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1. 发明公开

EP0203541A2 Therapeutic and prophylactic agents for peptic ulcer, compounds contained therein and processes for their production 失效
标题翻译：治疗和预防剂用于治疗消化性溃疡，所述化合物包含在其中的和它们的制备方法。
公开(公告)号：EP0203541A2
公开(公告)日：1986-12-03
申请号：EP86106993.8
申请日：1986-05-23
申请人： GREEN CROSS CORPORATION
发明人： Shiraga, Yusei , Fukaya, Chikara , Akira, Toshiaki , Iwai, Masakazu , Yokoyama, Kazumasa , Tabata, Mamoru , Fukui, Hiroshi , Tanaka, Shigeo , Iga, Yoshiro , Suyama, Tadakazu , Okano, Kanemichi
IPC分类号： C07C49/647 , C07C45/65 , C07C49/242 , C07C49/255 , A61K31/12 , C07C43/23 , C07C43/20
CPC分类号： C07C403/08 , C07C403/10 , C07C403/12 , C07C2601/16 , C07H15/18 , C07H15/203 , Y10S514/927
摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I):
wherein R, represents hydrogen or =0; R 2 represents hydrogen or-OR 5 ; R 3 represents hydrogen or-OR 6 ; R 4 represents -OR 7 in the case of the absence of double bond, R 5 , R 6 and R 7 each represents hydrogen or an organic residue;
X represents group (A):
or group (B):
wherein R 8 represents alkyl, and R 9 and R 10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R, and R 3 both represent hydrogen, R 2 represents -OR 5 , R 4 represents -OR 7 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a single bond, and when X represents group (B), then R 1 represents =0, R 2 and R 4 both represent hydrogen, R 3 represents-OR 6 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II):
wherein R 11 represents hydrogen or an organic residue, and R 12 , R 13 and R 14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.
摘要翻译：用于治疗消化性溃疡的治疗和预防剂，其含有通式（I）的化合物作为活性成分：（I）worin R1 darstellt氢或= O; R2 darstellt氢或-OR 5; R3 darstellt氢或-OR 6; R4 darstellt -OR7在不存在双键的情况下; R5，R6和R7各自darstellt氢或有机残基; X darstellt组（A）：= C = CH-COR8（A）或（B）组：（B）worin R8 darstellt烷基，和R9和R10各自darstellt氢或有机残基; 其条件做当X darstellt组（A）然后，氢R1和R3同时代表，R2 darstellt -OR 5; R4 darstellt OR7和的碳原子，其中X是连接和其中R 4连接的碳原子之间的键是单键，并且当X darstellt组（B），则R1 darstellt = O，R2 darstellt氢，R3 darstellt -OR 6和的碳原子，其中X是连接和其中R 4连接的碳原子之间的键是双键，或其药学上可接受的盐，或通式（II）的化合物：（ II）worin R11 darstellt氢或有机残基，并且R12，R13和R14各自darstellt到有机残基，或其药学上可接受的盐。通式饮食（I）和（II）可从包含在肉桂的热水提取物的化合物衍生的化合物。

2. 发明公开

EP0116911A1 Benzodiazepine derivatives 失效
标题翻译： Benzodiazepinderivate。
公开(公告)号：EP0116911A1
公开(公告)日：1984-08-29
申请号：EP84101345.1
申请日：1984-02-09
申请人： GREEN CROSS CORPORATION
发明人： Ueda, Yasuo , Shiraga, Yusei , Morimoto, Satoshi , Kagitani, Yoshio , Funakoshi, Satoshi , Suyama, Tadakazu
IPC分类号： C07D487/04 , A61K31/55
CPC分类号： C07D487/04
摘要： Benzodiazepine derivatives represented by the following general formula or pharmaceutically acceptable salts thereof:
wherein

R 1 is -COR 4 (R 4 is a carboxylic acid residue) or an alkyl or aralkyl group (these groups have a substituent selected from a carboxyl group, an amino group and a cyano group), R 2 is a lower alkyl group and R 3 is a hydrogen atom or a lower alkyl group.

