专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0314042A2 Novel copolymers and superoxide dismutase modified with said copolymers 失效
标题翻译： Copolymere und mit diesen Copolymeren modifizierte超氧化物歧化酶。
公开(公告)号：EP0314042A2
公开(公告)日：1989-05-03
申请号：EP88117672.1
申请日：1988-10-24
申请人： KURARAY CO., LTD. , Inoue, Masayasu
发明人： Inoue, Masayasu , Ebashi, Iwao , Watanabe, Nobukazu , Asano, Ryuzo , Nakahara, Fumio , Mori, Fumio
IPC分类号： C08F8/30 , C12N9/96 , A61K37/50
CPC分类号： C12N9/0089 , A61K38/446 , A61K47/58 , C08F8/30
摘要： Described are copolymers comprising the copolymer-constituting units characterized in the claims and having an average molecular weight of 400 to 20,000. Furthermore superoxide dismutase (SOD) derivatives are described which can be obtained by modification with the above copolymers and have a single chemical structure, retain most of the enzymatic activity of SOD and exhibit a much prolonged plasma half-life. Therefore, they are useful as medicinal chemicals.
摘要翻译：描述了包含权利要求书中特征的共聚物构成单元并且平均分子量为400至20,000的共聚物。此外，还描述了可以通过用上述共聚物进行改性而获得的具有单一化学结构的超氧化物歧化酶（SOD）衍生物，保留SOD的大部分酶活性并表现出延长的血浆半衰期。因此，它们作为药用化学品是有用的。

2. 发明公开

EP0314042A3 Novel copolymers and superoxide dismutase modified with said copolymers 失效
标题翻译：用新型共聚物改性的新型共聚物和超氧化物分散体
公开(公告)号：EP0314042A3
公开(公告)日：1989-08-30
申请号：EP88117672.1
申请日：1988-10-24
申请人： KURARAY CO., LTD. , Inoue, Masayasu
发明人： Inoue, Masayasu , Ebashi, Iwao , Watanabe, Nobukazu , Asano, Ryuzo , Nakahara, Fumio , Mori, Fumio
IPC分类号： C08F8/30 , C12N9/96 , A61K37/50
CPC分类号： C12N9/0089 , A61K38/446 , A61K47/58 , C08F8/30
摘要： Described are copolymers comprising the copolymer-constituting units characterized in the claims and having an average molecular weight of 400 to 20,000. Furthermore superoxide dismutase (SOD) derivatives are described which can be obtained by modification with the above copolymers and have a single chemical structure, retain most of the enzymatic activity of SOD and exhibit a much prolonged plasma half-life. Therefore, they are useful as medicinal chemicals.

3. 发明授权

EP0511600B1 Long chain carboxylic acid imide ester 失效
标题翻译：长链羧酸酯酰亚胺
公开(公告)号：EP0511600B1
公开(公告)日：1999-03-17
申请号：EP92107035.5
申请日：1992-04-24
申请人： KURARAY CO., LTD.
发明人： Ebashi, Iwao , Takigawa, Tetsuo , Inoue, Masayasu
IPC分类号： C07D401/12 , C07D211/46 , C07D405/12 , C07D405/14 , C07D401/14 , A61K31/445
CPC分类号： C07D209/48 , C07D207/46 , C07D209/76 , C07D211/94

4. 发明公开

EP0511600A2 Long chain carboxylic acid imide ester 失效
标题翻译： LangkettigerCarbonsäureimidester。
公开(公告)号：EP0511600A2
公开(公告)日：1992-11-04
申请号：EP92107035.5
申请日：1992-04-24
申请人： KURARAY CO., LTD.
发明人： Ebashi, Iwao , Takigawa, Tetsuo , Inoue, Masayasu
IPC分类号： C07D401/12 , C07D211/46 , C07D405/12 , C07D405/14 , C07D401/14 , A61K31/445
CPC分类号： C07D209/48 , C07D207/46 , C07D209/76 , C07D211/94
摘要： Provided is a long chain carboxylic acid imide ester (I) represented by the following general formula (I)

wherein W is a divalent long chain hydrocarbon group which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom and a group of -N(R¹)- (R¹ being a lower alkyl group) and X represents a divalent hydrocarbon group which may optionally be substituted, or salts thereof. The above long chain carboxylic acid imide ester or its salts is useful for modifying enzymes or proteins having biological activities to give their derivatives which have, while retaining most of the original biological activities, an extremely prolonged plasma half-life as compared with the proteins and have no antigenecities and can be administered to animals.
摘要翻译：提供由以下通式（I）表示的长链羧酸酰亚胺酯（I）其中W是二价长链烃基，其可任选地被一个或多个各自独立地选自的氧原子，硫原子和-N（R 1） - （R 1是低级烷基）的基团，X表示任选被取代的二价烃基或其盐。上述长链羧酸酰亚胺酯或其盐可用于修饰具有生物活性的酶或蛋白质以产生其衍生物，其与原始蛋白质相比具有极大延长的血浆半衰期，同时保留大部分原始生物活性，没有抗原性，可以给予动物。

5. 发明公开

EP0511600A3 Long chain carboxylic acid imide ester 失效
标题翻译：长链羧酸酰胺
公开(公告)号：EP0511600A3
公开(公告)日：1993-01-20
申请号：EP92107035.5
申请日：1992-04-24
申请人： KURARAY CO., LTD.
发明人： Ebashi, Iwao , Takigawa, Tetsuo , Inoue, Masayasu
IPC分类号： C07D401/12 , C07D211/46 , C07D405/12 , C07D405/14 , C07D401/14 , A61K31/445
CPC分类号： C07D209/48 , C07D207/46 , C07D209/76 , C07D211/94
摘要： Provided is a long chain carboxylic acid imide ester (I) represented by the following general formula (I)

wherein W is a divalent long chain hydrocarbon group which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom and a group of -N(R¹)- (R¹ being a lower alkyl group) and X represents a divalent hydrocarbon group which may optionally be substituted, or salts thereof. The above long chain carboxylic acid imide ester or its salts is useful for modifying enzymes or proteins having biological activities to give their derivatives which have, while retaining most of the original biological activities, an extremely prolonged plasma half-life as compared with the proteins and have no antigenecities and can be administered to animals.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式