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1. 发明授权

EP2967434B1 DEVICES FOR MONITORING OXYGENATION DURING TREATMENT WITH DELIVERY OF NITRIC OXIDE 无效转让
公开(公告)号：EP2967434B1
公开(公告)日：2019-12-11
申请号：EP14722023.0
申请日：2014-03-13
申请人： Ino Therapeutics LLC
发明人： FLANAGAN, Craig , NEWMAN, David , ACKER, Jaron , TOLMIE, Craig R.
IPC分类号： A61B5/08 , A61B5/1455 , A61M16/12

2. 发明公开

EP3466473A1 THERAPEUTIC GAS DELIVERY DEVICE WITH PULSED AND CONTINUOUS FLOW CONTROL 有权转让
公开(公告)号：EP3466473A1
公开(公告)日：2019-04-10
申请号：EP18207319.7
申请日：2014-03-14
申请人： INO Therapeutics LLC
发明人： ACKER, Jaron , KOHLMANN, Thomas , TOLMIE, Craig R.
IPC分类号： A61M16/12 , A61M16/00
摘要： Described is a therapeutic gas delivery device (200), in combination with a ventilator allowing for delivery of combined flow of breathing gas and therapeutic gas, the gas delivery device comprising an inlet to connect to a source of therapeutic gas (103), an outlet to connect to a device that introduces breathing gas and the therapeutic gas to a patient, at least one binary control valve (109) in fluid communication with the inlet and outlet that delivers a constant flow of the therapeutic gas, at least one proportional control valve (107) in fluid communication with the inlet and outlet that delivers a variable flow of the therapeutic gas, wherein the binary control valve and the proportional control valve are in parallel flow paths, a control system (115) that delivers the therapeutic gas through one or more of the binary control valve and the proportional control valve, wherein the control system is configured to deliver the therapeutic gas to a patient in an amount proportional to a flow of breathing gas.

3. 发明公开

EP2967434A1 DEVICES AND METHODS FOR MONITORING OXYGENATION DURING TREATMENT WITH DELIVERY OF NITRIC OXIDE 无效转让
标题翻译：装置及监测方法富氧期间释放的氮氧化物治理
公开(公告)号：EP2967434A1
公开(公告)日：2016-01-20
申请号：EP14722023.0
申请日：2014-03-13
申请人： Ino Therapeutics LLC
发明人： FLANAGAN, Craig , NEWMAN, David , ACKER, Jaron , TOLMIE, Craig R.
IPC分类号： A61B5/08 , A61B5/1455 , A61M16/12
摘要： The present invention provides devices and methods for calculating and monitoring oxygenation parameters during treatment with delivery of nitric oxide. The devices and methods of the present invention can calculate the oxygenation index based on measurements of mean airway pressure, saturation of oxygen and fraction of inspired oxygen derived from components of the present invention. Also described is a nitric oxide delivery device that incorporates a proximal pressure transducer.
摘要翻译：本发明提供的装置和方法，用于计算，并与输送一氧化氮治疗期间监测氧合参数。的设备和本发明的方法可以基于平均气道压力，氧饱和度，并从本发明的部件衍生吸入氧浓度的测量值计算氧合指数。如此描述是一氧化氮输送装置做了集成了一个近端压力换能器。

4. 发明公开

EP2776106A1 APPARATUS AND METHOD FOR MONITORING NITRIC OXIDE DELIVERY 审中-公开
标题翻译： VORRICHTUNG UND VERFAHREN ZURÜBERWACHUNGEINER STICKOXIDAUSGABE
公开(公告)号：EP2776106A1
公开(公告)日：2014-09-17
申请号：EP12791615.3
申请日：2012-11-07
申请人： Ino Therapeutics LLC
发明人： SCHNITMAN, Robert , MEDICIS, Joseph, J. , POTENZIANO, Jim , ACKER, Jaron , SCHMIDT, Jeffrey
IPC分类号： A61M16/12
CPC分类号： A61M16/104 , A61M16/0051 , A61M16/0057 , A61M16/024 , A61M16/0666 , A61M16/085 , A61M16/12 , A61M2016/0039 , A61M2016/102 , A61M2202/0275 , A61M2205/18 , A61M2205/3334 , A61M2205/502 , A61M2205/581 , A61M2205/583 , F04C2270/041
摘要： Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises an indicator to inform a user of the apparatus when the flow of breathing gas rises above or falls below a predetermined level or range. Also described is a method of monitoring nitric oxide delivery, wherein the flow of breathing gas is measured and displayed. In some embodiments, an alert is provided when the flow of breathing gas rises above or falls below a predetermined level or range.
摘要翻译：描述了一种用于监测一氧化氮递送的装置，其中这种装置包括一个指示器，用于当呼吸气体的气流高于或低于预定水平或范围时通知使用者该装置。还描述了监测一氧化氮递送的方法，其中测量和显示呼吸气体的流动。在一些实施例中，当呼吸气体的流量升高到或低于预定水平或范围时，提供警报。

