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1. 发明公开

EP0338088A1 PROCESS FOR PREPARING p-HYDROXYBENZOIC ACID 失效
标题翻译： VERFAHREN ZUR HERSTELLUNG VON P-HYDROXYBENZOESÄURE。
公开(公告)号：EP0338088A1
公开(公告)日：1989-10-25
申请号：EP88908975.1
申请日：1988-10-15
申请人： KAWASAKI STEEL CORPORATION
发明人： SUZUKI, Toshinobu; Kawasaki Steel Corporation , IJIRI, Makiko; Kawasaki Steel Corporation , SAIMA, Hitoshi; Kawasaki Steel Corporation , IIZUKA, Tokio; Kawasaki Steel Corporation , WAKUI, Tadahiro; Kawasaki Steel Corporation
IPC分类号： C07C65/03 , C07C51/15
CPC分类号： C07C51/15 , C07C65/03
摘要： p-Hydroxybenzoic acid can be prepared by reacting an alkali metal salt of pheno (excluding lithium and sodium salts) with carbon dioxide in the presence of at least one compound represented by general formulae (I) or (II) wherein, M represents an alkali metal other than lithium and sodium. In formula (I) R represents a substituent other than an aliphatic hydroxy group containing up to 4 carbon atoms, an aliphatic mercapto group containing up to 4 carbon atoms, a substituent containing at least one of these as a structural unit, and a hydrogen atom. In formula (II) R′ represents a substituent other than an aliphatic hydroxy group containing up to 4 carbon atoms, an aliphatic mercapto group containing up to 4 carbon atoms, and a substituent containing at least one of these as a structural unit. In formula (I) n represents an integer of 1 to 5 and the R groups may be the same or different when n is 2 or more. In formula (II) m represents an integer of 1 to 5 and 1 represents an integer of 0 to 4 provided that the M atoms may be the same or different when m is 1 or more and the R groups may be the same or different when 1 is 2 or more. The above-described reaction may be conducted using or not using an inert reaction medium.
ABSTRACT
Para-hydroxybenzoic acid is prepared by reacting an alkali metal salt of phenol except the lithium and sodium salts with carbon dioxide in the presence of at least one compound selected from compounds of the following formulae (I) and (II):
In formulae (I) and (II), M is an alkali metal except lithium and sodium; R is any substituent except an aliphatic hydroxy group having up to 4 carbon atoms, an aliphatic mercapto group having up to 4 carbon atoms, a substituent having at least one of them as its structural unit, and a hydrogen atom; R′ is any substituent except an aliphatic hydroxy group having up to 4 carbon atoms, an aliphatic mercapto group having up to 4 carbon atoms, and a substituent having at least one of them as its structural unit; in formula (I) n is an integer of 1 to 5, and R groups may be the same or different when n is more than one; in formula (II) m is an integer of 1 to 5 and ℓ is an integer of 0 to 4, and M alkali metals may be the same or different when m is one or more, and R′ groups may be the same or different when ℓ is more than one. The reaction may be carried out in the presence or absence of reaction medium.
摘要翻译：对羟基苯甲酸可以通过在至少一种由通式（I）或（II）表示的化合物存在下，使苯酚（不包括锂和钠盐）的碱金属盐与二氧化碳反应制备，其中M表示碱金属以外的锂和钠。在式（I）中，R表示除了含有至多4个碳原子的脂族羟基以外的取代基，含有至多4个碳原子的脂肪族巯基，含有至少一个作为结构单元的取代基，氢原子。在式（II）中，R min表示除了含有至多4个碳原子的脂族羟基以外的取代基，含有至多4个碳原子的脂肪族巯基，以及含有至少一个作为结构单元的取代基。在式（I）中，n表示1〜5的整数，当n为2以上时，R基可以相同或不同。在式（II）中，m表示1〜5的整数，1表示0〜4的整数，条件是当m为1以上时，M原子可以相同或不同，R基可以相同或不同， 1为2以上。上述反应可以使用或不使用惰性反应介质进行。通过使除了锂和钠盐之外的苯酚的碱金属盐与二氧化碳在至少一种选自下列通式（I）的化合物和/或其盐的化合物存在下进行反应来制备对羟基苯甲酸：（II）：在式（I）和（II）中，M是除了锂和钠之外的碱金属; R是具有至多4个碳原子的脂族羟基，具有至多4个碳原子的脂族巯基，至少有一个作为其结构单元的取代基和氢原子的任何取代基; R min是除了具有至多4个碳原子的脂肪族羟基以外的任何取代基，具有至多4个碳原子的脂肪族巯基，以及至少有一个作为其结构单元的取代基; 在式（I）中，n为1〜5的整数，当n大于1时，R基可以相同或不同; 在式（II）中，m为1〜5的整数，l为0〜4的整数，当m为1以上时，M碱金属可以相同或不同，Rmin可以相同或不同当l多于一个时。反应可以在存在或不存在反应介质的情况下进行。

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