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1. 发明授权

EP0599589B1 Wound dressing 失效
公开(公告)号：EP0599589B1
公开(公告)日：1999-02-03
申请号：EP93309306.4
申请日：1993-11-22
申请人： JOHNSON & JOHNSON MEDICAL, INC.
发明人： Arnold, Peter Stuart
IPC分类号： A61F13/00 , A61F13/02 , A61L15/16
CPC分类号： A61L15/44 , A61F13/0203 , A61F13/023 , A61F13/15252 , A61F2013/00731 , A61F2013/00748 , A61F2013/0091 , A61F2013/00927 , A61L15/24 , A61L15/26 , A61L15/30 , A61L15/325 , A61L15/425 , A61L15/60 , A61L2300/404 , A61L2300/412 , A61L2300/414

2. 发明授权

EP0648480B1 Wound implant materials 失效
标题翻译：伤口植入材料
公开(公告)号：EP0648480B1
公开(公告)日：2000-12-20
申请号：EP94306874.2
申请日：1994-09-20
申请人： JOHNSON & JOHNSON MEDICAL, INC.
发明人： Arnold, Peter Stuart
IPC分类号： A61F13/00 , A61F2/28
CPC分类号： A61L15/64 , A61F2002/30062 , A61F2002/30242 , A61F2002/30677 , A61F2210/0004 , A61F2230/0071 , A61F2250/0067 , A61L27/44 , A61L27/58 , A61L27/54 , A61L27/227 , A61L27/24 , C08L67/04 , C08L5/08 , C08L5/04 , C08L1/00

3. 发明公开

EP0648480A3 Wound implant materials 失效
标题翻译：材料伤口植入物。
公开(公告)号：EP0648480A3
公开(公告)日：1995-06-14
申请号：EP94306874.2
申请日：1994-09-20
申请人： JOHNSON & JOHNSON MEDICAL, INC.
发明人： Arnold, Peter Stuart
IPC分类号： A61F13/00 , A61F2/28
CPC分类号： A61L15/64 , A61F2002/30062 , A61F2002/30242 , A61F2002/30677 , A61F2210/0004 , A61F2230/0071 , A61F2250/0067 , A61L27/44 , A61L27/58 , A61L27/54 , A61L27/227 , A61L27/24 , C08L67/04 , C08L5/08 , C08L5/04 , C08L1/00
摘要： Wound implant materials are described comprising a plurality of bioabsorbable microspheres bound together by a bioabsorbable matrix, such as in a freeze-dried collagen matrix. The microspheres preferably comprise over 30% of the volume of the material, and preferably have diameters of 10 µm to 1500 µm. The microspheres and/or the matrix preferably comprise a polylactic/polyglycolic copolymer, collagen, cross-linked collagen, hyaluronic acid, cross-linked hyaluronic acid, an alginate or a cellulose derivative. The resulting implants are stronger and more slowly resorbed than conventional collagen sponge implants. Better control over the porosity of the implant is achieved.

4. 发明公开

EP0676341A1 Two-component packages 失效
标题翻译： ZWEI-Komponentenpackung。
公开(公告)号：EP0676341A1
公开(公告)日：1995-10-11
申请号：EP95302307.4
申请日：1995-04-06
申请人： JOHNSON & JOHNSON MEDICAL, INC.
发明人： Arnold, Peter Stuart , Hilton, Kevin , Warburton, Nina , Wilson, Brian
IPC分类号： B65D81/32
CPC分类号： B65D81/3222 , Y10S215/08
摘要： Two-component packages for storing two components which are to be isolated from each other during storage and mixed when the package is opened. The packages comprise an outer container (2) for a first component having a threaded neck (3). A closure cap (5) is provided to close the threaded neck (3). A capsule (6) for a second component is located inside the outer container (2) and extends into the threaded neck (3) of the outer container (2). A first ratchet means extends downwardly from the base of the closure cap (5) and engages with a second ratchet means on the top part (7) of the capsule (6), whereby the closure cap (5) can be screwed down without rotating the said top part (7) of the capsule (6), but cannot readily be unscrewed without also rotating the said top part (7). A rotation block (13,14) prevents rotation of a lower part (11) of the capsule (6). As a result, unscrewing the closure cap (5) exerts a torsional force on the capsule (6). Release means (12), such as a screw thread, are provided in the capsule (6) to release the contents of the capsule (6) when the said torsional force is applied.
摘要翻译：用于存储在存储期间彼此隔离并且打开包装时混合的两个组件的双组分包装。所述包装件包括用于具有螺纹颈部（3）的第一部件的外部容器（2）。提供封闭盖（5）以封闭螺纹颈部（3）。用于第二部件的胶囊（6）位于外部容器（2）的内部并延伸到外部容器（2）的螺纹颈部（3）中。第一棘轮装置从封闭盖（5）的底部向下延伸，并与胶囊（6）的顶部（7）上的第二棘轮装置接合，由此封闭盖（5）可以旋转而不旋转所述胶囊（6）的所述顶部部分（7），但是不能在不旋转所述顶部部分（7）的情况下容易地拧下螺丝。旋转块（13,14）防止胶囊（6）的下部（11）旋转。结果，拧开封闭盖（5）在胶囊（6）上施加扭转力。当所述扭转力被施加时，诸如螺纹的释放装置（12）设置在胶囊（6）中以释放胶囊（6）的内容物。

