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1. 发明授权

EP2383576B1 Micro-electrode grid array for top and bottom recording from samples 有权转让
标题翻译：用于样品的顶部和底部的记录微电极网格布置
公开(公告)号：EP2383576B1
公开(公告)日：2013-04-03
申请号：EP11163935.7
申请日：2011-04-27
申请人： IMEC , Katholieke Universiteit Leuven, K.U. Leuven R&D
发明人： Eberle, Wolfgang , Braeken, Dries , Huys, Roeland , Prodanov, Dimiter
IPC分类号： G01N33/543 , B01L3/00 , H05K3/00
CPC分类号： G01N33/5438 , B01L3/508 , B01L2300/0645 , B01L2300/0816 , Y10T29/49124

2. 发明公开

EP2377572A1 A bio-hybrid implant for connecting a neural interface with a host nervous system 审中-公开
标题翻译： Bio-Hybridimplantat zur Verbindung einer neuroen Schnittstelle mit einem Host-Nervensystem
公开(公告)号：EP2377572A1
公开(公告)日：2011-10-19
申请号：EP11162772.5
申请日：2011-04-18
申请人： IMEC , Katholieke Universiteit Leuven, K.U. Leuven R&D
发明人： Huys, Roeland , Braeken, Dries , Prodanov, Dimiter , Eberle, Wolfgang , Verstreken, Kris
IPC分类号： A61N1/05 , A61N1/372 , A61B5/04 , G06N3/06 , G01N33/487 , A61N1/36
CPC分类号： A61N1/0551 , A61B5/04001 , A61B5/4041 , A61B2562/125 , A61N1/00 , A61N1/372
摘要： A bio-hybrid implant suitable for recording and/or stimulating cells, the implant comprising
- at least one closed insulated chamber (1) containing a substrate (502) with a neural interface (13) for connecting neurons to an electronic circuit,
- at least one flexible guiding channel (10) having a first interface (11) to connect to at least one of the closed insulated chambers (1) and a second interface (9) to connect to a host's nerve system (7) or to another insulated chamber.
摘要翻译：一种适用于记录和/或刺激细胞的生物混合植入物，所述植入物包括 - 至少一个封闭绝缘室（1），其包含具有用于将神经元连接到电子电路的神经接口（13）的基底（502）， - 至少一个柔性引导通道（10）具有第一接口（11），以连接至至少一个闭合绝缘室（1）和第二接口（9），以连接到宿主的神经系统（7）或另一绝缘室室。

3. 发明公开

EP2383576A1 Micro-electrode grid array for top and bottom recording from samples 有权转让
标题翻译： Mikroelektrodengitteranordnung zur oberen und unteren Aufzeichnung aus Proben
公开(公告)号：EP2383576A1
公开(公告)日：2011-11-02
申请号：EP11163935.7
申请日：2011-04-27
申请人： IMEC , Katholieke Universiteit Leuven, K.U. Leuven R&D
发明人： Eberle, Wolfgang , Braeken, Dries , Huys, Roeland , Prodanov, Dimiter
IPC分类号： G01N33/543 , B01L3/00 , H05K3/00
CPC分类号： G01N33/5438 , B01L3/508 , B01L2300/0645 , B01L2300/0816 , Y10T29/49124
摘要： A mixed micro-fluidic multi-electrode grid array (MEGA) device (10) suitable for holding a tissue slice (6) and for recording and/or stimulating neuron cells from said tissue slice (6), the MEGA device (10) comprising at least a top substrate in the form of a grid (4) comprising at least an electrical and/or optical multi-electrode array and a bottom substrate in the form of a stack made of a grid (1) comprising an electrical and/or optical multi-electrode array and a backbone (2) underneath said grid (1) comprising a micro-fluidic perfusion system. Furthermore said MEGA device (10) comprises means (5) for pressing and positioning said first and second substrate together and adhering a tissue slice in between said two substrates.
摘要翻译：一种适用于保持组织切片（6）并用于从所述组织切片（6）记录和/或刺激神经元细胞的混合微流体多电极网格阵列（MEGA）装置（10），所述MEGA装置（10）包括至少包括栅格形式的顶部衬底（4），其包括至少电和/或光多电极阵列和由栅格（1）制成的堆叠形式的底部衬底，所述栅格包括电和/或光学多电极阵列和位于所述格栅（1）下方的骨架（2），其包括微流体灌注系统。此外，所述MEGA装置（10）包括用于将所述第一和第二基板压入并定位在一起并将组织切片粘附在所述两个基板之间的装置（5）。

