专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2984485A2 METHODS TO OBTAIN A NOVEL CLASS OF GRAM NEGATIVE BACTERIA ANTIBIOTICS WHICH TARGET AN UNKNOWN CELL DIVISION ASSOCIATED PROTEIN LOP1 审中-公开
标题翻译：制造方法类新颖的革兰氏阴性细菌抗生素与ADDRESSED是细胞分裂相关蛋白LOP1中未知
公开(公告)号：EP2984485A2
公开(公告)日：2016-02-17
申请号：EP14721523.0
申请日：2014-04-08
申请人： Institut Pasteur , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： MARTEYN, Benoît , SANSONETTI, Philippe
IPC分类号： G01N33/50 , G01N33/569
CPC分类号： G01N33/573 , C07K16/40 , C07K2317/76 , C12N15/1137 , C12N15/115 , C12N2310/11 , C12N2310/12 , C12N2310/16 , C12N2320/30 , C12Q1/37 , G01N33/566 , G01N33/569 , G01N2333/952
摘要： The present invention relates to methods to identify substances which affect bacterial cell division by interfering with the function of LOPl, comprising bringing into contact a purified protein selected from the group: FtsZ, FtsQ, FtsL, FtsI and FtsN; with purified LOPl protein and then assaying the formation of complexes between LOPl and the selected purified protein in the presence and absence of a substance to be tested and then selecting substances from step b) which affect the formation of complexes when present. The present invention also relates to inhibitors of the activity and expression of LOP 1

2. 发明公开

EP3114216A1 METHOD AND DEVICE FOR CONSERVING VIABLE AND FUNCTIONAL HUMAN POLYMORPHONUCLEAR NEUTROPHILS 审中-公开
标题翻译：方法和设备为维护可行的和功能性的人多形
公开(公告)号：EP3114216A1
公开(公告)日：2017-01-11
申请号：EP15714027.8
申请日：2015-03-09
申请人： Institut Pasteur , Institut National de la Santé et de la Recherche Médicale
发明人： MARTEYN, Benoît , SANSONETTI, Philippe , MONCEAUX, Valérie , UNGEHEUER, Marie-Noëlle
IPC分类号： C12N5/0787
CPC分类号： C12N5/0642 , C12N2500/02 , C12N2500/34 , C12N2501/73
摘要： A method for keeping leukocytes alive
ex vivo or in vitro , comprising maintaining the leukocytes in a medium comprising from 3 to 10 mM of glucose, in hypoxic conditions with P(02) ≤ 10 mM Hg.
摘要翻译：一种用于保活白细胞离体或在体外，包括在包含3至葡萄糖，在缺氧条件下用P（O 2）‰¤10毫米汞柱10mM的介质维护白细胞的方法。

3. 发明公开

EP2911698A1 GLYCOCONJUGATES AND THEIR USE AS POTENTIAL VACCINES AGAINST INFECTION BY SHIGELLA FLEXNERI 有权转让
标题翻译：糖复合物及其作为候选疫苗预防感染福氏痢疾杆菌
公开(公告)号：EP2911698A1
公开(公告)日：2015-09-02
申请号：EP13783923.9
申请日：2013-10-29
申请人： Institut Pasteur , Centre National de la Recherche Scientifique , Institut National de la Santé et de la Recherche Médicale , Université Paris Descartes
发明人： MULARD, Laurence , CHASSAGNE, Pierre , SANSONETTI, Philippe , PHALIPON, Armelle , TRAINCARD, François , NATO, Farida
IPC分类号： A61K47/48
CPC分类号： A61K47/4833 , A61K9/1271 , A61K38/164 , A61K47/48092 , A61K47/549 , A61K47/646 , C07K17/10 , C07K2317/76
摘要： The present invention relates to a conjugate comprising an oligo- or polysaccharide selected from the group consisting of: (X)
x -{BCDA}
n -(Y)
y (X)
x -{CDAB}
n -(Y)
y (X)
x -{DABC}
n -(Y)
y (X)
x -{ABCD}n-(Y)
y wherein A, B, C, D, X and Y, x, y and n are as defined in claim 1, said oligo- or polysaccharide being bound to a carrier.