5. 发明公开

EP0648480A2 Wound implant materials 失效
标题翻译：物资方面。
公开(公告)号：EP0648480A2
公开(公告)日：1995-04-19
申请号：EP94306874.2
申请日：1994-09-20
申请人： JOHNSON & JOHNSON MEDICAL, INC.
发明人： Arnold, Peter Stuart
IPC分类号： A61F13/00 , A61F2/28
CPC分类号： A61L15/64 , A61F2002/30062 , A61F2002/30242 , A61F2002/30677 , A61F2210/0004 , A61F2230/0071 , A61F2250/0067 , A61L27/44 , A61L27/58 , A61L27/54 , A61L27/227 , A61L27/24 , C08L67/04 , C08L5/08 , C08L5/04 , C08L1/00
摘要： Wound implant materials are described comprising a plurality of bioabsorbable microspheres bound together by a bioabsorbable matrix, such as in a freeze-dried collagen matrix. The microspheres preferably comprise over 30% of the volume of the material, and preferably have diameters of 10 µm to 1500 µm. The microspheres and/or the matrix preferably comprise a polylactic/polyglycolic copolymer, collagen, cross-linked collagen, hyaluronic acid, cross-linked hyaluronic acid, an alginate or a cellulose derivative. The resulting implants are stronger and more slowly resorbed than conventional collagen sponge implants. Better control over the porosity of the implant is achieved.
摘要翻译：描述的伤口植入材料包括通过生物可吸收的基质如冻干的胶原基质结合在一起的多个生物可吸收的微球。微球优选占材料体积的30％以上，优选具有10〜1500μm的直径。微球和/或基质优选包含聚乳酸/聚乙醇酸共聚物，胶原，交联胶原，透明质酸，交联透明质酸，藻酸盐或纤维素衍生物。所得到的植入物比常规胶原海绵植入物更强并且更缓慢吸收。实现更好地控制植入物的孔隙度。

6. 发明公开

EP0599589A1 Wound dressing 失效
标题翻译：伤口敷料
公开(公告)号：EP0599589A1
公开(公告)日：1994-06-01
申请号：EP93309306.4
申请日：1993-11-22
申请人： JOHNSON & JOHNSON MEDICAL, INC.
发明人： Arnold, Peter Stuart
IPC分类号： A61F13/00 , A61F13/02 , A61L15/16
CPC分类号： A61L15/44 , A61F13/0203 , A61F13/023 , A61F13/15252 , A61F2013/00731 , A61F2013/00748 , A61F2013/0091 , A61F2013/00927 , A61L15/24 , A61L15/26 , A61L15/30 , A61L15/325 , A61L15/425 , A61L15/60 , A61L2300/404 , A61L2300/412 , A61L2300/414
摘要： The invention provides wound dressings comprising a molecular filtration membrane (4) having a maximum pore size in the range of from 0.001µm to 0.5µm, and preferably in the range of from 0.01µm to 0.25µm. The wound dressings may also comprise an absorbent layer (3) atop the molecular filtration membrane and/or a wound contact layer (5) of wound-friendly bioabsorbable material for contacting the wound. In use, the molecular filtration membrane retains high molecular weight biopolymers and wound healing factors at the wound surface while excluding bacteria and allowing rapid egress of wound exudate through the membrane into the absorbent layer.
摘要翻译：本发明提供了包含分子过滤膜（4）的伤口敷料，所述分子过滤膜（4）的最大孔径为0.001μm至0.5μm，并且优选为0.01μm至0.25μm。伤口敷料还可以包括位于分子过滤膜顶上的吸收层（3）和/或用于接触伤口的伤口友好的生物可吸收材料的伤口接触层（5）。在使用中，分子过滤膜在伤口表面保留高分子量生物聚合物和伤口愈合因子，同时排除细菌并允许伤口渗出物快速通过膜进入吸收层。

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