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1. 发明公开

EP2995624A1 Nanobodies suitable for neuron degeneration therapy 审中-公开
标题翻译： NanokörperfürNeurondegenerationstherapie
公开(公告)号：EP2995624A1
公开(公告)日：2016-03-16
申请号：EP14306388.1
申请日：2014-09-09
申请人： INSTITUT PASTEUR
发明人： Prehaud, Christophe , Lafon, Monique , Lafaye, Pierre
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K47/48538 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/22 , C07K2319/33 , C12N2760/20122
摘要： The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and / or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. neurons, astrocytes and microglial cells).
摘要翻译：本发明处于通过血脑屏障传递给脑细胞的分子的领域。本发明涉及一种新颖的基于多肽的载体，其允许有效递送效应肽，跨越血脑屏障的神经元细胞，以及用于生产和测试这种载体的方法，包括用于测试这种分子穿过血脑屏障和/或分子对血脑屏障的毒性和/或已经与靶向人脑细胞（例如神经元，星形胶质细胞和小胶质细胞）交叉的分子的能力。

2. 发明公开

EP2592091A1 High MAST2-affinity polypeptides and uses thereof 有权
标题翻译：多肽线虫MAST2-Affinitätund deren Verwendungen
公开(公告)号：EP2592091A1
公开(公告)日：2013-05-15
申请号：EP11306454.7
申请日：2011-11-08
申请人： Institut Pasteur , Centre National de la Recherche Scientifique , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
发明人： Prehaud, Christophe , Lafon, Monique , Wolff, Nicolas , Khan, Zakir , Terrien, Elouan
IPC分类号： C07K14/435
CPC分类号： C12Q1/6883 , C07K14/005 , C07K14/435 , C07K2319/02 , C07K2319/05 , C07K2319/70 , C12N7/00 , C12N2799/027 , C12Q1/70 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/5023 , G01N33/5038 , G01N33/5058 , G01N2333/705
摘要： The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, said polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions comprising the same. The invention is also directed to the use of said polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.
摘要翻译：本发明涉及含有以MAST-2结合结构域结束的细胞质结构域的多肽，其为11至13个残基，其前两个残基为S和W，最后4个残基为Q，T，R和L 所述多肽对人MAST2蛋白的PDZ结构域具有高亲和力。本发明还涉及多核苷酸，载体，慢病毒颗粒，细胞以及包含其的组合物。本发明还涉及使用所述多肽，多核苷酸，载体，慢病毒颗粒，细胞和组合物来治疗和/或预防疾病，病症或病症，其改变中枢神经系统（CNS）和/或外周神经系统（PNS）。本发明还涉及细胞基因的分子特征，以确定分子的神经营养和/或神经保护活性。

3. 发明授权

EP2592091B1 High MAST2-affinity polypeptides and uses thereof 有权
标题翻译：高MAST2亲和性多肽及其用途
公开(公告)号：EP2592091B1
公开(公告)日：2017-09-20
申请号：EP11306454.7
申请日：2011-11-08
申请人： Institut Pasteur , Centre National de la Recherche Scientifique , Université Pierre et Marie Curie (Paris 6)
发明人： Prehaud, Christophe , Lafon, Monique , Wolff, Nicolas , Khan, Zakir , Terrien, Elouan
IPC分类号： C07K14/435
CPC分类号： C12Q1/6883 , C07K14/005 , C07K14/435 , C07K2319/02 , C07K2319/05 , C07K2319/70 , C12N7/00 , C12N2799/027 , C12Q1/70 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/5023 , G01N33/5038 , G01N33/5058 , G01N2333/705

4. 发明公开

EP2995949A1 New in vitro blood brain barrier model 审中-公开
标题翻译： Neues体外 - Blut-Gehirn-Schrankenmodell
公开(公告)号：EP2995949A1
公开(公告)日：2016-03-16
申请号：EP14306389.9
申请日：2014-09-09
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
发明人： Prehaud, Christophe , Lafon, Monique , Ceccaldi, Pierre-Emmanuel , Afonso, Philippe , Lafaye, Pierre
IPC分类号： G01N33/50 , C12M3/00 , C12N5/079 , C12N5/071
CPC分类号： G01N33/5082 , C12M21/08 , C12M23/34 , C12M25/02 , C12M29/04 , C12N5/0622 , C12N5/069 , C12N5/0691 , C12N2502/28 , G01N33/5014 , G01N33/5058 , G01N33/5064
摘要： The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and / or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. neurons, astrocytes and microglial cells).
摘要翻译：本发明处于通过血脑屏障传递给脑细胞的分子的领域。本发明涉及一种新颖的基于多肽的载体，其允许有效递送效应肽，跨越血脑屏障的神经元细胞，以及用于生产和测试这种载体的方法，包括用于测试这种分子穿过血脑屏障和/或分子对血脑屏障的毒性和/或已经与靶向人脑细胞（例如，神经元，星形胶质细胞和小胶质细胞）交叉的分子的能力。

5. 发明公开

EP2239330A1 Neuron generation, regeneration and protection 审中-公开
标题翻译： Neuronenerzeugung，-erneuerung und -schutz
公开(公告)号：EP2239330A1
公开(公告)日：2010-10-13
申请号：EP09290257.6
申请日：2009-04-07
申请人： Institut Pasteur
发明人： Prehaud, Christophe , Lafon, Monique , Schnell, Matthias Johannes
IPC分类号： C12N15/47 , C12N15/86 , C07K14/145 , A61K38/17 , A61K48/00
CPC分类号： C07K14/005 , A61K35/13 , A61K35/766 , A61K38/00 , A61K38/162 , C12N2760/20122 , Y02A50/465
摘要： The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of said non-apoptotic rabies virus G proteins, more particularly to their PDZ-BS, which shows a single-point mutation compared to the one of apoptotic rabies virus G proteins. The invention provides means for inducing and/or stimulating neurite outgrowth, which are useful in inducing neuron differentiation, for example for the treatment of a neoplasm of the nervous system, as well as in regenerating impaired neurons, for example for the treatment of a neurodegenerative disease, disorder or condition or in the treatment of a microbial infection, or in protecting neurons from neurotoxic agents or oxidative stress.
摘要翻译：本发明证明，与凋亡性狂犬病病毒G蛋白相反，某些非凋亡性狂犬病病毒G蛋白，如CVS-NIV菌株的G蛋白具有神经突增生促进作用。本发明进一步表明，这种神经突增生促进作用是由于所述非凋亡性狂犬病病毒G蛋白的细胞质尾巴，更特别是其PDZ-BS，其与凋亡性狂犬病病毒G相比显示单点突变蛋白质。本发明提供用于诱导和/或刺激神经突生长的方法，其可用于诱导神经元分化，例如用于治疗神经系统的肿瘤，以及再生受损的神经元，例如用于治疗神经变性疾病，病症或状况或治疗微生物感染，或保护神经元免受神经毒性物质或氧化应激。

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