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1. 发明公开

EP0191401A2 Novel antiallergic agents and process for their preparation 失效
标题翻译：抗过敏药以及它们的制备方法。
公开(公告)号：EP0191401A2
公开(公告)日：1986-08-20
申请号：EP86101417.3
申请日：1986-02-04
申请人： KYORIN PHARMACEUTICAL CO., LTD.
发明人： Irikura, Tsutomu , Nishino, Keigo , Okamura, Kyuya , Ikeda, Toshiya
IPC分类号： C07D471/04 , C07D235/28
CPC分类号： C07D471/04 , C07D235/28
摘要： The present invention is concerned with certain novel antiallergic agents and process for their preparation.

2. 发明授权

EP0287971B1 Benzimidazole derivatives and process for their preparations 失效
标题翻译：苯并咪唑衍生物及其制备方法
公开(公告)号：EP0287971B1
公开(公告)日：1993-02-24
申请号：EP88106058.6
申请日：1988-04-15
申请人： KYORIN PHARMACEUTICAL CO., LTD.
发明人： Masuzawa, Kuniyoshi , Okamura, Kyuya , Nishino, Keigo , Ohashi, Mitsuo , Awano, Katsuya
IPC分类号： C07D235/28 , C07D235/06 , C07D235/12 , C07D235/30 , C07C381/14 , C07C249/02 , C07C251/30
CPC分类号： C07D235/28 , C07D235/12

3. 发明公开

EP0287971A2 Benzimidazole derivatives and process for their preparations 失效
标题翻译：苯并咪唑衍生物和Verfahren zu ihrer Herstellung。
公开(公告)号：EP0287971A2
公开(公告)日：1988-10-26
申请号：EP88106058.6
申请日：1988-04-15
申请人： KYORIN PHARMACEUTICAL CO., LTD.
发明人： Masuzawa, Kuniyoshi , Okamura, Kyuya , Nishino, Keigo , Ohashi, Mitsuo , Awano, Katsuya
IPC分类号： C07D235/28 , C07D235/06 , C07D235/12 , C07D235/30 , C07C381/14 , C07C249/02 , C07C251/30
CPC分类号： C07D235/28 , C07D235/12
摘要： Benzimidazole derivatives of the following formula,
wherein R¹ indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 6 or dimethylaminopropyl group, R² indicates hydrogen atom or lower alkanoyl group having carbon atoms of 1 to 3, R³ indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or lower alkanoyl group having carbon atoms of 1 to 3, X indicates sulfur atom, sulfinyl group, sulfonyl group, amino group or methylene group, A indicates alkylene group having carbon atoms of 1 to 12, which alkylene group may optionally be substituted by hydroxy group or lower alkyl group having carbon atoms of 1 to 3, - (CHRʹ)n-CRʺ=CRʺ-(CHRʹ)m-,
(in which Rʹ and Rʺ are each independently hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or hydroxy group, and n and m are equal to 0, 1, 2 or 3), and Y indicates oxygen atom or sulfur atom; their acid or alkali salts and hydrate thereof are useful as antiallergic agents.
摘要翻译：下式的苯并咪唑衍生物其中R 1表示氢原子，碳原子数1〜6的低级烷基或二甲基氨基丙基，R 2表示氢原子或碳原子数1〜 3，R 3表示氢原子，碳原子数1〜3的低级烷酰基或碳原子数1〜3的低级烷酰基，X表示硫原子，亚磺酰基，磺酰基，氨基或亚甲基，A 表示碳原子数为1〜12的亚烷基，该亚烷基可以被羟基或碳原子数为1〜3的低级烷基取代， - （CHR'）n-CR“= CR” - （CHR '）m-，（其中R'和R“各自独立地为氢原子，具有1至3个碳原子的低级烷基或羟基，n和m等于0,1,2或 3），Y表示氧原子或硫原子; 它们的酸或碱盐及其水合物可用作抗过敏剂。

