urea or causing cells of said microorganism or product of treatment thereof to react on phenylpyruvic acid, fumaric acid and ammonium ion or urea in an aqueous solution; forming L-phenylalanine in the resultant culture broth or aqueous solution; and recovering L-phenylalanine therefrom.

5. 发明授权

EP0542240B1 Process for producing flavine nucleotides 失效
标题翻译：一种用于生产黄素核苷酸处理
公开(公告)号：EP0542240B1
公开(公告)日：1999-03-31
申请号：EP92119308.2
申请日：1992-11-11
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Kitatsuji, Katsura , Ishino, Shuichi , Teshiba, Sadao , Arimoto, Masaru
IPC分类号： C12N15/52 , C12P19/32 , C12P19/36 , C12N1/21
CPC分类号： C12N9/12 , C12N15/52 , C12P19/34 , C12P19/36

6. 发明公开

EP0542240A3 Process for producing flavine nucleotides 失效
标题翻译：生产黄酮核苷酸的方法
公开(公告)号：EP0542240A3
公开(公告)日：1994-08-03
申请号：EP92119308.2
申请日：1992-11-11
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Kitatsuji, Katsura , Ishino, Shuichi , Teshiba, Sadao , Arimoto, Masaru
IPC分类号： C12N15/52 , C12P19/32 , C12P19/36 , C12N1/21
CPC分类号： C12N9/12 , C12N15/52 , C12P19/34 , C12P19/36
摘要： Flavine nucleotides, which are useful as ingredients of nutrient compositions, raw materials for various pharmaceutical products, biochemical research reagents and so on, are produced from flavine nucleotide precursors and ATP by utilizing cells or a culture of a microorganism which belongs to the genus Escherichia , Enterobactor or Pseudomonas and harbors a recombinant DNA comprising a vector DNA and a DNA fragment carrying the genetic information relevant to the synthesis of FMN and/or FAD, or treated cells or a treated culture of the microorganism.
摘要翻译：通过利用属于埃希氏菌属的微生物的细胞或培养物，由黄素核苷酸前体和ATP产生用作营养组合物成分，各种药物产品的原料和生化研究试剂等的黄酮核苷酸， Enterobactor或Pseudomonas，并含有包含载体DNA和携带与FMN和/或FAD的合成相关的遗传信息或经处理的细胞或经处理的微生物培养物的DNA片段的重组DNA。

7. 发明授权

EP0151488B1 Process for producing L-phenylalanine 失效
标题翻译：生产L-苯乙胺的方法
公开(公告)号：EP0151488B1
公开(公告)日：1991-09-25
申请号：EP85101298.9
申请日：1985-02-07
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Araki, Kazumi , Ozeki, Toshitsugu , Ito, Yukiyoshi , Ishino, Shuichi , Anazawa, Hideharu , Kamimori, Shigeru
IPC分类号： C12P13/22 , C12N1/20
CPC分类号： C12P13/222 , Y10S435/822 , Y10S435/83 , Y10S435/832 , Y10S435/843 , Y10S435/847 , Y10S435/85 , Y10S435/852 , Y10S435/859 , Y10S435/873 , Y10S435/877 , Y10S435/879 , Y10S435/881

8. 发明公开

EP0151488A2 Process for producing L-phenylalanine 失效
标题翻译： Verfahren zur Herstellung von L-Phenylalanin。
公开(公告)号：EP0151488A2
公开(公告)日：1985-08-14
申请号：EP85101298.9
申请日：1985-02-07
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Araki, Kazumi , Ozeki, Toshitsugu , Ito, Yukiyoshi , Ishino, Shuichi , Anazawa, Hideharu , Kamimori, Shigeru
IPC分类号： C12P13/22 , C12N1/20
CPC分类号： C12P13/222 , Y10S435/822 , Y10S435/83 , Y10S435/832 , Y10S435/843 , Y10S435/847 , Y10S435/85 , Y10S435/852 , Y10S435/859 , Y10S435/873 , Y10S435/877 , Y10S435/879 , Y10S435/881
摘要： A process for producing L-phenylalanine is carried out by (1) culturing a microorganism belonging to the genus Citrobacter, Erwinia, Enterobacter, Klebsiella, Microbacterium, Salmonella, Bacillus, Corynebacterium or Flavobacterium having the ability to convert phenylpyruvic acid into L-phenylalanine in the presence of an amino group donor, in a culture medium containing phenylpyruvic acid and an amino group donor or causing cells of the microorganism or product of treatment thereof to react on phenylpyruvic acid and an amino group donor in an aqueous solution; or by (2) culturing a microorganism belonging to the genus Serratia, Escherichia, Pseudomonas, Enterobacter, Salmonella, Erwinia, Proteus, Citrobacter, Paracoccus, Arthrobacter, Bacillus, Brevibacterium, Corynebacterium, Flavobacterium, Klebsiella, Kluyvera or Micrococcus having the ability to convert phenypyruvic acid into L-phenylalanine in the presence of fumaric acid and ammonium ion or urea, in a culture medium containing phenylpyruvic acid, fumaric acid and ammonium ion or urea or causing cells of said microorganism or product of treatment thereof to react on phenylpyruvic acid, fumaric acid and ammonium ion or urea in an aqueous solution; forming L-phenylalanine in the resultant culture broth or aqueous solution; and recovering L-phenylalanine therefrom.
摘要翻译：通过（1）将苯丙酮酸转化为L-苯丙氨酸的能力培养属于柠檬酸杆菌属，欧文氏菌属，肠杆菌属，克雷伯杆菌属，微杆菌属，沙门氏菌属，芽孢杆菌属，棒杆菌属或黄杆菌属的微生物，进行L-苯丙氨酸生产的方法在含有苯丙酮酸和氨基供体的培养基中，氨基供体的存在或使微生物的细胞或其处理产物在水溶液中与苯基丙酮酸和氨基供体反应; 或通过（2）具有转化能力的沙雷氏菌属，埃希氏杆菌属，假单胞菌属，肠杆菌属，沙门氏菌属，欧文氏菌属，变形杆菌属，柠檬酸杆菌属，副球菌属，节杆菌属，芽孢杆菌属，短杆菌属，棒状杆菌属，黄杆菌属，克雷伯菌属，克鲁维酵母属或微球菌属的微生物在含有苯基丙酮酸，富马酸和铵离子或尿素的培养基中，在富马酸和铵离子或尿素的存在下，将苯丙氨酸转化成L-苯丙氨酸，或使所述微生物的细胞或其处理产物与苯基丙酮酸反应，富马酸和铵离子或尿素在水溶液中; 在所得培养液或水溶液中形成L-苯丙氨酸; 并从中回收L-苯丙氨酸。

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