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1. 发明授权

EP1061133B1 Process for preparing acetophenone products produced therefrom and organoleptic uses of said products 有权
标题翻译：一种用于生产的苯乙酮，它们的衍生产品和它们作为香料使用过程
公开(公告)号：EP1061133B1
公开(公告)日：2005-06-29
申请号：EP00303114.3
申请日：2000-04-13
申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.
发明人： Farbood, Mohamad I. , Kim, Augustine Yonghwi , Blocker, Robert W.
IPC分类号： C12P7/26 , C07C49/78 , A23L1/23 , A61K7/46
CPC分类号： C12P7/26 , Y10S435/822 , Y10S435/83

2. 发明公开

EP0578388A2 Fermentation process for preparing 10-hydroxy-C18-carboxylic acid and gamma-dodecalactone derivatives 失效
标题翻译： Verfahren zur fermentativen Herstellung von 10-Hydroxy-C18-Carbonsaure und Gamma-Dodekalaktonderivaten。
公开(公告)号：EP0578388A2
公开(公告)日：1994-01-12
申请号：EP93304599.9
申请日：1993-06-14
申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.
发明人： Farbood, Mohamad I. , Morris, James A. , McLean, Lynda B.
IPC分类号： C12P17/04 , C12P7/64 , C12N9/20 , C12N1/20
CPC分类号： C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P17/04
摘要： Described is a fermentation process for preparing 10-hydroxy-C 18 -carboxylic acid derivative containing compositions containing compounds defined according to the structure :

and gamma-dodecalactone derivative-containing compositions containing compounds defined according to the structure :

wherein the dashed lines represent the same or different carbon-carbon bonds; with each of the dashed lines representing a carbon-carbon single bond or a carbon-carbon double bond, products produced thereby and organoleptic uses thereof including uses for augmenting, enhancing or imparting aromas or flavors to or in consumable materials including but not limited to perfume compositions, colognes, perfumed articles, foodstuffs, chewing gums, beverages, toothpastes, hair preparations, tobacco compositions and smoking tobacco articles.
摘要翻译：描述了一种用于制备含有根据以下结构定义的化合物的含10至羟基-C18-羧酸衍生物的组合物的发酵方法：含有根据以下结构定义的化合物的含有和含γ-十二烷内酯衍生物的组合物其中虚线表示相同或不同的碳 - 碳键; 其中每条虚线表示碳 - 碳单键或碳 - 碳双键，由此产生的产品及其感官用途，包括用于增强，增强或赋予香味或香料至消耗材料的用途，包括但不限于香料组合物，古龙水，香料制品，食品，口香糖，饮料，牙膏，头发制剂，烟草组合物和烟草制品。

3. 发明公开

EP1061133A1 Process for preparing acetophenone products produced therefrom and organoleptic uses of said products 有权
标题翻译：一种用于生产的苯乙酮，它们的衍生产品和它们作为香料使用过程
公开(公告)号：EP1061133A1
公开(公告)日：2000-12-20
申请号：EP00303114.3
申请日：2000-04-13
申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.
发明人： Farbood, Mohamad I. , Kim, Augustine Yonghwi , Blocker, Robert W.
IPC分类号： C12P7/26 , C07C49/78 , A23L1/23 , A61K7/46
CPC分类号： C12P7/26 , Y10S435/822 , Y10S435/83
摘要： A process for producing acetephenone from a source of cinnamic acid is carried out with high amounts of oxygen and sugar in the presence of a bacteria species. Fragrance compositions and foodstuff compositions are augmented and enhanced by the presence of the product compound.
摘要翻译：一种用于从肉桂酸源生产acetephenone过程与在细菌物种的存在氧和糖的高含量的开展。香料组合物和食品组合物的东西被增强和由产品化合物的存在而增强。

4. 发明授权

EP0519481B1 Gamma octalactone-containing composition, fermentation process for producing the same and organoleptic uses thereof 失效
标题翻译：含有的γ-辛内酯的组合物，它们的制备发酵方法和其感官用途
公开(公告)号：EP0519481B1
公开(公告)日：1997-10-15
申请号：EP92110336.2
申请日：1992-06-19
申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.
发明人： Farbood, Mohamad I. , McLean, Lynda B. , Morris, James A. , Bondarovich, Henry A.
IPC分类号： C12P7/42 , C07D307/33 , C07D307/56 , C07D309/30 , A23L1/23 , C11D3/50 , C11B9/00 , A24B3/12 , A61K7/46
CPC分类号： C12P17/04 , A23L27/24 , A24B15/403 , A24B15/406 , C11B9/0076 , C11D3/50 , C12P7/42