4. 发明公开

EP2753639A1 POLYPEPTIDES TARGETING GLYCOSYLATED MUC2 PROTEINS, METHODS OF SYNTHESIS, THEIR NUCLEIC ACIDS AND USES THEREOF 失效
标题翻译： ON糖化蛋白MUC2多肽LOOKING，合成，及其核酸和方法及其用途
公开(公告)号：EP2753639A1
公开(公告)日：2014-07-16
申请号：EP12755887.2
申请日：2012-09-07
申请人： Institut Pasteur
发明人： MARTEYN, Benoit , COIC, Yves-Marie , BALEUX, Françoise , SANSONETTI, Philippe
IPC分类号： C07K14/195 , C07K14/335 , A61K38/16 , C12N1/15 , C12N1/21 , C12N5/10 , G01N33/68 , G01N33/58
CPC分类号： C07K14/335 , C07K7/08 , C07K14/195 , C07K14/315 , C07K2319/60 , C07K2319/61 , C12P21/02 , G01N33/6893
摘要： The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence comprises or consists of the consensus sequence P1 (X
a )P3(X
b )P5(X
c )P6(X
d )P7, presenting specific patterns. The polypeptides of the invention target glycosylated Muc2 proteins. The invention also relates to methods of synthesis of such polypeptides, to their nucleic acids and uses thereof. The polypeptidic sequence of the polypeptides of the invention can be part of the N-terminal sequence of a mucus-binding (MUB) domain, especially a mucus-binding (MUB) domain of several species. The invention also relates to chimeric molecule(s) comprising such polypeptides, which are labelled, and vectors, especially plasmids and population of cells or composition comprising polypeptides of the invention. Synthesis methods encompass biotechnological or chemical production. Polypeptides of the invention can be used in staining experiments, as a probe or marker for staining Muc2 protein(s) contained in mucus layer(s), to detect in vitro mucus production or mucus composition in human colon or monitoring any one of the following disease conditions: neoplasic disease(s), including mucinous carcinoma(s), gastric cancer(s) or colorectal cancer(s), especially colon cancer(s), cystic fibrosis, intestine inflammatory disease(s) such as inflammatory bowel disease (IBD) and ulcerative colitis. The invention also relates to a method for manufacturing a medicament. In a particular embodiment, use of polypeptides of the invention can be made for marking neutrophiles.
摘要翻译：本发明涉及通过共有序列定义的多肽，具有10至80个氨基酸残基，且其对多肽类序列包含或共有序列P1（XA）P3（X B）P5（X c）中的besteht长度 P6（X D）P7，呈现特定图案。本发明目标的多肽糖基化的蛋白质MUC2。因此，本发明涉及谋求多肽及其核酸及其用途的合成方法。本发明的多肽的多肽性序列可以是粘液结合（MUB）结构域的N-末端序列的一部分，尤其是爱粘液结合（MUB）几个物种的结构域。因此，本发明涉及嵌合分子（多个）被标记包括搜索多肽和载体，质粒特别喜欢和细胞或组合物包含本发明的多肽的群体。合成方法包括生物技术和化工生产。本发明的多肽可以在染色实验中使用，作为探针或标记物用于染色包含在粘液层（一个或多个）MUC2蛋白（S），以检测在体外粘液产生或在人结肠粘液组合物或监测以下中的任何一个疾病病症：肿瘤性疾病（一个或多个），包括粘液癌（S），胃癌（S）或结肠直肠癌（S），特别是结肠癌（S），囊性纤维化，肠的炎性疾病（一个或多个）：如炎性肠疾病（ IBD）和溃疡性结肠炎。因此本发明涉及一种用于制造药物的方法。在特定实施例中，使用本发明的多肽可用于标记的中性粒细胞进行。

6. 发明授权

EP2195457B1 SINGLE CELL BASED REPORTER ASSAY TO MONITOR GENE EXPRESSION PATTERNS WITH HIGH SPATIO-TEMPORAL RESOLUTION 有权
标题翻译：报道实验个别单元格BASIS具有高时空分辨率监测基因表达模式
公开(公告)号：EP2195457B1
公开(公告)日：2012-07-25
申请号：EP08804165.2
申请日：2008-09-12
申请人： Institut Pasteur
发明人： MHLANGA, Musa , ENNINGA, Jost , SANSONETTI, Philippe , NEHRBASS, Ulf
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , C12Q2563/179 , C12Q2525/301 , C12Q2565/1015
摘要： The invention relates to a double-stranded polynucleotide comprising on its positive strand considered from its 5' end to its 3' end, (i) a promoter of a gene of interest or several promoters of various genes of interest selected among genes which are endogenous to a determined cell, and, (ii) one or several barcode(s) wherein each barcode contains at least one barcode unit formed of at least one, especially of multiple, recognition binding sites each binding site being composed of a nucleotide sequence, and wherein each of said barcode(s) is under the control of at least one of said promoter(s) for transcription. It further concerns use of said polynucleotide to monitor gene expression patterns in living cells, especially in single cells, with a rapid and high spatio-temporal resolution.

