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1. 发明授权

EP2304441B1 A METHOD FOR THE SCREENING OF CONSERVED SECRETED PROTEINS 有权
标题翻译：一种筛选罐装的歧视性蛋白
公开(公告)号：EP2304441B1
公开(公告)日：2014-05-07
申请号：EP09772549.3
申请日：2009-07-03
申请人： Institut de Recherche pour le Développement ( IRD)
发明人： CORRALES, Rosa, Milagros , MATHIEU-DAUDE, Françoise , SERENO, Denis
IPC分类号： G01N33/569 , C07K14/44 , C07K16/20
CPC分类号： G01N33/56905 , A61K39/00 , C07K14/44 , Y02A50/41 , Y02A50/414 , Y02A50/416
摘要： Conserved polypeptides from protozoan parasitic species which are secreted through the endoplasmic reticulum/Golgi dependent secretory pathway, their identification and their use.

2. 发明公开

EP1678305A2 SOUCHES DE PROTOZOAIRE DE VIRULENCE ATTENUEE ET LEUR UTILISATION 有权
标题翻译： PROTOZOANSTAMM毒力降低的种婴儿利什曼原虫及其使用
公开(公告)号：EP1678305A2
公开(公告)日：2006-07-12
申请号：EP04805294.8
申请日：2004-10-25
申请人： Institut de Recherche pour le Développement ( IRD) , Universidade Do Porto
发明人： CORDEIRA DA SILVA, Anabela , OUAISSI, Ali , SERENO, Denis , VERGNES, Baptiste
IPC分类号： C12N15/30
CPC分类号： A61K39/002 , A61K35/68 , A61K38/00 , C12N1/10 , Y02A50/41 , Y02A50/414 , Y02A50/416
摘要： The invention relates to a protozoan strain, belonging to the Trypanosomatidae family, whose virulence is lower than that of the corresponding wild strain, characterized in that at least one copy of the SIR2 gene, which is present in the genome of said strain, is inactivated.

3. 发明授权

EP1685156B1 NOUVEAUX MOYENS POUR LA PRÉVENTION DES LEISHMANIOSES 失效
标题翻译：新的代理预防利什曼病
公开(公告)号：EP1685156B1
公开(公告)日：2010-04-07
申请号：EP04805492.8
申请日：2004-11-19
申请人： Institut de Recherche pour le Développement ( IRD)
发明人： LEMESRE, Jean-Loup , CAVALEYRA, Mireille , SERENO, Denis , HOLZMULLER, Philippe
IPC分类号： C07K14/44
CPC分类号： A61K39/008 , C07K14/44 , C07K14/473 , Y02A50/41

4. 发明公开

EP2304441A2 A METHOD FOR THE SCREENING OF CONSERVED SECRETED PROTEINS 有权
标题翻译：一种筛选罐装的歧视性蛋白
公开(公告)号：EP2304441A2
公开(公告)日：2011-04-06
申请号：EP09772549.3
申请日：2009-07-03
申请人： Institut de Recherche pour le Développement ( IRD)
发明人： CORRALES, Rosa, Milagros , MATHIEU-DAUDE, Françoise , SERENO, Denis
IPC分类号： G01N33/569 , C07K14/44 , A61K48/00 , A61K39/002 , C07K16/20 , C12N15/00 , C12N5/00
CPC分类号： G01N33/56905 , A61K39/00 , C07K14/44 , Y02A50/41 , Y02A50/414 , Y02A50/416
摘要： Conserved polypeptides from protozoan parasitic species which are secreted through the endoplasmic reticulum/Golgi dependent secretory pathway, their identification and their use.

5. 发明授权

EP1768669B1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LEISHMANIASIS 有权
标题翻译：药物组合物利什曼病治疗
公开(公告)号：EP1768669B1
公开(公告)日：2009-11-11
申请号：EP05772459.3
申请日：2005-07-15
申请人： Institut de Recherche pour le Développement ( IRD)
发明人： OUAISSI, Ali , SERENO, Denis , VERGNES, Baptiste
IPC分类号： A61K31/455 , A61P33/02
CPC分类号： A61K31/455 , Y02A50/409 , A61K2300/00
摘要： The present invention relates to the use of at least one compound of the following general formula (I): wherein R represents OH or NH 2 , or of precursors or derivatives thereof, or of the pharmaceutically acceptable salts of the compound or of its precursors or derivatives, for the manufacture of a medicament intended for the prevention or the treatment of parasitic diseases, in particular of protozoan parasitic diseases, more particularly of leishmaniosis, and especially for the prevention or the treatment of parasitic diseases occurring in immunodepressed patients.