4. 发明公开

EP0302422A3 Urea derivatives 失效
标题翻译：尿素衍生物
公开(公告)号：EP0302422A3
公开(公告)日：1990-02-07
申请号：EP88112393.9
申请日：1988-07-29
申请人： KYORIN PHARMACEUTICAL CO., LTD.
发明人： Matsukubo, Hiroshi , Matsumoto, Toyomi , Miyashita, Mitsutomo , Okamura, Kyuya , Taga, Fukutaro , Sekiguchi, Haruo , Hamada, Katsuhiro
IPC分类号： C07D295/08 , C07D211/46 , C07D211/14 , A61K31/445 , A61K31/41
CPC分类号： C07D295/096 , C07D211/14 , C07D211/46
摘要： Urea derivatives of the following formula,
wherein R₁ indicates a piperidino group or pyrrolidino group which may be substituted with hydroxy group or lower alkyl group having 1 to 3 carbon atoms; A indicates an ethylene group, propylene group, butylene group or butenylene group; R₂ indicates a straight or branched alkyl group having 1 to 20 carbon atoms, cycloalkyl group having 3 to 6 carbon atoms, benzyl group, or phenyl group which may have 1 to 3 substituents such as lower alkyl group having 1 to 6 carbon atoms, lower alkoxy group having 1 to 3 carbon atoms, halogen atom, trifluoromethyl group, amino group, nitro group or methylenedioxy group; X indicates an oxygen or sulfur atom, the hydrates and pharmaceutically acceptable acid addition salts thereof are useful as antiulcer agents.

5. 发明授权

EP0186796B1 Sulfamoylbenzoic acid derivatives, process for their preparation 有权
标题翻译：磺酰苯甲酸衍生物及其制备方法
公开(公告)号：EP0186796B1
公开(公告)日：1989-09-27
申请号：EP85115296.7
申请日：1985-12-03
申请人： KYORIN PHARMACEUTICAL CO., LTD.
发明人： Irikura, Tsutomu , Okamura, Kyuya , Okubo, Hideo , Mizuguchi, Hidemichi , Yamanaka, Shigeru
IPC分类号： C07D295/22 , C07D317/66 , A61K31/495
CPC分类号： C07D295/32 , C07D317/66

6. 发明公开

EP0254149A3 The process for the manufacture of spiro-linked pyrrolidine-2,5-diones 失效
标题翻译：螺旋连接的吡咯啉-2,5-二酮的制备方法
公开(公告)号：EP0254149A3
公开(公告)日：1989-08-30
申请号：EP87109949.5
申请日：1987-07-09
申请人： KYORIN PHARMACEUTICAL CO., LTD.
发明人： Masuzawa, Kuniyoshi , Okamura, Kyuya , Fujimori, Shizuyoshi , Kinoshita, Susumu , Matsukubo, Hiroshi
IPC分类号： C07D498/20 , C07D471/20 , C07D513/20 , C07D498/06 , C07D471/06 , C07D513/06
CPC分类号： C07D471/06 , C07D471/20 , C07D498/06 , C07D498/20 , C07D513/06 , C07D513/20
摘要： This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of the formula;
which have potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications. The invented processes are useful as improved and convenient method for a large scale manufacture.

7. 发明公开

EP0191401A3 Novel antiallergic agents and process for their preparation 失效
标题翻译：新型抗菌剂及其制备方法
公开(公告)号：EP0191401A3
公开(公告)日：1988-01-07
申请号：EP86101417
申请日：1986-02-04
申请人： KYORIN PHARMACEUTICAL CO., LTD.
发明人： Irikura, Tsutomu , Nishino, Keigo , Okamura, Kyuya , Ikeda, Toshiya
IPC分类号： C07D471/04 , C07D235/28 , A61K31/435 , A61K31/415 , C07D231/00 , C07D221/00
CPC分类号： C07D471/04 , C07D235/28
摘要： The present invention is concerned with certain novel antiallergic agents and process for their preparation.

