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1. 发明授权

EP2537529B1 LOXL2 INHIBITORY ANTIBODIES AND USES THEREOF 失效
公开(公告)号：EP2537529B1
公开(公告)日：2018-10-17
申请号：EP12172222.7
申请日：2008-08-01
申请人： Gilead Biologics, Inc.
发明人： Smith, Victoria , Garcia, Carlos Aurelio , Biermann, Donna Hiroko Tokuoka , Ogg, Scott , Van Vlasselaer, Peter , Barry, Vivian E. , Marshall, Derek , Holzer, Alison Kay , Rodriguez, Hector , Oyasu, Miho , McCauley, Scott Alan
IPC分类号： C07K16/40 , A61K39/395 , A61P35/00
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12Q1/6886 , G01N33/57423 , G01N33/57438 , G01N33/57484 , G01N2333/90633
摘要： The present disclosure provides innovative methodology and related compositions and kits for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX and an inhibitor of a LOXL, or a synergistic combination of an inhibitor of LOX or LOXL combined with other therapeutic agents. Also provided are innovative methods for selecting agents that prevent or inhibit tumor invasion, angiogenesis and metastasis, by contacting cells that are in an epithelial-mesenchymal transition (EMT) state with a candidate agent and detecting a change in the EMT state of the cells. Methods and related compositions and kits for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using molecules or agents that specifically recognize processed forms of LOX or LOXL are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL. Such diseases or conditions include pathological cardiovascular conditions and diseases such as hypertension, hypertensive heart disease, myocardial infarction, atherosclerosis, and restenosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal scaring, keloid formation, and Alzheimer's disease.

2. 发明公开

EP2537529A1 LOX AND LOXL2 INHIBITORS ANTIBODIES AND USES THEREOF 失效
标题翻译： LOX- UND LOXL2-HEMMER UND VERWENDUNGEN DAVON
公开(公告)号：EP2537529A1
公开(公告)日：2012-12-26
申请号：EP12172222.7
申请日：2008-08-01
申请人： Gilead Biologics, Inc.
发明人： Smith, Victoria , Garcia, Carlos Aurelio , Biermann, Donna Hiroko Tokuoka , Ogg, Scott , Van Vlasselaer, Peter , Barry, Vivian E. , Marshall, Derek , Holzer, Alison Kay , Rodriguez, Hector , Oyasu, Miho , McCauley, Scott Alan
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12Q1/6886 , G01N33/57423 , G01N33/57438 , G01N33/57484 , G01N2333/90633
摘要： The present application relates to anti-LOX and anti-LOXL2 antibodies and their use in purification, diagnostic and therapeutic methods. Antibodies include monoclonal antibodies, humanized antibodies and functional fragments thereof. Anti-LOX and anti-LOXL2 antibodies can be used to identify and treat conditions such as a fibrotic condition, angiogenesis, or to prevent a transition from an epithelial cell state to a mesenchymal cell state.
摘要翻译：本申请涉及抗LOX和抗LOXL2抗体及其在纯化，诊断和治疗方法中的用途。抗体包括单克隆抗体，人源化抗体及其功能片段。抗LOX和抗LOXL2抗体可用于鉴定和治疗诸如纤维化病症，血管发生或预防从上皮细胞状态向间充质细胞状态的转变。