6. 发明公开

EP3234837A1 SYSTÈME ET PROCÉDÉ D'IDENTIFICATION AUTOMATISÉE DE DIPTÈRES HÉMATOPHAGES 审中-公开
标题翻译： SYSTÈMEETPROCÉDÉD'IDENTIFICATIONAUTOMATISÉEDEDIPTÈRESHÉMATOPHAGES
公开(公告)号：EP3234837A1
公开(公告)日：2017-10-25
申请号：EP15825611.5
申请日：2015-12-16
申请人： Institut de Recherche pour le Développement (IRD)
发明人： SERENO, Denis , CANNET, Arnaud , AKHOUNDI, Mohammad , ROMAIN, Olivier , HISTACHE, Aymeric
IPC分类号： G06F19/00
CPC分类号： G16H50/70 , G06F19/00 , Y02A90/26
摘要： The invention concerns a system and a method for the automated identification of haematophagous Diptera that are vectors of infectious diseases. The system according to the invention comprises: - a database containing reference image data of wings of a plurality of species of haematophagous Diptera that are vectors of infectious diseases, said image data being obtained from optical interference patterns of said wings; a portable device comprising means for acquiring images of a wing removed from a captured Diptera specimen; - a support for holding the wing removed from the captured Diptera specimen; - means for transmitting image data of the removed wing to the database; and - means for comparing the image data of the removed wing with the reference image data of the database and for identifying the captured Diptera with a view to determining if said Diptera is a haematophagous Diptera that is a vector of infectious diseases. The invention applies to the identification of haematophagous Diptera that are vectors of infectious diseases.
摘要翻译：本发明涉及用于自动识别作为传染病媒介的食虫双翅目的系统和方法。根据本发明的系统包括： - 含有作为传染病媒介的多种食蚁兽双翅类的翅膀的参考图像数据的数据库，所述图像数据是从所述翅膀的光学干涉图案获得的; 便携式装置，其包括用于获取从捕获的双翅目标本移除的机翼的图像的装置; - 支持从捕获的双翅目标本中取出机翼; - 用于将去除的机翼的图像数据发送到数据库的装置; 以及 - 用于比较被去除的翅膀的图像数据与数据库的参考图像数据并且用于识别捕获的双翅目以便确定双翅目是否是传染病向量的食蚁兽双翅目的装置。本发明适用于鉴定传染病媒介的食虫双翅目。

7. 发明公开

EP1768669A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LEISHMANIASIS 有权
标题翻译：药物组合物利什曼病治疗
公开(公告)号：EP1768669A1
公开(公告)日：2007-04-04
申请号：EP05772459.3
申请日：2005-07-15
申请人： Institut de Recherche pour le Développement ( IRD)
发明人： OUAISSI, Ali , SERENO, Denis , VERGNES, Baptiste
IPC分类号： A61K31/455 , A61P33/02
CPC分类号： A61K31/455 , Y02A50/409 , A61K2300/00
摘要： The present invention relates to the use of at least one compound of the following general formula (I): wherein R represents OH or NH 2 , or of precursors or derivatives thereof, or of the pharmaceutically acceptable salts of the compound or of its precursors or derivatives, for the manufacture of a medicament intended for the prevention or the treatment of parasitic diseases, in particular of protozoan parasitic diseases, more particularly of leishmaniosis, and especially for the prevention or the treatment of parasitic diseases occurring in immunodepressed patients.

8. 发明授权

EP1678305B1 SOUCHE DE PROTOZOAIRE DE L'ESPÈCE LEISHMANIA INFANTUM DE VIRULENCE ATTENUEE ET SON UTILISATION 有权
标题翻译： PROTOZOANSTAMM毒力降低的种婴儿利什曼原虫及其使用
公开(公告)号：EP1678305B1
公开(公告)日：2011-11-23
申请号：EP04805294.8
申请日：2004-10-25
申请人： Institut de Recherche pour le Développement ( IRD) , Universidade Do Porto
发明人： CORDEIRA DA SILVA, Anabela , OUAISSI, Ali , SERENO, Denis , VERGNES, Jean-Baptiste
IPC分类号： C12N15/30
CPC分类号： A61K39/002 , A61K35/68 , A61K38/00 , C12N1/10 , Y02A50/41 , Y02A50/414 , Y02A50/416
摘要： The invention relates to a protozoan strain, belonging to the Trypanosomatidae family, whose virulence is lower than that of the corresponding wild strain, characterized in that at least one copy of the SIR2 gene, which is present in the genome of said strain, is inactivated.

9. 发明公开

EP1685156A2 NOUVEAUX MOYENS POUR LA PR VENTION DES LEISHMANIOSES 失效
标题翻译：新的代理预防利什曼病
公开(公告)号：EP1685156A2
公开(公告)日：2006-08-02
申请号：EP04805492.8
申请日：2004-11-19
申请人： Institut de Recherche pour le Développement ( IRD)
发明人： LEMESRE, Jean-Loup , CAVALEYRA, Mireille , SERENO, Denis , HOLZMULLER, Philippe
IPC分类号： C07K14/44
CPC分类号： A61K39/008 , C07K14/44 , C07K14/473 , Y02A50/41
摘要： The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of Leishmania, said nucleic acids responding to one of the sequences SEQ ID No.1, SEQ ID No.2, SEQ ID No.3, SEQ ID No.4, SEQ ID No. 5 et SEQ ID No. 11 and coding for a protein respectively exhibiting a sequence SEQ ID No. 6, SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No.10 et SEQ ID No. 12. The invention can be used for over-expression of the genes of Leishmania coding for an excretion/secretion antigen.

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