5. 发明公开

EP0519481A3 Octalactone-containing composition, fermentation process for producing same and organoleptic uses thereof 失效
标题翻译：含有八氢内酯的组合物，用于生产其的发酵方法和其感官用途
公开(公告)号：EP0519481A3
公开(公告)日：1994-03-30
申请号：EP92110336.2
申请日：1992-06-19
申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.
发明人： Farbood, Mohamad I. , McLean, Lynda B. , Morris, James A. , Bondarovich, Henry A.
IPC分类号： C12P7/42 , C07D307/33 , C07D307/56 , C07D309/30 , A23L1/23 , C11D3/50 , C11B9/00 , A24B3/12 , A61K7/46
CPC分类号： C12P17/04 , A23L27/24 , A24B15/403 , A24B15/406 , C11B9/0076 , C11D3/50 , C12P7/42
摘要： The present invention is directed to a microbiological process for the production of compositions containing a major proportion of gamma octalactone generically defined according to the structure:

containing the stereoisomers having the structures:
摘要翻译：本发明涉及用于生产含有主要部分通常根据以下结构定义的γ-八聚内酯的组合物的微生物方法：含有具有以下结构的立体异构体：

6. 发明公开

EP0354000A2 Process for preparing compositions containing unsaturated lactones, products produced thereby and organoleptic uses of said products 失效
标题翻译：一种用于容纳由此产生的化合物和感官使用这些化合物的不饱和内酯类的混合物的制备方法。
公开(公告)号：EP0354000A2
公开(公告)日：1990-02-07
申请号：EP89307821.2
申请日：1989-08-01
申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.
发明人： Farbood, Mohamad I. , Morris, James A. , Sprecker, Mark A. , Bienkowski, Lynda J. , Miller, Kevin P. , Vock, Manfred Hugo , Hagedorn, Myrna Lee
IPC分类号： C12P7/42 , C12P7/40 , C07D313/00 , C07D313/04 , C11B9/00 , A23L1/23
CPC分类号： C11B9/0073 , A24B15/403 , C12P7/40 , C12P7/42 , C12P17/02
摘要： Described is a process for the preparation of compositions of matter containing unsaturated lactones defined according to the generic structure:
wherein R represents C 6 alkyl or alkenyl; and X represents C 2 , C 4 or C 6 alkylene or alkenylene; with the provisos that R is C 6 alkyl when X is alkenylene and R is C 6 alkenyl when X is alkylene by means of the sequential steps of (i) fermentation of castor oil or ricinoleic acid using a microorganism selected from the group consisting of: Candida petrophilum, ATCC 20226; Candida oleophila, ATCC 20177; Candida sp., ATCC 20504; and Candida sake, ATCC 28137 whereby gamma hydroxydecanoic acid and a mixture of other acids defined according to the generic structure:
is formed wherein Y represents an oxo-saturated, oxo-unsaturated or di-unsaturated C 9 , C 11 or C 13 moiety according to the reaction:
(ii) lactonization of the resulting gamma hydroxydecanoic acid by means of simultaneous acidification and heating according to the reaction:
and (iii) lactonization (via distillation) of one or more of the resulting acids defined according to the structure:
to form one or more lactones defined according to the generic structure:
according to the reaction:
wherein the sum of the number of carbon atoms in the X moiety and in the R moiety is equal to the number of carbon atoms in the Y moiety minus 1.
Also described are the products produced according to such process as well as their organoleptic utilities for augmenting or enhancing the aroma or taste of consumable materials selected from the group consisting of perfume compositions, colognes, perfumed articles, perfumed polymers, foodstuffs, chewing gums, medicinal products, toothpastes, chewing tobaccos and smoking tobaccos.
摘要翻译：描述的是用于定义gemäß到通用结构物包含不饱和内酯类的组合物的制备方法： worinřdarstellt -C 6烷基或烯基; 和X darstellt C2，C4或C6亚烷基或亚烯基; 但条件做R是C6烷基当X是亚烯基，R为-C 6烯基。当X是由蓖麻油或使用选自中选择的微生物的蓖麻油酸（i）的发酵的连续步骤的装置的亚烷基：念珠菌petrophilum ，ATCC 20226; 假丝酵母菌，ATCC 20177; 假丝酵母，ATCC第二万○五百零四; 和念珠菌起见，ATCC 28137由此伽马羟基癸酸和雅丁定义的一般结构中的其他酸的混合物：形成worin氧饱和，氧代的不饱和或二不饱和C9，C11或C13部分gemäßY的darstellt 向反应：（ii）通过同时酸化和加热雅丁到反应的手段产生的伽玛羟基癸酸的内酯化：一个或多个所产生的酸的和（iii）的内酯化（通过蒸馏）中所定义雅鼎的结构：以形成雅丁定义的一般结构中的一个或多个内酯：雅丁到反应： worin碳原子的数目的在X部分和R部分的总和等于碳原子的在Y部分的数量减1。因此描述了雅丁对于这样的过程，以及它们用于增强或提高消耗材料selecte的气味或味道的感官公用事业生产的产品 ð选自香水组合物，古龙水，加香制品，香聚合物，食品，口香糖，药用产品，牙膏，口香糖烟草和吸烟的烟草。

