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1. 发明公开

EP3571226A2 BONE-TARGETING ANTIBODIES 审中-公开
公开(公告)号：EP3571226A2
公开(公告)日：2019-11-27
申请号：EP18709437.0
申请日：2018-01-19
申请人： Genzyme Corporation
发明人： QIU, Huawei , PARK, Sunghae , STEFANO, James
IPC分类号： C07K16/22 , A61P19/08 , A61K39/00

2. 发明授权

EP3415633B1 ENGINEERED ANTI-TGF-BETA ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS 有权
公开(公告)号：EP3415633B1
公开(公告)日：2020-10-28
申请号：EP18181808.9
申请日：2014-03-11
申请人： Genzyme Corporation
发明人： WEI, Ronnie , MOULIN, Aaron , MATHIEU, Magali , PAN, Clark , PARK, Sunghae , QIU, Huawei
IPC分类号： C12P21/08 , A61K39/00 , C07K16/22 , C07K14/495 , A61K39/395

3. 发明公开

EP2971048A2 ENGINEERED ANTI-TGF-BETA ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS 有权转让
标题翻译：抗人TGF-β抗原反应蛋白抗体基因突变体
公开(公告)号：EP2971048A2
公开(公告)日：2016-01-20
申请号：EP14779440.8
申请日：2014-03-11
申请人： Genzyme Corporation
发明人： WEI, Ronnie , MOULIN, Aaron , MATHIEU, Magali , PAN, Clark , PARK, Sunghae , QIU, Huawei
IPC分类号： C12P21/08 , A61K39/00 , C07K16/22 , C07K14/495 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-β (TGFβ). TGFβ-isoform selective antibodies or antigen-binding fragments thereof may selectively bind human TGFβ1, compared to human TGFβ2 and human TGFβ3, or may selectively bind human TGFβ3, compared to human TGFβ1 and human TGFβ2. The design of the antibodies or antigen-binding fragments thereof is facilitated by a co-crystal structure of a recombinant Fab fragment of GC1008 bound to TGFβ2 and by another co-crystal structure of the scFv version of GC1008 bound to TGFβ1.
摘要翻译：将抗体或其抗原结合片段工程化以结合转化生长因子 - （TGF＆BGR）。与人TGF-β1和人TGFβb相比，与人TGF-β2和人TGFβb3相比，TGF-β1 - 异构选择性抗体或其抗原结合片段可以选择性地结合人TGF-β1;或者可以选择性地结合人TGFβb; 2。抗体或其抗原结合片段的设计通过与TGFβ2结合的GC1008的重组Fab片段和通过结合TGF-β1的scFv版本的GC1008的另一个共晶结构的共晶结构来促进。

4. 发明公开

EP2793948A1 THYROID STIMULATING HORMONE COMPOSITIONS 有权转让
标题翻译： SCHILDDRÜSENSTIMULIERENDEHORMONZUSAMMENSETZUNGEN
公开(公告)号：EP2793948A1
公开(公告)日：2014-10-29
申请号：EP12812433.6
申请日：2012-12-04
申请人： Genzyme Corporation
发明人： PAN, Clark , PARK, Sunghae , QIU, Huawei
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/48215 , A61K38/00 , A61K38/24 , A61K47/60
摘要： Described herein are compositions of Thyroid Stimulating Hormone (TSH), wherein at least one polyalkylene glycol polymer is attached to a carbohydrate site of the TSH. Also described are compositions of mutated Thyroid Stimulating Hormone (TSH) and at least one polyalkylene glycol polymer, wherein the mutated TSH comprises a TSH in which one or more amino acid residues has been substituted with cysteine residue, and the polyalkylene glycol polymer is attached to the mutated TSH at the site of the substituted cysteine residue. Pharmaceutical compositions comprising these TSH compositions and method of treating a thyroid condition in a patient in need thereof, by administering to the patient an effective amount of the pharmaceutical compositions are also described.
摘要翻译：本文描述的是甲状腺刺激激素（TSH）的组合物，其中至少一种聚亚烷基二醇聚合物连接到TSH的碳水化合物位点。还描述了突变的甲状腺刺激激素（TSH）和至少一种聚亚烷基二醇聚合物的组合物，其中突变的TSH包含其中一个或多个氨基酸残基被半胱氨酸残基取代的TSH，并且聚亚烷基二醇聚合物连接到在取代的半胱氨酸残基位点处的突变的TSH。还描述了包含这些TSH组合物的药物组合物和在有需要的患者中治疗甲状腺疾病的方法，通过向患者施用有效量的药物组合物。

5. 发明公开

EP4200019A1 FGFR3 ANTIBODIES AND METHODS OF USE 审中-实审
公开(公告)号：EP4200019A1
公开(公告)日：2023-06-28
申请号：EP21770357.8
申请日：2021-08-20
申请人： Genzyme Corporation
发明人： SABBAGH, Yves , CHEN, Yangde , BRONDYK, William , QIU, Huawei , PARK, Sunghae , WEI, Ronnie , QIU, Yu , ZHOU, Yanfeng , LEMOINE, Cendrine , CHO, HyunSuk
IPC分类号： A61P19/08 , C07K16/28

6. 发明公开

EP4110404A1 MODIFIED BINDING POLYPEPTIDES FOR OPTIMIZED DRUG CONJUGATION 审中-实审
公开(公告)号：EP4110404A1
公开(公告)日：2023-01-04
申请号：EP21713806.4
申请日：2021-02-26
申请人： GENZYME CORPORATION
发明人： BRUN, Marie-Priscille , DUFFIEUX, Francis , PARK, Sunghae , QIU, Huawei , ZHOU, Qun
IPC分类号： A61K47/68 , A61K47/60 , C07K16/00

7. 发明授权

EP2971048B1 ENGINEERED ANTI-TGF-BETA ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS 有权转让
公开(公告)号：EP2971048B1
公开(公告)日：2018-10-31
申请号：EP14779440.8
申请日：2014-03-11
申请人： Genzyme Corporation
发明人： WEI, Ronnie , MOULIN, Aaron , MATHIEU, Magali , PAN, Clark , PARK, Sunghae , QIU, Huawei
IPC分类号： C12P21/08 , A61K39/00 , C07K16/22 , C07K14/495 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-β (TGFβ). TGFβ-isoform selective antibodies or antigen-binding fragments thereof may selectively bind human TGFβ1, compared to human TGFβ2 and human TGFβ3, or may selectively bind human TGFβ3, compared to human TGFβ1 and human TGFβ2. The design of the antibodies or antigen-binding fragments thereof is facilitated by a co-crystal structure of a recombinant Fab fragment of GC1008 bound to TGFβ2 and by another co-crystal structure of the scFv version of GC1008 bound to TGFβ1.

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