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1. 发明公开

EP0265947A3 Dihydropyridine derivatives, process for their preparation, pharmaceutical composition and use 失效
标题翻译：二氢吡啶衍生物，其制备方法，药物组合物和用途
公开(公告)号：EP0265947A3
公开(公告)日：1988-10-26
申请号：EP87115905
申请日：1987-10-29
申请人： GREEN CROSS CORPORATION
发明人： Ashimori, Atsuyuki , Ono, Taizo Haitsu Higashiyama 22 , Inoue, Yoshihisa , Fukaya, Chikara , Yokoyama, Kazumasa
IPC分类号： C07D211/90 , C07D401/04 , C07D401/14 , C07D417/12 , C07D417/14 , A61K31/445
CPC分类号： C07D401/04 , C07D401/14 , C07D417/12 , C07D417/14
摘要： Dihydropyridine derivatives represented by formula (I): wherein Ri, R 2 , R 3 and R 6 , which may be the same or different, each represents an alkyl group, a cycloalkyl group or an alkoxyalkyl group; R 4 and R 5 , which may be the same or different, each represents a hydrogen atom, a halogen atom, a nitro group, a halogenated alkyl group, an alkylsulfonyl group, a halogenated alkoxy group, an alkylsulfinyl group, an alkyl group, a cycloalkyl group, an alkoxy group, a cyano group, an alkoxycarbonyl group or an alkylthio group (provided that R 4 and R 5 are not hydrogen atoms at the same time); X represents a vinylene group or an azomethine group; A and B are each an alkylene group or an alkenylene group; R 7 and Rs, which may be the same or different, each represents a hydrogen atom, an alkyl group, an alkenyl group, an aralkyl group, an aryl group, or a heterocyclic group (provided that R 7 and R 8 may combine with the adjacent nitrogen atom to form a hetero ring), and acid addition salts of the dihydropyridine derivative of formula (I), and use of the same in the preparation of a medicament for the treatment of vascular disorders.

2. 发明公开

EP0265947A2 Dihydropyridine derivatives, process for their preparation, pharmaceutical composition and use 失效
标题翻译：二氢吡啶衍生物，它们的制备方法，药物组合物和用途。
公开(公告)号：EP0265947A2
公开(公告)日：1988-05-04
申请号：EP87115905.9
申请日：1987-10-29
申请人： GREEN CROSS CORPORATION
发明人： Ashimori, Atsuyuki , Ono, Taizo Haitsu Higashiyama 22 , Inoue, Yoshihisa , Fukaya, Chikara , Yokoyama, Kazumasa
IPC分类号： C07D211/90 , C07D401/04 , C07D401/14 , C07D417/12 , C07D417/14 , A61K31/445
CPC分类号： C07D401/04 , C07D401/14 , C07D417/12 , C07D417/14
摘要： Dihydropyridine derivatives represented by formula (I):
wherein Ri, R 2 , R 3 and R 6 , which may be the same or different, each represents an alkyl group, a cycloalkyl group or an alkoxyalkyl group; R 4 and R 5 , which may be the same or different, each represents a hydrogen atom, a halogen atom, a nitro group, a halogenated alkyl group, an alkylsulfonyl group, a halogenated alkoxy group, an alkylsulfinyl group, an alkyl group, a cycloalkyl group, an alkoxy group, a cyano group, an alkoxycarbonyl group or an alkylthio group (provided that R 4 and R 5 are not hydrogen atoms at the same time); X represents a vinylene group or an azomethine group; A and B are each an alkylene group or an alkenylene group; R 7 and Rs, which may be the same or different, each represents a hydrogen atom, an alkyl group, an alkenyl group, an aralkyl group, an aryl group, or a heterocyclic group (provided that R 7 and R 8 may combine with the adjacent nitrogen atom to form a hetero ring), and acid addition salts of the dihydropyridine derivative of formula (I), and use of the same in the preparation of a medicament for the treatment of vascular disorders.
摘要翻译：由式（I）表示的二氢吡啶衍生物： worin R1，R2，R3和R6，其可以是相同或不同的，烷基，环烷基或烷氧基，在组中的每个darstellt; R4和R5可以相同或不同，各自darstellt氢原子，卤原子，硝基，卤代烷基，烷基磺酰基在基，卤代烷氧基，以烷基亚磺酰基烷基氧基，环组，以烷氧基，氰基，烷氧基羰基或在烷基硫基（提供确实R4和R5不同时为氢原子）; X表示在甲亚胺基团的亚乙烯基或; A和B各自为亚烷基或亚烯基的; R7和R8，其可以是相同或不同的，各自为芳烷基基团darstellt氢原子，烷基的氮烯基于芳基，或杂环基（条件没有R7和R8可与相邻的结合原子结合形成杂环），和式（I的二氢吡啶衍生物的酸加成盐），和在制备用于治疗血管疾病的治疗中使用相同的。

3. 发明公开

EP0257616A3 Dihydropyridine derivates and pharmaceutical composition thereof 失效
标题翻译：二氢吡啶衍生物及其药物组合物
公开(公告)号：EP0257616A3
公开(公告)日：1989-01-11
申请号：EP87112302.2
申请日：1987-08-25
申请人： THE GREEN CROSS CORPORATION
发明人： Ashimori, Atsuyuki , Ono, Taizo / 22 Heights Higashiyama, Nishi-iru , Inoue, Yoshihisa , Fukaya, Chikara , Yokoyama, Kazumasa
IPC分类号： C07D211/90 , C07D401/04 , A61K31/445 , C07C215/76 , C07C219/34 , C07D295/08
CPC分类号： C07D401/04 , C07D211/90
摘要： The object of the present invention is to provide dihydropyridine derivatives and acid addition salts thereof which have still more excellent pharmacological activities.

