专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3333574A4 ENVIRONMENT-RESPONSIVE DYE-ACCUMULATED NANO PARTICLES, AND METHOD FOR ANALYZING INTRACELLULAR ENVIRONMENT 无效
公开(公告)号：EP3333574A4
公开(公告)日：2018-06-20
申请号：EP16832838
申请日：2016-07-26
申请人： KONICA MINOLTA INC
发明人： AIMIYA TAKUJI , FURUSAWA NAOKO
IPC分类号： G01N33/52 , A61K49/00 , C09B67/08 , G01N33/48 , G01N33/84
CPC分类号： G01N33/48 , A61K49/0032 , A61K49/0041 , A61K49/0093 , C09B67/0005 , C09B67/0013 , G01N33/52 , G01N33/84
摘要： An object of the invention is to provide an environmentally-responsive dye-accumulated nanoparticle for grasping an intracellular environment such as pH with respect to each cell. The invention provides an environmentally-responsive dye-accumulated nanoparticle, in which an environmentally-responsive dye is accumulated on the surface of, or inside a thermosetting resin particle, and which has an average particle diameter of 30 to 800 nm, wherein the accumulated amount of the environmentally-responsive dye is 200 to 10,000,000 molecules/particle. The environmentally-responsive dye has dependence on pH, or a Ca ion in terms of fluorescence intensity, and the thermosetting resin is a melamine resin.

2. 发明公开

EP3173785A4 LABELING REAGENT CONTAINING A MOLECULARLY TARGETED DRUG 有权
公开(公告)号：EP3173785A4
公开(公告)日：2018-02-14
申请号：EP15823991
申请日：2015-07-21
申请人： KONICA MINOLTA INC
发明人： AIMIYA TAKUJI , FURUSAWA NAOKO
IPC分类号： G01N33/48 , A61K49/00 , C07D401/14
CPC分类号： G01N33/57438 , A61K49/00 , C07D401/14 , G01N33/48 , G01N33/582
摘要： An object of the present invention is to provide a labeling agent which exhibits excellent binding to a target molecule in a bioassay or histological staining method that relates to a compound containing a nitrogen-containing aromatic ring. The labeling agent according to the present invention is a labeling agent having a structure in which a molecular target drug, which is a compound containing a nitrogen atom-containing aromatic ring, is bound with a label via a divalent linking group, wherein one end of the divalent linking group is bound to a carbon atom of the nitrogen atom-containing aromatic ring. The label is preferably a fluorescent substance-integrated nanoparticle, and the nitrogen atom-containing aromatic ring is preferably a pyridine ring.

3. 发明公开

EP3040724A4 METHOD FOR DETERMINING QUANTITY OF BIOLOGICAL MATERIAL IN TISSUE SECTION 有权
标题翻译： GEWEBESCHNITT的VERFAHREN ZUM BESTIMMEN DER MENGE VON BIOLOGISCHEM材料
公开(公告)号：EP3040724A4
公开(公告)日：2017-05-03
申请号：EP14847697
申请日：2014-09-16
申请人： KONICA MINOLTA INC
发明人： OKADA FUMINORI , AIMIYA TAKUJI , GONDA KOHSUKE , OHUCHI NORIAKI , WATANABE MIKA
IPC分类号： G01N33/53 , G01N21/64 , G01N33/48 , G01N33/536
CPC分类号： G01N21/6458 , G01N21/6428 , G01N33/5088 , G01N33/56966 , G01N2021/6439 , G01N2201/12 , G01N2333/70596
摘要： An object of the present invention is to provide a method of detecting a specific tissue or cell in a sample tissue section and accurately specifying both the position(s) and amount of a biological substance of interest that is expressed on the specific tissue or cell. The method of quantifying a biological substance in a tissue section according to the present invention comprises: (1) performing bright-field observable immunostaining that specifically stains a first biological substance in the tissue section (first immunostaining); (2) performing immunostaining with a fluorescent substance-containing nanoparticle that specifically stains a second biological substance in the tissue section (second immunostaining); (3) specifying the expression position(s) of the second biological substance in the tissue section by comparing the position of a stained image of the first immunostaining and the position of a stained image of the second immunostaining; and (4) determining the expression amount of the second biological substance by measuring the fluorescence intensity of the stained image of the second immunostaining.
摘要翻译：本发明的一个目的是提供一种检测样本组织切片中的特定组织或细胞并准确指定在特定组织或细胞上表达的感兴趣生物学物质的位置和量的方法。根据本发明的定量组织切片中的生物物质的方法包括：（1）进行特异性染色组织切片中的第一生物物质的明场可观察的免疫染色（第一免疫染色）; （2）用特异性染色组织切片中的第二生物物质的含荧光物质的纳米粒子进行免疫染色（第二免疫染色）; （3）通过比较第一免疫染色的染色图像的位置和第二免疫染色的染色图像的位置，指定第二生物物质在组织切片中的表达位置; 和（4）通过测量第二免疫染色的染色图像的荧光强度来确定第二生物物质的表达量。

4. 发明公开

EP2687234A4 SILICA NANOPARTICLES FOR DIAGNOSTIC IMAGING, METHOD FOR MANUFACTURING SAME, AND LABELING AGENT FOR BIOSUBSTANCE 审中-公开
标题翻译：纳米SiO2用于诊断成像，及其制造方法的生物材料商标代理
公开(公告)号：EP2687234A4
公开(公告)日：2014-09-24
申请号：EP12759886
申请日：2012-03-15
申请人： KONICA MINOLTA INC
发明人： AIMIYA TAKUJI , FURUSAWA NAOKO , NAKANO YASUSHI
IPC分类号： A61K49/00 , A61K49/04 , A61K49/10 , A61K49/18
CPC分类号： G01N21/6486 , A61K49/0093 , A61K49/0423 , B82Y5/00

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式