5. 发明公开

EP3308820A1 APPARATUS FOR MONITORING NITRIC OXIDE DELIVERY 有权转让
标题翻译：用于监测一氧化氮递送的装置
公开(公告)号：EP3308820A1
公开(公告)日：2018-04-18
申请号：EP17199979.0
申请日：2014-03-13
申请人： Ino Therapeutics LLC
发明人： TOLMIE, Craig R. , SCHNITMAN, Robert , MEDICIS, Joseph J. , POTENZIANO, Jim , ACKER, Jaron , SCHMIDT, Jeffrey
IPC分类号： A61M16/10 , A61M16/12 , C01B21/20 , C01B21/24 , A61M16/20 , A61M16/00 , A61M16/06
CPC分类号： A61M16/12 , A61M16/0666 , A61M2016/0039 , A61M2016/102 , A61M2202/0275 , A61M2205/18 , A61M2205/505 , C01B21/24
摘要： Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises a display that provides a visual and/or numeric indication of the calculated dose of nitric oxide. Also described is a method of monitoring nitric oxide delivery, wherein the breathing gas flow rate and therapeutic gas flow rate are measured and used to determine the calculated dose of nitric oxide, which is then displayed. In some embodiments, an alert is provided when the calculated dose rises above or falls below a predetermined level or range.
摘要翻译：描述了用于监测一氧化氮递送的设备，其中这种设备包括显示器，该显示器提供所计算的一氧化氮剂量的视觉和/或数字指示。还描述了一种监测一氧化氮递送的方法，其中测量呼吸气体流速和治疗气体流速并将其用于确定一氧化氮的计算剂量，然后显示一氧化氮的计算剂量。在一些实施例中，当所计算的剂量上升或下降到预定水平或范围以下时提供警报。

6. 发明公开

EP2833952A1 BREATHING APPARATUS DETECTION AND PURGING 无效转让
标题翻译： ERKENNUNG UND REINIGUNG EINESATEMHILFSGERÄTS
公开(公告)号：EP2833952A1
公开(公告)日：2015-02-11
申请号：EP13716927.2
申请日：2013-04-03
申请人： INO Therapeutics LLC
发明人： ACKER, Jaron , KOHLMANN, Thomas
IPC分类号： A61M16/00 , A61M16/06 , A61M16/20
摘要： Described are methods for safer nitric oxide delivery, as well as apparatuses for performing these methods. The methods may include detecting the presence or absence of a nasal cannula, and stopping the delivery of nitric oxide or providing an alert if the cannula is disconnected. The methods may also include purging the nasal cannula if it is reconnected after a disconnection or if it is replaced by a new cannula. Other methods pertain to automatic purging of the delivery conduit if the elapsed time between successive deliveries of therapeutic gas exceeds a predetermined period of time.
摘要翻译：描述了用于更安全的一氧化氮递送的方法以及用于执行这些方法的装置。所述方法可以包括检测鼻插管的存在或不存在，以及如果套管断开，则停止一氧化氮的递送或提供警报。所述方法还可以包括如果在断开连接之后重新连接或者如果它被新的插管替代，则清洗鼻插管。如果治疗气体的连续输送之间的经过时间超过预定时间段，则其它方法涉及自动清除输送管道。

