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1. 发明公开

EP2464736A1 CYTOSOLIC ISOBUTANOL PATHWAY LOCALIZATION FOR THE PRODUCTION OF ISOBUTANOL 审中-公开
标题翻译：路径位置胞浆异丁醇用于生产异丁醇
公开(公告)号：EP2464736A1
公开(公告)日：2012-06-20
申请号：EP10808746.1
申请日：2010-08-12
申请人： Gevo, Inc.
发明人： URANO, Jun , DUNDON, Catherine, Asleson , MEINHOLD, Peter , FELDMAN, Renny , ARISTIDOU, Aristos , HAWKINS, Andrew , BUELTER, Thomas , PETERS, Matthew , LIES, Doug , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , BERRY, Ruth , KALRA, Ishmeet
IPC分类号： C12P7/16
CPC分类号： C12N15/81 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12P7/16 , Y02E50/10
摘要： The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects of the invention, the recombinant microorganisms may comprise a cytosolically active isobutanol pathway enzymes. In some embodiments, the invention provides mutated, modified, and/or chimeric isobutanol pathway enzymes with cytosolic activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

2. 发明公开

EP2147111A1 ENGINEERED MICROORGANISMS FOR PRODUCING ISOPROPANOL 审中-公开
标题翻译：操纵微生物FOR异丙醇生产
公开(公告)号：EP2147111A1
公开(公告)日：2010-01-27
申请号：EP08746347.7
申请日：2008-04-18
申请人： Gevo, Inc.
发明人： SUBBIAN, Ezhilkani , MEINHOLD, Peter , BUELTER, Thomas , HAWKINS, Andrew C.
IPC分类号： C12P7/66 , C12N1/20
CPC分类号： C12P7/04
摘要： In an embodiment, there is disclosed a recombinant microbial host cell having each of the DNA molecules encoding a polypeptide or group of polypeptides that catalyze the conversion: (i) Acetyl-CoA to Acetate and CoA (conversion 1) (ii) Acetyl-CoA to Acetoacetyl-CoA and CoA (conversion 2) (iii) Acetoacetyl-CoA and Acetate to Acetoacetate and Acetyl-CoA (conversion 3.1) (iv) Acetoacetate to Acetone and CO2 (conversion 4) (v) Acetone and NAD(P)H and H+ to Isopropanol and NAD(P)+ (conversion 5) wherein the at least one DNA molecule is heterologous to the microbial host cell and wherein the microbial host cell produces isopropanol. In another embodiment, a method is disclosed for the production of isopropanol including providing a recombinant microbial host cell, the host cell of (i) with a fermentable carbon substrate in a fermentation medium under conditions whereby isopropanol is produced, and recovering the isopropanol.

3. 发明授权

EP2504422B1 METHODS OF INCREASING DIHYDROXY ACID DEHYDRATASE ACTIVITY TO IMPROVE PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS 有权
标题翻译：方法用于提高DIHYDROXIDSÄURE脱水酶活性为燃料，化学品和氨基酸提高了生产
公开(公告)号：EP2504422B1
公开(公告)日：2016-01-27
申请号：EP10833900.3
申请日：2010-11-24
申请人： GEVO, Inc.
发明人： URANO, Jun , DUNDON, Catherine Asleson , MEINHOLD, Peter , FELDMAN, Renny , ARISTIDOU, Aristos , HAWKINS, Andrew , BUELTER, Thomas , PETERS, Matthew , LIES, Doug , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , ALBERT, Lynne
IPC分类号： C12N1/00
CPC分类号： C12P7/16 , C07K14/395 , C12N9/88 , C12P13/02 , C12P13/06 , C12P13/08 , C12Y402/01009 , Y02E50/10

