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1. 发明公开

EP1086214A1 MICRONEEDLE DEVICES AND METHODS OF MANUFACTURE AND USE THEREOF 有权
标题翻译：微针装置和方法生产同样
公开(公告)号：EP1086214A1
公开(公告)日：2001-03-28
申请号：EP99928580.2
申请日：1999-06-10
申请人： GEORGIA TECH RESEARCH CORPORATION
发明人： PRAUSNITZ, Mark, R. , ALLEN, Mark, G. , MCALLISTER, Devin, V. , HENRY, Sebastien , CROS, Florent, Paul, Marcel
IPC分类号： C12N15/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B81B2201/055
摘要： Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers. In a preferred embodiment, the microneedle devices permit drug delivery (or removal or sensing of body fluids) at clinically relevant rates across skin or other tissue barriers, without damage, pain, or irritation to the tissue. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

2. 发明授权

EP1187653B1 DEVICES FOR ENHANCED MICRONEEDLE PENETRATION OF BIOLOGICAL BARRIERS 无效
标题翻译：器件为微针叶生物皮肤层扩穿透
公开(公告)号：EP1187653B1
公开(公告)日：2010-03-31
申请号：EP00939538.5
申请日：2000-06-02
申请人： GEORGIA TECH RESEARCH CORPORATION
发明人： PRAUSNITZ, Mark, R. , ALLEN, Mark, G. , HENRY, Sebastien , MCALLISTER, Devin, V. , ACKLEY, Donald, E. , GUJRAL, Inder-Jeet , JACKSON, Thomas
IPC分类号： A61M37/00 , A61B10/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150274 , A61B5/150389 , A61B5/150412 , A61B5/150946 , A61B5/150969 , A61B5/150984 , A61B5/157 , A61B10/0045 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M5/1723 , A61M5/422 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B81B2201/055
摘要： Microneedle devices are provided for delivery of drugs across biological tissue and for controlled sampling of biological fluids in a minimally-invasive, painless, and convenient manner. The devices permit 1) drug delivery at clinically relevant rates across or into skin or other tissue barriers, and/or 2) in vivo sensing or withdrawal of biological fluids from the body, particularly from or through the skin or other tissue barriers. Drug delivery devices preferably include a plurality of hollow microneedles attached to or integrated into a substrate, and at least one reservoir (containing drug) selectably in communication with the microneedles, wherein the amount of drug to be delivered can be selectively altered. Withdrawal or sensing microneedle devices preferably include microneedles attached to or integrated into a substrate, and at least one collection chamber and/or sensor in communication with the microneedles.

3. 发明公开

EP1187653A2 DEVICES AND METHODS FOR ENHANCED MICRONEEDLE PENETRATION OF BIOLOGICAL BARRIERS 无效
标题翻译： VORRICHTUNGEN ZURVERGRÖSSERTENPENETRATION VON MIKRONADELN IN BIOLOGISCHEN HAUTSCHICHTEN
公开(公告)号：EP1187653A2
公开(公告)日：2002-03-20
申请号：EP00939538.5
申请日：2000-06-02
申请人： GEORGIA TECH RESEARCH CORPORATION
发明人： PRAUSNITZ, Mark, R. , ALLEN, Mark, G. , HENRY, Sebastien , MCALLISTER, Devin, V. , ACKLEY, Donald, E. , GUJRAL, Inder-Jeet , JACKSON, Thomas
IPC分类号： A61M37/00 , A61B10/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150274 , A61B5/150389 , A61B5/150412 , A61B5/150946 , A61B5/150969 , A61B5/150984 , A61B5/157 , A61B10/0045 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M5/1723 , A61M5/422 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B81B2201/055
摘要： Microneedle devices are provided for delivery of drugs across biological tissue and for controlled sampling of biological fluids in a minimally-invasive, painless, and convenient manner. The devices permit 1) drug delivery at clinically relevant rates across or into skin or other tissue barriers, and/or 2) in vivo sensing or withdrawal of biological fluids from the body, particularly from or through the skin or other tissue barriers. Drug delivery devices preferably include a plurality of hollow microneedles attached to or integrated into a substrate, and at least one reservoir (containing drug) selectably in communication with the microneedles, wherein the amount of drug to be delivered can be selectively altered. Withdrawal or sensing microneedle devices preferably include microneedles attached to or integrated into a substrate, and at least one collection chamber and/or sensor in communication with the microneedles.
摘要翻译：提供微针装置用于在生物组织之间递送药物，并以微创，无痛和方便的方式对生物流体进行受控取样。这些装置允许1）在临床上相关的速率穿过或进入皮肤或其他组织屏障的药物递送，和/或2）体内生物流体从身体，特别是从皮肤或通过皮肤感测或撤回或其他组织屏障。药物递送装置优选地包括附接到基底上或整合到基底中的多个中空微针，以及可选地与微针连通的至少一个储存器（含有药物），其中待递送的药物的量可以选择性地改变。提取或感测微针器件优选地包括附接到衬底或集成到衬底中的微针以及与微针通信的至少一个收集室和/或传感器。优选实施例还包括用于诱导生物流体（例如间隙液）的装置，以通过微针被吸入并进入收集室进行分析。还提供了微针装置和用于通过改善微针阵列和可变形的弹性生物屏障（例如人皮肤）的相互作用来增强分子穿过组织的方法。装置和方法的作用是：1）限制弹性，2）适应弹性，3）利用替代方式，为微针穿透生物屏障创造空穴，而不仅仅是将微针底物直接压到屏障表面或4）组合1）-3）。