7. 发明授权

EP2968828B1 THERAPEUTIC GAS DELIVERY DEVICE WITH PULSED AND CONTINUOUS FLOW CONTROL 有权转让
公开(公告)号：EP2968828B1
公开(公告)日：2018-11-21
申请号：EP14721120.5
申请日：2014-03-14
申请人： INO Therapeutics LLC
发明人： ACKER, Jaron , KOHLMANN, Thomas , TOLMIE, Craig R.
IPC分类号： A61M16/12
CPC分类号： A61M16/203 , A61M16/024 , A61M16/0672 , A61M16/12 , A61M2016/0027 , A61M2202/0233 , A61M2202/0275 , A61M2202/0007

8. 发明公开

EP2968828A2 THERAPEUTIC GAS DELIVERY DEVICE WITH PULSED AND CONTINUOUS FLOW CONTROL 有权转让
标题翻译：具有脉冲和连续流量控制的治疗气体供给机构
公开(公告)号：EP2968828A2
公开(公告)日：2016-01-20
申请号：EP14721120.5
申请日：2014-03-14
申请人： INO Therapeutics LLC
发明人： ACKER, Jaron , KOHLMANN, Thomas , TOLMIE, Craig R.
IPC分类号： A61M16/12
CPC分类号： A61M16/203 , A61M16/024 , A61M16/0672 , A61M16/12 , A61M2016/0027 , A61M2202/0233 , A61M2202/0275 , A61M2202/0007
摘要： Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve and at least one binary control valve. The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths.

9. 发明授权

EP2968824B1 APPARATUS FOR MONITORING NITRIC OXIDE DELIVERY 无效转让
标题翻译：用于监测一氧化氮递送的装置
公开(公告)号：EP2968824B1
公开(公告)日：2017-11-29
申请号：EP14720777.3
申请日：2014-03-13
申请人： Ino Therapeutics LLC
发明人： TOLMIE, Craig R. , SCHNITMAN, Robert , MEDICIS, Joseph J. , POTENZIANO, Jim , ACKER, Jaron , SCHMIDT, Jeffrey
IPC分类号： A61M16/10 , A61M16/12 , C01B21/20 , C01B21/24 , A61M16/20 , A61M16/00 , A61M16/06
CPC分类号： A61M16/12 , A61M16/0666 , A61M2016/0039 , A61M2016/102 , A61M2202/0275 , A61M2205/18 , A61M2205/505 , C01B21/24

10. 发明公开

EP2968824A1 APPARATUS AND METHOD FOR MONITORING NITRIC OXIDE DELIVERY 无效转让
标题翻译： VORRICHTUNG ZURÜBERWACHUNGEINER STICKOXIDAUSGABE
公开(公告)号：EP2968824A1
公开(公告)日：2016-01-20
申请号：EP14720777.3
申请日：2014-03-13
申请人： Ino Therapeutics LLC
发明人： TOLMIE, Craig R. , SCHNITMAN, Robert , MEDICIS, Joseph J. , POTENZIANO, Jim , ACKER, Jaron , SCHMIDT, Jeffrey
IPC分类号： A61M16/10 , A61M16/12 , C01B21/20 , C01B21/24 , A61M16/20 , A61M16/00 , A61M16/06
CPC分类号： A61M16/12 , A61M16/0666 , A61M2016/0039 , A61M2016/102 , A61M2202/0275 , A61M2205/18 , A61M2205/505 , C01B21/24
摘要： Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises a display that provides a visual and/or numeric indication of the calculated dose of nitric oxide. Also described is a method of monitoring nitric oxide delivery, wherein the breathing gas flow rate and therapeutic gas flow rate are measured and used to determine the calculated dose of nitric oxide, which is then displayed. In some embodiments, an alert is provided when the calculated dose rises above or falls below a predetermined level or range.
摘要翻译：描述了用于监测一氧化氮递送的装置，其中这种装置包括提供计算的一氧化氮剂量的视觉和/或数值指示的显示器。还描述了监测一氧化氮递送的方法，其中测量呼吸气体流速和治疗气体流速并用于确定计算出的一氧化氮的剂量，然后显示该剂量。在一些实施例中，当所计算的剂量高于或低于预定水平或范围时，提供警报。

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