7. 发明公开

EP1118672A3 Production of food flavor-acceptable jasmonic acid and methyl jasmonate by Diplodia gossypina 审中-公开
标题翻译：茉莉酸和甲酯的生产如由孢gossypina用于食品调味料
公开(公告)号：EP1118672A3
公开(公告)日：2002-10-16
申请号：EP00311431.1
申请日：2000-12-20
申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.
发明人： Farbood, Mohamad I. , Blocker, Robert W. , McLean, Lynda B. , McLean, Michael P. , Kim, Augustine Younghwi , Sprecker, Mark A. , Kossiakoff, Nicolas , Hagedorn, Myrna
IPC分类号： C12P7/40 , C12P7/62 , C12N1/14 , C07C59/82 , C07C67/08 , C07C69/738 , A61K7/46 , A61K7/16 , A24B15/34 , A23L1/23
CPC分类号： C07C69/738 , A23L27/203 , A23L27/24 , A24B15/34 , C07C59/82 , C07C2601/08 , C11B9/003 , C12N1/14 , C12P7/40 , C12P7/62
摘要： Described is a bioprocess for the high-yield production of food flavor-acceptable jasmonic acid and methyl jasmonate, as well as a novel jasmonic acid isomer produced thereby and organoleptic uses thereof. The process yields at least 5% of the "cis" isomer defined according the structure: (wherein R is hydrogen or methyl) or at least 5% of the "cis" isomer defined according to the structure: (wherein R is hydrogen or methyl). Compositions containing at least 98% of the isomer having the structure: with an optical rotation (α20D) of +58° are novel. Compositions containing at least 98% of the isomer having the structure: with an optical rotation (α20D) of +58° are also novel. The process of our invention comprises the cultivation under aerobic condition of one or more specific strain of Diplodia gossypina in a nutrient medium followed either by (1) isolation of the jasmonic acid product or (2) esterification of the jasmonic acid to form methyl jasmonate followed by the isolation of the methyl jasmonate and novel products produced by such process.

8. 发明公开

EP1118672A2 Production of food flavor-acceptable jasmonic acid and methyl jasmonate by Diplodia gossypina 审中-公开
标题翻译： Herstellung vonJasmonsäureund Methylester alsGewürzmittelfürNahrungsmittel durch Diplodia gossypina
公开(公告)号：EP1118672A2
公开(公告)日：2001-07-25
申请号：EP00311431.1
申请日：2000-12-20
申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.
发明人： Farbood, Mohamad I. , Blocker, Robert W. , McLean, Lynda B. , McLean, Michael P. , Kim, Augustine Younghwi , Sprecker, Mark A. , Kossiakoff, Nicolas , Hagedorn, Myrna
IPC分类号： C12P7/40 , C12P7/62 , C12N1/14 , C07C59/82 , C07C67/08 , C07C69/738 , A61K7/46 , A61K7/16 , A24B15/34 , A23L1/23
CPC分类号： C07C69/738 , A23L27/203 , A23L27/24 , A24B15/34 , C07C59/82 , C07C2601/08 , C11B9/003 , C12N1/14 , C12P7/40 , C12P7/62
摘要： Described is a bioprocess for the high-yield production of food flavor-acceptable jasmonic acid and methyl jasmonate, as well as a novel jasmonic acid isomer produced thereby and organoleptic uses thereof. The process yields at least 5% of the "cis" isomer defined according the structure:
(wherein R is hydrogen or methyl) or at least 5% of the "cis" isomer defined according to the structure:
(wherein R is hydrogen or methyl). Compositions containing at least 98% of the isomer having the structure:
with an optical rotation (α 20 D ) of +58° are novel. Compositions containing at least 98% of the isomer having the structure:
with an optical rotation (α 20 D ) of +58° are also novel. The process of our invention comprises the cultivation under aerobic condition of one or more specific strain of Diplodia gossypina in a nutrient medium followed either by (1) isolation of the jasmonic acid product or (2) esterification of the jasmonic acid to form methyl jasmonate followed by the isolation of the methyl jasmonate and novel products produced by such process.
摘要翻译：描述了用于高产量生产食用香料可接受的茉莉酸和茉莉酮酸甲酯的生物工艺，以及由此产生的新颖的茉莉酸异构体及其感官用途。该方法得到根据以下结构定义的至少5％的“顺式”异构体：根据以下结构定义的（其中R是氢或甲基）或至少5％的“顺式”异构体：其中R是氢或甲基）。含有至少98％具有结构的异构体的组合物：具有+58°的旋光度（α20_D）的是新颖的。含有至少98％具有+58°的旋光度（α20_D）的具有结构：的异构体的组合物也是新颖的。本发明的方法包括在营养培养基中培养一种或多种特异性棉铃虫特异菌株的好氧条件，然后通过（1）分离茉莉酸产物或（2）茉莉酸酯化形成茉莉酸甲酯，随后通过分离这种方法生产的茉莉酸甲酯和新产品。