4. 发明公开

EP2121949A2 BUTANOL PRODUCTION BY METABOLICALLY ENGINEERED YEAST 有权
标题翻译：用代谢工程酵母生产丁醇
公开(公告)号：EP2121949A2
公开(公告)日：2009-11-25
申请号：EP07871733.7
申请日：2007-12-21
申请人： GEVO, Inc.
发明人： GUNAWARDENA, Uvini , MEINHOLD, Peter , PETERS, Matthew W. , URANO, Jun , FELDMAN, Reid M. Renny
IPC分类号： C12P7/16
CPC分类号： C12P7/16 , C12N9/0008 , C12N9/88 , C12N9/93 , Y02E50/10
摘要： There are disclosed metabolically-engineered yeast and methods of producing n-butanol. In an embodiment, metabolically-engineered yeast is capable of metabolizing a carbon source to produce n-butanol, at least one pathway produces increased cytosolic acetyl-CoA relative to cytosolic acetyl-CoA produced by a wild-type yeast, and at least one heterologous gene encodes and expresses at least one enzyme for a metabolic pathway capable of utilizing NADH to convert acetyl-CoA to n-butanol. In another embodiment, a method of producing n-butanol includes (a) providing metabolically-engineered yeast capable of metabolizing a carbon source to produce n-butanol, at least one pathway produces increased cytosolic acetyl-CoA relative to cytosolic acetyl-CoA produced by a wild-type yeast, and at least one heterologous gene encodes and expresses at least one enzyme for a metabolic pathway utilizing NADH to convert acetyl-CoA to n-butanol; and (b) culturing the yeast to produce n-butanol. Other embodiments are also disclosed.
摘要翻译：公开了代谢工程酵母和生产正丁醇的方法。在一个实施方案中，代谢工程化的酵母能够代谢碳源以产生正丁醇，相对于由野生型酵母产生的胞质乙酰-CoA，至少一种途径产生增加的胞质乙酰-CoA，并且至少一种异源基因编码和表达至少一种能够利用NADH将乙酰-CoA转化为正丁醇的代谢途径的酶。在另一个实施方案中，生产正丁醇的方法包括（a）提供能够代谢碳源以产生正丁醇的代谢工程化的酵母，至少一个途径产生相对于由胞质乙酰-CoA产生的胞质乙酰-CoA增加的胞质乙酰-CoA 野生型酵母，并且至少一种异源基因编码并表达至少一种用于利用NADH将乙酰-CoA转化为正丁醇的代谢途径的酶; 和（b）培养酵母以产生正丁醇。其他实施例也被公开。

5. 发明公开

EP2102327A2 ENGINEERED MICROORGANISMS FOR PRODUCING N-BUTANOL AND RELATED METHODS 审中-公开
标题翻译：操纵微生物FOR正丁醇和有关程序的制造
公开(公告)号：EP2102327A2
公开(公告)日：2009-09-23
申请号：EP07874335.8
申请日：2007-12-03
申请人： GEVO, Inc.
发明人： BUELTER, Thomas , HAWKINS, Andrew , KERSH, Kalib , MEINHOLD, Peter , PETERS, Matthew , SUBBIAN, Ezhilkani
IPC分类号： C12N1/21 , C12N15/09
CPC分类号： C12N15/52
摘要： A recombinant microorganism expressing at least a heterologous enzyme of an NADH-dependent pathway for conversion of a carbon source to n-butanol, metabolic intermediate and/or a derivative thereof and capable of producing n-butanol, a metabolic intermediate and/or a derivative thereof at a high yield and related methods. The recombinant microorganism engineered to inactivate a native enzyme of one or more pathways that compete with NADH-dependent heterologous pathway, and/or to balance the NADH-dependent heterologous pathway with respect to NADH production and consumption.

6. 发明授权

EP2235193B1 YEAST ORGANISM PRODUCING ISOBUTANOL AT A HIGH YIELD 有权
标题翻译：酵母生物收入丰富的生产异丁醇
公开(公告)号：EP2235193B1
公开(公告)日：2015-11-25
申请号：EP08867473.4
申请日：2008-12-23
申请人： GEVO, Inc.
发明人： FELDMAN, Reid, M. Renny , GUNAWARDENA, Uvini , URANO, Jun , MEINHOLD, Peter , ARISTIDOU, Aristos , DUNDON, Catherine, Asleson , SMITH, Christopher
IPC分类号： C12N9/88 , C12P7/16
CPC分类号： C12N9/88 , C12P7/16 , C12Y401/01001 , Y02E50/10

