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1. 发明授权

EP2955516B1 VITAMIN D MEASUREMENT METHOD AND MEASUREMENT KIT 有权
标题翻译：维生素D测量方法和测量工具包
公开(公告)号：EP2955516B1
公开(公告)日：2017-06-28
申请号：EP14749104.7
申请日：2014-01-20
申请人： Fujirebio Inc.
发明人： UCHIDA, Yoshiaki , SAKYU, Takuya , OMI, Kazuya
IPC分类号： G01N33/48
CPC分类号： G01N33/82 , Y10T436/203332

2. 发明公开

EP2450454A1 METHOD FOR EVALUATION OF CULTURED CELLS, AND METHOD FOR SCREENING OF BIOMARKER 审中-公开
标题翻译：用于评估培养细胞方法和方法用于研究的生物标志物
公开(公告)号：EP2450454A1
公开(公告)日：2012-05-09
申请号：EP10794075.1
申请日：2010-06-25
申请人： FUJIREBIO INC.
发明人： HOTTA, Yoshiyuki , OMI, Kazuya , OKA, Asako
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6883 , C12Q1/6881 , C12Q1/6886 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178
摘要： Disclosed are novel means by which evaluation of cultured cells and screening of biomarkers can be attained without consuming the cultured cells. A method for evaluating cultured cells according to the present invention comprises culturing cells in a serum-free medium, and measuring at least one nucleic acid released from the cells into the culture medium. A method for screening of a biomarker according to the present invention comprises culturing cells in a serum-free medium, and measuring a nucleic acid(s) released from the cells into the culture medium. Nucleic acid used as an indicator is e.g. microRNA.
摘要翻译：公开的是，通过该培养的细胞和生物标志物的筛选评价，可以不消耗培养细胞来实现新颖的装置。一种用于评估gemäß到本发明的培养细胞的方法包括培养在无血清培养基中的细胞，并测量至少一个核酸从细胞中释放到培养基中。一种用于生物标记gemäß到本发明的筛选方法包括培养在无血清培养基中的细胞，并测量从细胞中释放到培养基中的核酸（或多个）。使用的核酸作为指示剂例如是微小RNA。

3. 发明公开

EP2669296A1 ANTI-IL28B ANTIBODY AND METHOD FOR ASSAYING IL28B USING SAME 审中-公开
标题翻译： ANTI-IL28B-ANTIKÖRPERUND VERFAHRENFÜREINEN TEST AUF IL28B DAMIT
公开(公告)号：EP2669296A1
公开(公告)日：2013-12-04
申请号：EP12739012.8
申请日：2012-01-17
申请人： FUJIREBIO INC.
发明人： FUJII, Nobuyuki , SHIRAKAWA, Takashi , OMI, Kazuya
IPC分类号： C07K16/24 , G01N33/53 , G01N33/543 , G01N33/576 , G01N33/577
CPC分类号： G01N33/6869 , C07K16/244 , C07K2317/33 , C07K2317/34 , G01N33/5767 , G01N2800/52
摘要： Disclosed is a novel antibody which can recognize interleukin 28B (IL28B) distinctly from interleukin 28A (IL28A). Although there are no more than 7 residues difference between IL28A and IL28B in a secreted form, the antibody according to the present invention can distinguish IL28B from IL28A, and enables specific detection and quantification of IL28B. IL28B is expected to be a marker for predicting beforehand whether HCV infection can be treated with pegylated interferon + ribavirin combination therapy or not. The present invention makes it possible to measure IL28B by simple, rapid and low-cost immunoassay, and thus can contribute to clinical practice of the therapy of HCV infections.
摘要翻译：公开了一种能明确识别白介素28A（IL28A）的白细胞介素28B（IL28B）的新型抗体。尽管分泌型IL28A和IL28B之间的差异不超过7个，但根据本发明的抗体可以区分IL28B与IL28A，并能够特异性检测和定量IL28B。 IL28B预计是预先预测HCV感染是否可以用聚乙二醇化干扰素+利巴韦林联合疗法治疗的标志物。本发明使得可以通过简单，快速和低成本的免疫测定来测量IL28B，从而可以有助于HCV感染治疗的临床实践。

4. 发明授权

EP2759551B1 ANTIBODIES BINDING TO AN AFFINITY COMPLEX COMPRISING 25OH VITAMIN D2 OR D3 AND AN ANTIBODY THERETO 有权
公开(公告)号：EP2759551B1
公开(公告)日：2019-05-22
申请号：EP12833103.0
申请日：2012-07-04
申请人： Fujirebio Inc.
发明人： OMI, Kazuya , ANDO, Tsuyoshi , UCHIDA, Yoshiaki , GOISHI, Katsutoshi , OKA, Asako , SHIRAKAWA, Takashi , SAKYU, Takuya
IPC分类号： C07K16/42 , C07K16/26 , C07K16/44 , G01N33/53 , G01N33/531 , G01N33/543