3. 发明公开

EP2543389A3 Methods and compositions inhibiting a lysyl oxidase (-like) protein for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis 审中-公开
标题翻译：方法和组合物用于治疗和纤维化的诊断，肿瘤侵袭，血管发生和转移
公开(公告)号：EP2543389A3
公开(公告)日：2013-04-24
申请号：EP12172214.4
申请日：2008-08-01
申请人： Gilead Biologics, Inc.
发明人： Smith, Victoria , Garcia, Carlos Aurelio , Biermann, Donna Hiroko Tokuoka , Ogg, Scott , Van Vlasselaer, Peter , Barry, Vivian E. , Marshall, Derek , Holzer, Alison Kay , Rodriguez, Hector , Oyasu, Miho , McCauley, Scott Alan
IPC分类号： A61K39/395 , A61P35/00 , C07K16/40
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12Q1/6886 , G01N33/57423 , G01N33/57438 , G01N33/57484 , G01N2333/90633
摘要： The present disclosure provides innovative methodology and related compositions and kits for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX and an inhibitor of a LOXL, or a synergistic combination of an inhibitor of LOX or LOXL combined with other therapeutic agents. Also provided are innovative methods for selecting agents that prevent or inhibit tumor invasion, angiogenesis and metastasis, by contacting cells that are in an epithelial-mesenchymal transition (EMT) state with a candidate agent and detecting a change in the EMT state of the cells. Methods and related compositions and kits for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using molecules or agents that specifically recognize processed forms of LOX or LOXL are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL. Such diseases or conditions include pathological cardiovascular conditions and diseases such as hypertension, hypertensive heart disease, myocardial infarction, atherosclerosis, and restenosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal scaring, keloid formation, and Alzheimer's disease.

4. 发明公开

EP2543389A2 Methods and compositions inhibiting a lysyl oxidase (-like) protein for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis 审中-公开
标题翻译：方法和组合物用于治疗和纤维化的诊断，肿瘤侵袭，血管发生和转移
公开(公告)号：EP2543389A2
公开(公告)日：2013-01-09
申请号：EP12172214.4
申请日：2008-08-01
申请人： Gilead Biologics, Inc.
发明人： Smith, Victoria , Garcia, Carlos Aurelio , Biermann, Donna Hiroko Tokuoka , Ogg, Scott , Van Vlasselaer, Peter , Barry, Vivian E. , Marshall, Derek , Holzer, Alison Kay , Rodriguez, Hector , Oyasu, Miho , McCauley, Scott Alan
IPC分类号： A61K39/395 , A61P35/00 , C07K16/40
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12Q1/6886 , G01N33/57423 , G01N33/57438 , G01N33/57484 , G01N2333/90633
摘要： The present disclosure provides innovative methodology and related compositions and kits for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX and an inhibitor of a LOXL, or a synergistic combination of an inhibitor of LOX or LOXL combined with other therapeutic agents. Also provided are innovative methods for selecting agents that prevent or inhibit tumor invasion, angiogenesis and metastasis, by contacting cells that are in an epithelial-mesenchymal transition (EMT) state with a candidate agent and detecting a change in the EMT state of the cells. Methods and related compositions and kits for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using molecules or agents that specifically recognize processed forms of LOX or LOXL are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL. Such diseases or conditions include pathological cardiovascular conditions and diseases such as hypertension, hypertensive heart disease, myocardial infarction, atherosclerosis, and restenosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal scaring, keloid formation, and Alzheimer's disease.
摘要翻译：本公开提供了创新的方法和相关的组合物和用于通过使用在赖氨酰氧化酶或赖氨酰氧化酶样蛋白质的加工形式抑制剂预防和治疗与异常细胞增殖，血管生成和纤维化，相关的各种疾病，在抑制剂LOX和试剂盒抑制剂的LOXL，或与其它治疗剂组合或LOX LOXL的抑制剂的协同组合的。这样提供了用于选择剂并防止或抑制肿瘤侵袭，血管生成和转移，通过接触细胞并在上皮 - 间质转化（EMT）的状态与候选试剂和检测在细胞中的EMT状态的变化的创新方法。因此，提供了用于诊断或监测与异常细胞增殖，血管生成和纤维化相关的各种疾病，通过使用分子或试剂没有特异性识别LOX或LOXL的加工形式的方法和相关组合物和试剂盒。所以提供了可用于预防或治疗与纤维化组合物，包含LOX或LOXL的抑制剂相关的各种疾病和病症的方法和相关组合物，医疗装置，系统和试剂盒。搜索的疾病或状况包括心血管病理状况和疾病：如高血压，高血压性心脏疾病，心肌梗死，动脉粥样硬化和再狭窄，肝纤维化，肾纤维化，肺纤维化，皮肤瘢痕，瘢痕形成，和阿尔茨海默氏病。

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