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1. 发明公开

EP2892419A1 MOVEMENT DISORDER THERAPY SYSTEM, DEVICES AND METHODS, AND INTELLIGENT METHODS OF TUNING 审中-实审
标题翻译：系统，设备和方法的运动障碍治疗和智能自整定THEREFOR
公开(公告)号：EP2892419A1
公开(公告)日：2015-07-15
申请号：EP13834991.5
申请日：2013-09-10
申请人： Great Lakes Neuro Technologies Inc.
发明人： HELDMAN, Dustin A. , PULLIAM, Christopher L. , GIUFFRIDA, Joseph P. , MERA, Thomas O.
IPC分类号： A61B5/00
CPC分类号： A61N1/37235 , A61B5/0022 , A61B5/1101 , A61B5/1118 , A61B5/1124 , A61B5/1125 , A61B5/4082 , A61B5/4836 , A61B5/4839 , A61B5/6825 , A61B5/6887 , A61B5/7264 , A61B2505/07 , A61B2560/0214 , A61B2560/0271 , A61B2560/0276 , A61B2560/0456 , A61B2562/0219 , A61B2562/08 , A61N1/0534 , A61N1/36067 , A61N1/36082 , A61N1/36132 , A61N1/36139 , A61N1/37247 , A61N1/37282 , G06F19/00 , G06F19/3481 , G16H40/63 , G16H50/20 , G16H50/50
摘要： The present invention relates to methods for tuning treatment parameters in movement disorder therapy systems. The present invention further relates to a system for screening patients to determine viability as candidates for certain therapy modalities, such as deep brain stimulation (DBS). The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of tuning a therapy device using objective quantified movement disorder symptom data acquired by a movement disorder diagnostic device to determine the therapy setting or parameters to be provided to the subject via his or her therapy device. The present invention also provides treatment and tuning remotely, allowing for home monitoring of subjects.

2. 发明公开

EP2734110A1 MOVEMENT DISORDER MONITORING SYSTEM AND METHOD FOR CONTINUOUS MONITORING 有权转让
标题翻译：系统和方法连续运动障碍监测
公开(公告)号：EP2734110A1
公开(公告)日：2014-05-28
申请号：EP12814166.0
申请日：2012-07-11
申请人： Great Lakes Neuro Technologies Inc.
发明人： GIUFFRIDA, Joseph P. , HELDMAN, Dustin A. , MERA, Thomas O.
IPC分类号： A61B5/103
CPC分类号： A61B5/4839 , A61B5/0022 , A61B5/0024 , A61B5/0488 , A61B5/1101 , A61B5/1123 , A61B5/4082 , A61B5/4836 , A61B5/6824 , A61B5/6826 , A61B5/7225 , A61B5/7264 , A61B5/7267 , A61B2562/0219 , A61M5/1723 , A61N1/36067 , A61N1/36139 , A61N1/37282
摘要： The present invention relates to a movement disorder monitor, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a treatment delivery system for treating a subject in response to changes in the severity of a subject's symptoms. The present invention further provides for a system and method, which can accurately quantify symptoms of movement disorders, utilizing continuously obtained kinetic information to be analyzed, accurately distinguishing between symptoms of movement disorders and activities of daily living, relating quantified symptoms to a standard clinical rating scale, and correlating a subject's symptoms with certain physiological and environmental factors. The present invention still further provides for home monitoring of symptoms in subjects with these movement disorders in order to capture the complex fluctuation patterns of the disease over the course of days, weeks, months, or years.

3. 发明公开

EP2714188A1 METHOD AND SYSTEM FOR TUNING OF MOVEMENT DISORDER THERAPY DEVICES 有权
标题翻译：方法和系统的设备组成的用于移动障碍的治疗设定
公开(公告)号：EP2714188A1
公开(公告)日：2014-04-09
申请号：EP12793105.3
申请日：2012-05-31
申请人： Great Lakes Neuro Technologies Inc.
发明人： GIUFFRIDA, Joseph P. , HELDMAN, Dustin A. , MERA, Thomas O.
IPC分类号： A61N1/36
CPC分类号： A61N1/37247 , A61N1/36067 , A61N1/36135 , A61N1/36139 , A61N1/3615 , A61N1/36171 , A61N1/36175 , G06F19/00
摘要： A system and method for tuning the parameters of a therapeutic medical device comprises a movement measurement data acquisition system capable of wireless transmission; processing comprising kinematic feature extraction, a scoring algorithm trained using scores from expert clinicians, a therapeutic device parameter setting adjustment suggestion algorithm preferably trained using the parameter setting adjustment judgments of expert clinicians; and a display and/or means of updating the parameter settings of the treatment device. The invention facilitates the treatment of movement disorders including Parkinson's disease, essential tremor and the like by optimizing deep brain stimulation (DBS) parameter settings, eliminating as much as possible motor symptoms and reducing time and costs of surgical and outpatient procedures and improving patient outcomes. In preferred embodiments, the system provides recommendations for treatment which may be semi-automatically or automatically applied to update the parameter settings of a treatment device such as a DBS implant.
摘要翻译：一种用于调谐的治疗医疗装置的参数的系统和方法包括能够无线传输的移动的测量数据采集系统; 包括处理运动特征提取，使用评分从临床专家，治疗设备参数设置调整建议算法优选地使用参数设定临床专家的调整判决训练受训评分算法; 和显示器和/或更新所述处理装置的参数设定手段。本发明有利于运动障碍，包括帕金森氏病的治疗，特发性震颤和优化深部脑刺激（DBS）的参数设置，消除尽可能多的运动症状和减少时间和手术和门诊手术费用和提高患者的治疗效果等。植入物在优选的实施例中，系统提供了用于治疗建议，其中可半自动地或自动应用到更新处理装置的参数设定：如DBS。

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