9. 发明公开

EP0354000A3 Process for preparing compositions containing unsaturated lactones, products produced thereby and organoleptic uses of said products 失效
标题翻译：制备含有不饱和脂肪酸酯的组合物的方法，生产的产品和有机产品的有机产品
公开(公告)号：EP0354000A3
公开(公告)日：1991-08-14
申请号：EP89307821.2
申请日：1989-08-01
申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.
发明人： Farbood, Mohamad I. , Morris, James A. , Sprecker, Mark A. , Bienkowski, Lynda J. , Miller, Kevin P. , Vock, Manfred Hugo , Hagedorn, Myrna Lee
IPC分类号： C12P7/42 , C12P7/40 , C07D313/00 , C07D313/04 , C11B9/00 , A23L1/23
CPC分类号： C11B9/0073 , A24B15/403 , C12P7/40 , C12P7/42 , C12P17/02
摘要： Described is a process for the preparation of compositions of matter containing unsaturated lactones defined according to the generic structure:
wherein R represents C 6 alkyl or alkenyl; and X represents C 2 , C 4 or C 6 alkylene or alkenylene; with the provisos that R is C 6 alkyl when X is alkenylene and R is C 6 alkenyl when X is alkylene by means of the sequential steps of (i) fermentation of castor oil or ricinoleic acid using a microorganism selected from the group consisting of: Candida petrophilum, ATCC 20226; Candida oleophila, ATCC 20177; Candida sp., ATCC 20504; and Candida sake, ATCC 28137 whereby gamma hydroxydecanoic acid and a mixture of other acids defined according to the generic structure:
is formed wherein Y represents an oxo-saturated, oxo-unsaturated or di-unsaturated C 9 , C 11 or C 13 moiety according to the reaction:
(ii) lactonization of the resulting gamma hydroxydecanoic acid by means of simultaneous acidification and heating according to the reaction:
and (iii) lactonization (via distillation) of one or more of the resulting acids defined according to the structure:
to form one or more lactones defined according to the generic structure:
according to the reaction:
wherein the sum of the number of carbon atoms in the X moiety and in the R moiety is equal to the number of carbon atoms in the Y moiety minus 1. Also described are the products produced according to such process as well as their organoleptic utilities for augmenting or enhancing the aroma or taste of consumable materials selected from the group consisting of perfume compositions, colognes, perfumed articles, perfumed polymers, foodstuffs, chewing gums, medicinal products, toothpastes, chewing tobaccos and smoking tobaccos.

10. 发明公开

EP0419026A1 Process and means for producing diol and lactone 失效
标题翻译： Verfahren und Mittel zur Herstellung eines Diols und Lactons。
公开(公告)号：EP0419026A1
公开(公告)日：1991-03-27
申请号：EP90308823.5
申请日：1990-08-10
申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.
发明人： Farbood, Mohamad I. , Morris, James A. , Downey, Arthur E.
IPC分类号： C12N1/14 , C12P17/04 , C12P7/02 , C12P17/06
CPC分类号： C12R1/645 , C12P7/02 , C12P17/04 , C12P17/06
摘要： There is provided processes and means for producing diol and lactone. The means essentially comprises a microorganism selected from the group consisting of

(i) Cryptococcus albidus
(Saito [Skinner var. albidus ], ATCC 20918;
(ii) Bensingtonia ciliata , ATCC 20919;
(iii) Cryptococcus laurentii , ATCC 20920; and
(iv) Cryptococcus albidus , ATCC 20921, or mixtures of two or more thereof.
摘要翻译：提供了生产二醇和内酯的方法和方法。所述方法基本上包含选自以下的微生物：（i）隐球酵母（Saito [Skinner var。albidus]，ATCC 20918;（ii）Bensingtonia ciliata，ATCC 20919;（iii）月桂树隐球菌ATCC 20920;和）白色隐球菌ATCC 20921，或其两种或多种的混合物

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