4. 发明授权

EP2343550B1 Improved microneedle 有权
标题翻译：改进微针
公开(公告)号：EP2343550B1
公开(公告)日：2013-11-06
申请号：EP09180939.2
申请日：2009-12-30
申请人： IMEC
发明人： Huys, Roeland , Eberle, Wolfgang , Braeken, Dries
IPC分类号： G01N33/487
CPC分类号： G01N33/48728 , C12M35/02

5. 发明公开

EP3332703A1 A SURGICAL INSERTION DEVICE 审中-公开
公开(公告)号：EP3332703A1
公开(公告)日：2018-06-13
申请号：EP17204937.1
申请日：2017-12-01
申请人： IMEC vzw , Universiteit Gent
发明人： Op de Beeck, Maria , Vandecasteele, Bjorn , Braeken, Dries
IPC分类号： A61B5/04 , A61B17/34
CPC分类号： A61B17/3494 , A61B5/04 , A61B5/686 , A61B17/0218 , A61B17/3468 , A61B17/7083 , A61B17/7097 , A61B17/8894 , A61B2090/0801 , A61B2090/0811 , A61B2560/063 , A61B2562/028
摘要： A surgical insertion device (1) is disclosed, comprising an elongated central flat region (2) tapering from the proximal end having a device area (4), configured to receive an electronic device (5), towards the distal end having a sharp tip (3).

6. 发明公开

EP2808056A1 Optical stimulation device 有权转让
标题翻译： Optische Stimulationsvorrichtung
公开(公告)号：EP2808056A1
公开(公告)日：2014-12-03
申请号：EP13169700.5
申请日：2013-05-29
申请人： IMEC , Katholieke Universiteit Leuven
发明人： Hoffman, Luis Diego Leon , Braeken, Dries , Musa, Silke
IPC分类号： A61N5/06
摘要： In an aspect of the invention, a stimulation device is presented, the device comprising: a probe attached to a first support, the probe comprising at least one grating coupler for coupling light into the probe; and at least one optical source for providing an optical stimulation signal mounted on a second support; and at least one means for detachably attaching the first support to the second support; and wherein the position of the at least one optical source is aligned with the position of the at least one grating coupler to allow light emitted from the at least one optical source to be received by the at least one grating coupler.
摘要翻译：在本发明的一个方面，提出了一种刺激装置，该装置包括：附接到第一支撑件的探针，该探针包括用于将光耦合到探针中的至少一个光栅耦合器; 以及用于提供安装在第二支撑件上的光刺激信号的至少一个光源; 以及用于将第一支撑件可拆卸地附接到第二支撑件的至少一个装置; 并且其中所述至少一个光源的位置与所述至少一个光栅耦合器的位置对准，以允许由所述至少一个光源发射的光被所述至少一个光栅耦合器接收。

7. 发明公开

EP2343550A1 Improved microneedle 有权
标题翻译： Verbesserte Mikronadel
公开(公告)号：EP2343550A1
公开(公告)日：2011-07-13
申请号：EP09180939.2
申请日：2009-12-30
申请人： IMEC
发明人： Huys, Roeland , Eberle, Wolfgang , Braeken, Dries
IPC分类号： G01N33/487
CPC分类号： G01N33/48728 , C12M35/02
摘要： The electronic device for sensing and/or actuating comprises a device surface to which an biological cell (40) is applied, further comprising a sensor and/or an actuator (25), and an access channel (20) with a channel port (21), said channel port being located in said surface. The access channel (20) is designed such that the biological cell (40) entering the access channel (20) is provided access to the sensor (25). Particularly the cell (40) forms a protruding portion (41) by entering the access channel (20), which portion is sensed. The access channel (20) may be provided with a specific sensor port at which the sensor (25) is present. The device may be used for sensing or actuating biological cells, such as neurons, for instance in electroporation treatments.
摘要翻译：用于感测和/或致动的电子设备包括被施加生物单元（40）的设备表面，还包括传感器和/或致动器（25）以及具有通道端口（21）的接入通道（20）），所述通道端口位于所述表面中。进入通道（20）被设计成使得进入通道（20）的生物体（40）被提供到传感器（25）的通路。特别地，电池（40）通过进入入口通道（20）形成突出部分（41），该部分被感测。进入通道（20）可以设置有传感器（25）存在的特定传感器端口。该装置可用于感测或致动生物细胞，例如神经元，例如在电穿孔治疗中。

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