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    • 4. 发明公开
    • Automatic analyzer
    • 自动分析仪
    • EP2093573A2
    • 2009-08-26
    • EP09001326.9
    • 2009-01-30
    • Hitachi High-Technologies Corporation
    • Kamihara, KumikoMimura, TomonoriFukuzono, Shinichi
    • G01N35/00
    • G01N35/00663Y10T436/101666
    • Measurement of the uncertainty used for quality control involves a plurality of factors, such as equipment state including the maintenance of equipment, reagent, standard liquid, control substance, and the like. When the uncertainty exceeds a clinical permissible value, time-consuming and labor is required for an ordinary medical technologist to investigate and determine the factor in uncertainty, based on technologist's experiences. An object of the present invention is to automatically investigate factor in complicated uncertainty, particularly from the view point of reagents and samples which are subject to quality change and prone to affect the measurement quality. To accomplish the above object, quality control samples having a plurality of concentration levels are measured to calculate the average, coefficient of variation, standard deviation, and other numerical values. When quality control samples having n (n>=2) different concentration levels are measured, the present invention provides the method to presume the factor in uncertainty, the factor being specific to each of 3 n different combinations of variation patterns.
    • 用于质量控制的不确定度的测量包括多种因素,例如包括设备维护,试剂,标准液体,对照物质等的设备状态。 当不确定性超过临床允许值时,普通医学技术人员需要耗费时间和劳动力,根据技术人员的经验调查和确定不确定性因素。 本发明的目的是自动调查复杂不确定性的因素,特别是从质量变化的试剂和样品的角度考虑,容易影响测量质量。 为了实现上述目的,测量具有多个浓度水平的质量控制样品,以计算平均值,变异系数,标准偏差和其它数值。 当测量具有n(n> = 2)不同浓度水平的质量控制样品时,本发明提供了确定不确定性因子的方法,该因子特异于3种不同组合的变化模式。
    • 5. 发明公开
    • Automatic analyzer
    • 自动分析仪
    • EP2093573A3
    • 2015-08-05
    • EP09001326.9
    • 2009-01-30
    • Hitachi High-Technologies Corporation
    • Kamihara, KumikoMimura, TomonoriFukuzono, Shinichi
    • G01N35/00
    • G01N35/00663Y10T436/101666
    • Measurement of the uncertainty used for quality control involves a plurality of factors, such as equipment state including the maintenance of equipment, reagent, standard liquid, control substance, and the like. When the uncertainty exceeds a clinical permissible value, time-consuming and labor is required for an ordinary medical technologist to investigate and determine the factor in uncertainty, based on technologist's experiences. An object of the present invention is to automatically investigate factor in complicated uncertainty, particularly from the view point of reagents and samples which are subject to quality change and prone to affect the measurement quality. To accomplish the above object, quality control samples having a plurality of concentration levels are measured to calculate the average, coefficient of variation, standard deviation, and other numerical values. When quality control samples having n (n>=2) different concentration levels are measured, the present invention provides the method to presume the factor in uncertainty, the factor being specific to each of 3 n different combinations of variation patterns.
    • 用于质量控制的不确定度的测量涉及多个因素,例如包括设备维护,试剂,标准液体,控制物质等的设备状态。 当不确定性超过临床允许值时,基于技术专家的经验,普通医疗技术人员需要耗费大量时间和人力来调查和确定不确定因素。 本发明的一个目的是自动研究复杂不确定性中的因素,特别是从经受质量改变并易于影响测量质量的试剂和样品的角度来看。 为了实现上述目的,测量具有多个浓度水平的质量控制样本以计算平均值,变化系数,标准偏差和其他数值。 当测量具有n(n≥2)不同浓度水平的质量控制样品时,本发明提供了推定不确定因素的方法,该因子对于3n种不同的变化模式组合中的每一种都是特定的。
    • 7. 发明公开
    • Method and appartus for analyzing nucleic acid amplification
    • Verfahren undGerätezur分析vonNukleinsäuren-Amplifikation。
    • EP2233579A1
    • 2010-09-29
    • EP10006311.4
    • 2005-09-26
    • Hitachi High-Technologies CorporationTochigi Prefectural Office
    • Maeda, KoshiFukuzono, ShinichiSugano, Kokichi
    • C12Q1/68
    • C12Q1/686C12Q2600/158C12Q2565/501
    • There is provided a method of detecting or analyzing nucleic acid with a high reliability and reproducibility, capable of sampling target nucleic acid from initial target nucleic acid having not less than two types of sequences different from each other in a ratio which is proportional to that of initial target nucleic acid. A method of detecting or analyzing nucleic acid by sampling target nucleic acid from not less than two types of target nucleic acid samples having base sequences different in at least one base, and subjecting the sampled nucleic acid sample to detection or analysis; comprising steps of: obtaining the number of copies of initial target nucleic acid from the concentration of a nucleic acid in an initial target nucleic acid sample; and sampling the target nucleic acid of a predetermined number or more of copies from the initial target nucleic acid sample.
    • 提供了一种检测或分析具有高可靠性和重复性的核酸的方法,其能够从具有不同于两种类型的序列的初始靶核酸中以与 初始靶核酸。 通过从不少于两种具有不同于至少一个碱基的碱基序列的靶核酸样品中取样靶核酸,并对取样的核酸样品进行检测或分析来检测或分析核酸的方法; 包括以下步骤:从初始靶核酸样品中的核酸浓度获得初始靶核酸的拷贝数; 并从初始靶核酸样品取样预定数目或更多个拷贝的靶核酸。