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2. 发明公开

EP1987840A1 Prime-boost vaccine for the protection of equines against viral infection 有权
标题翻译： Prime-Boostimpfstoff zum Schutz von Pferden vor viraler Infektion
公开(公告)号：EP1987840A1
公开(公告)日：2008-11-05
申请号：EP07008858.8
申请日：2007-05-02
申请人： Intervet International BV
发明人： Van de Zande, Saskia
IPC分类号： A61K39/145 , A61K39/245 , A61K39/12
CPC分类号： A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/5254 , A61K2039/543 , A61K2039/545 , A61K2039/552 , A61K2039/55511 , A61K2039/55544 , A61K2039/55577 , A61K2039/70 , C12N2710/16734 , C12N2760/16134 , C12N2760/16161
摘要： It has been found that adequate protection against viral infection in equines can be achieved when vaccination with a live viral vaccine (prime) is followed by vaccination with an inactivated vaccine (boost) for the same virus, wherein the two shots are given no longer than 8 weeks apart.
The invention therefore provides a method for vaccination of equines against infection with an equine viral pathogen, wherein an animal is first vaccinated with a (prime) vaccine comprising an attenuated form of the pathogen, followed by a vaccination with a (boost) vaccine comprising the same pathogen in inactivated form, and wherein the boost vaccine is administered no longer than eight weeks after the prime vaccine.
The method of the invention is especially useful for vaccination against viral infections such as infections with EIV and/or EHV-1/EHV-4.
Especially for EIV, it has been found that when equines are vaccinated with such a prime-boost vaccine regimen according to the invention, the equines are protected against clinical signs after a challenge with a virulent EIV.
摘要翻译：已经发现，当用活病毒疫苗（初始）接种疫苗之后，用相同病毒的灭活疫苗（增强）接种疫苗后，可以实现对马中的病毒感染的充分保护，其中两次给药不再 8周。因此，本发明提供了用马接种马病毒感染的方法，其中首先用包含减毒形式的病原体的（初级）疫苗接种动物，然后用（加强）疫苗接种疫苗，其包含相同的灭活形式的病原体，并且其中所述增强疫苗在所述主要疫苗之后不超过8周施用。本发明的方法对于针对病毒感染例如EIV和/或EHV-1 / EHV-4感染是特别有用的。特别是对于EIV，已经发现当使用根据本发明的初次 - 加强疫苗方案接种马时，在用有毒的EIV攻击后，马被保护免受临床症状。

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