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2. 发明公开

EP1624050A2 Multiply-substituted protease variants 有权
标题翻译： Mehrfach取代蛋白酶变体
公开(公告)号：EP1624050A2
公开(公告)日：2006-02-08
申请号：EP05015947.4
申请日：1998-10-23
申请人： GENENCOR INTERNATIONAL, INC. , The Procter and Gamble Company
发明人： Schellenberger, Volker , Kellis, James T, jr., Genencor International, Inc , Paech, Christian , Nadherny, Joanne , Naki, Donald P., c/o Genencor International, Inc. , Poulose, Ayrookaran J. , Collier, Katherine D., c/o Genencor Int., Inc. , Caldwell, Robert M., c/o Genencor Int., Inc. , Baeck, André C.
IPC分类号： C11D3/386 , C12N9/54
CPC分类号： C12N9/54 , A23G4/123 , A23K20/189 , A61K8/66 , A61K2800/86 , A61Q11/00 , A61Q19/00 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/3907 , C11D3/3945 , C12Y304/00 , C12Y304/21062
摘要： Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue corresponds to position 103 in combination with one or more of the following substitutions at residue positions corresponding to positions 4, 1, 3, 8, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274 and 275 of Bacillus amyloliquefaciens subtilisin, wherein when a substitution at a position corresponding to residue position 103 is combined with a substitution at a position corresponding to residue position 76, there is also a substitution at one or more residue positions other than residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265 or 274 of Bacillus amyloliquefaciens subtilisin.
摘要翻译：公开了衍生自天然存在或重组非人蛋白酶的DNA序列的新型蛋白酶变体。一般来说，变体蛋白酶通过体外修饰编码天然存在或重组蛋白酶的前体DNA序列获得，以产生前体蛋白酶的氨基酸序列中的多个氨基酸残基的取代。这种变体蛋白酶具有与前体蛋白酶不同的性质，例如改变的洗涤性能。取代的氨基酸残基对应于位置103，与对应于位置4,3,38,10,12,13,16,17,18,19,20,21的残基位置的一个或多个以下取代相结合，22,24,27,33,37,38,42,43,48,55,57,58,61,62,68,72,75,76,77,78,79,86,87,89,97 ，98,99,101,102,104,106,107,109,111,114,116,117,119,121,123,126,128,130,131,133,134,137,140,141,142 ，146,147,158,159,160,166,167,170,173,174,177,181,182,183,184,185,188,192,194,198,203,204,205,206,209 ，210,211,212,213,214,215,216,217,218,222,224,227,228,230,232,236,237,238,240,242,243,244,245,246,247 ，248,249,251,252,253,254,255,256,257,258,259,260,261,262,263,265,268,269,270,271,272,274和275解淀粉芽孢杆菌枯草杆菌蛋白酶其中当在对应于残基位置103的位置处的取代与对应于res的位置处的取代相结合时空位位置76，除了对应于位置27,99,101,104,107,109,123,128,166,204,206,210,216,217,29的残余位置之外的一个或多个残留位置处还有替代。 218,222,260,265或274的解淀粉芽孢杆菌枯草杆菌蛋白酶。

4. 发明公开

EP1624050A3 Multiply-substituted protease variants 有权
标题翻译：多取代蛋白酶变体
公开(公告)号：EP1624050A3
公开(公告)日：2006-06-21
申请号：EP05015947.4
申请日：1998-10-23
申请人： GENENCOR INTERNATIONAL, INC. , The Procter and Gamble Company
发明人： Schellenberger, Volker , Kellis, James T, jr., Genencor International, Inc , Paech, Christian , Nadherny, Joanne , Naki, Donald P., c/o Genencor International, Inc. , Poulose, Ayrookaran J. , Collier, Katherine D., c/o Genencor Int., Inc. , Caldwell, Robert M., c/o Genencor Int., Inc. , Baeck, André C.
IPC分类号： C11D3/386 , C12N9/54
CPC分类号： C12N9/54 , A23G4/123 , A23K20/189 , A61K8/66 , A61K2800/86 , A61Q11/00 , A61Q19/00 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/3907 , C11D3/3945 , C12Y304/00 , C12Y304/21062
摘要： Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue corresponds to position 103 in combination with one or more of the following substitutions at residue positions corresponding to positions 4, 1, 3, 8, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274 and 275 of Bacillus amyloliquefaciens subtilisin, wherein when a substitution at a position corresponding to residue position 103 is combined with a substitution at a position corresponding to residue position 76, there is also a substitution at one or more residue positions other than residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265 or 274 of Bacillus amyloliquefaciens subtilisin.

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