7. 发明公开

EP2504422A1 METHODS OF INCREASING DIHYDROXY ACID DEHYDRATASE ACTIVITY TO IMPROVE PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS 有权
标题翻译：方法用于提高DIHYDROXIDSÄURE脱水酶活性为燃料，化学品和氨基酸提高了生产
公开(公告)号：EP2504422A1
公开(公告)日：2012-10-03
申请号：EP10833900.3
申请日：2010-11-24
申请人： GEVO, Inc.
发明人： URANO, Jun , DUNDON, Catherine Asleson , MEINHOLD, Peter , FELDMAN, Renny , ARISTIDOU, Aristos , HAWKINS, Andrew , BUELTER, Thomas , PETERS, Matthew , LIES, Doug , PORTER-SCHEINMAN, Stephanie , SMITH, Christopher , ALBERT, Lynne
IPC分类号： C12N1/00
CPC分类号： C12P7/16 , C07K14/395 , C12N9/88 , C12P13/02 , C12P13/06 , C12P13/08 , C12Y402/01009 , Y02E50/10
摘要： The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

8. 发明公开

EP2446043A1 YEAST ORGANISMS FOR THE PRODUCTION OF ISOBUTANOL 审中-公开
标题翻译：酵母生物用于生产异丁醇
公开(公告)号：EP2446043A1
公开(公告)日：2012-05-02
申请号：EP10792562.0
申请日：2010-06-22
申请人： GEVO, Inc.
发明人： FELDMAN, Reid M. Renny , GUNAWARDENA, Uvini , URANO, Jun , MEINHOLD, Peter , ARISTIDOU, Aristos , DUNDON, Catherine Asleson , SMITH, Christopher
IPC分类号： C12P7/16
CPC分类号： C12P7/16 , C12N1/16 , Y02E50/10
摘要： The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

9. 发明公开

EP2215243A2 METHODS FOR THE ECONOMICAL PRODUCTION OF BIOFUEL PRECURSOR THAT IS ALSO A BIOFUEL FROM BIOMASS 审中-公开
标题翻译：生物燃料的先行者经济生产工程学谁也为生物燃料从生物质
公开(公告)号：EP2215243A2
公开(公告)日：2010-08-11
申请号：EP08844864.2
申请日：2008-10-31
申请人： GEVO, Inc.
发明人： HAWKINS, Andrew, C. , GLASSNER, David, A. , BUELTER, Thomas , WADE, James , MEINHOLD, Peter , PETERS, Matthew, W. , GRUBER, Patrick, R. , EVANKO, William, A , ARISTIDOU, Aristos, A. , LANDWEHR, Marco
IPC分类号： C12P7/16 , C12N1/21 , C12N15/52 , C10L1/02 , C12N9/02 , C12N9/10 , C12N9/88 , C12N15/53 , C12N15/54 , C12N15/60
CPC分类号： C12P7/16 , C07K14/245 , C10G1/04 , C10G2300/1014 , C10G2300/4025 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0006 , C12N9/0036 , C12N9/2414 , C12N9/2417 , C12N9/2428 , C12N9/2434 , C12P7/04 , C12P7/24 , C12P7/62 , C12Y106/01002 , C12Y302/01001 , C12Y302/01003 , Y02E50/10 , Y02E50/16 , Y02P30/20
摘要： Methods for producing a biofuel precursor are provided. Also provided are biocatalysts that convert a feedstock to a biofuel precursor.

10. 发明授权

EP2346998B1 ENGINEERED MICROORGANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS 有权转让
标题翻译：技术操纵微生物以能力生产目标化合物的厌氧条件的
公开(公告)号：EP2346998B1
公开(公告)日：2016-01-27
申请号：EP09824214.2
申请日：2009-11-02
申请人： GEVO, Inc. , California Institute of Technology
发明人： BUELTER, Thomas , MEINHOLD, Peter , FELDMAN, Reid M. Renny , ECKL, Eva , HAWKINS, Andrew , ARISTIDOU, Aristos , DUNDON, Catherine Asleson , LIES, Doug , BASTIAN, Sabine , ARNOLD, Frances , URANO, Jun
IPC分类号： C12N1/20 , C12N1/00 , C12P7/06
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0036 , Y02E50/10 , Y02E50/17

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