The above compounds are low in toxicity and have antitumor activity.

3. 发明授权

EP0114685B1 Fibronectin complexes 失效
标题翻译：纤维素复合物
公开(公告)号：EP0114685B1
公开(公告)日：1990-04-04
申请号：EP84100587.9
申请日：1984-01-20
申请人： THE GREEN CROSS CORPORATION
发明人： Kagitani, Yoshio , Tanaka, Kenji , Ueda, Yasuo , Shiraga, Yusei , Nakajima, Tunetaka , Doi, Takuji , Ohmura, Takao , Funakoshi, Satoshi , Suyama, Tadakazu
IPC分类号： C07K15/00 , A61K37/04 , A61K47/00
CPC分类号： C07K14/78 , A61K38/00 , A61K47/6435 , Y10S530/829 , Y10S530/83

4. 发明公开

EP0114685A2 Fibronectin complexes 失效
标题翻译：纤连蛋白复合物
公开(公告)号：EP0114685A2
公开(公告)日：1984-08-01
申请号：EP84100587.9
申请日：1984-01-20
申请人： THE GREEN CROSS CORPORATION
发明人： Kagitani, Yoshio , Tanaka, Kenji , Ueda, Yasuo , Shiraga, Yusei , Nakajima, Tunetaka , Doi, Takuji , Ohmura, Takao , Funakoshi, Satoshi , Suyama, Tadakazu
IPC分类号： C07K15/00 , A61K37/04 , A61K47/00
CPC分类号： C07K14/78 , A61K38/00 , A61K47/6435 , Y10S530/829 , Y10S530/83
摘要： Described is a complex comprising a fibronectin and a physiologically active substance having a functional group capable of combining with a protein. If necessary, a protein cross-linking agent is used to link the physiologically active substance to the fibronectin.
Physiologically active substances, such as antibiotics, can preferentially or selectively be transported by means of such complexes to a morbid region, for example an injured tissue or an area showing neoplastic cell proliferation.
The complex fibronectin is administered in order to cure morbid regions.
摘要翻译：描述了包含纤连蛋白和具有能够与蛋白质结合的官能团的生理活性物质的复合物。如果需要，使用蛋白质交联剂将生理活性物质连接至纤连蛋白。诸如抗生素的生理活性物质可以优先地或选择性地通过这样的复合物运输至病态区域，例如受伤组织或显示肿瘤细胞增殖的区域。施用复合纤维连接蛋白以治愈病态区域。

5. 发明授权

EP0203541B1 Therapeutic and prophylactic agents for peptic ulcer, compounds contained therein and processes for their production 失效
标题翻译：用于胶囊的化学和预防剂，包含其的化合物及其生产方法
公开(公告)号：EP0203541B1
公开(公告)日：1991-02-27
申请号：EP86106993.8
申请日：1986-05-23
申请人： GREEN CROSS CORPORATION
发明人： Shiraga, Yusei , Fukaya, Chikara , Akira, Toshiaki , Iwai, Masakazu , Yokoyama, Kazumasa , Tabata, Mamoru , Fukui, Hiroshi , Tanaka, Shigeo , Iga, Yoshiro , Suyama, Tadakazu , Okano, Kanemichi
IPC分类号： C07C49/647 , C07C45/65 , C07C49/242 , C07C49/255 , A61K31/12 , C07C43/23 , C07C43/20
CPC分类号： C07C403/08 , C07C403/10 , C07C403/12 , C07C2601/16 , C07H15/18 , C07H15/203 , Y10S514/927