4. 发明公开

EP3283158A1 DRUG DELIVERY DEVICES HAVING SEPARABLE MICRONEEDLES 有权转让
标题翻译：具有可分离微胶囊的药物递送装置
公开(公告)号：EP3283158A1
公开(公告)日：2018-02-21
申请号：EP16718962.0
申请日：2016-04-18
申请人： Georgia Tech Research Corporation
发明人： MCALLISTER, Devin V. , PRAUSNITZ, Mark R. , HENRY, Sebastien
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0007 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： The devices 400, 500 include microneedles 450, 550 that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release.

5. 发明公开

EP3134149A1 MICRONEEDLES AND METHODS OF MANUFACTURE THEREOF 审中-公开
标题翻译： MIKRONADELN UND VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP3134149A1
公开(公告)日：2017-03-01
申请号：EP15783359.1
申请日：2015-04-24
申请人： Georgia Tech Research Corporation
发明人： MCALLISTER, Devin , PRAUSNITZ, Mark , HENRY, Sebastien , GUO, Xin Dong
IPC分类号： A61M5/158
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053
摘要： A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.
摘要翻译：提供微针阵列用于将药物或其它物质施用到生物组织中。阵列包括基底; 从所述基底基板的一侧延伸的第一漏斗部分; 和两个或多个从第一漏斗部分延伸的固体微针，其中两个或更多个微针包含感兴趣的物质。还提供了制作微针阵列的方法。该方法可以包括提供具有两个或更多个空腔的无孔和透气模具，每个腔限定微针; 用包括感兴趣的物质和液体载体的流体材料填充空腔; 干燥流体材料以除去液体载体的至少一部分并形成包括感兴趣物质的多个微针，其中填充物在施加在模具的相对表面之间的压力差下进行。

6. 发明授权

EP1086214B1 MICRONEEDLE DEVICES AND METHODS OF THEIR MANUFACTURE 有权
标题翻译：微针装置和方法生产同样
公开(公告)号：EP1086214B1
公开(公告)日：2009-11-25
申请号：EP99928580.2
申请日：1999-06-10
申请人： GEORGIA TECH RESEARCH CORPORATION
发明人： PRAUSNITZ, Mark, R. , ALLEN, Mark, G. , MCALLISTER, Devin, V. , HENRY, Sebastien , CROS, Florent, Paul, Marcel
IPC分类号： C12N15/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B81B2201/055
摘要： Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers. In a preferred embodiment, the microneedle devices permit drug delivery (or removal or sensing of body fluids) at clinically relevant rates across skin or other tissue barriers, without damage, pain, or irritation to the tissue. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

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