8. 发明公开

EP0253319A3 The process for the manufacture of spiro-linked pyrrolidine-2,5-dione derivatives 失效
标题翻译：螺旋连接的吡咯烷-2,5-二酮衍生物的制备方法
公开(公告)号：EP0253319A3
公开(公告)日：1989-08-30
申请号：EP87109950.3
申请日：1987-07-09
申请人： KYORIN PHARMACEUTICAL CO., LTD.
发明人： Masuzawa, Kuniyoshi , Okamura, Kyuya , Kasuga, Kazunori , Fujimori, Shizuyoshi , Kinoshita, Susumu , Matsukubo, Hiroshi
IPC分类号： C07D498/20 , C07D471/20 , C07D513/20
CPC分类号： C07D471/20 , C07D498/20 , C07D513/20
摘要： This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of formula;
which have a potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications. The invented processes are useful as improved and convenient method for a large scale manufacture.

9. 发明公开

EP0287971A3 Benzimidazole derivatives and process for their preparations 失效
标题翻译：苯并咪唑衍生物及其制备方法
公开(公告)号：EP0287971A3
公开(公告)日：1989-03-22
申请号：EP88106058.6
申请日：1988-04-15
申请人： KYORIN PHARMACEUTICAL CO., LTD.
发明人： Masuzawa, Kuniyoshi , Okamura, Kyuya , Nishino, Keigo , Ohashi, Mitsuo , Awano, Katsuya
IPC分类号： C07D235/28 , C07D235/06 , C07D235/12 , C07D235/30 , C07C381/14 , C07C249/02 , C07C251/30
CPC分类号： C07D235/28 , C07D235/12
摘要： Benzimidazole derivatives of the following formula,
wherein R¹ indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 6 or dimethylaminopropyl group, R² indicates hydrogen atom or lower alkanoyl group having carbon atoms of 1 to 3, R³ indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or lower alkanoyl group having carbon atoms of 1 to 3, X indicates sulfur atom, sulfinyl group, sulfonyl group, amino group or methylene group, A indicates alkylene group having carbon atoms of 1 to 12, which alkylene group may optionally be substituted by hydroxy group or lower alkyl group having carbon atoms of 1 to 3, - (CHRʹ)n-CRʺ=CRʺ-(CHRʹ)m-,
(in which Rʹ and Rʺ are each independently hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or hydroxy group, and n and m are equal to 0, 1, 2 or 3), and Y indicates oxygen atom or sulfur atom; their acid or alkali salts and hydrate thereof are useful as antiallergic agents.

10. 发明公开

EP0186796A1 Sulfamoylbenzoic acid derivatives, process for their preparation 有权
标题翻译：磺酰基苯并噻唑，维他命Zu ihrer Herstellung。
公开(公告)号：EP0186796A1
公开(公告)日：1986-07-09
申请号：EP85115296.7
申请日：1985-12-03
申请人： KYORIN PHARMACEUTICAL CO., LTD.
发明人： Irikura, Tsutomu , Okamura, Kyuya , Okubo, Hideo , Mizuguchi, Hidemichi , Yamanaka, Shigeru
IPC分类号： C07D295/22 , C07D317/66 , A61K31/495
CPC分类号： C07D295/32 , C07D317/66
摘要： Sufamoylbenzoic acid derivatives of formula (I):
wherein R, is a chlorine atom or phenoxy group, R 2 is a hydrogen atom, halogen atom, lower alkyl group, lower alkoxy group or methylenedioxy group.
These compounds possess directic and uricosuric activities.
摘要翻译：式（I）的磺酰基苯甲酸衍生物：... 其中R1是氯原子或苯氧基，R2是氢原子，卤素原子，低级烷基，低级烷氧基或亚甲二氧基。这些化合物具有直接和尿酸活性。

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