6. 发明公开

EP0203541A3 Therapeutic and prophylactic agents for peptic ulcer, compounds contained therein and processes for their production 失效
标题翻译：用于胶囊的治疗剂和预防剂，含有化合物及其生产方法
公开(公告)号：EP0203541A3
公开(公告)日：1987-03-18
申请号：EP86106993
申请日：1986-05-23
申请人： GREEN CROSS CORPORATION
发明人： Shiraga, Yusei , Fukaya, Chikara , Akira, Toshiaki , Iwai, Masakazu , Yokoyama, Kazumasa , Tabata, Mamoru , Fukui, Hiroshi , Tanaka, Shigeo , Iga, Yoshiro , Suyama, Tadakazu , Okano, Kanemichi
IPC分类号： C07C49/647 , C07C45/65 , C07C49/242 , C07C49/255 , A61K31/12 , C07C43/23 , C07C43/20
CPC分类号： C07C403/08 , C07C403/10 , C07C403/12 , C07C2601/16 , C07H15/18 , C07H15/203 , Y10S514/927
摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I):
wherein R, represents hydrogen or =0; R 2 represents hydrogen or-OR 5 ; R 3 represents hydrogen or-OR 6 ; R 4 represents -OR 7 in the case of the absence of double bond, R 5 , R 6 and R 7 each represents hydrogen or an organic residue;
X represents group (A):
or group (B):
wherein R 8 represents alkyl, and R 9 and R 10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R, and R 3 both represent hydrogen, R 2 represents -OR 5 , R 4 represents -OR 7 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a single bond, and when X represents group (B), then R 1 represents =0, R 2 and R 4 both represent hydrogen, R 3 represents-OR 6 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II):
wherein R 11 represents hydrogen or an organic residue, and R 12 , R 13 and R 14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.
摘要翻译：含有作为活性成分的通式（I）的化合物的消化性溃疡的治疗和预防剂：其中R1表示氢或= O; R2代表氢或-OR5; R3表示氢或-OR6; 在不存在双键的情况下，R 4表示-OR 7; R5，R6和R7各自表示氢或有机残基; X表示基团（A）：= C = CH-COR 8（A）或基团（B）：其中R 8表示烷基，R 9和R 10各自表示氢或有机残基; 条件是当X表示基团（A）时，则R 1和R 3都表示氢，R 2表示-OR 5; R4表示OR7，X所连接的碳原子和与R4连接的碳原子之间的键为单键，当X表示基团（B）时，R 1表示= O，R 2表示氢，R 3表示 -OR 6，X所连接的碳原子和R 4连接的碳原子之间的键是双键，或其药学上可接受的盐，或通式（II）的化合物： II）其中R11表示氢或有机残基，R12，R13和R14各自表示有机残基或其药学上可接受的盐。通式（I）和（II）的化合物可以衍生自肉桂热水提取物中所含的化合物。

7. 发明公开

EP0114685A3 Fibronectin complexes 失效
标题翻译：纤维素复合物
公开(公告)号：EP0114685A3
公开(公告)日：1987-02-04
申请号：EP84100587
申请日：1984-01-20
申请人： GREEN CROSS CORPORATION
发明人： Kagitani, Yoshio , Tanaka, Kenji , Ueda, Yasuo , Shiraga, Yusei , Nakajima, Tunetaka , Doi, Takuji , Ohmura, Takao , Funakoshi, Satoshi , Suyama, Tadakazu
IPC分类号： C07G07/00 , A61K37/04 , A61K47/00
CPC分类号： C07K14/78 , A61K38/00 , A61K47/6435 , Y10S530/829 , Y10S530/83
摘要： Described is a complex comprising a fibronectin and a physiologically active substance having a functional group capable of combining with a protein. If necessary, a protein cross-linking agent is used to link the physiologically active substance to the fibronectin. Physiologically active substances, such as antibiotics, can preferentially or selectively be transported by means of such complexes to a morbid region, for example an injured tissue or an area showing neoplastic cell proliferation. The complex fibronectin is administered in order to cure morbid regions.

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