7. 发明公开

EP2083853A2 SHIGELLA IPAD PROTEIN AND ITS USE AS A VACCINE AGAINST SHIGELLA INFECTION 有权
标题翻译：志贺氏菌，iPad的蛋白质和其作为疫苗志贺氏菌感染
公开(公告)号：EP2083853A2
公开(公告)日：2009-08-05
申请号：EP07859250.8
申请日：2007-10-12
申请人： Institut Pasteur
发明人： ALLAOUI, Adbelmounaaïm , SANSONETTI, Philippe , SANI, Musa , BOTTEAUX, Anne , PARSOT, Claude , BOEKEMA, Egbert, J.
IPC分类号： A61K39/00
CPC分类号： A61K39/0283 , Y02A50/476
摘要： The present invention relates to compositions and methods for blocking entry of Shigella into a cell of an animal, to therefore providing protection against, or reduce the severity of Shigella infections. More particularly it relates to the use of the IpaD protein obtained from natural sources and/or through synthesis or recombinant technology, and conjugates thereof to induce neutralizing antibodies having protective activity against several serotypes of Shigella, in particular S. flexneri. The composition of the invention is useful to prevent and/or treat shigellosis caused by a bacterium of the Shigella family.

8. 发明授权

EP2753639B1 POLYPEPTIDES TARGETING GLYCOSYLATED MUC2 PROTEINS, METHODS OF SYNTHESIS, THEIR NUCLEIC ACIDS AND USES THEREOF 失效
标题翻译： ON糖化蛋白MUC2多肽LOOKING，合成，及其核酸和方法及其用途
公开(公告)号：EP2753639B1
公开(公告)日：2017-03-01
申请号：EP12755887.2
申请日：2012-09-07
申请人： Institut Pasteur
发明人： MARTEYN, Benoit , COIC, Yves-Marie , BALEUX, Françoise , SANSONETTI, Philippe
IPC分类号： C07K14/195 , C07K14/335 , A61K38/16 , C12N1/15 , C12N1/21 , C12N5/10 , G01N33/68 , G01N33/58 , C07K14/315 , C07K7/08
CPC分类号： C07K14/335 , C07K7/08 , C07K14/195 , C07K14/315 , C07K2319/60 , C07K2319/61 , C12P21/02 , G01N33/6893

9. 发明公开

EP2903630A1 A NOD2-DEPENDENT PATHWAY OF CYTOPROTECTION OF STEM CELLS 审中-公开
标题翻译：干细胞的细胞保护NOD2相关的路径
公开(公告)号：EP2903630A1
公开(公告)日：2015-08-12
申请号：EP13779756.9
申请日：2013-10-03
申请人： Institut Pasteur
发明人： SANSONETTI, Philippe , NIGRO, Giulia
IPC分类号： A61K38/05 , C12N5/074
CPC分类号： A61K38/14 , A61K38/05 , C12N5/068 , C12N2501/054 , G01N33/502 , G01N33/5073 , G01N33/5076 , G01N2333/904
摘要： The present invention is directed to an agonist of NOD2 for use in therapy for increasing the autonomous capacity of survival of vertebrate adult stem cells, without loss of their capacity to multiply and differentiate, and preferably the capacity of survival of intestinal stem cells, especially in response to a stress. The invention also concerns the use of an agonist of Nod2 for increasing in vitro or ex vivo the autonomous capacity of survival, without loss of multiplication and differentiation capacity of mammalian adult stem cell. The invention also discloses different media and support for mammalian adult stem cells. The invention also concerns an in vitro screening process for identifying molecules capable increasing, in response to a stress, the autonomous capacity of survival, without loss of multiplication and differentiation capacity of mammalian adult stem cells.

10. 发明授权

EP1642132B1 GLYCOCONJUGATES AND THEIR USE AS POTENTIAL VACCINES AGAINST INFECTION BY SHIGELLA FLEXNERI 有权转让
标题翻译：糖复合物及其作为候选疫苗抗感染与志贺菌
公开(公告)号：EP1642132B1
公开(公告)日：2011-06-22
申请号：EP04744281.9
申请日：2004-07-02
申请人： INSTITUT PASTEUR , INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： PHALIPON, Armelle , NATO, Farida , MULARD, Laurence , SANSONETTI, Philippe , GRANDJEAN, Cyrille , BALEUX, Francoise , BELOT, Frédéric
IPC分类号： G01N33/569 , C07K16/12 , A61K47/48 , C07H3/06 , G01N33/563 , A61K39/112
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： The present invention relates to a saccharide selected from the group consisting of: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{B(E)CD} €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{(E)CDAB}n €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{AB(E)CD}n Wherein A, B, C, E, D and n are as defined in claim 1. The invention also relates to derivatives thereof, pharmaceutical compositions comprising said derivatives, and kit for the diagnostic of Shigella flexneri type 2a infection comprising said derivatives.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式