5. 发明公开

EP2759551A1 ANTIBODY AGAINST AFFINITY COMPLEX 有权
标题翻译： ANTIKÖRPERGEGENAFFINITÄTSKOMPLEX
公开(公告)号：EP2759551A1
公开(公告)日：2014-07-30
申请号：EP12833103.0
申请日：2012-07-04
申请人： Fujirebio Inc.
发明人： OMI, Kazuya , ANDO, Tsuyoshi , UCHIDA, Yoshiaki , GOISHI, Katsutoshi , OKA, Asako , SHIRAKAWA, Takashi , SAKYU, Takuya
IPC分类号： C07K16/42 , C07K16/26 , C07K16/44 , G01N33/53 , G01N33/531
CPC分类号： G01N33/54306 , C07K16/26 , C07K16/44 , C07K2317/24 , C07K2317/32 , C07K2317/92 , G01N33/531 , G01N33/743 , G01N33/78 , G01N33/82
摘要： The present invention provides a means and a method for specifically measuring a substance such as a small substance with high sensitivity by a sandwich method. Specifically, the present invention provides an antibody capable of specifically binding to an affinity complex and a method of measuring of the affinity complex comprising measuring the affinity complex using the antibody capable of specifically binding to the affinity complex. The antibody of the present invention may be a full-length antibody. The antibody of the present invention may also have a region derived from an immunoglobulin from an animal having an ability of gene conversion (e.g., a complementarity-determining region, a framework region, or a variable region). Examples of at least one factor that constitutes the affinity complex include a small substance or a protein (e.g., antibody).
摘要翻译：本发明提供了通过夹心法特异性地测量诸如具有高灵敏度的小物质的物质的方法和方法。具体地，本发明提供能够特异性结合亲和复合物的抗体和测定亲和络合物的方法，包括使用能够特异性结合亲和复合物的抗体测定亲和复合物。本发明的抗体可以是全长抗体。本发明的抗体还可以具有源自具有基因转化能力（例如互补决定区，框架区或可变区）的动物的免疫球蛋白的区域。构成亲和络合物的至少一个因子的实例包括小物质或蛋白质（例如抗体）。

6. 发明公开

EP2592419A1 METHOD FOR DETECTION OF INFECTION WITH HUMAN CYTOMEGALOVIRUS 审中-公开
标题翻译： VERFAHREN ZUM NACHWEIS EINER INFEKTION MIT DEM MENSCHLICHEN ZYTOMEGALOVIRUS
公开(公告)号：EP2592419A1
公开(公告)日：2013-05-15
申请号：EP11803572.4
申请日：2011-07-05
申请人： FUJIREBIO INC.
发明人： FUJII, Nobuyuki , HONDA, Hideo , UCHIDA, Yoshiaki , OMI, Kazuya
IPC分类号： G01N33/569 , C07K14/045 , G01N33/53
CPC分类号： G01N33/6854 , C07K14/005 , C12N2710/16122 , G01N33/56994 , G01N2333/045 , G01N2469/20
摘要： A novel means by which HCMV infection can be detected with a high sensitivity and whose practicality is high is disclosed. The present inventors synthesized as many as 15 kinds of HCMV proteins in their full length forms, and intensively studied their reactivities with sera from HCMV-infected patients to find that all the infected patients can be detected without fail when using the pp28 full length protein as an antigen. The pp28 full length protein can be synthesized and purified as a recombinant protein in a large scale by using Escherichia coli, and can be commercially used as an antigen for HCMV tests.
摘要翻译：公开了一种以高灵敏度检测HCMV感染并且其实用性高的新颖手段。本发明人以其全长形式合成多达15种HCMV蛋白，并且深入研究了与来自HCMV感染患者的血清的反应性，发现当使用pp28全长蛋白作为所有感染患者时，可以检测到所有感染的患者抗原。通过使用大肠杆菌可以大量合成和纯化pp28全长蛋白质作为重组蛋白，并且可以商业上用作HCMV测试的抗原。

7. 发明公开

EP2955516A1 VITAMIN D MEASUREMENT METHOD AND MEASUREMENT KIT 有权
标题翻译：维生素D和测定方法的测定试剂盒
公开(公告)号：EP2955516A1
公开(公告)日：2015-12-16
申请号：EP14749104.7
申请日：2014-01-20
申请人： Fujirebio Inc.
发明人： UCHIDA, Yoshiaki , SAKYU, Takuya , OMI, Kazuya
IPC分类号： G01N33/48
CPC分类号： G01N33/82 , Y10T436/203332
摘要： The present invention provides a method of measuring a vitamin D.
Specifically, the present invention provides a method of measuring a vitamin D, comprising:
(1) treating a sample with a surfactant having a steroid skeleton; and
(2) detecting the vitamin D in the treated sample.
The present invention also provides a kit for measuring a vitamin D, comprising:
(1) a surfactant having a steroid skeleton; and
(2) an affinity substance for a vitamin D and/or a vitamin D standard.
Examples of the surfactant having the steroid skeleton may include a bile acid or a derivative thereof or a salt thereof.