4. 发明公开

EP0257616A2 Dihydropyridine derivates and pharmaceutical composition thereof 失效
标题翻译： Dihydropyridinderivate和deren pharmazeutische Zusammensetzungen。
公开(公告)号：EP0257616A2
公开(公告)日：1988-03-02
申请号：EP87112302.2
申请日：1987-08-25
申请人： THE GREEN CROSS CORPORATION
发明人： Ashimori, Atsuyuki , Ono, Taizo / 22 Heights Higashiyama, Nishi-iru , Inoue, Yoshihisa , Fukaya, Chikara , Yokoyama, Kazumasa
IPC分类号： C07D211/90 , C07D401/04 , A61K31/445 , C07C215/76 , C07C219/34 , C07D295/08
CPC分类号： C07D401/04 , C07D211/90
摘要： The object of the present invention is to provide dihydropyridine derivatives and acid addition salts thereof which have still more excellent pharmacological activities.
摘要翻译：本发明的目的是提供具有更优异的药理活性的二氢吡啶衍生物及其酸加成盐。

5. 发明公开

EP0216542A1 Dihydropyridine derivatives 失效
标题翻译： Dihydropyridinderivate。
公开(公告)号：EP0216542A1
公开(公告)日：1987-04-01
申请号：EP86306770.8
申请日：1986-09-02
申请人： THE GREEN CROSS CORPORATION
发明人： Fukaya, Chikara , Ashimori, Atsuyuki , Ono, Taizo Haitsu Higashiyama 22 , Yokoyama, Kazamasa
IPC分类号： C07D401/04 , C07D401/14 , A61K31/44
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14
摘要： A dihydropyridine derivative has the preferred formula
wherein R', denotes methyl, chlorine, bromine, fluorine, trifluoromethyl, nitro, cyano or methoxy, R 7 denotes benzyl; and the dihydropyridine links to the 2-, 3-, or 4-position of the pyridine.
The compound has an activity as a Ca-antagonist, and is useful for treating vascular disorders such as coronary artery disease, celebral artery disease, and hypertension.
摘要翻译：二氢吡啶衍生物具有优选的式... CHEM>其中R min 1表示甲基，氯，溴，氟，三氟甲基，硝基，氰基或甲氧基，R 7表示苄基; 并且二氢吡啶与吡啶的2-，3-或4-位相连。化合物具有作为Ca拮抗剂的活性，可用于治疗血管疾病如冠状动脉疾病，冠状动脉疾病和高血压。

6. 发明授权

EP0257616B1 Dihydropyridine derivates and pharmaceutical composition thereof 失效
标题翻译：二氢吡啶衍生物及其药物组合物
公开(公告)号：EP0257616B1
公开(公告)日：1992-10-28
申请号：EP87112302.2
申请日：1987-08-25
申请人： THE GREEN CROSS CORPORATION
发明人： Ashimori, Atsuyuki , Ono, Taizo / 22 Heights Higashiyama, Nishi-iru , Inoue, Yoshihisa , Fukaya, Chikara , Yokoyama, Kazumasa
IPC分类号： C07D211/90 , C07D401/04 , A61K31/445 , C07C215/76 , C07C219/34 , C07D295/08
CPC分类号： C07D401/04 , C07D211/90

7. 发明授权

EP0216542B1 Dihydropyridine derivatives 失效
标题翻译：二氢吡啶衍生物
公开(公告)号：EP0216542B1
公开(公告)日：1991-12-11
申请号：EP86306770.8
申请日：1986-09-02
申请人： THE GREEN CROSS CORPORATION
发明人： Fukaya, Chikara , Ashimori, Atsuyuki , Ono, Taizo Haitsu Higashiyama 22 , Yokoyama, Kazamasa
IPC分类号： C07D401/04 , C07D401/14 , A61K31/44
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14

8. 发明授权

EP0265947B1 Dihydropyridine derivatives, process for their preparation, pharmaceutical composition and use 失效
标题翻译：二氢吡啶衍生物，其制备方法，药物组合物和用途
公开(公告)号：EP0265947B1
公开(公告)日：1990-10-17
申请号：EP87115905.9
申请日：1987-10-29
申请人： GREEN CROSS CORPORATION
发明人： Ashimori, Atsuyuki , Ono, Taizo Haitsu Higashiyama 22 , Inoue, Yoshihisa , Fukaya, Chikara , Yokoyama, Kazumasa
IPC分类号： C07D211/90 , C07D401/04 , C07D401/14 , C07D417/12 , C07D417/14 , A61K31/445
CPC分类号： C07D401/04 , C07D401/14 , C07D417/12 , C07D417/14

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