8. 发明公开

EP2524964A1 ANTIBODY SPECIFIC TO ACTIVATED EGFR 审中-公开
标题翻译： FÜRDEN AKTIVIERTEN EGFR SPEZIFISCHERANTIKÖRPER
公开(公告)号：EP2524964A1
公开(公告)日：2012-11-21
申请号：EP11732843.5
申请日：2011-01-07
申请人： Fujirebio Inc.
发明人： ISE, Nobuyuki , OMI, Kazuya
IPC分类号： C12N15/09 , C07K16/28 , G01N33/574 , C12P21/08
CPC分类号： C07K16/2863 , G01N2333/71
摘要： Disclosed is a means for accurately measuring activated EGFR regardless of whether phosphorylation has occurred or not. The antibody or antigen-binding fragment thereof according to the present invention can bind to activated EGFR regardless of whether the activated EGFR is in a phosphorylated form or in a nonphosphorylated form. By carrying out an immunoassay using the antibody or antigen-binding fragment thereof, activated EGFR in a sample can be measured more accurately than by conventional methods. Abnormal activation of EGFR is responsible for the onset of cancer, and is regarded as a therapeutic target. Therefore, the antibody or antigen-binding fragment thereof according to the present invention is also useful for detection of cancers, in particular, cancers to which a molecular target drug(s) whose target is EGFR is(are) to be administered.
摘要翻译：公开了用于精确测量活化的EGFR的方法，而不管是否发生磷酸化。根据本发明的抗体或其抗原结合片段可以结合活化的EGFR，而不管活化的EGFR是磷酸化形式还是非磷酸化形式。通过使用抗体或其抗原结合片段进行免疫测定，可以比常规方法更准确地测量样品中的活化EGFR。 EGFR的异常激活是癌症的发病的原因，被认为是治疗靶点。因此，根据本发明的抗体或其抗原结合片段也可用于检测癌症，特别是其靶标为EGFR的分子靶向药物被施用的癌症。

9. 发明公开

EP2487250A1 METHOD FOR DETECTING FUSION GENE 审中-公开
标题翻译： VERFAHREN ZUR ERKENNUNG VON FUSIONSGENEN
公开(公告)号：EP2487250A1
公开(公告)日：2012-08-15
申请号：EP10821891.8
申请日：2010-09-28
申请人： FUJIREBIO INC.
发明人： OMI, Kazuya
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/16
摘要： Disclosed is a means which enables simple and rapid detection of the presence of any fusion genes including even unknown fusion genes. The method for measuring a fusion gene(s) according to the present invention is applied to a sample separated from a living body, and comprises: measuring expressions of a 5'-region and a 3'-region of one of the component genes of the fusion gene(s) which may be present in the living body, wherein said 5'-region is upstream of and said 3'-region is downstream of a fusion point in said one of the component genes; and comparing the expression of the 5'-region with the expression of the 3'-region. The fusion gene to be measured is e.g. a fusion gene between ALK gene and another gene.
摘要翻译：公开了一种能够简单快速地检测包括甚至未知的融合基因的融合基因的存在的方法。将根据本发明的融合基因的测定方法应用于从活体分离的样品，并且包括：测定其中一个成分基因的5'区和3'区的表达可能存在于生物体中的融合基因，其中所述5'区域位于所述一个组分基因中的融合点的上游，所述3'-区域是融合点的下游; 并比较5'-区的表达与3'区的表达。要测量的融合基因是例如。 ALK基因与另一基因之间的融合基因。

10. 发明公开

EP2957907A1 METHOD FOR DETECTING c-MET GENE-AMPLIFIED CELL 审中-公开
标题翻译： VERFAHREN ZUR ERKENNUNG EINER C-MET-GEN-VERSTÄRKTENZELLE
公开(公告)号：EP2957907A1
公开(公告)日：2015-12-23
申请号：EP14751191.9
申请日：2014-01-21
申请人： Fujirebio Inc.
发明人： ISE, Nobuyuki , OMI, Kazuya , HIGASHIYAMA, Shigeki , TAKEMORI, Nobuaki
IPC分类号： G01N33/48 , C07K16/28 , C12Q1/48 , G01N27/62 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57492 , C07K16/2863 , C07K16/32 , G01N33/57423 , G01N2333/71
摘要： The present invention provides a method for detecting a c-MET gene amplification cell. Specifically, the present invention provides a method for detecting a c-MET gene amplification cell, comprising measuring a soluble c-MET in a sample utilizing a region specific for the soluble c-MET, wherein the soluble c-MET is formed by cleavage between the lysine residue (K) and the valine residue (V) in the partial region GKVI (SEQ ID NO:2) in a c-MET extracellular domain.
摘要翻译：本发明提供了检测c-MET基因扩增细胞的方法。具体地，本发明提供了一种检测c-MET基因扩增细胞的方法，其包括使用对可溶性c-MET特异性的区域测量样品中的可溶性c-MET，其中可溶性c-MET由 c-MET细胞外结构域中部分区域GKVI（SEQ ID NO：2）中的赖氨酸残基（K）和缬氨酸残基（V）。

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